Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of NOP2 mRNA] | CTD | PMID:31150632 | (-)-alpha-phellandrene | decreases expression | ISO | NOP2 (Homo sapiens) | 6480464 | alpha phellandrene results in decreased expression of NOP2 mRNA | CTD | PMID:25075043 | 1,2-dimethylhydrazine | multiple interactions | ISO | Nop2 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of NOP2 mRNA | CTD | PMID:22206623 | 1-chloro-2,4-dinitrobenzene | affects binding | ISO | NOP2 (Homo sapiens) | 6480464 | Dinitrochlorobenzene binds to NOP2 protein | CTD | PMID:32991956 | 17alpha-ethynylestradiol | increases expression | ISO | Nop2 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of NOL1 mRNA | CTD | PMID:17942748 | 17beta-estradiol | increases expression | ISO | NOP2 (Homo sapiens) | 6480464 | Estradiol results in increased expression of NOP2 mRNA | CTD | PMID:23019147 and PMID:31614463 | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | Nop2 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:30294300 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | NOP2 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NOP2 mRNA | CTD | PMID:22903824 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Nop2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of NOL1 mRNA | CTD | PMID:21570461 | 3-chloropropane-1,2-diol | increases expression | EXP | | 6480464 | alpha-Chlorohydrin results in increased expression of NOP2 protein | CTD | PMID:34915118 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | NOP2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NOP2 mRNA | CTD | PMID:28628672 | 4,4'-diaminodiphenylmethane | increases expression | ISO | Nop2 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of NOL1 mRNA | CTD | PMID:18648102 | 4,4'-sulfonyldiphenol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of NOP2 mRNA | CTD | PMID:36041667 | acrolein | multiple interactions | ISO | NOP2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of NOP2 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of NOP2 mRNA | CTD | PMID:32699268 | acrylamide | increases expression | ISO | NOP2 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of NOP2 mRNA | CTD | PMID:32763439 | aflatoxin B1 | increases methylation | ISO | NOP2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of NOP2 gene | CTD | PMID:27153756 | all-trans-retinoic acid | decreases expression | ISO | Nop2 (Mus musculus) | 6480464 | Tretinoin results in decreased expression of NOL1 mRNA | CTD | PMID:16604517 | alpha-phellandrene | decreases expression | ISO | NOP2 (Homo sapiens) | 6480464 | alpha phellandrene results in decreased expression of NOP2 mRNA | CTD | PMID:25075043 | alpha-pinene | multiple interactions | ISO | NOP2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of NOP2 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of NOP2 mRNA | CTD | PMID:32699268 | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of NOP2 mRNA | CTD | PMID:30779732 | benzo[a]pyrene | increases expression | ISO | NOP2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of NOP2 mRNA | CTD | PMID:26238291 | benzoates | decreases expression | ISO | NOP2 (Homo sapiens) | 6480464 | Benzoates analog results in decreased expression of NOP2 mRNA | CTD | PMID:29472718 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of NOP2 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | ISO | NOP2 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of NOP2 protein | CTD | PMID:37567409 | bisphenol A | decreases expression | ISO | Nop2 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of NOP2 mRNA | CTD | PMID:37894381 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of NOP2 mRNA | CTD | PMID:36041667 | bisphenol A | decreases methylation | ISO | NOP2 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of NOP2 gene | CTD | PMID:31601247 | bisphenol A | affects expression | ISO | NOP2 (Homo sapiens) | 6480464 | bisphenol A affects the expression of NOP2 mRNA | CTD | PMID:30903817 | bisphenol F | multiple interactions | ISO | NOP2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NOP2 mRNA | CTD | PMID:28628672 | bisphenol F | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of NOP2 mRNA | CTD | PMID:36041667 | cadmium dichloride | increases expression | ISO | NOP2 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of NOP2 mRNA | CTD | PMID:12160620 | caffeine | affects phosphorylation | ISO | NOP2 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of NOP2 protein | CTD | PMID:35688186 | carbon nanotube | increases expression | ISO | Nop2 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chlorpyrifos | increases expression | ISO | Nop2 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of NOP2 mRNA | CTD | PMID:37019170 | chrysene | increases expression | ISO | Nop2 (Mus musculus) | 6480464 | chrysene results in increased expression of NOP2 mRNA | CTD | PMID:26377693 | cisplatin | decreases expression | ISO | NOP2 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of NOP2 mRNA | CTD | PMID:27594783 | coumarin | decreases phosphorylation | ISO | NOP2 (Homo sapiens) | 6480464 | coumarin results in decreased phosphorylation of NOP2 protein | CTD | PMID:35688186 | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of NOP2 mRNA | CTD | PMID:26577399 | cyclosporin A | increases expression | ISO | NOP2 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of NOP2 mRNA | CTD | PMID:25562108 | dexamethasone | multiple interactions | ISO | NOP2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NOP2 mRNA | CTD | PMID:28628672 | diazinon | affects expression | EXP | | 6480464 | Diazinon affects the expression of NOP2 mRNA | CTD | PMID:22546817 | diazinon | increases methylation | ISO | NOP2 (Homo sapiens) | 6480464 | Diazinon results in increased methylation of NOP2 gene | CTD | PMID:22964155 | dieldrin | affects expression | EXP | | 6480464 | Dieldrin affects the expression of NOP2 mRNA | CTD | PMID:22546817 | dioxygen | decreases expression | ISO | NOP2 (Homo sapiens) | 6480464 | Oxygen deficiency results in decreased expression of NOP2 mRNA | CTD | PMID:26516004 | dioxygen | multiple interactions | EXP | | 6480464 | [Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in increased expression of NOP2 mRNA | CTD | PMID:33729688 | dioxygen | multiple interactions | ISO | Nop2 (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of NOP2 mRNA | CTD | PMID:30529165 | doxorubicin | decreases expression | ISO | NOP2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of NOP2 mRNA | CTD | PMID:29803840 | epoxiconazole | decreases expression | ISO | Nop2 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of NOP2 mRNA | CTD | PMID:35436446 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of NOP2 mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | ISO | Nop2 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of NOP2 mRNA | CTD | PMID:22206623 | FR900359 | affects phosphorylation | ISO | NOP2 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of NOP2 protein | CTD | PMID:37730182 | genistein | increases expression | ISO | NOP2 (Homo sapiens) | 6480464 | Genistein results in increased expression of NOP2 mRNA | CTD | PMID:23019147 | glafenine | increases expression | EXP | | 6480464 | Glafenine results in increased expression of NOP2 mRNA | CTD | PMID:24136188 | hydrogen peroxide | multiple interactions | ISO | Nop2 (Mus musculus) | 6480464 | [Hydrogen Peroxide co-treated with N-(oxo-5 more ... | CTD | PMID:31494107 | indometacin | multiple interactions | ISO | NOP2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NOP2 mRNA | CTD | PMID:28628672 | ivermectin | decreases expression | ISO | NOP2 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of NOP2 protein | CTD | PMID:32959892 | lead(0) | decreases expression | ISO | NOP2 (Homo sapiens) | 6480464 | Lead results in decreased expression of NOP2 mRNA | CTD | PMID:19921347 | methotrexate | affects expression | ISO | Nop2 (Mus musculus) | 6480464 | Methotrexate affects the expression of NOL1 mRNA | CTD | PMID:18502557 | methylmercury chloride | increases expression | ISO | NOP2 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of NOP2 mRNA | CTD | PMID:28001369 | nickel atom | increases expression | ISO | NOP2 (Homo sapiens) | 6480464 | Nickel results in increased expression of NOP2 mRNA | CTD | PMID:24768652 and PMID:25583101 | okadaic acid | decreases expression | ISO | Nop2 (Mus musculus) | 6480464 | Okadaic Acid results in decreased expression of NOP2 mRNA | CTD | PMID:25270620 | ozone | multiple interactions | ISO | NOP2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of NOP2 mRNA more ... | CTD | PMID:32699268 | paracetamol | affects expression | ISO | Nop2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of NOL1 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of NOP2 mRNA | CTD | PMID:33387578 | paraquat | increases expression | EXP | | 6480464 | Paraquat results in increased expression of NOP2 mRNA | CTD | PMID:32680482 | perfluorononanoic acid | increases expression | ISO | NOP2 (Homo sapiens) | 6480464 | perfluoro-n-nonanoic acid results in increased expression of NOP2 mRNA | CTD | PMID:32588087 | pirinixic acid | increases expression | ISO | Nop2 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of NOP2 mRNA | CTD | PMID:23811191 | pregnenolone 16alpha-carbonitrile | increases expression | ISO | Nop2 (Mus musculus) | 6480464 | Pregnenolone Carbonitrile results in increased expression of NOP2 mRNA | CTD | PMID:28903501 | resveratrol | multiple interactions | ISO | NOP2 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of NOP2 mRNA | CTD | PMID:23557933 | rotenone | increases expression | EXP | | 6480464 | Rotenone results in increased expression of NOP2 mRNA | CTD | PMID:28374803 | SB 431542 | multiple interactions | ISO | NOP2 (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in decreased expression of NOP2 protein | CTD | PMID:37664457 | sunitinib | increases expression | ISO | NOP2 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of NOP2 mRNA | CTD | PMID:31533062 | T-2 toxin | increases expression | ISO | NOP2 (Homo sapiens) | 6480464 | T-2 Toxin results in increased expression of NOP2 mRNA | CTD | PMID:34581912 | temozolomide | increases expression | ISO | NOP2 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of NOP2 mRNA | CTD | PMID:31758290 | tetrachloromethane | increases expression | ISO | Nop2 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of NOP2 mRNA | CTD | PMID:27339419 and PMID:31919559 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of NOP2 mRNA] | CTD | PMID:31150632 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of NOP2 mRNA | CTD | PMID:31150632 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of NOP2 mRNA | CTD | PMID:34492290 | trimellitic anhydride | increases expression | ISO | Nop2 (Mus musculus) | 6480464 | trimellitic anhydride results in increased expression of NOL1 mRNA | CTD | PMID:19042947 | Triptolide | increases expression | ISO | Nop2 (Mus musculus) | 6480464 | triptolide results in increased expression of NOP2 mRNA | CTD | PMID:32835833 | valproic acid | affects expression | ISO | Nop2 (Mus musculus) | 6480464 | Valproic Acid affects the expression of NOP2 mRNA | CTD | PMID:17292431 | valproic acid | decreases expression | ISO | Nop2 (Mus musculus) | 6480464 | Valproic Acid results in decreased expression of NOL1 mRNA | CTD | PMID:19136453 and PMID:20546886 | valproic acid | increases expression | ISO | NOP2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of NOP2 mRNA | CTD | PMID:23179753 | valproic acid | affects expression | ISO | NOP2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of NOP2 mRNA | CTD | PMID:25979313 | |