Wfdc6b (WAP four-disulfide core domain 6B) - Rat Genome Database

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Gene: Wfdc6b (WAP four-disulfide core domain 6B) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Wfdc6b
Name: WAP four-disulfide core domain 6B
RGD ID: 1303277
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be active in extracellular space.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: WAP four-disulfide core 6-like 1; WAP four-disulfide core domain protein 6B; Wfdc6l1
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,758,317 - 173,766,797 (+)NCBIGRCr8
mRatBN7.23153,339,051 - 153,346,940 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3153,339,110 - 153,347,132 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3157,149,285 - 157,155,854 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,648,250 - 165,654,819 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,391,877 - 163,398,598 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03161,071,019 - 161,078,173 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3161,071,019 - 161,078,173 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03167,249,154 - 167,256,308 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,634,498 - 155,641,866 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13155,540,533 - 155,547,902 (+)NCBI
Celera3151,948,390 - 151,955,168 (+)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A genomic analysis of rat proteases and protease inhibitors. Puente XS and Lopez-Otin C, Genome Res 2004 Apr;14(4):609-22.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Wfdc6b
175 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:108
Count of miRNA genes:89
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000048654
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145956084157309487Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3145956084161299569Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium
Low 1 2 13 3
Below cutoff 1 2 1 1 1 30 18 18 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000048654   ⟹   ENSRNOP00000042819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3153,339,140 - 153,347,132 (+)Ensembl
Rnor_6.0 Ensembl3161,071,019 - 161,078,173 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097649   ⟹   ENSRNOP00000086668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3153,339,110 - 153,346,632 (+)Ensembl
RefSeq Acc Id: NM_001413016   ⟹   NP_001399945
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83173,758,390 - 173,766,279 (+)NCBI
mRatBN7.23153,339,051 - 153,346,940 (+)NCBI
RefSeq Acc Id: XM_063284322   ⟹   XP_063140392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83173,758,317 - 173,766,797 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001399945 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140392 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE51900 (Get FASTA)   NCBI Sequence Viewer  
  EDL96507 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000042819.1
  ENSRNOP00000086668
  ENSRNOP00000086668.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000042819   ⟸   ENSRNOT00000048654
RefSeq Acc Id: ENSRNOP00000086668   ⟸   ENSRNOT00000097649
RefSeq Acc Id: NP_001399945   ⟸   NM_001413016
- Peptide Label: precursor
- UniProtKB: A0A8I6A6P2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140392   ⟸   XM_063284322
- Peptide Label: isoform X1
Protein Domains
BPTI/Kunitz inhibitor   WAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IE19-F1-model_v2 AlphaFold Q6IE19 1-182 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303277 AgrOrtholog
BioCyc Gene G2FUF-46844 BioCyc
Ensembl Genes ENSRNOG00000031823 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048654.2 UniProtKB/TrEMBL
  ENSRNOT00000097649 ENTREZGENE
  ENSRNOT00000097649.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.410.10 UniProtKB/TrEMBL
  4.10.75.10 UniProtKB/TrEMBL
InterPro Elafin-like_sf UniProtKB/TrEMBL
  Kunitz_BPTI_sf UniProtKB/TrEMBL
  Prot_inh_Kunz-m UniProtKB/TrEMBL
  Prtase_inh_Kunz-CS UniProtKB/TrEMBL
  Whey_acidic_protein_4-diS_core UniProtKB/TrEMBL
KEGG Report rno:408225 UniProtKB/TrEMBL
NCBI Gene 408225 ENTREZGENE
PANTHER EPPIN UniProtKB/TrEMBL
  WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 6B UniProtKB/TrEMBL
Pfam Kunitz_BPTI UniProtKB/TrEMBL
  WAP UniProtKB/TrEMBL
PhenoGen Wfdc6b PhenoGen
PRINTS BASICPTASE UniProtKB/TrEMBL
PROSITE BPTI_KUNITZ_1 UniProtKB/TrEMBL
  BPTI_KUNITZ_2 UniProtKB/TrEMBL
  WAP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031823 RatGTEx
SMART SM00131 UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_Kunz-m UniProtKB/TrEMBL
  SSF57256 UniProtKB/TrEMBL
UniProt A0A8I6A6P2 ENTREZGENE, UniProtKB/TrEMBL
  Q6IE19_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Wfdc6b  WAP four-disulfide core domain 6B  Wfdc6l1  WAP four-disulfide core 6-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-14 Wfdc6l1  WAP four-disulfide core 6-like 1      Symbol and Name status set to provisional 70820 PROVISIONAL