Ctsql2 (cathepsin Q-like 2) - Rat Genome Database

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Gene: Ctsql2 (cathepsin Q-like 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ctsql2
Name: cathepsin Q-like 2
RGD ID: 1303225
Description: Predicted to enable cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Predicted to be involved in immune response; positive regulation of apoptotic signaling pathway; and proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome; INTERACTS WITH 3,7-dihydropurine-6-thione; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8173,704,585 - 3,710,404 (+)NCBIGRCr8
mRatBN7.2173,698,973 - 3,704,787 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl173,698,918 - 3,704,685 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx173,718,508 - 3,724,326 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0175,260,145 - 5,265,963 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0173,714,950 - 3,720,768 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0174,062,294 - 4,068,108 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl174,063,432 - 4,068,100 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0176,292,659 - 6,297,345 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,419,305 - 9,425,119 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1179,420,452 - 9,424,881 (+)NCBI
Celera173,827,889 - 3,833,703 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Cathepsin Q, a novel lysosomal cysteine protease highly expressed in placenta. Sol-Church K, etal., Biochem Biophys Res Commun 2000 Jan 27;267(3):791-5.
Additional References at PubMed
PMID:12477932   PMID:15060002  


Genomics

Variants

.
Variants in Ctsql2
12 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:113
Count of miRNA genes:95
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000045847
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat

Markers in Region
AI013770  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2173,704,578 - 3,704,696 (+)MAPPERmRatBN7.2
Rnor_6.0174,067,900 - 4,068,017NCBIRnor6.0
Rnor_5.0176,297,132 - 6,297,249UniSTSRnor5.0
RGSC_v3.4179,424,911 - 9,425,028UniSTSRGSC3.4
Celera173,833,495 - 3,833,612UniSTS
RH 3.4 Map1747.6UniSTS
Cytogenetic Map17p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

nervous system reproductive system
High
Medium
Low 8 5
Below cutoff 5

Sequence


RefSeq Acc Id: ENSRNOT00000024208   ⟹   ENSRNOP00000024208
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl173,698,918 - 3,704,685 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000073585   ⟹   ENSRNOP00000066947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl173,629,082 - 3,633,428 (+)Ensembl
Rnor_6.0 Ensembl174,063,432 - 4,068,100 (+)Ensembl
RefSeq Acc Id: NM_001002813   ⟹   NP_001002813
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8173,704,585 - 3,710,399 (+)NCBI
mRatBN7.2173,698,973 - 3,704,787 (+)NCBI
Rnor_6.0174,062,294 - 4,068,108 (+)NCBI
Rnor_5.0176,292,659 - 6,297,345 (+)NCBI
RGSC_v3.4179,419,305 - 9,425,119 (+)RGD
Celera173,827,889 - 3,833,703 (+)RGD
Sequence:
RefSeq Acc Id: XM_063276678   ⟹   XP_063132748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8173,705,723 - 3,710,404 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001002813 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132748 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97257 (Get FASTA)   NCBI Sequence Viewer  
  CAE48375 (Get FASTA)   NCBI Sequence Viewer  
  EDL93851 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024208
  ENSRNOP00000024208.4
  ENSRNOP00000066947
RefSeq Acc Id: NP_001002813   ⟸   NM_001002813
- Peptide Label: precursor
- UniProtKB: Q4QRC2 (UniProtKB/TrEMBL),   M0RBK8 (UniProtKB/TrEMBL),   A0A9K3Y7W0 (UniProtKB/TrEMBL),   A0A8L2QDS9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066947   ⟸   ENSRNOT00000073585
RefSeq Acc Id: ENSRNOP00000024208   ⟸   ENSRNOT00000024208
RefSeq Acc Id: XP_063132748   ⟸   XM_063276678
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4QRC2-F1-model_v2 AlphaFold Q4QRC2 1-343 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303225 AgrOrtholog
BioCyc Gene G2FUF-10477 BioCyc
Ensembl Genes ENSRNOG00000017946 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000048693 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024208 ENTREZGENE
  ENSRNOT00000024208.5 UniProtKB/TrEMBL
  ENSRNOT00000073585 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.2250 UniProtKB/TrEMBL
  Cysteine proteinases UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7460188 IMAGE-MGC_LOAD
InterPro Papain_like_cys_pep_sf UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/TrEMBL
  Pept_his_AS UniProtKB/TrEMBL
  Peptidase_C1A UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/TrEMBL
  Peptidase_C1A_papain-like UniProtKB/TrEMBL
  Prot_inhib_I29 UniProtKB/TrEMBL
KEGG Report rno:408201 UniProtKB/TrEMBL
MGC_CLONE MGC:114219 IMAGE-MGC_LOAD
NCBI Gene 408201 ENTREZGENE
PANTHER CATHEPSIN Q UniProtKB/TrEMBL
  CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/TrEMBL
Pfam Inhibitor_I29 UniProtKB/TrEMBL
  Peptidase_C1 UniProtKB/TrEMBL
PhenoGen Ctsql2 PhenoGen
PRINTS PAPAIN UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_ASN UniProtKB/TrEMBL
  THIOL_PROTEASE_HIS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017946 RatGTEx
  ENSRNOG00000048693 RatGTEx
SMART Inhibitor_I29 UniProtKB/TrEMBL
  Pept_C1 UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A0A8L2QDS9 ENTREZGENE, UniProtKB/TrEMBL
  A0A9K3Y7W0 ENTREZGENE, UniProtKB/TrEMBL
  M0RBK8 ENTREZGENE
  Q4QRC2 ENTREZGENE, UniProtKB/TrEMBL
  Q6IE73_RAT UniProtKB/TrEMBL
UniProt Secondary M0RBK8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-14 Ctsql2  cathepsin Q-like 2      Symbol and Name status set to provisional 70820 PROVISIONAL