Ppp1r11 (protein phosphatase 1, regulatory (inhibitor) subunit 11) - Rat Genome Database

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Gene: Ppp1r11 (protein phosphatase 1, regulatory (inhibitor) subunit 11) Rattus norvegicus
Analyze
Symbol: Ppp1r11
Name: protein phosphatase 1, regulatory (inhibitor) subunit 11
RGD ID: 1303163
Description: Predicted to enable protein phosphatase 1 binding activity; protein serine/threonine phosphatase inhibitor activity; and ubiquitin protein ligase activity. Predicted to be involved in defense response to Gram-positive bacterium; negative regulation of cytokine production; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human PPP1R11 (protein phosphatase 1 regulatory inhibitor subunit 11); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 ubiquitin-protein ligase PPP1R11; HcgV; MGC94346; protein phosphatase 1 regulatory subunit 11; t-complex testis expressed-5; Tctex5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8201,606,583 - 1,610,090 (+)NCBIGRCr8
mRatBN7.2201,601,350 - 1,604,857 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl201,601,346 - 1,604,846 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx201,654,115 - 1,657,630 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0201,657,612 - 1,661,127 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0201,599,076 - 1,602,598 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0202,094,931 - 2,098,438 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl202,094,931 - 2,098,433 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0204,131,645 - 4,135,152 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4201,694,086 - 1,697,593 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1201,694,117 - 1,697,205 (+)NCBI
Celera202,309,914 - 2,313,421 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Transcriptional analysis of the 69-kb sequence centromeric to HLA-J: a dense and complex structure of five genes. Coriton O, etal., Mamm Genome 2000 Dec;11(12):1127-31.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:9843442   PMID:15060004   PMID:15489334   PMID:19300506   PMID:27805901  


Genomics

Comparative Map Data
Ppp1r11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8201,606,583 - 1,610,090 (+)NCBIGRCr8
mRatBN7.2201,601,350 - 1,604,857 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl201,601,346 - 1,604,846 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx201,654,115 - 1,657,630 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0201,657,612 - 1,661,127 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0201,599,076 - 1,602,598 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0202,094,931 - 2,098,438 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl202,094,931 - 2,098,433 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0204,131,645 - 4,135,152 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4201,694,086 - 1,697,593 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1201,694,117 - 1,697,205 (+)NCBI
Celera202,309,914 - 2,313,421 (+)NCBICelera
Cytogenetic Map20p12NCBI
PPP1R11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38630,061,265 - 30,070,333 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl630,066,709 - 30,070,333 (+)EnsemblGRCh38hg38GRCh38
GRCh37630,034,975 - 30,038,110 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,142,911 - 30,146,089 (+)NCBINCBI36Build 36hg18NCBI36
Build 34630,142,967 - 30,146,085NCBI
Celera631,633,185 - 31,636,363 (+)NCBICelera
Cytogenetic Map6p22.1NCBI
HuRef629,833,104 - 29,836,282 (+)NCBIHuRef
CHM1_1630,036,981 - 30,040,159 (+)NCBICHM1_1
T2T-CHM13v2.0629,931,133 - 29,934,607 (+)NCBIT2T-CHM13v2.0
Ppp1r11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391737,259,247 - 37,262,684 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1737,259,248 - 37,262,633 (-)EnsemblGRCm39 Ensembl
GRCm381736,948,355 - 36,951,792 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1736,948,356 - 36,951,741 (-)EnsemblGRCm38mm10GRCm38
MGSCv371737,085,300 - 37,088,737 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361736,557,340 - 36,569,082 (-)NCBIMGSCv36mm8
Celera1740,371,894 - 40,375,330 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1719.16NCBI
Ppp1r11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955583198,233 - 202,486 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955583198,233 - 201,312 (+)NCBIChiLan1.0ChiLan1.0
PPP1R11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2544,660,268 - 44,667,412 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1640,623,201 - 40,631,034 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0629,844,971 - 29,851,792 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1630,515,139 - 30,518,390 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl630,515,139 - 30,518,384 (+)Ensemblpanpan1.1panPan2
PPP1R11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13526,289,430 - 26,292,281 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3526,289,471 - 26,291,497 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.03526,597,984 - 26,600,853 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3526,597,618 - 26,600,847 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13526,252,583 - 26,255,419 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03526,313,257 - 26,316,092 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03527,783,473 - 27,786,313 (+)NCBIUU_Cfam_GSD_1.0
Ppp1r11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494632,615,984 - 32,619,307 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936723970,226 - 975,952 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936723973,516 - 975,930 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl722,633,859 - 22,636,971 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1722,634,074 - 22,636,987 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2724,991,270 - 24,994,181 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11742,429,564 - 42,432,758 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1742,430,478 - 42,432,659 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604429,722,307 - 29,725,544 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475425,336,151 - 25,338,388 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475425,336,151 - 25,338,389 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp1r11
15 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:374
Count of miRNA genes:181
Interacting mature miRNAs:191
Transcripts:ENSRNOT00000001013
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724519Bp144Blood pressure QTL 1440.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2013624629Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat

Markers in Region
Tctex5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2201,603,657 - 1,603,859 (+)MAPPERmRatBN7.2
Rnor_6.0202,097,239 - 2,097,440NCBIRnor6.0
Rnor_5.0204,133,953 - 4,134,154UniSTSRnor5.0
RGSC_v3.4201,696,394 - 1,696,595UniSTSRGSC3.4
Celera202,312,222 - 2,312,423UniSTS
Cytogenetic Map20p12UniSTS
RH131374  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2201,604,849 - 1,605,054 (+)MAPPERmRatBN7.2
Rnor_6.0202,098,431 - 2,098,635NCBIRnor6.0
Rnor_5.0204,135,145 - 4,135,349UniSTSRnor5.0
RGSC_v3.4201,697,586 - 1,697,790UniSTSRGSC3.4
Celera202,313,414 - 2,313,618UniSTS
RH 3.4 Map2015.8UniSTS
Cytogenetic Map20p12UniSTS
RH131842  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2201,604,598 - 1,604,808 (+)MAPPERmRatBN7.2
Rnor_6.0202,098,180 - 2,098,389NCBIRnor6.0
Rnor_5.0204,134,894 - 4,135,103UniSTSRnor5.0
RGSC_v3.4201,697,335 - 1,697,544UniSTSRGSC3.4
Celera202,313,163 - 2,313,372UniSTS
RH 3.4 Map2011.0UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 2 5 74 35 41 11 2
Low 6 6 6
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000001013   ⟹   ENSRNOP00000001013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl201,601,346 - 1,604,846 (+)Ensembl
Rnor_6.0 Ensembl202,094,931 - 2,098,433 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl202,095,237 - 2,097,590 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl202,095,275 - 2,097,735 (+)Ensembl
RefSeq Acc Id: NM_212542   ⟹   NP_997707
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8201,606,583 - 1,610,090 (+)NCBI
mRatBN7.2201,601,350 - 1,604,857 (+)NCBI
Rnor_6.0202,094,931 - 2,098,438 (+)NCBI
Rnor_5.0204,131,645 - 4,135,152 (+)NCBI
RGSC_v3.4201,694,086 - 1,697,593 (+)RGD
Celera202,309,914 - 2,313,421 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255870   ⟹   XP_006255932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8201,606,858 - 1,610,082 (+)NCBI
mRatBN7.2201,601,656 - 1,604,852 (+)NCBI
Rnor_6.0202,095,242 - 2,098,428 (+)NCBI
Rnor_5.0204,131,645 - 4,135,152 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098471   ⟹   XP_038954399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8201,606,584 - 1,610,082 (+)NCBI
mRatBN7.2201,601,907 - 1,604,852 (+)NCBI
RefSeq Acc Id: NP_997707   ⟸   NM_212542
- UniProtKB: Q6AXZ8 (UniProtKB/Swiss-Prot),   Q6MFY6 (UniProtKB/Swiss-Prot),   A6KR78 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255932   ⟸   XM_006255870
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000001013   ⟸   ENSRNOT00000001013
RefSeq Acc Id: XP_038954399   ⟸   XM_039098471
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6MFY6-F1-model_v2 AlphaFold Q6MFY6 1-127 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701273
Promoter ID:EPDNEW_R11797
Type:initiation region
Name:Ppp1r11_1
Description:protein phosphatase 1, regulatory subunit 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0202,094,989 - 2,095,049EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303163 AgrOrtholog
BioCyc Gene G2FUF-4978 BioCyc
Ensembl Genes ENSRNOG00000000780 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055009082 UniProtKB/Swiss-Prot
  ENSRNOG00060003409 UniProtKB/Swiss-Prot
  ENSRNOG00065028577 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001013.8 UniProtKB/TrEMBL
  ENSRNOT00055015375 UniProtKB/Swiss-Prot
  ENSRNOT00060005613 UniProtKB/Swiss-Prot
  ENSRNOT00065049261 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7133103 IMAGE-MGC_LOAD
InterPro PPI_Ypi1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:294207 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94346 IMAGE-MGC_LOAD
NCBI Gene 294207 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE PPP1R11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam PPI_Ypi1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppp1r11 PhenoGen
RatGTEx ENSRNOG00000000780 RatGTEx
  ENSRNOG00055009082 RatGTEx
  ENSRNOG00060003409 RatGTEx
  ENSRNOG00065028577 RatGTEx
UniProt A0A8L2Q0D7_RAT UniProtKB/TrEMBL
  A6KR78 ENTREZGENE, UniProtKB/TrEMBL
  PP1RB_RAT UniProtKB/Swiss-Prot
  Q6AXZ8 ENTREZGENE
  Q6MFY6 ENTREZGENE
UniProt Secondary Q6AXZ8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Ppp1r11  protein phosphatase 1, regulatory (inhibitor) subunit 11      Symbol and Name status set to approved 1299863 APPROVED
2005-07-14 Ppp1r11  protein phosphatase 1, regulatory (inhibitor) subunit 11      Symbol and Name status set to provisional 70820 PROVISIONAL