Stfa2l1 (stefin A2-like 1) - Rat Genome Database

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Gene: Stfa2l1 (stefin A2-like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Stfa2l1
Name: stefin A2-like 1
RGD ID: 1303106
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in peeling skin syndrome 4. Orthologous to human CSTA (cystatin A).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: stefin A2; stefin-3; Stfa2
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81177,946,133 - 77,950,202 (-)NCBIGRCr8
mRatBN7.21164,440,792 - 64,444,858 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,440,792 - 64,444,858 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1173,260,329 - 73,264,168 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01165,922,563 - 65,926,406 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,953,859 - 64,957,680 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,395,889 - 67,400,201 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,395,889 - 67,400,201 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,484,782 - 70,489,094 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41166,263,202 - 66,267,857 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11166,320,790 - 66,325,446 (-)NCBI
Celera1163,910,012 - 63,914,005 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A genomic analysis of rat proteases and protease inhibitors. Puente XS and Lopez-Otin C, Genome Res 2004 Apr;14(4):609-22.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Stfa2l1
35 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:25
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000045639
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium 18 18 18
Low 12 8 8 8 16 21 1
Below cutoff 10 3 3 14 2 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000045639   ⟹   ENSRNOP00000043178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1164,440,792 - 64,444,858 (-)Ensembl
Rnor_6.0 Ensembl1167,395,889 - 67,400,201 (-)Ensembl
RefSeq Acc Id: NM_001004129   ⟹   NP_001004129
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81177,946,133 - 77,950,202 (-)NCBI
mRatBN7.21164,440,792 - 64,444,858 (-)NCBI
Rnor_6.01167,395,889 - 67,400,201 (-)NCBI
Rnor_5.01170,484,782 - 70,489,094 (-)NCBI
RGSC_v3.41166,263,202 - 66,267,857 (-)RGD
Celera1163,910,012 - 63,914,005 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001004129 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE51902 (Get FASTA)   NCBI Sequence Viewer  
  EDM11284 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000043178
  ENSRNOP00000043178.3
Reference Protein Sequences
RefSeq Acc Id: NP_001004129   ⟸   NM_001004129
- UniProtKB: Q6IE17 (UniProtKB/TrEMBL),   D3ZEL6 (UniProtKB/TrEMBL),   A0A9K3Y852 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000043178   ⟸   ENSRNOT00000045639
Protein Domains
Cystatin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IE17-F1-model_v2 AlphaFold Q6IE17 1-103 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303106 AgrOrtholog
BioCyc Gene G2FUF-21226 BioCyc
Ensembl Genes ENSRNOG00000033929 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045639 ENTREZGENE
  ENSRNOT00000045639.5 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.10 UniProtKB/TrEMBL
InterPro Cystatin_sf UniProtKB/TrEMBL
  Prot_inh_cystat UniProtKB/TrEMBL
  Prot_inh_cystat_CS UniProtKB/TrEMBL
  Prot_inh_stefinA UniProtKB/TrEMBL
KEGG Report rno:408214 UniProtKB/TrEMBL
NCBI Gene 408214 ENTREZGENE
PANTHER PTHR11414 UniProtKB/TrEMBL
  STEFIN-3 UniProtKB/TrEMBL
Pfam Cystatin UniProtKB/TrEMBL
PhenoGen Stfa2l1 PhenoGen
PRINTS STEFINA UniProtKB/TrEMBL
PROSITE CYSTATIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033929 RatGTEx
SMART SM00043 UniProtKB/TrEMBL
Superfamily-SCOP SSF54403 UniProtKB/TrEMBL
UniProt A0A9K3Y852 ENTREZGENE, UniProtKB/TrEMBL
  D3ZEL6 ENTREZGENE
  Q6IE17 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary D3ZEL6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-18 Stfa2l1  stefin A2-like 1  Stfa2  stefin A2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-14 Stfa2  stefin A2      Symbol and Name status set to provisional 70820 PROVISIONAL