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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1550529 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HYAL1 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1352194 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HYAL1 mRNA | CTD | PMID:12377990 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1550529 | 6480464 | Tetrachlorodibenzodioxin affects the expression of HYAL1 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1550529 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of HYAL1 mRNA | CTD | PMID:19770486 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1550529 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HYAL1 mRNA | CTD | PMID:17942748 | 4,4'-diaminodiphenylmethane | affects expression | ISO | RGD:1550529 | 6480464 | 4,4'-diaminodiphenylmethane affects the expression of HYAL1 mRNA | CTD | PMID:18648102 | aflatoxin B1 | affects expression | ISO | RGD:1352194 | 6480464 | Aflatoxin B1 affects the expression of HYAL1 protein | CTD | PMID:20106945 | ciguatoxin CTX1B | affects expression | ISO | RGD:1550529 | 6480464 | Ciguatoxins affects the expression of HYAL1 mRNA | CTD | PMID:18353800 | clofibrate | decreases expression | EXP | | 6480464 | Clofibrate results in decreased expression of HYAL1 mRNA | CTD | PMID:12851107 | cobalt dichloride | decreases expression | ISO | RGD:1352194 | 6480464 | cobaltous chloride results in decreased expression of HYAL1 mRNA | CTD | PMID:19376846 | copper(2+) sulfate | decreases expression | ISO | RGD:1352194 | 6480464 | Copper Sulfate results in decreased expression of HYAL1 mRNA | CTD | PMID:19549813 | cyclosporin A | decreases expression | ISO | RGD:1352194 | 6480464 | Cyclosporine results in decreased expression of HYAL1 mRNA | CTD | PMID:20106945 | diarsenic trioxide | increases expression | ISO | RGD:1352194 | 6480464 | arsenic trioxide results in increased expression of HYAL1 mRNA | CTD | PMID:20458559 | diarsenic trioxide | increases expression | ISO | RGD:1352194 | 6480464 | arsenic trioxide results in increased expression of HYAL1 mRNA | CTD | PMID:20458559 PMID:22521957 | enalapril | decreases expression | EXP | | 6480464 | Enalapril results in decreased expression of HYAL1 mRNA; more ... | CTD | PMID:20933085 | phenobarbital | increases expression | ISO | RGD:1550529 | 6480464 | Phenobarbital results in increased expression of HYAL1 mRNA | CTD | PMID:19270015 | phenobarbital | decreases expression | ISO | RGD:1550529 | 6480464 | Phenobarbital results in decreased expression of HYAL1 mRNA | CTD | PMID:23091169 | phenobarbital | affects expression | ISO | RGD:1352194 | 6480464 | Phenobarbital affects the expression of HYAL1 mRNA | CTD | PMID:19159669 | pirinixic acid | multiple interactions | ISO | RGD:1550529 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of HYAL1 mRNA | CTD | PMID:19710929 | pirinixic acid | increases expression | ISO | RGD:1550529 | 6480464 | pirinixic acid results in increased expression of HYAL1 mRNA | CTD | PMID:18301758 | valproic acid | affects expression | ISO | RGD:1550529 | 6480464 | Valproic Acid affects the expression of HYAL1 mRNA | CTD | PMID:17292431 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Glycosaminoglycan degradation |
| Lysosome | |
| Metabolic pathways | |
Disease Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Glycosaminoglycan degradation |
| Lysosome | |
| Metabolic pathways | |
References - curated| 1. |
Jacobson A, etal., Int J Cancer 2002 Nov 20;102(3):212-9. |
| 2. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 3. |
RGD automated data pipeline |
| 4. |
RGD automated import pipeline for gene-chemical interactions |
| 5. |
RGD Automated Pipelines |
| 6. |
Triggs-Raine B, etal., Proc Natl Acad Sci U S A. 1999 May 25;96(11):6296-300. |
References - uncurated| PubMed | 16837837 |
RGD Disease Portals| Hyal1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Hyal1 (Rattus norvegicus) |
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| HYAL1 (Homo sapiens) |
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| Hyal1 (Mus musculus) |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_207616 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06057029 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01056978 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB100600 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473954 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_207616 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_997499 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_997499 | (Get FASTA) |
| GenBank Protein | BAD14368 | (Get FASTA) |
| EDL77243 | (Get FASTA) | |
| Q76HN1 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000015858 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000021408 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000021408 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 367166 | ENTREZGENE |
| Gene3D-CATH | Aldolase_TIM | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000015858 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 5277 | ENTREZGENE |
| InterPro | Aldolase_TIM | UniProtKB/Swiss-Prot |
| EG-like_dom | UniProtKB/Swiss-Prot | |
| Glyco_hydro_catalytic_core | UniProtKB/Swiss-Prot | |
| Hyaluronidase | UniProtKB/Swiss-Prot | |
| IPI | IPI00551819 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:367166 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | Glyco_hydro_56 | UniProtKB/Swiss-Prot |
| Pfam | Glyco_hydro_56 | UniProtKB/Swiss-Prot |
| PIRSF | Hyaluronidase | UniProtKB/Swiss-Prot |
| PRINTS | GLHYDRLASE56 | UniProtKB/Swiss-Prot |
| PROSITE | EGF_1 | UniProtKB/Swiss-Prot |
| EGF_2 | UniProtKB/Swiss-Prot | |
| EGF_3; FALSE_NEG | UniProtKB/Swiss-Prot | |
| SMART | EGF | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Glyco_hydro_cat | UniProtKB/Swiss-Prot |
| UniGene | Rn.124438 | ENTREZGENE |
| UniProt | F1M963_RAT | UniProtKB/TrEMBL |
| HYAL1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2006-03-30 | Hyal1 | hyaluronoglucosaminidase 1 | hyaluronidase 1 | Name updated | 10779 | APPROVED | |
| 2005-02-14 | Hyal1 | hyaluronidase 1 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
| More on Hyal1 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1303060 |
| Created: | 2004-12-03 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




