Ano7 (anoctamin 7) - Rat Genome Database

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Gene: Ano7 (anoctamin 7) Rattus norvegicus
Analyze
Symbol: Ano7
Name: anoctamin 7
RGD ID: 1302987
Description: Predicted to enable intracellular calcium activated chloride channel activity and phospholipid scramblase activity. Predicted to be involved in calcium activated phospholipid scrambling and chloride transmembrane transport. Predicted to act upstream of or within calcium activated phospholipid scrambling; chloride transport; and establishment of localization in cell. Predicted to be located in endoplasmic reticulum and nucleus. Predicted to be active in plasma membrane. Orthologous to human ANO7 (anoctamin 7); INTERACTS WITH 1-naphthyl isothiocyanate; bisphenol A; copper atom.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: anoctamin-7; anoctamin-7-like; LOC108352008; new gene expressed in prostate; new gene expressed in prostate homolog; Ngep; Tmem16g; transmembrane protein 16G
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,364,915 - 101,392,711 (+)NCBIGRCr8
mRatBN7.2993,917,524 - 93,945,323 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl993,917,524 - 93,945,323 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9102,353,072 - 102,380,835 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,489,080 - 107,516,906 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09105,845,224 - 105,873,051 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09100,511,610 - 100,551,798 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9100,511,610 - 100,551,798 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09100,167,965 - 100,206,289 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4992,655,567 - 92,683,022 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1992,860,335 - 92,887,791 (+)NCBI
Celera991,452,448 - 91,479,937 (+)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate. Bera TK, etal., Proc Natl Acad Sci U S A 2004 Mar 2;101(9):3059-64. Epub 2004 Feb 23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20056604   PMID:21984732   PMID:22075693   PMID:22946059   PMID:23532839  


Genomics

Comparative Map Data
Ano7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,364,915 - 101,392,711 (+)NCBIGRCr8
mRatBN7.2993,917,524 - 93,945,323 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl993,917,524 - 93,945,323 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9102,353,072 - 102,380,835 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,489,080 - 107,516,906 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09105,845,224 - 105,873,051 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09100,511,610 - 100,551,798 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9100,511,610 - 100,551,798 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09100,167,965 - 100,206,289 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4992,655,567 - 92,683,022 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1992,860,335 - 92,887,791 (+)NCBI
Celera991,452,448 - 91,479,937 (+)NCBICelera
Cytogenetic Map9q36NCBI
ANO7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,188,677 - 241,240,308 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,188,509 - 241,225,976 (+)EnsemblGRCh38hg38GRCh38
GRCh372242,128,092 - 242,165,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,776,597 - 241,813,464 (+)NCBINCBI36Build 36hg18NCBI36
Build 342241,847,913 - 241,883,960NCBI
Celera2235,798,107 - 235,834,087 (+)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2233,884,969 - 233,920,917 (+)NCBIHuRef
CHM1_12242,134,022 - 242,170,841 (+)NCBICHM1_1
T2T-CHM13v2.02241,688,481 - 241,740,793 (+)NCBIT2T-CHM13v2.0
Ano7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,301,518 - 93,332,026 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,301,652 - 93,332,025 (+)EnsemblGRCm39 Ensembl
GRCm38193,373,796 - 93,404,304 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,373,930 - 93,404,303 (+)EnsemblGRCm38mm10GRCm38
MGSCv37195,270,473 - 95,300,079 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,204,302 - 95,233,908 (+)NCBIMGSCv36mm8
Celera196,318,620 - 96,348,001 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.24NCBI
ANO7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213143,889,593 - 143,927,594 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B143,904,553 - 143,944,845 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B128,458,076 - 128,496,307 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B247,254,473 - 247,291,208 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B247,254,473 - 247,290,136 (+)Ensemblpanpan1.1panPan2
ANO7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12551,209,628 - 51,226,581 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2551,209,003 - 51,226,959 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2551,422,236 - 51,439,610 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02551,404,038 - 51,421,359 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2551,403,971 - 51,420,621 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12551,251,742 - 51,269,024 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02550,991,250 - 51,008,563 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02551,267,753 - 51,285,089 (+)NCBIUU_Cfam_GSD_1.0
Ano7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303192,584,907 - 192,594,745 (+)NCBIHiC_Itri_2
ANO7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.115139,951,191 - 139,956,575 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ANO7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110127,249,352 - 127,285,485 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10127,249,970 - 127,285,409 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604072,096,404 - 72,133,453 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ano7
132 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:36
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000033233
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)992491589100929786Rat

Markers in Region
RH131965  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2993,916,895 - 93,917,110 (+)MAPPERmRatBN7.2
Rnor_6.09100,510,982 - 100,511,196NCBIRnor6.0
Rnor_5.09100,167,337 - 100,167,551UniSTSRnor5.0
RGSC_v3.4992,654,939 - 92,655,153UniSTSRGSC3.4
Celera991,451,820 - 91,452,034UniSTS
RH 3.4 Map9811.0UniSTS
Cytogenetic Map9q36UniSTS
BF417869  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2993,939,215 - 93,939,386 (+)MAPPERmRatBN7.2
Rnor_6.09100,545,692 - 100,545,862NCBIRnor6.0
Rnor_6.09100,533,856 - 100,534,026NCBIRnor6.0
Rnor_5.09100,190,211 - 100,190,381UniSTSRnor5.0
Rnor_5.09100,198,720 - 100,198,890UniSTSRnor5.0
RGSC_v3.4992,676,916 - 92,677,086UniSTSRGSC3.4
Celera991,473,830 - 91,474,000UniSTS
Cytogenetic Map9q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2
Low 1 10 9
Below cutoff 3 22 16 8 16 5 5 8 28 20 2 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000033233   ⟹   ENSRNOP00000033330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl993,917,524 - 93,945,323 (+)Ensembl
Rnor_6.0 Ensembl9100,511,610 - 100,551,798 (+)Ensembl
RefSeq Acc Id: NM_001004071   ⟹   NP_001004071
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,364,915 - 101,392,711 (+)NCBI
mRatBN7.2993,917,524 - 93,945,323 (+)NCBI
Rnor_6.09100,511,610 - 100,551,798 (+)NCBI
Rnor_5.09100,167,965 - 100,206,289 (+)NCBI
RGSC_v3.4992,655,567 - 92,683,022 (+)RGD
Celera991,452,448 - 91,479,937 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001004071 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein DAA04565 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000033330
  ENSRNOP00000033330.4
  ENSRNOP00060011771
GenBank Protein Q6IFT6 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001004071   ⟸   NM_001004071
- UniProtKB: Q6IFT6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000033330   ⟸   ENSRNOT00000033233

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IFT6-F1-model_v2 AlphaFold Q6IFT6 1-860 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696873
Promoter ID:EPDNEW_R7398
Type:initiation region
Name:Ano7_1
Description:anoctamin 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.09100,511,600 - 100,511,660EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1302987 AgrOrtholog
BioCyc Gene G2FUF-26644 BioCyc
Ensembl Genes ENSRNOG00000023427 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00060009030 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000033233 ENTREZGENE
  ENSRNOT00000033233.3 UniProtKB/Swiss-Prot
  ENSRNOT00060015146 UniProtKB/Swiss-Prot
InterPro Anoct_dimer UniProtKB/Swiss-Prot
  Anoctamin UniProtKB/Swiss-Prot
  Anoctamin_TM UniProtKB/Swiss-Prot
KEGG Report rno:367318 UniProtKB/Swiss-Prot
NCBI Gene 367318 ENTREZGENE
PANTHER PTHR12308 UniProtKB/Swiss-Prot
  PTHR12308:SF22 UniProtKB/Swiss-Prot
Pfam Anoct_dimer UniProtKB/Swiss-Prot
  Anoctamin UniProtKB/Swiss-Prot
PhenoGen Ano7 PhenoGen
RatGTEx ENSRNOG00000023427 RatGTEx
  ENSRNOG00060009030 RatGTEx
UniProt ANO7_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ano7  anoctamin 7  LOC108352008  anoctamin-7-like  Data merged from RGD:11386283 737654 PROVISIONAL
2016-08-02 LOC108352008  anoctamin-7-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-25 Ano7  anoctamin 7  Tmem16g  transmembrane protein 16G  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Tmem16g  transmembrane protein 16G  Ngep  new gene expressed in prostate  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-14 Ngep  new gene expressed in prostate      Symbol and Name status set to provisional 70820 PROVISIONAL