Scn1a<sup>m1Kyo</sup> (sodium voltage-gated channel alpha subunit 1; ENU induced mutant1, Kyo) - Rat Genome Database

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Gene: Scn1am1Kyo (sodium voltage-gated channel alpha subunit 1; ENU induced mutant1, Kyo) Rattus norvegicus
Analyze
Symbol: Scn1am1Kyo
Name: sodium voltage-gated channel alpha subunit 1; ENU induced mutant1, Kyo
RGD ID: 12792283
Description: A missense mutant N1417H (4246A>G) in the third pore region of the sodium channel was induced by ethylnitrosourea (ENU) mutagenesis.
ASSOCIATED WITH increased susceptibility to induction of seizure by inducing agent; ASSOCIATED WITH Febrile Seizures
Type: allele  of Scn1a  
Previously known as: Scn1aKyo811; Scn1am1; Scn1a^[m1Kyo]; Scn1am1Kyo; sodium voltage-gated channel alpha subunit 1; mutant1; sodium voltage-gated channel alpha subunit 1; mutant1, Kyo
Is Marker For: Strains:   F344-Scn1am1Kyo   WTC.F344-Scn1am1Kyo/Kyo   F344-Cacna1agryScn1am1Kyo/Okym  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. A missense mutation of the gene encoding voltage-dependent sodium channel (Nav1.1) confers susceptibility to febrile seizures in rats. Mashimo T, etal., J Neurosci. 2010 Apr 21;30(16):5744-53. doi: 10.1523/JNEUROSCI.3360-09.2010.

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Scn1am1Kyo-var1 chr3 50969024 50969024 T G point_mutation mRatBN7.2
Scn1am1Kyo-var1 chr3 52408707 52408707 T G point_mutation Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Scn1am1Kyo
F344-Cacna1agryScn1am1Kyo/Okym     F344-Scn1am1Kyo     WTC.F344-Scn1am1Kyo/Kyo    


Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-16 Scn1am1Kyo  sodium voltage-gated channel alpha subunit 1; ENU induced mutant1, Kyo  Scn1am1Kyo  sodium voltage-gated channel alpha subunit 1; mutant1, Kyo  Name changed 629549 APPROVED
2017-03-15 Scn1am1Kyo  sodium voltage-gated channel alpha subunit 1; mutant1, Kyo  Scn1am1  sodium voltage-gated channel alpha subunit 1; mutant1  Name and Symbol changed 629549 APPROVED