Pla2g4a (phospholipase A2 group IVA) - Rat Genome Database

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Gene: Pla2g4a (phospholipase A2 group IVA) Ictidomys tridecemlineatus
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Symbol: Pla2g4a
Name: phospholipase A2 group IVA
RGD ID: 12708106
Description: ENCODES a protein that exhibits calcium-dependent phospholipase A2 activity (ortholog); histone acetyltransferase binding (ortholog); INVOLVED IN arachidonic acid metabolic process (ortholog); arachidonic acid secretion (ortholog); cellular response to antibiotic (ortholog); PARTICIPATES IN cyclooxygenase mediated pathway of arachidonic acid metabolism; endothelin signaling pathway; Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); amyotrophic lateral sclerosis (ortholog); asthma (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog); zymogen granule (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cytosolic phospholipase A2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934485,712,619 - 85,843,081 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364813,559,358 - 3,689,833 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364813,559,377 - 3,689,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
arachidonic acid metabolic process  (IEA,ISO)
arachidonic acid secretion  (IEA,ISO)
cellular response to antibiotic  (IEA,ISO)
cellular response to homocysteine  (ISO)
decidualization  (ISO)
establishment of localization in cell  (IEA,ISO)
fatty acid biosynthetic process  (IEA)
fatty acid metabolic process  (IEA)
glycerol metabolic process  (IEA)
glycerophospholipid catabolic process  (IEA)
icosanoid biosynthetic process  (IEA,ISO)
leukotriene biosynthetic process  (IEA)
lipid catabolic process  (IEA)
lipid metabolic process  (IEA)
luteolysis  (ISO)
monoacylglycerol biosynthetic process  (IEA)
ovulation from ovarian follicle  (ISO)
phosphatidylcholine acyl-chain remodeling  (IEA)
phosphatidylcholine catabolic process  (IEA)
phosphatidylglycerol catabolic process  (IEA)
phospholipid catabolic process  (IEA)
platelet activating factor biosynthetic process  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of fever generation  (ISO)
positive regulation of macrophage activation  (IEA)
positive regulation of platelet activation  (IEA)
positive regulation of prostaglandin biosynthetic process  (ISO)
positive regulation of prostaglandin secretion  (IEA,ISO)
positive regulation of T-helper 1 type immune response  (IEA)
positive regulation of vesicle fusion  (ISO)
prostaglandin biosynthetic process  (IEA)
prostaglandin metabolic process  (IEA)
regulation of cell population proliferation  (IEA,ISO)
response to calcium ion  (ISO)
response to glucocorticoid  (ISO)
response to hormone  (ISO)
response to hydrogen peroxide  (ISO)
response to lipopolysaccharide  (ISO)
response to methylmercury  (ISO)
response to organic substance  (ISO)
response to organonitrogen compound  (ISO)
response to vitamin D  (ISO)
surfactant homeostasis  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pla2g4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934485,712,619 - 85,843,081 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364813,559,358 - 3,689,833 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364813,559,377 - 3,689,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLA2G4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381186,828,949 - 186,988,981 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1186,828,949 - 186,988,981 (+)EnsemblGRCh38hg38GRCh38
GRCh371186,798,081 - 186,958,113 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361185,064,655 - 185,224,736 (+)NCBINCBI36Build 36hg18NCBI36
Build 341183,529,761 - 183,689,770NCBI
Celera1159,908,366 - 160,068,522 (+)NCBICelera
Cytogenetic Map1q31.1NCBI
HuRef1158,032,476 - 158,192,352 (+)NCBIHuRef
CHM1_11188,219,298 - 188,379,410 (+)NCBICHM1_1
T2T-CHM13v2.01186,183,301 - 186,343,553 (+)NCBIT2T-CHM13v2.0
Pla2g4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391149,705,369 - 149,837,041 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1149,705,369 - 149,837,041 (-)EnsemblGRCm39 Ensembl
GRCm381149,829,618 - 149,961,290 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1149,829,618 - 149,961,290 (-)EnsemblGRCm38mm10GRCm38
MGSCv371151,676,752 - 151,808,414 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361151,591,840 - 151,723,502 (-)NCBIMGSCv36mm8
Celera1152,270,492 - 152,407,425 (-)NCBICelera
Cytogenetic Map1G1NCBI
cM Map163.51NCBI
Pla2g4a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81364,427,921 - 64,572,352 (-)NCBIGRCr8
mRatBN7.21361,877,818 - 62,022,261 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1361,877,813 - 62,022,266 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1364,503,114 - 64,647,490 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01365,794,043 - 65,938,034 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01363,055,598 - 63,199,601 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01367,062,252 - 67,206,688 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1366,988,937 - 67,206,693 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01372,027,801 - 72,172,613 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41364,135,729 - 64,280,815 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11364,149,803 - 64,294,883 (-)NCBI
Celera1361,840,531 - 61,984,375 (-)NCBICelera
Cytogenetic Map13q21NCBI
Pla2g4a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540625,257,355 - 25,394,206 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540625,257,361 - 25,392,079 (+)NCBIChiLan1.0ChiLan1.0
PLA2G4A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2162,725,111 - 62,884,722 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1162,405,808 - 62,566,032 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01162,362,600 - 162,521,974 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11166,512,870 - 166,672,114 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,512,870 - 166,672,101 (+)Ensemblpanpan1.1panPan2
PLA2G4A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1719,804,412 - 19,955,215 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl719,832,664 - 19,966,936 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha719,327,033 - 19,477,842 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0719,541,768 - 19,692,656 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl719,570,229 - 19,692,274 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1719,447,440 - 19,598,170 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0719,556,751 - 19,707,439 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0719,688,892 - 19,840,168 (+)NCBIUU_Cfam_GSD_1.0
PLA2G4A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9127,859,051 - 128,162,638 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19127,853,581 - 128,164,825 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29140,386,385 - 140,623,416 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLA2G4A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12542,443,480 - 42,590,895 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2542,443,385 - 42,590,431 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605543,569,644 - 43,761,073 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pla2g4a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248146,597,005 - 6,744,286 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248146,597,248 - 6,744,294 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSSTOT00000014612   ⟹   ENSSTOP00000013089
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364813,559,826 - 3,651,788 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000030548   ⟹   ENSSTOP00000031303
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364813,559,358 - 3,689,833 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000038826   ⟹   ENSSTOP00000031367
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364813,614,765 - 3,663,985 (-)Ensembl
RefSeq Acc Id: XM_013356145   ⟹   XP_013211599
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934485,712,628 - 85,843,081 (-)NCBI
SpeTri2.0NW_0049364813,559,377 - 3,689,797 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040277568   ⟹   XP_040133502
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934485,712,619 - 85,817,335 (-)NCBI
Protein Sequences
Protein RefSeqs XP_013211599 (Get FASTA)   NCBI Sequence Viewer  
  XP_040133502 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000013089.3
  ENSSTOP00000031303.1
  ENSSTOP00000031367.1
GenBank Protein KAG3258507 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_013211599   ⟸   XM_013356145
- UniProtKB: A0A287DCN1 (UniProtKB/TrEMBL),   I3MN89 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040133502   ⟸   XM_040277568
- UniProtKB: A0A287DCN1 (UniProtKB/TrEMBL),   I3MN89 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000031367   ⟸   ENSSTOT00000038826
RefSeq Acc Id: ENSSTOP00000013089   ⟸   ENSSTOT00000014612
RefSeq Acc Id: ENSSTOP00000031303   ⟸   ENSSTOT00000030548
Protein Domains
C2   PLA2c


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000014608 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000014612.3 UniProtKB/TrEMBL
  ENSSTOT00000030548.1 UniProtKB/TrEMBL
  ENSSTOT00000038826.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.150 UniProtKB/TrEMBL
  Cytosolic phospholipase A2 catalytic domain UniProtKB/TrEMBL
InterPro Acyl_Trfase/lysoPLipase UniProtKB/TrEMBL
  C2_cPLA2 UniProtKB/TrEMBL
  C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  LysoPLipase_cat_dom UniProtKB/TrEMBL
  Synaptotagmin_plant UniProtKB/TrEMBL
NCBI Gene Pla2g4a ENTREZGENE
PANTHER C2 CALCIUM/LIPID-BINDING ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE-RELATED UniProtKB/TrEMBL
  CYTOSOLIC PHOSPHOLIPASE A2 UniProtKB/TrEMBL
  CYTOSOLIC PHOSPHOLIPASE A2 UniProtKB/TrEMBL
  EXTENDED SYNAPTOTAGMIN-RELATED UniProtKB/TrEMBL
Pfam PF00168 UniProtKB/TrEMBL
  PLA2_B UniProtKB/TrEMBL
PROSITE PLA2C UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
SMART PLAc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
  SSF52151 UniProtKB/TrEMBL
UniProt A0A287DCN1 ENTREZGENE, UniProtKB/TrEMBL
  A0A287DCS5_ICTTR UniProtKB/TrEMBL
  I3MN89 ENTREZGENE, UniProtKB/TrEMBL