Aldh9a1 (aldehyde dehydrogenase 9 family member A1)

Gene: Aldh9a1 (aldehyde dehydrogenase 9 family member A1) Ictidomys tridecemlineatus

Analyze

Symbol:

Aldh9a1

Name:

aldehyde dehydrogenase 9 family member A1

RGD ID:

12700933

Description:

ENCODES a protein that exhibits 4-trimethylammoniobutyraldehyde dehydrogenase activity (ortholog); aldehyde dehydrogenase (NAD+) activity (ortholog); amine binding (ortholog); INVOLVED IN carnitine metabolic process (ortholog); cellular aldehyde metabolic process (ortholog); kidney development (ortholog); PARTICIPATES IN carnitine biosynthetic pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); COVID-19 (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN cytoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

4-trimethylaminobutyraldehyde dehydrogenase

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	101,783,295 - 101,803,263 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936481	19,630,045 - 19,650,009 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chemical and Drug Induced Liver Injury (ISO)

COVID-19 (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

parathyroid carcinoma (ISO)

prostate cancer (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carnitine biosynthetic process (IEA)

carnitine metabolic process (IEA,ISO)

cellular aldehyde metabolic process (ISO)

kidney development (ISO)

liver development (ISO)

protein homotetramerization (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (IEA)

Molecular Function

4-trimethylammoniobutyraldehyde dehydrogenase activity (IEA,ISO)

aldehyde dehydrogenase (NAD+) activity (ISO)

amine binding (ISO)

aminobutyraldehyde dehydrogenase activity (IEA,ISO)

betaine-aldehyde dehydrogenase activity (IEA)

formaldehyde dehydrogenase activity (ISO)

identical protein binding (ISO)

NAD binding (ISO)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor (IEA)

small molecule binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

carnitine biosynthetic pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Aldh9a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	101,783,295 - 101,803,263 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936481	19,630,045 - 19,650,009 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ALDH9A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	165,662,216 - 165,698,562 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	165,662,216 - 165,698,562 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	165,631,453 - 165,667,799 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	163,898,073 - 163,934,524 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	162,363,110 - 162,399,758	NCBI
Celera	1	138,736,605 - 138,773,321 (-)	NCBI		Celera
Cytogenetic Map	1	q24.1	NCBI
HuRef	1	136,878,922 - 136,915,629 (-)	NCBI		HuRef
CHM1_1	1	167,054,030 - 167,090,476 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	165,008,653 - 165,044,991 (-)	NCBI		T2T-CHM13v2.0

Aldh9a1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	167,177,560 - 167,196,100 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	167,177,560 - 167,196,101 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	167,349,963 - 167,368,530 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	167,349,991 - 167,368,532 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	169,280,122 - 169,298,661 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	169,186,888 - 169,204,961 (+)	NCBI		MGSCv36	mm8
Celera	1	169,767,504 - 169,786,077 (+)	NCBI		Celera
Cytogenetic Map	1	H2.3	NCBI
cM Map	1	74.74	NCBI

Aldh9a1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	82,038,679 - 82,055,478 (+)	NCBI		GRCr8
mRatBN7.2	13	79,505,738 - 79,522,539 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	79,505,695 - 79,540,568 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	82,135,618 - 82,152,413 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	83,442,832 - 83,459,515 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	80,680,560 - 80,697,225 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	85,580,828 - 85,597,497 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	85,580,828 - 85,597,493 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	90,223,961 - 90,240,186 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	83,017,312 - 83,034,047 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	83,031,512 - 83,047,451 (+)	NCBI
Celera	13	79,210,686 - 79,227,775 (+)	NCBI		Celera
Cytogenetic Map	13	q24	NCBI

Aldh9a1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955462	10,998,147 - 11,017,360 (+)	NCBI	ChiLan1.0	ChiLan1.0

ALDH9A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	84,066,891 - 84,103,431 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	83,735,548 - 83,772,060 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	141,094,261 - 141,130,613 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	144,883,828 - 144,919,718 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	144,883,839 - 144,919,670 (-)	Ensembl	panpan1.1		panPan2

ALDH9A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	17,644,464 - 17,664,462 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	17,644,459 - 17,663,886 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	17,701,135 - 17,721,198 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	17,699,030 - 17,719,264 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	38	17,698,130 - 17,718,197 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	18,049,253 - 18,069,354 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	18,343,405 - 18,363,616 (+)	NCBI		UU_Cfam_GSD_1.0

ALDH9A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	4	85,029,914 - 85,057,650 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	92,685,909 - 92,713,569 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ALDH9A1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	63,184,220 - 63,223,865 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666055	64,944,943 - 64,983,521 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Aldh9a1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624826	3,994,183 - 4,026,696 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624826	3,994,188 - 4,026,437 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005319856	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010004404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005319856 ⟹ XP_005319913

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	101,783,295 - 101,803,263 (+)	NCBI
SpeTri2.0	NW_004936481	19,630,045 - 19,650,009 (+)	NCBI

Sequence:

show sequence

CAGGCCCCGCCCCGCCCCGCGGCCCGGCGCCCACCTCGGCGCAGACAGATGGTCCTCCGAGCCC
TGCTGGCCGCGCTGCCCACGCTGCTCCGCGCCCCTCGGCCTGCTTGCGTCGCCGCCATGAGCAC
TGGCACCTTCACAGTGTCGCAGCCCCTCAACTATCGCGGCGGGGCCCGCGTGGAGCCGGTGGAC
GCCTCCGGCACCGAGACGGCCTTCGAGCCCGCCACCGGCCGAATAATAGCTACTTTCACATGTT
CTGGTGAAAAGGAAGTAGATTTGGCTGTTCAAAATGCAAAGGCTGCTTTTAAACTATGGAGTAA
GAAATCTGGCTTGGAGCGGTGCCGAATCCTCTTGGAGGCTGCCAAGATAATAAGGGAGCGAACG
GAGGACATTGCCACTGTGGAGACCATCAACAATGGCAAGTCCGTCTTTGAGGCCCGCTTGGACG
TGGCGTCCTGCTGGCAGTGCCTGGAGTACTTTGCGGGCTTGGCTGGGTCCCTGGCTGGTGAACA
CGTCCAGCTCCCAGGAGGATCCTTTGGTTACACCAGAAGAGAGCCACTTGGGGTGTGTGTGGGG
ATAGGAGCCTGGAACTACCCCTTTCAGATCGCCTGTTGGAAGTCTGCTCCTGCTTTGGCCTGCG
GTAACGCTATGGTCTTTAAACCGTCTCCCTTCACGCCCGTTTCCGCCCTGCTCCTGGCTGAGAT
CTATGCGGAGGCCGGCGTGCCTCCTGGGCTCTTCAATGTGGTGCAGGGAGGGGCCGCCACGGGC
CAGTTTCTATGTCAGCATCCCGACGTGGCCAAGGTCTCCTTCACTGGAAGCGTGCCCACTGGTG
TGAAGATCATGGAACTGTCAGCTAAAGGGATCAAACCTGTGACCTTGGAACTCGGGGGCAAGTC
TCCACTCATCATCTTCTCCGACTGCGACTTGGAGAATGCCGTGAGGGGGGCCATGATGGCCAAC
TTCCTCACTCAAGGCCAGGTTTGCTGCAATGGCACAAGAGTGTTTGTGCAAAGGGCGATTCTTG
ATAAATTCACAGAAGAAGTGGTGGAACAGACCCAGAAGATAAAAATTGGAGATCCCCTTCTGGA
AGATACGAGGATGGGCCCGCTCATCAACCGGCCACACCTGGAGCGGGTCCTGGGGTTTGTTAAG
TCGGCAAAGCAGCAGGGTGCCAGAGTGTTGTGTGGCGGAGATCCGTATGTACCCCAGGATCCCA
AACTGAAAGATGGATATTACATGAGACCTTGTGTGTTAACTGATTGCCGAGACGACATGACCTG
TGTGAGGGAAGAGATCTTCGGACCCGTCATGTCCATCCTGCCCTTCGACACTGAAGCCGAGGTT
CTGGAACGAGCCAACGACACCACCTTTGGACTGGCAGCTGGCGTCTTCACGAGGGACATCCAGC
GGGCTCACAGAGTGGCGGCTGAGCTTCAGGCGGGGTCCTGCTTCATAAACAACTACAACGTCAG
CCCGGTGGAGCTGCCCTTCGGGGGCTACAAGAAGTCAGGGTTCGGCAGAGAGAACGGCCGGGTG
ACAATTGAGTATTATTCACAGCTCAAGACCGTGTACGTGGAGATGGGCGATGTGGAAACTGCGT
TTTGAACAGCCACAGTGAGGCCGTCCGCGGGCGGGGCTCTCTGGACAAGGCAGCGCGGGGTTGG
AACCAGGTCCTCCCCAGCCAGGGTGGGCATTCTGCCACTAGTGTGCCCAGCCTCCTGAACCCAC
TCCAGGTCCAGACTTGGGGCCCTTGAGGGTTAGGGATTGGTTGTGCCTTATTCTTCACCTTTCA
GTTACCTTCCTAATCGAAAATGTGTTGCAAGTGCCACTTAGTCACAAATCCAGACGGTTTTGAT
CTTCCTCAGTGAAAATTTCTGTGAAATCTTTAAAGCCAGCAGCACACTTCCAGAGAGCAGGCAG
AGGGACCAGGACGCCCCGTGCTCCACCCGCGAGCACGTTGGGGCTCTGGCCCGGAGAACGCGCT
CTGGTGGCTCCCAGTGGGGTCAGCAGAGGCAACACCTGGTGTTCACGGTTTTAGTCTCGTCCCG
TCATTCCAGCCAGGAAGCTGCTGATGAGGGGACCCGACTCTGGCCGGTAGCTTGGGGGGCGGGG
GGTTCCACTCCCTCTTTGTGGGCGGGAGCGAAACAATGGAATAAAGTGCATCTGCTGTTG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005319913	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000022146.1
GenBank Protein	KAG3258845	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005319913 ⟸ XM_005319856

- UniProtKB:

I3NCP9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVLRALLAALPTLLRAPRPACVAAMSTGTFTVSQPLNYRGGARVEPVDASGTETAFEPATGRII
ATFTCSGEKEVDLAVQNAKAAFKLWSKKSGLERCRILLEAAKIIRERTEDIATVETINNGKSVF
EARLDVASCWQCLEYFAGLAGSLAGEHVQLPGGSFGYTRREPLGVCVGIGAWNYPFQIACWKSA
PALACGNAMVFKPSPFTPVSALLLAEIYAEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTG
SVPTGVKIMELSAKGIKPVTLELGGKSPLIIFSDCDLENAVRGAMMANFLTQGQVCCNGTRVFV
QRAILDKFTEEVVEQTQKIKIGDPLLEDTRMGPLINRPHLERVLGFVKSAKQQGARVLCGGDPY
VPQDPKLKDGYYMRPCVLTDCRDDMTCVREEIFGPVMSILPFDTEAEVLERANDTTFGLAAGVF
TRDIQRAHRVAAELQAGSCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVYVEMG
DVETAF

hide sequence

Protein Domains

Aldehyde dehydrogenase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000022883	UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000022772.2	UniProtKB/TrEMBL
InterPro	Ald_DH/histidinol_DH	UniProtKB/TrEMBL
	Ald_DH_C	UniProtKB/TrEMBL
	Ald_DH_CS_CYS	UniProtKB/TrEMBL
	Ald_DH_CS_GLU	UniProtKB/TrEMBL
	Ald_DH_N	UniProtKB/TrEMBL
	Aldehyde_DH_dom	UniProtKB/TrEMBL
NCBI Gene	Aldh9a1	ENTREZGENE
PANTHER	4-TRIMETHYLAMINOBUTYRALDEHYDE DEHYDROGENASE	UniProtKB/TrEMBL
	ALDEHYDE DEHYDROGENASE-RELATED	UniProtKB/TrEMBL
Pfam	Aldedh	UniProtKB/TrEMBL
PROSITE	ALDEHYDE_DEHYDR_CYS	UniProtKB/TrEMBL
	ALDEHYDE_DEHYDR_GLU	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53720	UniProtKB/TrEMBL
UniProt	I3NCP9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB