Prrx1 (paired related homeobox 1)

Gene: Prrx1 (paired related homeobox 1) Ictidomys tridecemlineatus

Analyze

Symbol:

Prrx1

Name:

paired related homeobox 1

RGD ID:

12688496

Description:

ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN artery morphogenesis (ortholog); cartilage development (ortholog); embryonic cranial skeleton morphogenesis (ortholog); ASSOCIATED WITH 1q24 Deletion Syndrome (ortholog); agnathia-otocephaly complex (ortholog); atrial fibrillation (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

paired mesoderm homeobox protein 1; paired related homeobox 1, transcript variant X1; paired related homeobox 1, transcript variant X2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	98,358,502 - 98,426,095 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936481	16,205,240 - 16,272,850 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936481	16,208,243 - 16,272,836 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

1q24 Deletion Syndrome (ISO)

agnathia-otocephaly complex (ISO)

atrial fibrillation (ISO)

demyelinating disease (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

parathyroid carcinoma (ISO)

Prostatic Neoplasms (ISO)

Retrognathia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

artery morphogenesis (IEA,ISO)

cartilage development (IEA,ISO)

embryonic cranial skeleton morphogenesis (IEA,ISO)

embryonic limb morphogenesis (IEA,ISO)

embryonic skeletal system morphogenesis (IEA,ISO)

inner ear morphogenesis (IEA,ISO)

mesenchymal cell proliferation (IEA,ISO)

middle ear morphogenesis (IEA,ISO)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

neuron fate determination (IEA,ISO)

neuronal stem cell population maintenance (IEA,ISO)

positive regulation of mesenchymal cell proliferation (IEA,ISO)

positive regulation of smoothened signaling pathway (IEA,ISO)

positive regulation of stem cell proliferation (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

regulation of DNA-templated transcription (IEA)

regulation of neuron projection regeneration (IEA,ISO)

regulation of transcription by RNA polymerase II (IEA)

roof of mouth development (IEA,ISO)

smoothened signaling pathway (IEA,ISO)

stem cell proliferation (IEA,ISO)

transcription by RNA polymerase II (IEA)

Cellular Component

cytosol (IEA)

nucleoplasm (IEA)

nucleus (IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IEA)

HMG box domain binding (IEA)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA)

RNA polymerase II general transcription initiation factor activity (IEA)

RNA polymerase II-specific DNA-binding transcription factor binding (IEA)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Prrx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	98,358,502 - 98,426,095 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936481	16,205,240 - 16,272,850 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936481	16,208,243 - 16,272,836 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PRRX1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	170,662,768 - 170,739,421 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	170,662,728 - 170,739,421 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	170,633,272 - 170,708,562 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	168,899,937 - 168,975,165 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	143,742,929 - 143,818,153 (+)	NCBI		Celera
Cytogenetic Map	1	q24.2	NCBI
HuRef	1	141,857,178 - 141,932,397 (+)	NCBI		HuRef
CHM1_1	1	172,055,608 - 172,130,854 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	170,018,992 - 170,095,719 (+)	NCBI		T2T-CHM13v2.0

Prrx1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	163,072,688 - 163,142,714 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	163,072,688 - 163,141,279 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	163,245,119 - 163,315,145 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	163,245,119 - 163,313,710 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	165,175,250 - 165,243,781 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	165,081,794 - 165,150,325 (-)	NCBI		MGSCv36	mm8
Celera	1	165,686,221 - 165,753,419 (-)	NCBI		Celera
Cytogenetic Map	1	H2.1	NCBI
cM Map	1	70.53	NCBI

Prrx1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	78,136,783 - 78,205,379 (-)	NCBI		GRCr8
mRatBN7.2	13	75,600,777 - 75,671,896 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	75,601,706 - 75,670,866 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	78,222,273 - 78,288,991 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	79,522,828 - 79,589,543 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	76,777,727 - 76,846,595 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	81,147,038 - 81,215,559 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	81,147,348 - 81,214,546 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	86,039,713 - 86,107,919 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	78,961,648 - 79,028,882 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	78,975,835 - 79,043,069 (-)	NCBI
Celera	13	75,343,320 - 75,409,614 (-)	NCBI		Celera
Cytogenetic Map	13	q22	NCBI

Prrx1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955462	6,919,899 - 6,991,733 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955462	6,919,905 - 6,991,733 (+)	NCBI	ChiLan1.0	ChiLan1.0

PRRX1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	79,023,160 - 79,101,125 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	78,696,682 - 78,773,306 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	146,151,633 - 146,227,926 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	149,867,365 - 149,943,810 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	149,867,634 - 149,943,810 (+)	Ensembl	panpan1.1		panPan2

PRRX1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	28,065,570 - 28,138,734 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	28,068,711 - 28,138,787 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	27,598,170 - 27,671,127 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	27,867,506 - 27,940,906 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	27,867,529 - 27,939,818 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	27,717,090 - 27,790,221 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	27,751,956 - 27,825,122 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	27,988,098 - 28,061,291 (-)	NCBI		UU_Cfam_GSD_1.0

PRRX1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	80,427,687 - 80,501,646 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	80,427,682 - 80,502,689 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	87,973,831 - 88,044,655 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PRRX1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	58,347,686 - 58,423,454 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	58,347,704 - 58,421,980 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	59,994,168 - 60,070,286 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Prrx1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624826	8,361,033 - 8,435,656 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624826	8,361,039 - 8,435,488 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005319820	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005319821	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010004404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000021062 ⟹ ENSSTOP00000022194

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936481	16,205,240 - 16,272,850 (-)	Ensembl

RefSeq Acc Id:

ENSSTOT00000041027 ⟹ ENSSTOP00000028980

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936481	16,205,240 - 16,272,850 (-)	Ensembl

RefSeq Acc Id:

XM_005319820 ⟹ XP_005319877

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	98,358,502 - 98,426,095 (-)	NCBI
SpeTri2.0	NW_004936481	16,208,243 - 16,272,836 (-)	NCBI

Sequence:

show sequence

CTCTCGCCCACAGCGTTTGGTGTTGATTCGAGCGGGAAGAGGGGGGTGGGTGGGATTGGAGGGG
GAGACCATGACCTCCAGCTACGGGCACGTTCTGGAGCGGCAACCGGCGCTGGGCGGCCGCTTGG
ACAGCCCGGGCAACCTCGACACCCTGCAGGCGAAAAAGAACTTCTCCGTCAGTCACCTGCTAGA
CCTGGAGGAAGCCGGGGACATGGTCGCAGCCCAGGCGGACGAAAGCGTGGGCGAGGCGGGCCGG
AGCCTGCTGGAGTCGCCGGGACTCACCAGTGGCAGCGACACCCCGCAGCAGGACAATGATCAGC
TGAACTCAGAGGAGAAGAAGAAGAGAAAGCAGCGGAGAAACAGGACAACCTTCAACAGCAGCCA
GCTGCAGGCCTTGGAGCGTGTGTTTGAGCGGACGCACTACCCGGATGCCTTCGTGCGGGAAGAC
CTTGCGCGCCGTGTGAACCTCACCGAGGCCAGAGTGCAGGTGTGGTTTCAGAACAGAAGAGCCA
AGTTCCGCAGGAACGAGAGAGCCATGCTGGCCAACAAAAATGCTTCCCTCCTCAAATCCTACTC
AGGAGACGTGAGTGCCGTGGAGCAGCCCATCGTCCCTCGTCCTGCTCCGAGACCCACCGACTAT
CTCTCCTGGGGGACAGCATCCCCATACAGCGCCATGGCTACTTACTCTGCCACATGTGCCAACA
ATAGCCCTGCTCAGGGCATCAACATGGCCAACAGCATTGCCAACCTGAGACTGAAGGCCAAGGA
ATATAGTTTACAGAGGAACCAAGTGCCAACAGTCAACTGAGGAAAAAAAAATTTAAACAGGCCT
AAGAAGAAATCAAAAACCATAAGACACCTATCCTGCTCTGTCATTTCTTCATCCGCTGGGAAAA
AAAAAAA

hide sequence

RefSeq Acc Id:

XM_005319821 ⟹ XP_005319878

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	98,361,590 - 98,426,095 (-)	NCBI
SpeTri2.0	NW_004936481	16,208,338 - 16,272,833 (-)	NCBI

Sequence:

show sequence

TCGCCCACAGCGTTTGGTGTTGATTCGAGCGGGAAGAGGGGGGTGGGTGGGATTGGAGGGGGAG
ACCATGACCTCCAGCTACGGGCACGTTCTGGAGCGGCAACCGGCGCTGGGCGGCCGCTTGGACA
GCCCGGGCAACCTCGACACCCTGCAGGCGAAAAAGAACTTCTCCGTCAGTCACCTGCTAGACCT
GGAGGAAGCCGGGGACATGGTCGCAGCCCAGGCGGACGAAAGCGTGGGCGAGGCGGGCCGGAGC
CTGCTGGAGTCGCCGGGACTCACCAGTGGCAGCGACACCCCGCAGCAGGACAATGATCAGCTGA
ACTCAGAGGAGAAGAAGAAGAGAAAGCAGCGGAGAAACAGGACAACCTTCAACAGCAGCCAGCT
GCAGGCCTTGGAGCGTGTGTTTGAGCGGACGCACTACCCGGATGCCTTCGTGCGGGAAGACCTT
GCGCGCCGTGTGAACCTCACCGAGGCCAGAGTGCAGGTGTGGTTTCAGAACAGAAGAGCCAAGT
TCCGCAGGAACGAGAGAGCCATGCTGGCCAACAAAAATGCTTCCCTCCTCAAATCCTACTCAGG
AGACGTGAGTGCCGTGGAGCAGCCCATCGTCCCTCGTCCTGCTCCGAGACCCACCGACTATCTC
TCCTGGGGGACAGCATCCCCATACAGATCCTCGTCCCTCCCAAGATGTTGTTTACACGAGGGGC
TTCATAACGGATTCTAACGGAAGACACTGAAAAGCGCCATGGCTACTTACTCTGCCACATGTGC
CAACAATAGCCCTGCTCAGGGCATCAACATGGCCAACAGCATTGCCAACCTGAGACTGAAGGCC
AAGGAATATAGTTTACAGAGGAACCAAGTGCCAACAGTCAACTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005319877	(Get FASTA)	NCBI Sequence Viewer
	XP_005319878	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000022194.2
	ENSSTOP00000028980.1
GenBank Protein	KAG3258759	(Get FASTA)	NCBI Sequence Viewer
	KAG3258760	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005319877 ⟸ XM_005319820
- Peptide Label:	isoform X1
- UniProtKB:	I3NCU7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTSSYGHVLERQPALGGRLDSPGNLDTLQAKKNFSVSHLLDLEEAGDMVAAQADESVGEAGRSL LESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPDAFVREDLA RRVNLTEARVQVWFQNRRAKFRRNERAMLANKNASLLKSYSGDVSAVEQPIVPRPAPRPTDYLS WGTASPYSAMATYSATCANNSPAQGINMANSIANLRLKAKEYSLQRNQVPTVN hide sequence

RefSeq Acc Id:	XP_005319878 ⟸ XM_005319821
- Peptide Label:	isoform X2
- UniProtKB:	A0A287D629 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTSSYGHVLERQPALGGRLDSPGNLDTLQAKKNFSVSHLLDLEEAGDMVAAQADESVGEAGRSL LESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPDAFVREDLA RRVNLTEARVQVWFQNRRAKFRRNERAMLANKNASLLKSYSGDVSAVEQPIVPRPAPRPTDYLS WGTASPYRSSSLPRCCLHEGLHNGF hide sequence

RefSeq Acc Id:

ENSSTOP00000028980 ⟸ ENSSTOT00000041027

RefSeq Acc Id:

ENSSTOP00000022194 ⟸ ENSSTOT00000021062

Protein Domains

Homeobox OAR

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000023298	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000021062.2	UniProtKB/TrEMBL
	ENSSTOT00000041027.1	UniProtKB/TrEMBL
Gene3D-CATH	Homeodomain-like	UniProtKB/TrEMBL
InterPro	Homeobox-like_sf	UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/TrEMBL
	OAR_dom	UniProtKB/TrEMBL
	PRRX1/2	UniProtKB/TrEMBL
NCBI Gene	Prrx1	ENTREZGENE
PANTHER	PAIRED MESODERM HOMEOBOX PROTEIN 1	UniProtKB/TrEMBL
	PTHR46385	UniProtKB/TrEMBL
Pfam	Homeodomain	UniProtKB/TrEMBL
	OAR	UniProtKB/TrEMBL
PROSITE	HOMEOBOX_1	UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/TrEMBL
	OAR	UniProtKB/TrEMBL
SMART	HOX	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/TrEMBL
UniProt	A0A287D629	ENTREZGENE, UniProtKB/TrEMBL
	I3NCU7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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