Enpp1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) - Rat Genome Database

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Pathways
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Gene: Enpp1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) Ictidomys tridecemlineatus
Analyze
Symbol: Enpp1
Name: ectonucleotide pyrophosphatase/phosphodiesterase 1
RGD ID: 12666129
Description: ENCODES a protein that exhibits ATP binding (ortholog); calcium ion binding (ortholog); cyclic-GMP-AMP hydrolase activity (ortholog); INVOLVED IN 3'-phosphoadenosine 5'-phosphosulfate metabolic process (ortholog); adipose tissue development (ortholog); adult locomotory behavior (ortholog); PARTICIPATES IN insulin signaling pathway; niacin metabolic pathway; pantothenic acid metabolic pathway; ASSOCIATED WITH Aortic Calcification (ortholog); aortic valve disease 1 (ortholog); arterial calcification of infancy (ortholog); FOUND IN apical dendrite (ortholog); basal dendrite (ortholog); cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ectonucleotide pyrophosphatase/phosphodiesterase family member 1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1-like; LOC101964456; LOC106145595; uncharacterized LOC106145595
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946120,195,622 - 120,237,836 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004937067194,375 - 246,607 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
3'-phosphoadenosine 5'-phosphosulfate metabolic process  (ISO)
adipose tissue development  (ISO)
adult locomotory behavior  (ISO)
adult walking behavior  (ISO)
aorta development  (ISO)
apoptotic process involved in development  (ISO)
artery development  (ISO)
articular cartilage development  (ISO)
ATP metabolic process  (ISO)
axon regeneration  (ISO)
B-1 B cell homeostasis  (ISO)
biomineral tissue development  (ISO)
bone development  (ISO)
bone growth  (ISO)
bone mineralization  (ISO)
bone mineralization involved in bone maturation  (ISO)
bone remodeling  (ISO)
bone resorption  (ISO)
bone trabecula formation  (ISO)
calcium ion homeostasis  (ISO)
cartilage development  (ISO)
cell morphogenesis  (ISO)
cell population proliferation  (ISO)
cellular homeostasis  (ISO)
cellular response to acidic pH  (ISO)
cellular response to cAMP  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to sodium phosphate  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cementum mineralization  (ISO)
central nervous system myelination  (ISO)
cerebellum development  (ISO)
cerebral cortex development  (ISO)
collagen-activated signaling pathway  (ISO)
defense response to protozoan  (ISO)
determination of adult lifespan  (ISO)
diphosphate metabolic process  (ISO)
endochondral bone morphogenesis  (ISO)
endochondral ossification  (ISO)
establishment of localization in cell  (ISO)
fat cell differentiation  (ISO)
fat pad development  (ISO)
fatty acid metabolic process  (ISO)
fibroblast growth factor receptor signaling pathway  (ISO)
gene expression  (ISO)
generation of precursor metabolites and energy  (ISO)
glucose homeostasis  (ISO)
glucose import  (ISO)
glycolytic process  (ISO)
heart development  (ISO)
hematopoietic stem cell migration to bone marrow  (ISO)
hippocampus development  (ISO)
hormone metabolic process  (ISO)
inflammatory response to antigenic stimulus  (ISO)
inhibition of non-skeletal tissue mineralization  (ISO)
inorganic diphosphate transport  (ISO)
intracellular phosphate ion homeostasis  (ISO)
kidney development  (ISO)
leukocyte activation involved in inflammatory response  (ISO)
ligamentous ossification  (ISO)
liver development  (ISO)
long-term synaptic potentiation  (ISO)
macrophage differentiation  (ISO)
magnesium ion homeostasis  (ISO)
melanocyte differentiation  (ISO)
microglia differentiation  (ISO)
microglial cell migration  (ISO)
middle ear morphogenesis  (ISO)
mitochondrion organization  (ISO)
morphogenesis of an epithelium  (ISO)
mRNA transcription by RNA polymerase II  (ISO)
mucus secretion  (ISO)
multicellular organism growth  (ISO)
muscle cell cellular homeostasis  (ISO)
negative regulation of bone mineralization  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of glucose import  (ISO)
negative regulation of glycogen biosynthetic process  (ISO)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of ossification  (ISO)
negative regulation of protein autophosphorylation  (ISO)
neuron apoptotic process  (ISO)
nucleoside triphosphate catabolic process  (ISO)
odontogenesis  (ISO)
olfactory bulb development  (ISO)
oligodendrocyte apoptotic process  (ISO)
organic phosphonate metabolic process  (ISO)
ossification  (ISO)
osteoblast differentiation  (ISO)
osteoclast differentiation  (ISO)
phosphate ion homeostasis  (ISO)
phosphate-containing compound metabolic process  (ISO)
plasma cell differentiation  (ISO)
post-embryonic forelimb morphogenesis  (ISO)
response to ATP  (ISO)
response to dietary excess  (ISO)
response to Gram-positive bacterium  (ISO)
response to inorganic substance  (ISO)
response to insulin  (ISO)
response to magnesium ion  (ISO)
response to mechanical stimulus  (ISO)
response to platelet-derived growth factor  (ISO)
response to sodium phosphate  (ISO)
response to vitamin B6  (ISO)
response to wounding  (ISO)
sensory perception of mechanical stimulus  (ISO)
sensory perception of sound  (ISO)
sensory perception of temperature stimulus  (ISO)
sequestering of triglyceride  (ISO)
skin development  (ISO)
smoothened signaling pathway  (ISO)
spinal cord development  (ISO)
striatum development  (ISO)
T cell differentiation  (ISO)
tooth mineralization  (ISO)
vascular associated smooth muscle cell migration  (ISO)
vascular associated smooth muscle cell proliferation  (ISO)
vasculogenesis  (ISO)
vitamin D3 metabolic process  (ISO)
Wnt signaling pathway  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Enpp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946120,195,622 - 120,237,836 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004937067194,375 - 246,607 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENPP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386131,808,020 - 131,895,155 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6131,808,016 - 131,895,155 (+)EnsemblGRCh38hg38GRCh38
GRCh376132,129,160 - 132,216,295 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366132,170,853 - 132,254,043 (+)NCBINCBI36Build 36hg18NCBI36
Build 346132,170,852 - 132,254,043NCBI
Celera6132,876,272 - 132,963,416 (+)NCBICelera
Cytogenetic Map6q23.2NCBI
HuRef6129,704,724 - 129,791,900 (+)NCBIHuRef
CHM1_16132,392,926 - 132,480,050 (+)NCBICHM1_1
T2T-CHM13v2.06133,002,962 - 133,090,181 (+)NCBIT2T-CHM13v2.0
Enpp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391024,513,812 - 24,588,057 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1024,513,812 - 24,588,057 (-)EnsemblGRCm39 Ensembl
GRCm381024,637,914 - 24,712,159 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1024,637,914 - 24,712,159 (-)EnsemblGRCm38mm10GRCm38
MGSCv371024,361,217 - 24,431,908 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361024,330,827 - 24,401,518 (-)NCBIMGSCv36mm8
Celera1025,583,320 - 25,641,223 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1012.26NCBI
Enpp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8122,518,051 - 22,583,044 (+)NCBIGRCr8
mRatBN7.2120,698,746 - 20,763,741 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl120,698,764 - 20,763,715 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx120,475,435 - 20,539,162 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0126,475,432 - 26,539,171 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0120,675,339 - 20,739,097 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0121,748,201 - 21,813,205 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,748,261 - 21,813,371 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,228,262 - 23,292,896 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,223,678 - 21,287,411 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1121,223,940 - 21,288,766 (+)NCBI
Celera119,451,097 - 19,514,516 (+)NCBICelera
Cytogenetic Map1p12NCBI
Enpp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543612,415,737 - 12,480,359 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543612,416,147 - 12,477,214 (+)NCBIChiLan1.0ChiLan1.0
ENPP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25151,797,817 - 151,882,874 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16149,704,715 - 149,789,744 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06129,591,858 - 129,673,000 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16133,698,904 - 133,783,644 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6133,698,640 - 133,783,644 (+)Ensemblpanpan1.1panPan2
ENPP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11251,985 - 322,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1252,103 - 322,718 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha11,243,885 - 1,317,644 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0144,146 - 117,941 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl148,283 - 118,098 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1193,290 - 167,054 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0138,450 - 112,214 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01209,085 - 282,880 (-)NCBIUU_Cfam_GSD_1.0
ENPP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl131,722,721 - 31,796,595 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1131,724,290 - 31,796,594 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2135,240,330 - 35,281,377 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ENPP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11341,670,416 - 41,755,549 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604013,807,051 - 13,921,708 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Enpp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247535,917,689 - 5,982,308 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247535,918,005 - 5,983,480 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_040282060   ⟹   XP_040137994
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946120,195,622 - 120,237,836 (+)NCBI
Protein Sequences
Protein RefSeqs XP_040137994 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3290257 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_040137994   ⟸   XM_040282060


Additional Information

Database Acc Id Source(s)
NCBI Gene Enpp1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-26 Enpp1  ectonucleotide pyrophosphatase/phosphodiesterase 1  LOC101964456  ectonucleotide pyrophosphatase/phosphodiesterase family member 1  Symbol and/or name change 5135510 APPROVED
2021-03-25 LOC101964456  ectonucleotide pyrophosphatase/phosphodiesterase family member 1  LOC106145595  ectonucleotide pyrophosphatase/phosphodiesterase family member 1-like  Data merged from RGD:12723044 737654 PROVISIONAL
2017-07-13 LOC106145595  ectonucleotide pyrophosphatase/phosphodiesterase family member 1-like    uncharacterized LOC106145595  Symbol and/or name change 5135510 APPROVED
2017-07-13 LOC101964456  ectonucleotide pyrophosphatase/phosphodiesterase family member 1  Enpp1  ectonucleotide pyrophosphatase/phosphodiesterase 1  Symbol and/or name change 5135510 APPROVED