Ppp4c (protein phosphatase 4 catalytic subunit)

Gene: Ppp4c (protein phosphatase 4 catalytic subunit) Ictidomys tridecemlineatus

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Symbol:

Ppp4c

Name:

protein phosphatase 4 catalytic subunit

RGD ID:

12663589

Description:

ENCODES a protein that exhibits lamin binding (ortholog); phosphatase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN cellular response to interleukin-1 (ortholog); dephosphorylation (ortholog); negative regulation of protein phosphorylation (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); chromosome 16p11.2 deletion syndrome, 593-kb (ortholog); FOUND IN chromatin (ortholog); nucleus (ortholog); protein phosphatase 4 complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

serine/threonine-protein phosphatase 4 catalytic subunit

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	124,310,098 - 124,318,235 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936501	12,407,920 - 12,416,108 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936501	12,407,968 - 12,416,057 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

autistic disorder (ISO)

chromosome 16p11.2 deletion syndrome, 593-kb (ISO)

chromosome 16p11.2 duplication syndrome (ISO)

coronary artery disease (ISO)

coronin-1A deficiency (ISO)

episodic kinesigenic dyskinesia 1 (ISO)

genetic disease (ISO)

Glycogen Storage Disease XII (ISO)

Neurodevelopmental Disorders (ISO)

oligoasthenoteratozoospermia (ISO)

schizophrenia (ISO)

spondylocostal dysostosis 5 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to interleukin-1 (ISO)

dephosphorylation (ISO)

double-strand break repair via homologous recombination (IEA)

negative regulation of protein phosphorylation (ISO)

regulation of double-strand break repair (IEA)

regulation of double-strand break repair via homologous recombination (IEA)

Cellular Component

centrosome (IEA)

chromatin (IEA,ISO)

cytoplasm (IEA)

cytosol (IEA)

nucleoplasm (IEA)

nucleus (IEA,ISO)

plasma membrane (IEA)

protein phosphatase 4 complex (IEA,ISO)

Molecular Function

hydrolase activity (IEA)

lamin binding (ISO)

myosin phosphatase activity (IEA)

phosphatase activity (ISO)

phosphoprotein phosphatase activity (IEA)

protein binding (ISO)

protein serine/threonine phosphatase activity (IEA)

protein-containing complex binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

ataxia telangiectasia-mutated (ATM) signaling pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Ppp4c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	124,310,098 - 124,318,235 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936501	12,407,920 - 12,416,108 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936501	12,407,968 - 12,416,057 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PPP4C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	30,075,994 - 30,085,376 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	30,075,978 - 30,085,376 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	30,087,315 - 30,096,697 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	29,994,886 - 30,004,196 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	29,994,884 - 30,004,196	NCBI
Celera	16	72,699,024 - 72,708,334 (-)	NCBI		Celera
Cytogenetic Map	16	p11.2	NCBI
HuRef	16	27,748,654 - 27,757,965 (+)	NCBI		HuRef
CHM1_1	16	31,303,142 - 31,312,452 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	30,358,641 - 30,368,019 (+)	NCBI		T2T-CHM13v2.0

Ppp4c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	126,385,038 - 126,391,729 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	126,385,038 - 126,391,668 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	126,785,866 - 126,792,557 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	126,785,866 - 126,792,496 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	133,929,382 - 133,935,985 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	126,577,016 - 126,583,619 (-)	NCBI		MGSCv36	mm8
Celera	7	126,633,213 - 126,639,847 (-)	NCBI		Celera
Cytogenetic Map	7	F3	NCBI
cM Map	7	69.25	NCBI

Ppp4c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	190,823,447 - 190,830,247 (-)	NCBI		GRCr8
mRatBN7.2	1	181,392,899 - 181,399,703 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	181,392,923 - 181,399,659 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	189,744,214 - 189,750,778 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	196,930,287 - 196,936,851 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	189,597,625 - 189,604,186 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	198,219,012 - 198,225,775 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	198,219,054 - 198,225,580 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	205,198,880 - 205,205,643 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	185,961,286 - 185,967,851 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	186,111,715 - 186,111,884 (-)	NCBI
Celera	1	179,048,421 - 179,054,986 (-)	NCBI		Celera
Cytogenetic Map	1	q36	NCBI

Ppp4c
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955493	6,894,849 - 6,901,344 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955493	6,894,849 - 6,901,344 (-)	NCBI	ChiLan1.0	ChiLan1.0

PPP4C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	30,825,628 - 30,835,235 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	35,390,648 - 35,400,068 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1	16	30,450,550 - 30,459,889 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	30,450,467 - 30,464,446 (+)	Ensembl	panpan1.1		panPan2

PPP4C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	18,085,048 - 18,092,861 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	18,085,116 - 18,092,854 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	19,663,615 - 19,671,457 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	18,220,957 - 18,228,799 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	18,221,033 - 18,228,784 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	18,019,909 - 18,027,751 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	17,935,306 - 17,943,149 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	18,250,933 - 18,258,775 (+)	NCBI		UU_Cfam_GSD_1.0

PPP4C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	18,262,823 - 18,271,586 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	18,262,817 - 18,271,588 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

PPP4C
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	26,573,636 - 26,585,814 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	26,573,638 - 26,585,849 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	2,956,076 - 2,965,196 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ppp4c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624782	13,174,376 - 13,180,995 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624782	13,174,585 - 13,181,055 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005323822	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010004404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000028690 ⟹ ENSSTOP00000022746

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936501	12,407,920 - 12,416,108 (-)	Ensembl

RefSeq Acc Id:

ENSSTOT00000031912 ⟹ ENSSTOP00000032048

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936501	12,408,275 - 12,410,769 (-)	Ensembl

RefSeq Acc Id:

XM_005323822 ⟹ XP_005323879

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	124,310,098 - 124,318,235 (-)	NCBI
SpeTri2.0	NW_004936501	12,407,968 - 12,416,057 (-)	NCBI

Sequence:

show sequence

CTTCCGCGGCGGGGCCGGAAGTAGAAGCGGCGGTGGCGGCGGCCCAAAGCGGAGGGAAGGAGGG
AAGCAAGCGAGTCCGAGAGCCCGAGCCAGAGTCGCAGCGGCGGAGACCCCTGTGCGGTGCGGAG
GGGGCGGTGGCCCCGACTCTGACCCGCGCCGGGGGGGTGGGCCATGGCGGAGATCAGCGACCTG
GACCGGCAGATCGAGCAGCTACGGCGCTGCGAGCTCATCAAGGAGAGCGAAGTCAAGGCCCTGT
GCGCTAAGGCCAGAGAGATCTTGGTAGAGGAGAGCAATGTGCAGAGGGTGGACTCCCCAGTCAC
CGTGTGCGGCGACATCCATGGACAATTCTATGACCTCAAGGAGCTATTCAGAGTGGGTGGCGAT
GTCCCTGAGACCAACTACCTCTTTATGGGGGACTTTGTGGACCGTGGCTTCTACAGTGTTGAAA
CCTTCCTTCTACTCCTGGCACTTAAGGTTCGCTATCCTGACCGCATCACCCTGATCCGGGGCAA
CCATGAGAGCCGGCAGATCACGCAGGTCTATGGCTTCTATGATGAGTGCCTACGCAAATATGGT
TCGGTGACTGTGTGGCGCTACTGCACTGAGATCTTTGACTACCTCAGCCTGTCAGCCATCATCG
ATGGCAAGATCTTCTGTGTGCACGGGGGCCTCTCCCCCTCCATCCAGACTCTGGACCAGATCCG
GACAATTGATCGAAAGCAGGAAGTGCCACATGATGGACCCATGTGTGACCTCCTCTGGTCTGAC
CCTGAAGATACAACAGGCTGGGGTGTGAGCCCCCGTGGAGCCGGCTACCTGTTTGGCAGTGACG
TGGTGGCCCAGTTCAACGCAGCCAATGACATTGATATGATCTGCCGTGCCCACCAACTAGTGAT
GGAAGGTTACAAGTGGCACTTCAATGAGACCGTGCTCACTGTGTGGTCAGCACCCAACTACTGC
TACCGCTGTGGCAATGTGGCAGCCATCTTGGAGCTGGATGAGCATCTCCAGAAAGATTTTATCA
TCTTTGAGGCTGCTCCCCAGGAGACACGGGGCATCCCCTCCAAGAAGCCGGTGGCCGACTACTT
CCTGTGACCCTTCGGCCCTGCCCCCTCCAACCTTTCTGGCCCTTGGACCACTGTGACTCTGCCC
TCTCCCCAGTCGGAGGCTGGGCAAGGAGGGGCTGTCCCCAGCTCTGCTCTTCCCCCAAGAGGGC
GTTTCAAGGGTGAGGACTTTCTCTGGAGAGGTTTGGAGCCTTAGCTCCATGCTCCTCCTCTCCT
TTCTCCCCACTTGAACCATGAAGTTTCCAGTAATTTTTTGTTTTTCTTTTTTCCTTTTTTTTGT
TTGTTTGTTTTTAGATAAAAGTTTTGAGAAAAAAAGAAAAAAAATTCTAATAAAAGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005323879	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000022746.1
	ENSSTOP00000032048.1
GenBank Protein	KAG3259591	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005323879 ⟸ XM_005323822

- UniProtKB:

I3NEE9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAEISDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKE
LFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYD
ECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPM
CDLLWSDPEDTTGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTV
WSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQETRGIPSKKPVADYFL

hide sequence

RefSeq Acc Id:

ENSSTOP00000032048 ⟸ ENSSTOT00000031912

RefSeq Acc Id:

ENSSTOP00000022746 ⟸ ENSSTOT00000028690

Protein Domains

Serine/threonine specific protein phosphatases

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000027743	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000028690.2	UniProtKB/TrEMBL
	ENSSTOT00000031912.1	UniProtKB/TrEMBL
Gene3D-CATH	3.60.21.10	UniProtKB/TrEMBL
InterPro	Calcineurin-like_PHP_ApaH	UniProtKB/TrEMBL
	Metallo-depent_PP-like	UniProtKB/TrEMBL
	PPA2-like	UniProtKB/TrEMBL
	Ser/Thr-sp_prot-phosphatase	UniProtKB/TrEMBL
NCBI Gene	Ppp4c	ENTREZGENE
PANTHER	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT	UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED	UniProtKB/TrEMBL
Pfam	Metallophos	UniProtKB/TrEMBL
PRINTS	STPHPHTASE	UniProtKB/TrEMBL
PROSITE	SER_THR_PHOSPHATASE	UniProtKB/TrEMBL
SMART	PP2Ac	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56300	UniProtKB/TrEMBL
UniProt	A0A287DES2_ICTTR	UniProtKB/TrEMBL
	I3NEE9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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