Src (SRC proto-oncogene, non-receptor tyrosine kinase)

Gene: Src (SRC proto-oncogene, non-receptor tyrosine kinase) Ictidomys tridecemlineatus

Analyze

Symbol:

Src

Name:

SRC proto-oncogene, non-receptor tyrosine kinase

RGD ID:

12640784

Description:

ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); enzyme binding (ortholog); insulin receptor binding (ortholog); INVOLVED IN adherens junction organization (ortholog); bone resorption (ortholog); branching involved in mammary gland duct morphogenesis (ortholog); PARTICIPATES IN altered Reelin signaling pathway; dopamine signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH Aicardi-Goutieres Syndrome 5 (ortholog); autosomal recessive polycystic kidney disease (ortholog); brain ischemia (ortholog); FOUND IN caveola (ortholog); dendritic filopodium (ortholog); dendritic growth cone (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

proto-oncogene tyrosine-protein kinase Src; SRC proto-oncogene, non-receptor tyrosine kinase, transcript variant X1; SRC proto-oncogene, non-receptor tyrosine kinase, transcript variant X2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	174,890,047 - 174,922,678 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936561	3,825,787 - 3,844,483 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936561	3,826,802 - 3,844,406 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aicardi-Goutieres Syndrome 5 (ISO)

autosomal recessive polycystic kidney disease (ISO)

brain ischemia (ISO)

Breast Neoplasms (ISO)

Cardiomegaly (ISO)

colitis (ISO)

colon adenocarcinoma (ISO)

colon cancer (ISO)

colon carcinoma (ISO)

Colonic Neoplasms (ISO)

colorectal cancer (ISO)

colorectal carcinoma (ISO)

Colorectal Neoplasms (ISO)

disease of cellular proliferation (ISO)

ductal carcinoma in situ (ISO)

focal epilepsy (ISO)

genetic disease (ISO)

Hearing Loss, Noise-Induced (ISO)

hepatocellular carcinoma (ISO)

hypertension (ISO)

Kidney Reperfusion Injury (ISO)

Liver Metastasis (ISO)

lung adenocarcinoma (ISO)

lung metastasis (ISO)

lung squamous cell carcinoma (ISO)

Lymphatic Metastasis (ISO)

myelofibrosis (ISO)

nasopharynx carcinoma (ISO)

Neoplasm Invasiveness (ISO)

Neoplasm Metastasis (ISO)

Neuralgia (ISO)

pancreatic acinar cell adenocarcinoma (ISO)

Parkinsonism (ISO)

prostate cancer (ISO)

Reperfusion Injury (ISO)

sensorineural hearing loss (ISO)

status epilepticus (ISO)

stomach cancer (ISO)

Stroke (ISO)

Thrombocytopenia 6 (ISO)

Trauma and Stressor Related Disorders (ISO)

type 2 diabetes mellitus (ISO)

urinary bladder cancer (ISO)

Williams-Beuren syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adherens junction organization (ISO)

angiotensin-activated signaling pathway (IEA)

bone resorption (IEA,ISO)

branching involved in mammary gland duct morphogenesis (IEA,ISO)

cell adhesion (IEA)

cell differentiation (IEA)

cell migration (IEA,ISO)

cell-cell adhesion (ISO)

cellular response to angiotensin (ISO)

cellular response to fatty acid (ISO)

cellular response to fluid shear stress (IEA,ISO)

cellular response to hydrogen peroxide (IEA,ISO)

cellular response to hypoxia (ISO)

cellular response to insulin stimulus (ISO)

cellular response to lipopolysaccharide (ISO)

cellular response to peptide hormone stimulus (IEA)

cellular response to platelet-derived growth factor stimulus (IEA,ISO)

cellular response to progesterone stimulus (ISO)

cellular response to prolactin (ISO)

cellular response to reactive oxygen species (IEA,ISO)

cellular response to transforming growth factor beta stimulus (IEA,ISO)

DNA biosynthetic process (ISO)

epidermal growth factor receptor signaling pathway (IEA,ISO)

focal adhesion assembly (IEA)

forebrain development (IEA,ISO)

innate immune response (IEA)

integrin-mediated signaling pathway (IEA)

interleukin-6-mediated signaling pathway (IEA)

intestinal epithelial cell development (IEA)

intracellular signal transduction (IEA,ISO)

learning or memory (ISO)

myoblast proliferation (ISO)

negative regulation of anoikis (IEA)

negative regulation of apoptotic process (IEA)

negative regulation of extrinsic apoptotic signaling pathway (IEA)

negative regulation of focal adhesion assembly (ISO)

negative regulation of gene expression (ISO)

negative regulation of hippo signaling (IEA)

negative regulation of intrinsic apoptotic signaling pathway (IEA)

negative regulation of mitochondrial depolarization (IEA)

negative regulation of protein-containing complex assembly (IEA)

negative regulation of telomere maintenance via telomerase (IEA)

neurotrophin TRK receptor signaling pathway (ISO)

odontogenesis (IEA,ISO)

oogenesis (IEA,ISO)

osteoclast development (IEA,ISO)

platelet-derived growth factor receptor signaling pathway (ISO)

positive regulation of apoptotic process (ISO)

positive regulation of bone resorption (ISO)

positive regulation of canonical Wnt signaling pathway (IEA,ISO)

positive regulation of cell adhesion (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of cytokine production (ISO)

positive regulation of dephosphorylation (IEA)

positive regulation of epithelial cell migration (IEA)

positive regulation of ERK1 and ERK2 cascade (IEA)

positive regulation of gene expression (ISO)

positive regulation of glucose metabolic process (ISO)

positive regulation of glycolytic process (ISO)

positive regulation of insulin receptor signaling pathway (ISO)

positive regulation of intracellular signal transduction (ISO)

positive regulation of lamellipodium morphogenesis (IEA)

positive regulation of male germ cell proliferation (ISO)

positive regulation of MAP kinase activity (ISO)

positive regulation of Notch signaling pathway (IEA)

positive regulation of outer hair cell apoptotic process (ISO)

positive regulation of ovarian follicle development (ISO)

positive regulation of peptidyl-tyrosine phosphorylation (IEA,ISO)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA)

positive regulation of platelet-derived growth factor receptor-beta signaling pathway (IEA,ISO)

positive regulation of podosome assembly (IEA,ISO)

positive regulation of protein localization to nucleus (IEA,ISO)

positive regulation of protein processing (IEA,ISO)

positive regulation of protein transport (ISO)

positive regulation of Ras protein signal transduction (ISO)

positive regulation of small GTPase mediated signal transduction (IEA)

positive regulation of smooth muscle cell migration (ISO)

positive regulation of TORC1 signaling (IEA)

positive regulation of vascular associated smooth muscle cell proliferation (ISO)

primary ovarian follicle growth (ISO)

progesterone receptor signaling pathway (IEA)

protein destabilization (IEA)

regulation of caveolin-mediated endocytosis (IEA)

regulation of cell projection assembly (IEA,ISO)

regulation of cell-cell adhesion (IEA)

regulation of early endosome to late endosome transport (IEA)

regulation of epithelial cell migration (IEA)

regulation of heart rate by cardiac conduction (IEA)

regulation of intracellular estrogen receptor signaling pathway (IEA,ISO)

regulation of toll-like receptor 3 signaling pathway (IEA)

response to acidic pH (ISO)

response to electrical stimulus (ISO)

response to fatty acid (ISO)

response to hydrogen peroxide (ISO)

response to interleukin-1 (IEA)

response to mechanical stimulus (ISO)

response to mineralocorticoid (ISO)

response to nutrient levels (ISO)

response to xenobiotic stimulus (ISO)

skeletal muscle cell proliferation (ISO)

spermatogenesis (ISO)

stress fiber assembly (IEA)

substrate adhesion-dependent cell spreading (IEA,ISO)

transcytosis (ISO)

transforming growth factor beta receptor signaling pathway (IEA)

uterus development (IEA,ISO)

Cellular Component

actin filament (IEA)

caveola (IEA,ISO)

cell junction (IEA)

cytoplasm (IEA)

cytoskeleton (IEA)

cytosol (IEA)

dendritic filopodium (ISO)

dendritic growth cone (ISO)

extrinsic component of cytoplasmic side of plasma membrane (IEA)

focal adhesion (IEA)

glutamatergic synapse (ISO)

late endosome (IEA)

lysosome (IEA)

membrane (IEA)

mitochondrial inner membrane (IEA)

mitochondrion (IEA)

neuronal cell body (ISO)

nucleoplasm (IEA)

nucleus (IEA)

perinuclear region of cytoplasm (IEA)

plasma membrane (IEA)

podosome (IEA)

postsynaptic specialization, intracellular component (ISO)

ruffle membrane (IEA)

synaptic membrane (ISO)

Molecular Function

ATP binding (IEA)

BMP receptor binding (IEA)

cell adhesion molecule binding (ISO)

connexin binding (IEA)

enzyme binding (IEA,ISO)

ephrin receptor binding (IEA)

heme binding (IEA)

insulin receptor binding (ISO)

integrin binding (IEA)

kinase activity (IEA)

non-membrane spanning protein tyrosine kinase activity (IEA)

nuclear estrogen receptor binding (ISO)

phospholipase activator activity (IEA)

phospholipase binding (IEA)

phosphoprotein binding (IEA)

protein binding (ISO)

protein domain specific binding (IEA)

protein kinase activity (IEA)

protein kinase binding (ISO)

protein kinase C binding (ISO)

protein tyrosine kinase activity (IEA,ISO)

protein-containing complex binding (ISO)

scaffold protein binding (IEA)

SH2 domain binding (IEA)

signaling receptor binding (IEA,ISO)

transmembrane transporter binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

altered Reelin signaling pathway (ISO)

dopamine signaling pathway (ISO)

E-cadherin signaling pathway (ISO)

eicosanoid signaling pathway (ISO)

endothelin signaling pathway (ISO)

ephrin - ephrin receptor bidirectional signaling axis (ISO)

epidermal growth factor/neuregulin signaling pathway (ISO)

estrogen signaling pathway (ISO)

FasL mediated signaling pathway (ISO)

fibroblast growth factor signaling pathway (ISO)

glypican signaling pathway (ISO)

mitochondrial autophagy pathway (ISO)

nerve growth factor signaling pathway (ISO)

nuclear factor kappa B signaling pathway (ISO)

phosphatidylinositol 3-kinase class I signaling pathway (ISO)

phosphatidylinositol 3-kinase-Akt signaling pathway (ISO)

platelet-derived growth factor signaling pathway (ISO)

Reelin signaling pathway (ISO)

scatter factor/hepatocyte growth factor signaling pathway (ISO)

signaling pathway pertinent to the brain and nervous system (ISO)

somatostatin signaling pathway (ISO)

sphingosine 1-phosphate signaling pathway (ISO)

syndecan signaling pathway (ISO)

ubiquitin/proteasome degradation pathway (ISO)

vascular endothelial growth factor signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Src
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	174,890,047 - 174,922,678 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936561	3,825,787 - 3,844,483 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936561	3,826,802 - 3,844,406 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SRC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	37,344,699 - 37,406,050 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	37,344,685 - 37,406,050 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	35,973,102 - 36,034,453 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	35,406,502 - 35,467,235 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	35,407,970 - 35,467,233	NCBI
Celera	20	32,680,370 - 32,741,098 (+)	NCBI		Celera
Cytogenetic Map	20	q11.23	NCBI
HuRef	20	32,708,654 - 32,769,187 (+)	NCBI		HuRef
CHM1_1	20	35,876,016 - 35,936,689 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	39,068,774 - 39,130,114 (+)	NCBI		T2T-CHM13v2.0

Src
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	157,265,828 - 157,313,758 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	157,260,364 - 157,313,782 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	157,423,906 - 157,471,838 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	157,418,444 - 157,471,862 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	157,250,029 - 157,297,574 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	157,115,734 - 157,163,279 (+)	NCBI		MGSCv36	mm8
Celera	2	163,383,913 - 163,416,616 (+)	NCBI		Celera
Cytogenetic Map	2	H1	NCBI
cM Map	2	78.35	NCBI

Src
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	166,511,616 - 166,559,463 (+)	NCBI		GRCr8
mRatBN7.2	3	146,091,969 - 146,139,492 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	146,091,841 - 146,139,476 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	149,950,044 - 149,963,314 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	158,451,340 - 158,464,620 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	156,193,067 - 156,206,340 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	153,547,807 - 153,595,643 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	153,580,861 - 153,595,642 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	158,123,674 - 158,171,912 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	148,157,256 - 148,170,524 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	148,063,164 - 148,076,433 (+)	NCBI
Celera	3	144,830,256 - 144,843,524 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

Src
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955445	19,215,161 - 19,228,695 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955445	19,213,210 - 19,227,670 (-)	NCBI	ChiLan1.0	ChiLan1.0

SRC
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	43,073,049 - 43,132,588 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	43,066,176 - 43,127,531 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	33,667,614 - 33,727,126 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	34,822,287 - 34,841,523 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	34,822,271 - 34,839,634 (+)	Ensembl	panpan1.1		panPan2

SRC
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	25,982,499 - 26,019,748 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	25,999,048 - 26,018,077 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	25,618,275 - 25,668,243 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	26,666,859 - 26,717,079 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	26,666,617 - 26,717,074 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	25,944,146 - 25,994,080 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	26,074,538 - 26,099,748 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	26,538,700 - 26,589,113 (+)	NCBI		UU_Cfam_GSD_1.0

SRC
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	40,471,009 - 40,524,860 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	40,470,970 - 40,524,862 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	45,907,305 - 45,942,026 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SRC
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	26,344,480 - 26,367,448 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	26,343,450 - 26,367,776 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	75,217,493 - 75,278,886 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Src
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624842	2,211,020 - 2,230,132 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624842	2,212,561 - 2,260,514 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013360583	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021729513	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040274308	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010003700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000019470 ⟹ ENSSTOP00000014871

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936561	3,825,787 - 3,844,483 (-)	Ensembl

RefSeq Acc Id:

ENSSTOT00000022804 ⟹ ENSSTOP00000017613

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936561	3,825,787 - 3,844,483 (-)	Ensembl

RefSeq Acc Id:

XM_013360583 ⟹ XP_013216037

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	174,890,047 - 174,922,678 (+)	NCBI
SpeTri2.0	NW_004936561	3,826,802 - 3,844,406 (-)	NCBI

Sequence:

show sequence

AGGACACTGAGGCCCAGAGACGGGGAGCGCCTGGCTTAGGACACTCAGCCTGGAAGGGCAGAGC
AGGGACTCCGCAGCGAGACTGCCGACTCCACGCCTGGTGTGTGTGCCCAGAGCCCAGCTGCTTC
CCAGGCCCTCTGGGGCGGCCTTGCCTTCCACCAGCCAGGACCATGGGTAGCAACAAGAGCAAGC
CGAAGGACGCCAGCCAGCGGCGCCGCAGCCTGGAGCCGGCCGAGAGCACCCACGCGGCGGGCGG
CGCCTTCCCGGCCTCGCAGACGCCCAGCAAGCCGGCCTCCGCCGACGGCCTCCGCGGCCCGGGC
GCCGCCTTCGCCCCCGCGGCCGCCGAGCCCAAGCTCTTCGGGGGCTTCAACTCGTCGGACACCG
TCACCTCCCCGCAGAGGGCGGGGCCCCTGGCCGGCGGAGTGACCACCTTTGTGGCCCTCTATGA
CTATGAGTCACGGACAGAGACCGACCTGTCCTTCAAGAAAGGGGAGCGGCTCCAGATTGTCAAC
AACACAGAGGGAGACTGGTGGCTGGCCCACTCGCTCAGCACGGGACAGACCGGCTACATCCCCA
GCAACTACGTGGCGCCTTCCGACTCCATCCAGGCTGAGGAATGGTATTTTGGCAAGATCACCAG
GCGGGAGTCGGAGCGGCTGCTGCTTAACACGGAGAACCCAAGGGGGACCTTCCTGGTGCGAGAG
AGCGAGACCACGAAAGGTGCCTACTGCCTCTCCGTGTCCGACTTTGACAACGCCAAGGGCCTCA
ACGTGAAGCACTACAAGATCCGCAAGCTGGACAGCGGGGGCTTCTACATCACCTCCCGCACCCA
GTTCAACAGCCTGCAGCAGCTGGTGGCCTACTACTCCAAACATGCAGACGGCCTGTGCCACCGC
CTCACCACCGTGTGCCCCACGTCCAAGCCGCAGACCCAGGGCCTGGCCAAGGACGCCTGGGAGA
TCCCCCGGGAGTCGCTGCGGCTGGAGGTCAAGCTGGGCCAGGGCTGCTTCGGGGAGGTGTGGAT
GGGAACCTGGAACGGCACCACCAGGGTGGCCATCAAGACCCTGAAGCCGGGCACCATGTCCCCA
GAGGCCTTCCTGCAGGAGGCCCAGGTCATGAAGAAGCTGCGGCACGAGAAGCTGGTGCAGCTGT
ACGCCGTGGTGTCGGAGGAGCCCATCTACATCGTCACGGAGTACATGAGCAAGGGGAGTTTGCT
GGACTTCCTCAAGGGGGAGACGGGCAAGTACCTGCGCCTGCCACAGCTGGTGGACATGGCCGCT
CAGATCGCCTCGGGCATGGCATACGTGGAGCGGATGAACTACGTGCACCGGGACCTCCGCGCCG
CTAACATCCTGGTCGGGGAGAACCTGGTGTGCAAGGTGGCCGACTTCGGGCTGGCCCGGCTCAT
CGAGGACAACGAGTACACGGCCCGGCAAGGGGCCAAATTCCCCATCAAGTGGACGGCTCCAGAA
GCCGCCCTCTACGGCCGGTTCACCATCAAGTCAGATGTGTGGTCCTTTGGAATCTTGCTGACGG
AGCTCACGACAAAGGGACGAGTGCCCTACCCTGGGATGGTGAATCGCGAGGTGCTGGATCAAGT
CGAGCGGGGCTACCGGATGCCCTGCCCGCCCGAGTGTCCCGAGTCCCTGCACGACCTCATGTGC
CAGTGCTGGCGGAAGGAGCCCGAGGAGAGGCCCACCTTTGAGTACCTGCAGGCCTTCCTGGAGG
ACTACTTCACGTCCACGGAGCCCCAGTACCAGCCCGGGGAGAACCTATAGGAGCAGGCGGGCCG
GACTGTTCTCGGCTCCAGCCCTGGGCAGCGGCCCGTGCGTGCGGGGCCTGGCCTCCTCTGCCGC
CCGCTGCTGCTCTCCTGCGGGGCTGACGGCCAGGGTCAAGGCTGCTCTGGCTCTGGGGCCACAG
AAGGGCTTTGGGACGTGGTGCACCCGTGAGGACGGGCCCAGAGCCGGCACAGTGACTGTCCCAG
GGCCTGCCCTGGCCACCGCCTCCTCTCCACTGTCCCTCCTCTGCCCATCCCTGGAGGAGACGCC
GGGGAGAAGGGCTGGGGCTGGGCGCCGTCTTCCCAGCCTCAACCTGCCGCTCGCCTGGTTCTGT
CCCTCCCCTGAGGCCCCGGCCCATCCCCACAGCTGGCCAAAGAGCCTTTCCAAAGAGGAGCGGT
GGCCCTCAGCCTCCCGCCGCCCGCCCCTCGCCATCTCTTTCTGAAACGCGGGTGGAGGTTGCTG
GCCCAGGGCCCCCTGCTCCAGCCCAGCGTGACCCAGCCCTGCCCCGTCCACCCCAGGGCCCTTG
GAGATCTTCCGTCCCCTTCTCCCGTCTTACCTTGGGAAAGCAGAGTCCGAGAGGATGTGACTTG
CCCAGATGCCAGAGCACTTGAGGGATGGCACCTGGTGCTCCCCTGTCTTCCTTGGGAACGAGAC
TTGTCCTCAGAGGCACTAGGGACAGACTAGAGCAGCCCAGGGGACAAGGGGCCAGGACGGGTTA
GAGAGGGCAAAGGCCTGTCTGGGGGTGGGGAGAACGGAGGTGGAGGCGGAGGTGGAGGCCAGGC
TGAGCCGGGAGGGAAGGAGCGGCCACAGGGGAGGGTGTGGGGGCTTCCGTCAGTCCCCGGGTGG
TCTGGTGCCTGGAGCCACCAGCCATGACAGGGCATTGCTCCCGGGTTCCAGAGGCAAGGGAGAG
CTAAGGCTGAGGCTCTGGGCGGGCCTCCGCAGGGAACCCCGGGCCTCCTTCCCAGTTTGTCCTG
AACATTTCAACGTGGTACCCGCTCTCCTCCCAAGCTGGCACCCTGAACTCTCGAGTAGGGCGAG
GAGTGCCTTGGCCAGGGTCGGAGAGGGCGGGCCCGGAGGGGCTGTGTGACCTCGGGCATCTGCT
GCTTCTCTGAGCTGTGGCGTCTGCCCCTCATGTGGCCGCGGTCTCTGCGGCTGCTCAGCCCTGT
CCACCCCTGTGGCAGGGCACCTGTGGTGAGCCCGTCGGGAGACTTGGGGCCCTGGCTCTGCTGT
TCAGGGTATGTGGTGGCTTCTCTTCCAGCCTCAGTGTGCCCATCTGTAAAGTGGGCAGCTGACG
ATTTGTGGCATCTTGCCAAGGGCCCCTGAGTATGTGTGTGTGCACGTGTGTGTGTCTCCATGTG
TGTCCATATTTAACATGTAAAAAATGCCCCCTCTCTGTCCCCTGACACGTGGTCCATTCCACCC
ACTGTCCCCATCACAGCAATAACGTCCCTGCTGCCAGGGGCTCTTGAGCCAGCCAGGCCCTGGC
AGGGGGGAAGGAGGCACCTGCCTAGGAAATTCCGACTTTTCCTTCTACACATGTCCATCTCCCA
GGTCTCTTCCTGTCCATCCCAGTCGAACCTGGGCCCGCCCACCCCTGCGCTCCCCATCACTCCT
CCAGCTGCCCAAGGCCCTGGGTGTAAGGCGTCTTCATACTGTCCTATTTTTTTTAAACAGTGTT
TTGTAGATTTCAGATGACTATGCAGAGGCCTCGGGGACCCCTGGCTCTGGGCAGGGCCTGGGGG
TCCCACATTCCATGGCCCAGGCTTGGGGGGGCGGGGGGACCTAGAATTGGTTGTAAATACTTTG
CATATTGTCTGATTAAACACAAAGAGACCTCAGAACGTG

hide sequence

RefSeq Acc Id:

XM_021729513 ⟹ XP_021585188

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	174,890,048 - 174,922,678 (+)	NCBI
SpeTri2.0	NW_004936561	3,826,802 - 3,844,406 (-)	NCBI

Sequence:

show sequence

AGGACACTGAGGCCCAGAGACGGGGAGCGCCTGGCTTAGGACACTCAGCCTGGAAGGGCAGAGC
AGGGACTCCGCAGCGAGACTGCCGACTCCACGCCTGGTGTGTGTGCCCAGAGCCCAGCTGCTTC
CCAGGCCCTCTGGGGCGGCCTTGCCTTCCACCAGCCAGGACCATGGGTAGCAACAAGAGCAAGC
CGAAGGACGCCAGCCAGCGGCGCCGCAGCCTGGAGCCGGCCGAGAGCACCCACGCGGCGGGCGG
CGCCTTCCCGGCCTCGCAGACGCCCAGCAAGCCGGCCTCCGCCGACGGCCTCCGCGGCCCGGGC
GCCGCCTTCGCCCCCGCGGCCGCCGAGCCCAAGCTCTTCGGGGGCTTCAACTCGTCGGACACCG
TCACCTCCCCGCAGAGGGCGGGGCCCCTGGCCGGCGGAGTGACCACCTTTGTGGCCCTCTATGA
CTATGAGTCACGGACAGAGACCGACCTGTCCTTCAAGAAAGGGGAGCGGCTCCAGATTGTCAAC
AACACGAGGAAGGTGGATGTCAGAGAGGGAGACTGGTGGCTGGCCCACTCGCTCAGCACGGGAC
AGACCGGCTACATCCCCAGCAACTACGTGGCGCCTTCCGACTCCATCCAGGCTGAGGAATGGTA
TTTTGGCAAGATCACCAGGCGGGAGTCGGAGCGGCTGCTGCTTAACACGGAGAACCCAAGGGGG
ACCTTCCTGGTGCGAGAGAGCGAGACCACGAAAGGTGCCTACTGCCTCTCCGTGTCCGACTTTG
ACAACGCCAAGGGCCTCAACGTGAAGCACTACAAGATCCGCAAGCTGGACAGCGGGGGCTTCTA
CATCACCTCCCGCACCCAGTTCAACAGCCTGCAGCAGCTGGTGGCCTACTACTCCAAACATGCA
GACGGCCTGTGCCACCGCCTCACCACCGTGTGCCCCACGTCCAAGCCGCAGACCCAGGGCCTGG
CCAAGGACGCCTGGGAGATCCCCCGGGAGTCGCTGCGGCTGGAGGTCAAGCTGGGCCAGGGCTG
CTTCGGGGAGGTGTGGATGGGAACCTGGAACGGCACCACCAGGGTGGCCATCAAGACCCTGAAG
CCGGGCACCATGTCCCCAGAGGCCTTCCTGCAGGAGGCCCAGGTCATGAAGAAGCTGCGGCACG
AGAAGCTGGTGCAGCTGTACGCCGTGGTGTCGGAGGAGCCCATCTACATCGTCACGGAGTACAT
GAGCAAGGGGAGTTTGCTGGACTTCCTCAAGGGGGAGACGGGCAAGTACCTGCGCCTGCCACAG
CTGGTGGACATGGCCGCTCAGATCGCCTCGGGCATGGCATACGTGGAGCGGATGAACTACGTGC
ACCGGGACCTCCGCGCCGCTAACATCCTGGTCGGGGAGAACCTGGTGTGCAAGGTGGCCGACTT
CGGGCTGGCCCGGCTCATCGAGGACAACGAGTACACGGCCCGGCAAGGGGCCAAATTCCCCATC
AAGTGGACGGCTCCAGAAGCCGCCCTCTACGGCCGGTTCACCATCAAGTCAGATGTGTGGTCCT
TTGGAATCTTGCTGACGGAGCTCACGACAAAGGGACGAGTGCCCTACCCTGGGATGGTGAATCG
CGAGGTGCTGGATCAAGTCGAGCGGGGCTACCGGATGCCCTGCCCGCCCGAGTGTCCCGAGTCC
CTGCACGACCTCATGTGCCAGTGCTGGCGGAAGGAGCCCGAGGAGAGGCCCACCTTTGAGTACC
TGCAGGCCTTCCTGGAGGACTACTTCACGTCCACGGAGCCCCAGTACCAGCCCGGGGAGAACCT
ATAGGAGCAGGCGGGCCGGACTGTTCTCGGCTCCAGCCCTGGGCAGCGGCCCGTGCGTGCGGGG
CCTGGCCTCCTCTGCCGCCCGCTGCTGCTCTCCTGCGGGGCTGACGGCCAGGGTCAAGGCTGCT
CTGGCTCTGGGGCCACAGAAGGGCTTTGGGACGTGGTGCACCCGTGAGGACGGGCCCAGAGCCG
GCACAGTGACTGTCCCAGGGCCTGCCCTGGCCACCGCCTCCTCTCCACTGTCCCTCCTCTGCCC
ATCCCTGGAGGAGACGCCGGGGAGAAGGGCTGGGGCTGGGCGCCGTCTTCCCAGCCTCAACCTG
CCGCTCGCCTGGTTCTGTCCCTCCCCTGAGGCCCCGGCCCATCCCCACAGCTGGCCAAAGAGCC
TTTCCAAAGAGGAGCGGTGGCCCTCAGCCTCCCGCCGCCCGCCCCTCGCCATCTCTTTCTGAAA
CGCGGGTGGAGGTTGCTGGCCCAGGGCCCCCTGCTCCAGCCCAGCGTGACCCAGCCCTGCCCCG
TCCACCCCAGGGCCCTTGGAGATCTTCCGTCCCCTTCTCCCGTCTTACCTTGGGAAAGCAGAGT
CCGAGAGGATGTGACTTGCCCAGATGCCAGAGCACTTGAGGGATGGCACCTGGTGCTCCCCTGT
CTTCCTTGGGAACGAGACTTGTCCTCAGAGGCACTAGGGACAGACTAGAGCAGCCCAGGGGACA
AGGGGCCAGGACGGGTTAGAGAGGGCAAAGGCCTGTCTGGGGGTGGGGAGAACGGAGGTGGAGG
CGGAGGTGGAGGCCAGGCTGAGCCGGGAGGGAAGGAGCGGCCACAGGGGAGGGTGTGGGGGCTT
CCGTCAGTCCCCGGGTGGTCTGGTGCCTGGAGCCACCAGCCATGACAGGGCATTGCTCCCGGGT
TCCAGAGGCAAGGGAGAGCTAAGGCTGAGGCTCTGGGCGGGCCTCCGCAGGGAACCCCGGGCCT
CCTTCCCAGTTTGTCCTGAACATTTCAACGTGGTACCCGCTCTCCTCCCAAGCTGGCACCCTGA
ACTCTCGAGTAGGGCGAGGAGTGCCTTGGCCAGGGTCGGAGAGGGCGGGCCCGGAGGGGCTGTG
TGACCTCGGGCATCTGCTGCTTCTCTGAGCTGTGGCGTCTGCCCCTCATGTGGCCGCGGTCTCT
GCGGCTGCTCAGCCCTGTCCACCCCTGTGGCAGGGCACCTGTGGTGAGCCCGTCGGGAGACTTG
GGGCCCTGGCTCTGCTGTTCAGGGTATGTGGTGGCTTCTCTTCCAGCCTCAGTGTGCCCATCTG
TAAAGTGGGCAGCTGACGATTTGTGGCATCTTGCCAAGGGCCCCTGAGTATGTGTGTGTGCACG
TGTGTGTGTCTCCATGTGTGTCCATATTTAACATGTAAAAAATGCCCCCTCTCTGTCCCCTGAC
ACGTGGTCCATTCCACCCACTGTCCCCATCACAGCAATAACGTCCCTGCTGCCAGGGGCTCTTG
AGCCAGCCAGGCCCTGGCAGGGGGGAAGGAGGCACCTGCCTAGGAAATTCCGACTTTTCCTTCT
ACACATGTCCATCTCCCAGGTCTCTTCCTGTCCATCCCAGTCGAACCTGGGCCCGCCCACCCCT
GCGCTCCCCATCACTCCTCCAGCTGCCCAAGGCCCTGGGTGTAAGGCGTCTTCATACTGTCCTA
TTTTTTTTAAACAGTGTTTTGTAGATTTCAGATGACTATGCAGAGGCCTCGGGGACCCCTGGCT
CTGGGCAGGGCCTGGGGGTCCCACATTCCATGGCCCAGGCTTGGGGGGGCGGGGGGACCTAGAA
TTGGTTGTAAATACTTTGCATATTGTCTGATTAAACACAAAGAGACCTCAGAACGTG

hide sequence

RefSeq Acc Id:

XM_040274308 ⟹ XP_040130242

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	174,890,047 - 174,922,678 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_013216037	(Get FASTA)	NCBI Sequence Viewer
	XP_021585188	(Get FASTA)	NCBI Sequence Viewer
	XP_040130242	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000014871.1
	ENSSTOP00000017613.1
GenBank Protein	KAG3263240	(Get FASTA)	NCBI Sequence Viewer
	KAG3263241	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_013216037 ⟸ XM_013360583
- Peptide Label:	isoform X3
- UniProtKB:	I3MZR7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGSNKSKPKDASQRRRSLEPAESTHAAGGAFPASQTPSKPASADGLRGPGAAFAPAAAEPKLFG GFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLST GQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNTENPRGTFLVRESETTKGAYCLSVSD FDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQG LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR HEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFE YLQAFLEDYFTSTEPQYQPGENL hide sequence

RefSeq Acc Id:	XP_021585188 ⟸ XM_021729513
- Peptide Label:	isoform X2
- UniProtKB:	I3MRX6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGSNKSKPKDASQRRRSLEPAESTHAAGGAFPASQTPSKPASADGLRGPGAAFAPAAAEPKLFG GFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTRKVDVREGDWWL AHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNTENPRGTFLVRESETTKGAY CLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTS KPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQ VMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY VERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPE ERPTFEYLQAFLEDYFTSTEPQYQPGENL hide sequence

RefSeq Acc Id:	XP_040130242 ⟸ XM_040274308
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSSTOP00000017613 ⟸ ENSSTOT00000022804

RefSeq Acc Id:

ENSSTOP00000014871 ⟸ ENSSTOT00000019470

Protein Domains

Protein kinase SH2 SH3

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000023905	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000019470.2	UniProtKB/TrEMBL
	ENSSTOT00000022804.2	UniProtKB/TrEMBL
Gene3D-CATH	3.30.505.10	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Kinase-like_dom_sf	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/TrEMBL
	SH3-like_dom_sf	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
	Tyr_kinase_AS	UniProtKB/TrEMBL
	Tyr_kinase_cat_dom	UniProtKB/TrEMBL
NCBI Gene	Src	ENTREZGENE
PANTHER	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC	UniProtKB/TrEMBL
	TYROSINE-PROTEIN KINASE	UniProtKB/TrEMBL
Pfam	PK_Tyr_Ser-Thr	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3_1	UniProtKB/TrEMBL
PRINTS	SH2DOMAIN	UniProtKB/TrEMBL
	SH3DOMAIN	UniProtKB/TrEMBL
	TYRKINASE	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
SMART	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
	TyrKc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50044	UniProtKB/TrEMBL
	SSF55550	UniProtKB/TrEMBL
	SSF56112	UniProtKB/TrEMBL
UniProt	I3MRX6	ENTREZGENE, UniProtKB/TrEMBL
	I3MZR7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - PID (archival)