Kmt5b (lysine methyltransferase 5B) - Rat Genome Database

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Gene: Kmt5b (lysine methyltransferase 5B) Ictidomys tridecemlineatus
Analyze
Symbol: Kmt5b
Name: lysine methyltransferase 5B
RGD ID: 12635159
Description: ENCODES a protein that exhibits chromatin binding (inferred); histone H4K20 methyltransferase activity (inferred); histone H4K20 monomethyltransferase activity (inferred); INVOLVED IN chromatin remodeling (inferred); DNA repair (inferred); methylation (inferred); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH Aicardi-Goutieres Syndrome 3 (ortholog); autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder 51 (ortholog); FOUND IN condensed chromosome, centromeric region (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: histone-lysine N-methyltransferase KMT5B; histone-lysine N-methyltransferase SUV420H1; lysine methyltransferase 5B, transcript variant X1; lysine methyltransferase 5B, transcript variant X2; lysine methyltransferase 5B, transcript variant X3; lysine methyltransferase 5B, transcript variant X4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049475,481,427 - 5,541,634 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365991,928,145 - 1,984,008 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365991,928,172 - 1,983,983 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Kmt5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049475,481,427 - 5,541,634 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365991,928,145 - 1,984,008 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365991,928,172 - 1,983,983 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KMT5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381168,154,863 - 68,213,648 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1168,154,863 - 68,213,852 (-)EnsemblGRCh38hg38GRCh38
GRCh371167,922,330 - 67,981,115 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,680,083 - 67,737,360 (-)NCBINCBI36Build 36hg18NCBI36
Build 341167,680,082 - 67,737,360NCBI
Celera1165,257,585 - 65,291,695 (-)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1164,258,962 - 64,316,330 (-)NCBIHuRef
CHM1_11167,807,859 - 67,865,062 (-)NCBICHM1_1
T2T-CHM13v2.01168,158,479 - 68,217,261 (-)NCBIT2T-CHM13v2.0
Kmt5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,816,436 - 3,868,303 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,817,421 - 3,868,303 (+)EnsemblGRCm39 Ensembl
GRCm38193,767,362 - 3,818,303 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,767,421 - 3,818,303 (+)EnsemblGRCm38mm10GRCm38
MGSCv37193,767,421 - 3,818,303 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36193,767,421 - 3,816,391 (+)NCBIMGSCv36mm8
Celera193,646,536 - 3,697,352 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map193.5NCBI
Kmt5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,429,672 - 210,479,042 (+)NCBIGRCr8
mRatBN7.21201,000,444 - 201,049,819 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1201,000,444 - 201,049,819 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1209,373,731 - 209,423,118 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,462,402 - 216,511,781 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01209,136,603 - 209,185,982 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,000,844 - 219,050,211 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,000,844 - 219,050,211 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,874,424 - 225,923,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,285,303 - 206,341,955 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11206,463,795 - 206,494,080 (+)NCBI
Celera1198,553,658 - 198,602,986 (+)NCBICelera
Cytogenetic Map1q43NCBI
Kmt5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542217,647,530 - 17,682,132 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542217,626,606 - 17,684,890 (+)NCBIChiLan1.0ChiLan1.0
KMT5B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2969,107,043 - 69,166,154 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11170,151,974 - 70,209,347 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01163,239,796 - 63,297,113 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11166,546,398 - 66,581,553 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,549,230 - 66,581,475 (-)Ensemblpanpan1.1panPan2
KMT5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11849,655,783 - 49,691,899 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1849,637,610 - 49,827,034 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,245,250 - 48,301,228 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01850,553,006 - 50,608,767 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1850,553,953 - 50,606,707 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11849,770,822 - 49,826,692 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01849,345,785 - 49,401,540 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01850,138,893 - 50,194,657 (+)NCBIUU_Cfam_GSD_1.0
KMT5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl24,711,023 - 4,765,979 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.124,710,510 - 4,768,237 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.223,275,853 - 3,332,604 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KMT5B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.116,308,565 - 6,367,272 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl16,308,742 - 6,367,393 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038103,594,512 - 103,653,258 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kmt5b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476718,655,193 - 18,716,252 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476718,654,682 - 18,716,087 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000020608   ⟹   ENSSTOP00000016530
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365991,928,145 - 1,984,008 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000040509   ⟹   ENSSTOP00000024464
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365991,944,348 - 1,974,224 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000042464   ⟹   ENSSTOP00000028959
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365991,928,145 - 1,984,008 (+)Ensembl
RefSeq Acc Id: XM_005333323   ⟹   XP_005333380
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049475,485,823 - 5,541,634 (+)NCBI
SpeTri2.0NW_0049365991,928,357 - 1,983,983 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013362016   ⟹   XP_013217470
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049475,485,823 - 5,541,634 (+)NCBI
SpeTri2.0NW_0049365991,928,172 - 1,983,983 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021731733   ⟹   XP_021587408
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049475,485,822 - 5,541,634 (+)NCBI
SpeTri2.0NW_0049365991,928,357 - 1,983,983 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040284002   ⟹   XP_040139936
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049475,485,823 - 5,541,634 (+)NCBI
RefSeq Acc Id: XM_040284003   ⟹   XP_040139937
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049475,481,427 - 5,541,634 (+)NCBI
RefSeq Acc Id: XM_040284004   ⟹   XP_040139938
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049475,481,427 - 5,541,634 (+)NCBI
RefSeq Acc Id: XM_040284005   ⟹   XP_040139939
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049475,501,921 - 5,541,634 (+)NCBI
RefSeq Acc Id: XM_040284006   ⟹   XP_040139940
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049475,485,831 - 5,532,022 (+)NCBI
RefSeq Acc Id: XM_040284007   ⟹   XP_040139941
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049475,485,833 - 5,537,532 (+)NCBI
RefSeq Acc Id: XR_005733412
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049475,485,830 - 5,537,532 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005333380   ⟸   XM_005333323
- Peptide Label: isoform X1
- UniProtKB: I3MWN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013217470   ⟸   XM_013362016
- Peptide Label: isoform X1
- UniProtKB: I3MWN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021587408   ⟸   XM_021731733
- Peptide Label: isoform X2
- UniProtKB: A0A287D5Y3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040139938   ⟸   XM_040284004
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040139937   ⟸   XM_040284003
- Peptide Label: isoform X1
- UniProtKB: I3MWN5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139936   ⟸   XM_040284002
- Peptide Label: isoform X1
- UniProtKB: I3MWN5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139940   ⟸   XM_040284006
- Peptide Label: isoform X4
- UniProtKB: A0A287CT54 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139941   ⟸   XM_040284007
- Peptide Label: isoform X5
- UniProtKB: A0A287CT54 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139939   ⟸   XM_040284005
- Peptide Label: isoform X3
RefSeq Acc Id: ENSSTOP00000028959   ⟸   ENSSTOT00000042464
RefSeq Acc Id: ENSSTOP00000016530   ⟸   ENSSTOT00000020608
RefSeq Acc Id: ENSSTOP00000024464   ⟸   ENSSTOT00000040509
Protein Domains
SET


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000024331 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000020608.2 UniProtKB/TrEMBL
  ENSSTOT00000040509.1 UniProtKB/TrEMBL
  ENSSTOT00000042464.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.1700 UniProtKB/TrEMBL
  2.170.270.10 UniProtKB/TrEMBL
InterPro Hist-Lys_N-MTase_N UniProtKB/TrEMBL
  KMT5B_SET UniProtKB/TrEMBL
  SET_dom UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/TrEMBL
  Suv4-20/Set9 UniProtKB/TrEMBL
  Suv4-20_animal UniProtKB/TrEMBL
NCBI Gene Kmt5b ENTREZGENE
PANTHER HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B UniProtKB/TrEMBL
  PTHR12977 UniProtKB/TrEMBL
Pfam SET UniProtKB/TrEMBL
PROSITE SAM_MT43_SUVAR420_2 UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
SMART SET UniProtKB/TrEMBL
Superfamily-SCOP SSF82199 UniProtKB/TrEMBL
UniProt A0A287CT54 ENTREZGENE, UniProtKB/TrEMBL
  A0A287D5Y3 ENTREZGENE, UniProtKB/TrEMBL
  I3MWN5 ENTREZGENE, UniProtKB/TrEMBL