Pak5 (p21 (RAC1) activated kinase 5) - Rat Genome Database

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Gene: Pak5 (p21 (RAC1) activated kinase 5) Ictidomys tridecemlineatus
Analyze
Symbol: Pak5
Name: p21 (RAC1) activated kinase 5
RGD ID: 12633315
Description: ENCODES a protein that exhibits ATP binding (inferred); nucleotide binding (inferred); protein kinase activity (inferred); INVOLVED IN learning (ortholog); locomotory behavior (ortholog); memory (ortholog); ASSOCIATED WITH Alagille syndrome (ortholog); ALAGILLE SYNDROME 1 (ortholog); congenital myasthenic syndrome 18 (ortholog); FOUND IN synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC110597698; serine/threonine-protein kinase PAK 5; serine/threonine-protein kinase PAK 7; uncharacterized LOC110597698
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640161,148,089 - 161,500,798 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364859,633,230 - 9,932,174 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364859,825,425 - 9,932,162 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
mitochondrion  (IEA)
nuclear membrane  (IEA)
nucleoplasm  (IEA)
synapse  (IEA,ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Pak5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640161,148,089 - 161,500,798 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364859,633,230 - 9,932,174 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364859,825,425 - 9,932,162 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAK5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38209,537,370 - 9,839,076 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl209,537,370 - 9,839,076 (-)EnsemblGRCh38hg38GRCh38
GRCh37209,518,017 - 9,819,724 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36209,466,037 - 9,767,522 (-)NCBINCBI36Build 36hg18NCBI36
Build 34209,466,036 - 9,767,522NCBI
Celera209,588,063 - 9,889,850 (-)NCBICelera
Cytogenetic Map20p12.2NCBI
HuRef209,470,003 - 9,771,581 (-)NCBIHuRef
CHM1_1209,519,190 - 9,820,790 (-)NCBICHM1_1
T2T-CHM13v2.0209,580,273 - 9,881,978 (-)NCBIT2T-CHM13v2.0
Pak5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392135,923,008 - 136,229,899 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2135,923,024 - 136,229,887 (-)EnsemblGRCm39 Ensembl
GRCm382136,081,088 - 136,387,968 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2136,081,104 - 136,387,967 (-)EnsemblGRCm38mm10GRCm38
MGSCv372135,906,824 - 136,213,703 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362135,773,340 - 136,079,379 (-)NCBIMGSCv36mm8
Celera2137,278,994 - 137,585,755 (-)NCBICelera
Cytogenetic Map2F3NCBI
cM Map267.32NCBI
Pak5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83143,848,404 - 144,156,674 (-)NCBIGRCr8
mRatBN7.23123,395,678 - 123,703,967 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3123,396,497 - 123,703,930 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3127,299,735 - 127,598,969 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03135,876,723 - 136,175,955 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03133,555,363 - 133,854,570 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03129,042,232 - 129,357,512 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3129,042,742 - 129,357,491 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03135,530,902 - 135,841,101 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43124,152,033 - 124,457,585 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13124,057,603 - 124,363,156 (-)NCBI
Celera3122,127,080 - 122,432,709 (-)NCBICelera
Cytogenetic Map3q36NCBI
Pak5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541519,511,822 - 19,619,663 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541519,509,727 - 19,826,087 (-)NCBIChiLan1.0ChiLan1.0
PAK5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22110,436,346 - 10,738,368 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12010,433,177 - 10,735,194 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0209,510,789 - 9,812,689 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1209,513,009 - 9,813,708 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl209,513,009 - 9,619,750 (-)Ensemblpanpan1.1panPan2
PAK5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12412,391,739 - 12,671,483 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2412,391,471 - 12,669,404 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2412,210,533 - 12,496,682 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02412,804,073 - 13,084,553 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2412,804,113 - 13,082,849 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12412,410,639 - 12,690,260 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02412,510,137 - 12,789,767 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02412,853,704 - 13,133,934 (+)NCBIUU_Cfam_GSD_1.0
PAK5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1718,461,062 - 18,785,313 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11718,461,060 - 18,785,869 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21720,828,842 - 21,258,863 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PAK5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1228,287,478 - 28,595,382 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl228,288,945 - 28,595,686 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607115,978,895 - 16,289,799 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pak5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474110,476,192 - 10,608,745 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474110,476,172 - 10,823,164 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000000439   ⟹   ENSSTOP00000000393
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364859,633,230 - 9,932,174 (+)Ensembl
RefSeq Acc Id: XM_021723159   ⟹   XP_021578834
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640161,201,921 - 161,500,798 (+)NCBI
SpeTri2.0NW_0049364859,825,425 - 9,932,162 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040274034   ⟹   XP_040129968
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640161,374,585 - 161,498,681 (+)NCBI
RefSeq Acc Id: XM_040274035   ⟹   XP_040129969
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640161,202,029 - 161,498,681 (+)NCBI
RefSeq Acc Id: XM_040274036   ⟹   XP_040129970
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640161,148,089 - 161,498,681 (+)NCBI
RefSeq Acc Id: XM_040274037   ⟹   XP_040129971
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640161,202,027 - 161,498,681 (+)NCBI
Protein Sequences
Protein RefSeqs XP_021578834 (Get FASTA)   NCBI Sequence Viewer  
  XP_040129968 (Get FASTA)   NCBI Sequence Viewer  
  XP_040129969 (Get FASTA)   NCBI Sequence Viewer  
  XP_040129970 (Get FASTA)   NCBI Sequence Viewer  
  XP_040129971 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000000393.3
GenBank Protein KAG3262843 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_021578834   ⟸   XM_021723159
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_040129970   ⟸   XM_040274036
- Peptide Label: isoform X3
- UniProtKB: I3LWM4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040129971   ⟸   XM_040274037
- Peptide Label: isoform X3
- UniProtKB: I3LWM4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040129969   ⟸   XM_040274035
- Peptide Label: isoform X3
- UniProtKB: I3LWM4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040129968   ⟸   XM_040274034
- Peptide Label: isoform X2
RefSeq Acc Id: ENSSTOP00000000393   ⟸   ENSSTOT00000000439
Protein Domains
CRIB   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000000439 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000000439.3 UniProtKB/TrEMBL
Gene3D-CATH 3.90.810.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CRIB_dom UniProtKB/TrEMBL
  CRIB_dom_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PAK5 UniProtKB/TrEMBL
  PAK_BD UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
NCBI Gene Pak5 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE TAO UniProtKB/TrEMBL
  SERINE_THREONINE-PROTEIN KINASE PAK 5 UniProtKB/TrEMBL
Pfam PBD UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE CRIB UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART PBD UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt I3LWM4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-25 Pak5  p21 (RAC1) activated kinase 5  LOC110597698  uncharacterized LOC110597698  Data merged from RGD:12955505 737654 PROVISIONAL