Pak6 (p21 (RAC1) activated kinase 6)

Gene: Pak6 (p21 (RAC1) activated kinase 6) Ictidomys tridecemlineatus

Analyze

Symbol:

Pak6

Name:

p21 (RAC1) activated kinase 6 (Ensembl:serine/threonine-protein kinase PAK 6)

RGD ID:

12605450

Description:

ENCODES a protein that exhibits ATP binding (inferred); nucleotide binding (inferred); protein kinase activity (inferred); INVOLVED IN learning (ortholog); locomotory behavior (ortholog); memory (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); clear cell renal cell carcinoma (ortholog); colorectal cancer (ortholog); FOUND IN postsynaptic density (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC101957470; serine/threonine-protein kinase PAK 6; serine/threonine-protein kinase PAK 6, transcript variant X1; serine/threonine-protein kinase PAK 6, transcript variant X2; serine/threonine-protein kinase PAK 6, transcript variant X3

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	85,863,845 - 85,899,290 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	3,713,406 - 3,747,356 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	3,692,058 - 3,747,355 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

clear cell renal cell carcinoma (ISO)

colorectal cancer (ISO)

genetic disease (ISO)

keratoconus (ISO)

mosaic variegated aneuploidy syndrome 1 (ISO)

Prostatic Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intracellular signal transduction (IEA)

learning (IEA,ISO)

locomotory behavior (IEA,ISO)

memory (IEA,ISO)

neuron projection arborization (IEA,ISO)

neuron projection extension (IEA,ISO)

regulation of MAPK cascade (IEA)

Cellular Component

cell junction (IEA)

cytoplasm (IEA)

fibrillar center (IEA)

nucleoplasm (IEA)

postsynaptic density (IEA,ISO)

Molecular Function

ATP binding (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activity (IEA)

protein serine/threonine kinase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Pak6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	85,863,845 - 85,899,290 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	3,713,406 - 3,747,356 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	3,692,058 - 3,747,355 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PAK6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	40,239,063 - 40,277,487 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	40,217,428 - 40,277,487 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	40,531,264 - 40,569,688 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	38,319,368 - 38,356,979 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	38,319,367 - 38,356,979	NCBI
Celera	15	17,275,604 - 17,335,680 (+)	NCBI		Celera
Cytogenetic Map	15	q15.1	NCBI
HuRef	15	17,352,605 - 17,412,646 (+)	NCBI		HuRef
CHM1_1	15	40,629,582 - 40,689,654 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	38,045,955 - 38,084,404 (+)	NCBI		T2T-CHM13v2.0

Pak6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	118,493,531 - 118,528,501 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	118,493,784 - 118,528,501 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	118,663,045 - 118,698,020 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	118,663,303 - 118,698,020 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	118,489,313 - 118,523,756 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	118,354,744 - 118,388,677 (+)	NCBI		MGSCv36	mm8
Celera	2	119,818,133 - 119,852,648 (+)	NCBI		Celera
Cytogenetic Map	2	E5	NCBI
cM Map	2	59.41	NCBI

Pak6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	126,092,576 - 126,128,320 (+)	NCBI		GRCr8
mRatBN7.2	3	105,638,248 - 105,674,399 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	105,638,653 - 105,672,975 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	109,312,014 - 109,345,868 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	117,907,575 - 117,941,432 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	115,567,941 - 115,601,794 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	110,442,175 - 110,486,317 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	110,442,637 - 110,487,526 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	116,987,226 - 117,027,426 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	105,141,150 - 105,191,676 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	105,080,467 - 105,088,577 (+)	NCBI
Celera	3	104,554,473 - 104,587,411 (+)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

Pak6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	7,178,524 - 7,212,053 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955416	7,190,584 - 7,211,705 (+)	NCBI	ChiLan1.0	ChiLan1.0

PAK6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	29,473,050 - 29,511,489 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	33,624,528 - 33,662,919 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	19,173,171 - 19,211,572 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	37,441,567 - 37,466,520 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	37,453,802 - 37,465,119 (+)	Ensembl	panpan1.1		panPan2

PAK6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	7,424,410 - 7,462,265 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	7,425,948 - 7,461,815 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	7,478,897 - 7,516,220 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	7,553,994 - 7,588,094 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	7,577,691 - 7,588,086 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	7,475,297 - 7,512,646 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	7,581,248 - 7,618,595 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	7,709,827 - 7,747,189 (+)	NCBI		UU_Cfam_GSD_1.0

PAK6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	131,039,318 - 131,076,631 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	131,039,313 - 131,077,420 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	146,145,830 - 146,151,173 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PAK6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	42,737,848 - 42,798,960 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	42,737,613 - 42,750,248 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	98,187,124 - 98,226,525 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pak6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624804	7,549,630 - 7,584,567 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624804	7,549,847 - 7,583,409 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005316395	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021725728	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021725730	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040276294	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010003700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000009634 ⟹ ENSSTOP00000008643

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936471	3,713,406 - 3,747,356 (+)	Ensembl

RefSeq Acc Id:

ENSSTOT00000042873 ⟹ ENSSTOP00000030730

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936471	3,724,450 - 3,747,356 (+)	Ensembl

RefSeq Acc Id:

XM_005316395 ⟹ XP_005316452

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	85,877,154 - 85,899,290 (+)	NCBI
SpeTri2.0	NW_004936471	3,725,280 - 3,747,355 (+)	NCBI

Sequence:

show sequence

TCCCGCGGCCTCTCCGAGCGCTCGCGGGCTTCTCGCTCGGCAGGCCTGCGGTGGACTAGCCCTG
GAAGGTCCTTGGTCTTCCCTCGGTGCCCAAGAGAGCTGACTGCTGAAGGGTGAGGAGACCCAAG
GAAGAGGAGTCAGGGAAGGCCTCCCGGAGGCACCATGTTCCGTAAGAAAAAGAAGAAACGCCCA
GAGATCTCAGCCCCACAGAACTTCCAACACCGTGTCCACACCTCCTTCGACCCCAAAGAGGGCA
AGTTTGTGGGCCTCCCACCACAATGGCAGAACATCCTGGATACACTGAGGCGCCCCAAGCCCGT
GGTGGACCCTTCACGCATCACACGAGTGCAGCTCCAGCCCATGAAGACAGTGGTACGGGGCAGC
TCGGTGCCAACAGATGGCTACATCTCAGGGCTGCTCAATGACATCCAGAAGTTGTCAGTCATCA
GTTCCAATACTCTGCGTGGTCGCAGCCCTACCAACCGGCGGCGGGCACAGTCTTTGGGGCTGCT
AGGGGATGAGCACTGGGCCAATGATCCGGACATGTACCTCCAGAGCCCCCAGTCTGAGCGCACT
GACCCCCACAGCCTCTACCTCAGCTGCAACGGGGGCACACCAGCAGGTCACAGGCAGATGCCAT
GGCCTGAACCACAGAGCCCACGGGTCCTGCCTAACGGGTTGGCCACCAAGGCACAGTCCCTGGG
CCCTGCTGAATTCCAGGGTGCCTCACAGCGCTGCCTGCAGCTGGGTGCCTGCCTGCAGAGCTCC
CCACCTGGCACCTCACCCCCTATGGCTACAGGGAGGCGGGGCGTGAAGACTGCCAAGCATGGCT
CTGAGGAAGCCCGGCCACAGTCTTGCCTGGTGGGCTCAGCCACAGGCAGGCCAGGTGGCGAAGG
CAGCCCTAGCCCGAAGGCCCAAGAGAACAGCCTCAAGCGCAGGTTATTTCGAAGCATGTTCCTC
TCCACTCCTGCCACGGCACCTCCAAGCAGCAGCAAGCCAGGCCTTCCACCACAGAGCAAGCCCA
ACTCTGCTTTCCGACCACCACAGAAAGACTCCCCTCCAAGCCTGGTGGCCAAGGCCCAATCCTT
GCCCTCAGAACAACCCATGGGGACCTTCAGTCCTCTGACCACCTCGGACACCAGCAGCCCCCAG
AAGTCCCTCCGCATAGCCCCAGCCACTGGCCCACTTCCAGGTCGGTCTTCCCCGGCGGGCTCCC
CCCGCACCCGGCATGCCCAGATCAGCACCAGCAACCTGTACCTGCCCCAGGACCCCACAGTGGC
CAAGGGTGCCCTGGCTAGTGAGGACACGGGCATTGTGACACATGAGCAGTTCAAGGCTGCACTC
AGGATGGTGGTGGACCAGGGTGACCCCCGGCTACTGCTGGACAGCTACGTGAAGATTGGCGAGG
GCTCCACGGGCATTGTTTGCCTAGCCCGAGAGAAGCACTCTGGCCGCCAGGTGGCCGTCAAGAT
GATGGACCTCAGGAAGCAGCAGCGCAGGGAGCTGCTCTTTAATGAGGTGGTGATCATGCGGGAC
TACCAGCACTTCAACGTGGTGGAGATGTACAAGAGTTACCTGGTGGGCGAGGAGCTGTGGGTGC
TAATGGAGTTCCTGCAGGGCGGGGCCCTCACAGACATCATCTCCCAAGTCAGGCTGAATGAGGA
GCAGATCGCCACTGTGTGTGAGGCTGTGCTGCAGGCCCTGGCCTACCTGCATGCCCAAGGTGTC
ATCCACCGGGACATCAAGAGTGATTCCATCCTGCTGACCCTTGACGGCAGGGTGAAGCTCTCGG
ACTTTGGATTCTGTGCTCAGATCAGCAAAGATGTCCCTAAGAGGAAGTCCCTGGTGGGAACCCC
CTACTGGATGGCTCCTGAAGTGATCTCAAGGTCTCTGTATGCCACTGAGGTGGATATCTGGTCT
CTGGGCATCATGGTGATTGAGATGGTGGATGGGGAGCCCCCCTATTTCAGTGACTCCCCAGTGC
AAGCCATGAAGAGGCTCCGGGACAACCCCCCACCCAAGCTGAAAAACTCTCACAAGGTATCCCC
AGTGCTGCGAGACTTCCTGGAGCGGATGCTGGTGCGGGATCCCCAAGAGAGAGCCACGGCCCAG
GAGCTCCTGGACCACCCTTTCCTGCTGCAGACAGGGCTGCCTGAGTGCTTGGTGCCCCTGATCC
AGCTCTACCGCAAGCAGACCTCCACCTGCTGAGCCCACTCTGAGTGCACCTGCCACCTGTGCCC
CACAGGCAGGGGACACTGGGCATCCAGCCCTCCAGCAGGGCTTGTCTGCCTCATTCTCTCAGTA
TTCTCTCCAAAGATTGAATGTGAAGTTCCACCCCTATCCTATTGCCCCTTTGCCCACTGGGCCA
GGCCGGACCTGCCCCCTTGGTCTCTCTCCCTCCCCAAAGAATCCCCAGTTGCCTTTGGGATGAT
GGAGACCCCCTCCTGCAAGATTACCCTTTGTTATTTGCACAGGGATATTTCTAAGAAACAGAGA
CCAGCACTCCTAGCCTCTGTGGTCAGCAAGCAGAAAAGGCTGCTGCAGACTTTTTAAAAGTAGT
TGTATACTAGCATCTCAAGCCACCCAAGAGGGCCAACTTCCCATCTTCACATGGATACTTGCTG
TTCTCAGCTCCACCTTCAAGCCTTGGGGTCTCAGAGGGCCACAGGGAAGGTTTTTATTACCTGA
ACCCTACTTCCTCCCTTGGTCTAACTTCCTAAAGGCACAGTCCTGCCTATACCTGCTCCCTGCC
CCACCTGTACTGCCTCTCCCCACACAGCCTATCAGAACTGTGAAAGGCCTGCTTCTAGGCCACG
GGAGGGGAAAGGGGGCATTTTCTGAGTGAAAGAGAAAGAATGGGGTTGGCGGTAAAAGTGGCCT
CACTATAGGTTGGAGAGAACTTCACGTGTGAGTATGTGTATATGTAAGGGGAGGAAGGACCCAA
TGGCCTGTGTCCCTTCAGTTACCCGCAGCCAGCTTCAGGAGGGCTATCCGAACCTCTTCTCCCA
CTAGGCTCAACTCTGAAGGGACCCCCTTTCTTGGCCTGGCTCCCTACCTCTCAAGTCCCATGTT
TCTTTTCAATCAGTGAATTGAGTCCACCAATGCTGGGGACTCACAAGATTCCTGAGTCTCTTCC
ATACTGTGGCGTCTGAGAGCCAGAGACAGGAATAGTAAGGCGATAAACTTAGTTTTCCTGTCAG
CTTCATCTCAATAACCAGGTCATCAGGGACCCGTCCTTCAGACTCTAGGCTGGGACAGAAGGTA
TACCACCTCCTGGGGGTCCATCACATCAGAAGGGCACCCCATCTGTGTGAACCTGCTGCCCCAG
CTGCCTCGTCAGACCCTTGCCCCCTTATCCTCCTTCCCTCTCCACCTTTTAGGCTATTGTGAGA
CAGGGAAGGCCAGGGAAGAATTCCGGGTGTCTGGACCCTTTCCAGATAATATTTTTAGATCCCT
CTGTCCCCTAGTGATCAGCTTTAGGGCAAAGAAATTGCAAGGACATTTTTTTTTAAGGGTCAGA
GTTTTAAAAACAAAAGGATCTTCCCTAGAAATTTTTGTGAATTGTTTGCACTTGTGCCTGTTTT
AAATTAAACTGAGTGTTTAAACCTC

hide sequence

RefSeq Acc Id:

XM_021725730 ⟹ XP_021581405

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	85,863,845 - 85,899,290 (+)	NCBI
SpeTri2.0	NW_004936471	3,712,181 - 3,747,355 (+)	NCBI

Sequence:

show sequence

GCAGCCATTCAGGTGACTAAGCCGGCCCACCGCCACTGAGTCACCCACCCGCCAGAGCTTTTCT
TCCTTTCTTTTTGCATTTAATTATTTTGGGAGCTGAAAACTTGGAGCTGCACCTGAGTCCCGCC
TCTTCTATCTCTCCCCTCCCTACCTTGGCTTGGAGGAAGATGGGTCTTGCTGTGAATCTGCCAC
TACTCCCTAAGGATATAGAAGTCATGGTGGGGGCCAGGGGTGCCCGCCAAGAGATTGTAGCTGG
CAGAGTGCAATAGCAGACATGGTGATCAGGCTGCCAGTGTGTCCTCTGGAGGTGTCAAGAGAGG
AAGGGGAGTCTTGTCCACACCAACTGCAGTTCTCTTGGGCTGGCTTTGAACTCGCCTCATGAGA
TGTTTCTGTAAATGAATGACTTCTAGGGTAACAGTGGCATTCGGAGAGTGAAGCTGGATTGGCT
TAAGCAGGCCTGTGCAGGGAGCGCCGCTTCCTGGGCTCCAGACAAGTGCCAGCCTGCAGTGGGA
GAGAGTGAGGCCCAGCTGCCTGAAGAAGCGGCCAAGGCCTGCGGTGGACTAGCCCTGGAAGGTC
CTTGGTCTTCCCTCGGTGCCCAAGAGAGCTGACTGCTGAAGGGTGAGGAGACCCAAGGAAGAGG
AGTCAGGGAAGGCCTCCCGGAGGCACCATGTTCCGTAAGAAAAAGAAGAAACGCCCAGAGATCT
CAGCCCCACAGAACTTCCAACACCGTGTCCACACCTCCTTCGACCCCAAAGAGGGCAAGTTTGT
GGGCCTCCCACCACAATGGCAGAACATCCTGGATACACTGAGGCGCCCCAAGCCCGTGGTGGAC
CCTTCACGCATCACACGAGTGCAGCTCCAGCCCATGAAGACAGTGGTACGGGGCAGCTCGGTGC
CAACAGATGGCTACATCTCAGGGCTGCTCAATGACATCCAGAAGTTGTCAGTCATCAGTTCCAA
TACTCTGCGTGGTCGCAGCCCTACCAACCGGCGGCGGGCACAGTCTTTGGGGCTGCTAGGGGAT
GAGCACTGGGCCAATGATCCGGACATGTACCTCCAGAGCCCCCAGTCTGAGCGCACTGACCCCC
ACAGCCTCTACCTCAGCTGCAACGGGGGCACACCAGCAGGTCACAGGCAGATGCCATGGCCTGA
ACCACAGAGCCCACGGGTCCTGCCTAACGGGTTGGCCACCAAGGCACAGTCCCTGGGCCCTGCT
GAATTCCAGGGTGCCTCACAGCGCTGCCTGCAGCTGGGTGCCTGCCTGCAGAGCTCCCCACCTG
GCACCTCACCCCCTATGGCTACAGGGAGGCGGGGCGTGAAGACTGCCAAGCATGGCTCTGAGGA
AGCCCGGCCACAGTCTTGCCTGGTGGGCTCAGCCACAGGCAGGCCAGGTGGCGAAGGCAGCCCT
AGCCCGAAGGCCCAAGAGAACAGCCTCAAGCGCAGGTTATTTCGAAGCATGTTCCTCTCCACTC
CTGCCACGGCACCTCCAAGCAGCAGCAAGCCAGGCCTTCCACCACAGAGCAAGCCCAACTCTGC
TTTCCGACCACCACAGAAAGACTCCCCTCCAAGCCTGGTGGCCAAGGCCCAATCCTTGCCCTCA
GAACAACCCATGGGGACCTTCAGTCCTCTGACCACCTCGGACACCAGCAGCCCCCAGAAGTCCC
TCCGCATAGCCCCAGCCACTGGCCCACTTCCAGGTCGGTCTTCCCCGGCGGGCTCCCCCCGCAC
CCGGCATGCCCAGATCAGCACCAGCAACCTGTACCTGCCCCAGGACCCCACAGTGGCCAAGGGT
GCCCTGGCTAGTGAGGACACGGGCATTGTGACACATGAGCAGTTCAAGGCTGCACTCAGGATGG
TGGTGGACCAGGGTGACCCCCGGCTACTGCTGGACAGCTACGTGAAGATTGGCGAGGGCTCCAC
GGGCATTGTTTGCCTAGCCCGAGAGAAGCACTCTGGCCGCCAGGTGGCCGTCAAGATGATGGAC
CTCAGGAAGCAGCAGCGCAGGGAGCTGCTCTTTAATGAGGTGGTGATCATGCGGGACTACCAGC
ACTTCAACGTGGTGGAGATGTACAAGAGTTACCTGGTGGGCGAGGAGCTGTGGGTGCTAATGGA
GTTCCTGCAGGGCGGGGCCCTCACAGACATCATCTCCCAAGTCAGGCTGAATGAGGAGCAGATC
GCCACTGTGTGTGAGGCTGTGCTGCAGGCCCTGGCCTACCTGCATGCCCAAGGTGTCATCCACC
GGGACATCAAGAGTGATTCCATCCTGCTGACCCTTGACGGCAGGGTGAAGCTCTCGGACTTTGG
ATTCTGTGCTCAGATCAGCAAAGATGTCCCTAAGAGGAAGTCCCTGGTGGGAACCCCCTACTGG
ATGGCTCCTGAAGTGATCTCAAGGTCTCTGTATGCCACTGAGGTGGATATCTGGTCTCTGGGCA
TCATGGTGATTGAGATGGTGGATGGGGAGCCCCCCTATTTCAGTGACTCCCCAGTGCAAGCCAT
GAAGAGGCTCCGGGACAACCCCCCACCCAAGCTGAAAAACTCTCACAAGGTATCCCCAGTGCTG
CGAGACTTCCTGGAGCGGATGCTGGTGCGGGATCCCCAAGAGAGAGCCACGGCCCAGGAGCTCC
TGGACCACCCTTTCCTGCTGCAGACAGGGCTGCCTGAGTGCTTGGTGCCCCTGATCCAGCTCTA
CCGCAAGCAGACCTCCACCTGCTGAGCCCACTCTGAGTGCACCTGCCACCTGTGCCCCACAGGC
AGGGGACACTGGGCATCCAGCCCTCCAGCAGGGCTTGTCTGCCTCATTCTCTCAGTATTCTCTC
CAAAGATTGAATGTGAAGTTCCACCCCTATCCTATTGCCCCTTTGCCCACTGGGCCAGGCCGGA
CCTGCCCCCTTGGTCTCTCTCCCTCCCCAAAGAATCCCCAGTTGCCTTTGGGATGATGGAGACC
CCCTCCTGCAAGATTACCCTTTGTTATTTGCACAGGGATATTTCTAAGAAACAGAGACCAGCAC
TCCTAGCCTCTGTGGTCAGCAAGCAGAAAAGGCTGCTGCAGACTTTTTAAAAGTAGTTGTATAC
TAGCATCTCAAGCCACCCAAGAGGGCCAACTTCCCATCTTCACATGGATACTTGCTGTTCTCAG
CTCCACCTTCAAGCCTTGGGGTCTCAGAGGGCCACAGGGAAGGTTTTTATTACCTGAACCCTAC
TTCCTCCCTTGGTCTAACTTCCTAAAGGCACAGTCCTGCCTATACCTGCTCCCTGCCCCACCTG
TACTGCCTCTCCCCACACAGCCTATCAGAACTGTGAAAGGCCTGCTTCTAGGCCACGGGAGGGG
AAAGGGGGCATTTTCTGAGTGAAAGAGAAAGAATGGGGTTGGCGGTAAAAGTGGCCTCACTATA
GGTTGGAGAGAACTTCACGTGTGAGTATGTGTATATGTAAGGGGAGGAAGGACCCAATGGCCTG
TGTCCCTTCAGTTACCCGCAGCCAGCTTCAGGAGGGCTATCCGAACCTCTTCTCCCACTAGGCT
CAACTCTGAAGGGACCCCCTTTCTTGGCCTGGCTCCCTACCTCTCAAGTCCCATGTTTCTTTTC
AATCAGTGAATTGAGTCCACCAATGCTGGGGACTCACAAGATTCCTGAGTCTCTTCCATACTGT
GGCGTCTGAGAGCCAGAGACAGGAATAGTAAGGCGATAAACTTAGTTTTCCTGTCAGCTTCATC
TCAATAACCAGGTCATCAGGGACCCGTCCTTCAGACTCTAGGCTGGGACAGAAGGTATACCACC
TCCTGGGGGTCCATCACATCAGAAGGGCACCCCATCTGTGTGAACCTGCTGCCCCAGCTGCCTC
GTCAGACCCTTGCCCCCTTATCCTCCTTCCCTCTCCACCTTTTAGGCTATTGTGAGACAGGGAA
GGCCAGGGAAGAATTCCGGGTGTCTGGACCCTTTCCAGATAATATTTTTAGATCCCTCTGTCCC
CTAGTGATCAGCTTTAGGGCAAAGAAATTGCAAGGACATTTTTTTTTAAGGGTCAGAGTTTTAA
AAACAAAAGGATCTTCCCTAGAAATTTTTGTGAATTGTTTGCACTTGTGCCTGTTTTAAATTAA
ACTGAGTGTTTAAACCTC

hide sequence

RefSeq Acc Id:

XM_040276294 ⟹ XP_040132228

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	85,864,817 - 85,899,290 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005316452	(Get FASTA)	NCBI Sequence Viewer
	XP_021581405	(Get FASTA)	NCBI Sequence Viewer
	XP_040132228	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000008643.2
	ENSSTOP00000030730.1
GenBank Protein	KAG3261604	(Get FASTA)	NCBI Sequence Viewer
	KAG3261605	(Get FASTA)	NCBI Sequence Viewer
	KAG3261606	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005316452 ⟸ XM_005316395

- UniProtKB:

I3MDX6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQL
QPMKTVVRGSSVPTDGYISGLLNDIQKLSVISSNTLRGRSPTNRRRAQSLGLLGDEHWANDPDM
YLQSPQSERTDPHSLYLSCNGGTPAGHRQMPWPEPQSPRVLPNGLATKAQSLGPAEFQGASQRC
LQLGACLQSSPPGTSPPMATGRRGVKTAKHGSEEARPQSCLVGSATGRPGGEGSPSPKAQENSL
KRRLFRSMFLSTPATAPPSSSKPGLPPQSKPNSAFRPPQKDSPPSLVAKAQSLPSEQPMGTFSP
LTTSDTSSPQKSLRIAPATGPLPGRSSPAGSPRTRHAQISTSNLYLPQDPTVAKGALASEDTGI
VTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRREL
LFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIISQVRLNEEQIATVCEAVLQ
ALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRS
LYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDNPPPKLKNSHKVSPVLRDFLERMLV
RDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC

hide sequence

RefSeq Acc Id:

XP_021581405 ⟸ XM_021725730

- UniProtKB:

I3MDX6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQL
QPMKTVVRGSSVPTDGYISGLLNDIQKLSVISSNTLRGRSPTNRRRAQSLGLLGDEHWANDPDM
YLQSPQSERTDPHSLYLSCNGGTPAGHRQMPWPEPQSPRVLPNGLATKAQSLGPAEFQGASQRC
LQLGACLQSSPPGTSPPMATGRRGVKTAKHGSEEARPQSCLVGSATGRPGGEGSPSPKAQENSL
KRRLFRSMFLSTPATAPPSSSKPGLPPQSKPNSAFRPPQKDSPPSLVAKAQSLPSEQPMGTFSP
LTTSDTSSPQKSLRIAPATGPLPGRSSPAGSPRTRHAQISTSNLYLPQDPTVAKGALASEDTGI
VTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRREL
LFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIISQVRLNEEQIATVCEAVLQ
ALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRS
LYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDNPPPKLKNSHKVSPVLRDFLERMLV
RDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC

hide sequence

RefSeq Acc Id:	XP_040132228 ⟸ XM_040276294
- UniProtKB:	I3MDX6 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSSTOP00000008643 ⟸ ENSSTOT00000009634

RefSeq Acc Id:

ENSSTOP00000030730 ⟸ ENSSTOT00000042873

Protein Domains

CRIB Protein kinase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000009629	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000009634.3	UniProtKB/TrEMBL
	ENSSTOT00000042873.1	UniProtKB/TrEMBL
Gene3D-CATH	3.90.810.10	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	CRIB_dom	UniProtKB/TrEMBL
	CRIB_dom_sf	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	PAK6	UniProtKB/TrEMBL
	PAK_BD	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
NCBI Gene	Pak6	ENTREZGENE
PANTHER	SERINE/THREONINE-PROTEIN KINASE PAK 6	UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN KINASE TAO	UniProtKB/TrEMBL
Pfam	PBD	UniProtKB/TrEMBL
	Pkinase	UniProtKB/TrEMBL
PROSITE	CRIB	UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
SMART	PBD	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/TrEMBL
UniProt	I3MDX6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-26	Pak6	p21 (RAC1) activated kinase 6	LOC101957470	serine/threonine-protein kinase PAK 6	Symbol and/or name change	5135510	APPROVED
2017-07-13	LOC101957470	serine/threonine-protein kinase PAK 6	Pak6	p21 (RAC1) activated kinase 6	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD