Mgll (monoglyceride lipase) - Rat Genome Database

Name: Mgll
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Mgll (monoglyceride lipase) Ictidomys tridecemlineatus

Analyze

Symbol:

Mgll

Name:

monoglyceride lipase

RGD ID:

12594391

Description:

ENCODES a protein that exhibits hydrolase activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN acylglycerol catabolic process (ortholog); arachidonic acid metabolic process (ortholog); long-term synaptic depression (ortholog); ASSOCIATED WITH alkaptonuria (ortholog); amenorrhea (ortholog); genetic disease (ortholog); FOUND IN axon (ortholog); cerebellar climbing fiber to Purkinje cell synapse (ortholog); cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MGLL (monoglyceride lipase)	NCBI	Ortholog
Mus musculus (house mouse):	Mgll (monoglyceride lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Mgll (monoglyceride lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mgll (monoglyceride lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MGLL (monoglyceride lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MGLL (monoglyceride lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MGLL (monoglyceride lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MGLL (monoglyceride lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mgll (monoglyceride lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404942	20,639,895 - 20,679,987 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936798	681,380 - 724,463 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936798	681,549 - 721,645 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alkaptonuria (ISO)

amenorrhea (ISO)

genetic disease (ISO)

immunodeficiency 21 (ISO)

liver cirrhosis (ISO)

osteoporosis (ISO)

Primary Lymphedema with Myelodysplasia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acylglycerol catabolic process (ISO)

acylglycerol metabolic process (IEA)

arachidonic acid metabolic process (ISO)

long-term synaptic depression (ISO)

monoacylglycerol catabolic process (ISO)

positive regulation of vasoconstriction (ISO)

regulation of axon extension (ISO)

regulation of endocannabinoid signaling pathway (ISO)

regulation of inflammatory response (ISO)

regulation of retrograde trans-synaptic signaling by endocanabinoid (ISO)

regulation of sensory perception of pain (ISO)

regulation of signal transduction (ISO)

Cellular Component

axon (ISO)

cerebellar climbing fiber to Purkinje cell synapse (ISO)

cytosol (ISO)

membrane (IEA)

parallel fiber to Purkinje cell synapse (ISO)

presynapse (ISO)

synapse (ISO)

varicosity (ISO)

Molecular Function

acylglycerol lipase activity (IEA)

hydrolase activity (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Mgll
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404942	20,639,895 - 20,679,987 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936798	681,380 - 724,463 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936798	681,549 - 721,645 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MGLL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	127,689,066 - 127,823,185 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	127,689,062 - 128,052,190 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	127,407,909 - 127,542,028 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	128,890,599 - 129,024,741 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	128,890,608 - 129,024,399	NCBI
Celera	3	125,834,761 - 125,969,898 (-)	NCBI		Celera
Cytogenetic Map	3	q21.3	NCBI
HuRef	3	124,788,663 - 124,922,449 (-)	NCBI		HuRef
CHM1_1	3	127,371,222 - 127,505,366 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	130,423,721 - 130,557,760 (-)	NCBI		T2T-CHM13v2.0

Mgll
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	88,701,397 - 88,805,342 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	88,701,394 - 88,805,342 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	88,724,412 - 88,828,360 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	88,724,412 - 88,828,360 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	88,674,406 - 88,778,354 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	88,690,469 - 88,793,998 (+)	NCBI		MGSCv36	mm8
Celera	6	90,660,468 - 90,766,558 (+)	NCBI		Celera
Cytogenetic Map	6	D1	NCBI
cM Map	6	39.51	NCBI

Mgll
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	122,749,436 - 122,851,440 (+)	NCBI		GRCr8
mRatBN7.2	4	121,192,186 - 121,294,187 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	121,192,195 - 121,294,179 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	126,663,831 - 126,765,859 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	122,438,590 - 122,540,610 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	121,062,826 - 121,164,848 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	120,671,436 - 120,773,458 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	120,671,489 - 120,771,088 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	185,912,102 - 186,014,066 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	122,822,493 - 122,922,892 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	123,068,176 - 123,167,195 (+)	NCBI
Celera	4	110,145,418 - 110,245,006 (+)	NCBI		Celera
Cytogenetic Map	4	q34	NCBI

Mgll
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955429	15,759,540 - 15,960,835 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955429	15,760,159 - 15,960,774 (+)	NCBI	ChiLan1.0	ChiLan1.0

MGLL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	125,612,275 - 125,743,766 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	125,619,904 - 125,748,488 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	124,733,770 - 124,865,302 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	132,040,430 - 132,171,731 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	132,040,430 - 132,171,731 (-)	Ensembl	panpan1.1		panPan2

MGLL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	1,765,650 - 1,880,710 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	1,766,216 - 1,943,588 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	1,803,361 - 1,918,069 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	1,787,245 - 1,901,999 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	1,788,085 - 1,901,966 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	1,508,582 - 1,623,257 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	1,835,979 - 1,950,579 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	1,795,784 - 1,910,369 (-)	NCBI		UU_Cfam_GSD_1.0

MGLL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	72,480,174 - 72,568,961 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	72,480,395 - 72,568,964 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	79,998,289 - 80,086,913 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MGLL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	53,092,970 - 53,354,316 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	53,218,672 - 53,354,448 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	113,000,703 - 113,137,279 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mgll
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624974	87,600 - 170,228 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624974	85,513 - 169,904 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013365262	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000020424 ⟹ ENSSTOP00000019904

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936798	681,382 - 721,516 (+)	Ensembl

RefSeq Acc Id:

ENSSTOT00000030678 ⟹ ENSSTOP00000031697

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936798	681,380 - 721,516 (+)	Ensembl

RefSeq Acc Id:

ENSSTOT00000038867 ⟹ ENSSTOP00000025707

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936798	705,305 - 724,463 (+)	Ensembl

RefSeq Acc Id:

XM_013365262 ⟹ XP_013220716

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404942	20,639,895 - 20,679,987 (+)	NCBI
SpeTri2.0	NW_004936798	681,549 - 721,645 (+)	NCBI

Sequence:

show sequence

ATGGGAGCCTGCCACGTGCCCACCCTCTACGTGGCACACTTTGCTAACAGAGTTCCTTCTTCCC
TCCTTAGGGCCCTTGTGTTTGTGTCCCATGGCGCCGGGGAACACTGTGGCCGCTATGACGAGCT
GGCTCAGATGCTGATGGGGCTGGACATCCTGGTGTTTGCGCATGACCACGTCGGCCACGGGCAG
AGCGAAGGGGAGAGGATGGTGGTGTCTGACTTCCACGTTTTCGTCAGGGACGTGCTACAGCACG
TGGACGTCATGCGGAAGGACTACCCCAGCCTCCCTGTCTTCCTCCTGGGCCACTCCATGGGAGG
TGCCATTGTGATCCTCACAGCGGCGGAGAGGCCGGGCCACTTCTGTGGGATGGTCCTCATCTCA
CCCCTGGTTCTGGCCAATCCCGAATCTGCAACAACTTTCAAGGTCCTCGCTGCGAAAGTGCTCA
ACCTTGTCCTGCCAAACATGTCCCTGGGGCCCATCGATTCCAGCGTCCTCTCCCGGAACAAGAC
AGAGGTTGAGCTTTACAACTCGGACCCTCTCATCTGCCGGGCGGGGCTGAAAGTGTGCTTTGGG
ATCCAACTACTCAACGCTGTCTCGCGGGTGGAGCGAGCCCTCCCCAAGCTGACCTTGCCCTTCC
TGCTGCTCCAGGGCTCCGCAGACCGCCTGTGTGACAGCAAAGGGGCCTACCTGCTCATGGAGTC
AGCCAAGAGCCAGGACAAGACTCTCAAGATTTACGAAGGTGCCTACCACGTCCTCCACAAAGAG
CTTCCGGAAGTGACCAACTCCGTCTTCCACGAAATAAACATGTGGGTCTCCCAAAGGATAACCA
TGGCTGTCCCCAGAGGGGTCCCCAGAGGGTCCCCGCCCTGAGTGCACTGGCCAAGGGACCAGCT
CATGGCCTGGGGGAAGCGGGCAGAGGGAGAACAGAGCTGGCTGCTTCCGAGTGGCTTAAAAACC
AACCCACCGCCAAACTGGAGGGACCCCTGGCGCAGTTAACTT

hide sequence

Protein Sequences


Protein RefSeqs	XP_013220716	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000019904.2
	ENSSTOP00000025707.1
	ENSSTOP00000031697.1

RefSeq Acc Id:

XP_013220716 ⟸ XM_013365262

- UniProtKB:

I3N6A8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGACHVPTLYVAHFANRVPSSLLRALVFVSHGAGEHCGRYDELAQMLMGLDILVFAHDHVGHGQ
SEGERMVVSDFHVFVRDVLQHVDVMRKDYPSLPVFLLGHSMGGAIVILTAAERPGHFCGMVLIS
PLVLANPESATTFKVLAAKVLNLVLPNMSLGPIDSSVLSRNKTEVELYNSDPLICRAGLKVCFG
IQLLNAVSRVERALPKLTLPFLLLQGSADRLCDSKGAYLLMESAKSQDKTLKIYEGAYHVLHKE
LPEVTNSVFHEINMWVSQRITMAVPRGVPRGSPP

hide sequence

RefSeq Acc Id:

ENSSTOP00000019904 ⟸ ENSSTOT00000020424

RefSeq Acc Id:

ENSSTOP00000031697 ⟸ ENSSTOT00000030678

RefSeq Acc Id:

ENSSTOP00000025707 ⟸ ENSSTOT00000038867

Protein Domains

Serine aminopeptidase S33

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000023185	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000020424.2	UniProtKB/TrEMBL
	ENSSTOT00000030678.1	UniProtKB/TrEMBL
	ENSSTOT00000038867.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1820	UniProtKB/TrEMBL
InterPro	AB_hydrolase	UniProtKB/TrEMBL
	AB_hydrolase_1	UniProtKB/TrEMBL
	Hydrolase_4	UniProtKB/TrEMBL
NCBI Gene	Mgll	ENTREZGENE
PANTHER	MONOGLYCERIDE LIPASE	UniProtKB/TrEMBL
	PHOSPHOLIPASE-RELATED	UniProtKB/TrEMBL
Pfam	Hydrolase_4	UniProtKB/TrEMBL
PRINTS	ABHYDROLASE	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53474	UniProtKB/TrEMBL
UniProt	A0A287CWM9_ICTTR	UniProtKB/TrEMBL
	A0A287DDR7_ICTTR	UniProtKB/TrEMBL
	I3N6A8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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