Hexim2 (HEXIM P-TEFb complex subunit 2)

Gene: Hexim2 (HEXIM P-TEFb complex subunit 2) Ictidomys tridecemlineatus

Analyze

Symbol:

Hexim2

Name:

HEXIM P-TEFb complex subunit 2

RGD ID:

12590611

Description:

ENCODES a protein that exhibits 7SK snRNA binding (inferred); cyclin-dependent protein serine/threonine kinase inhibitor activity (inferred); identical protein binding (inferred); INVOLVED IN negative regulation of DNA-templated transcription (inferred); negative regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear speck (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

hexamethylene bisacetamide inducible 2; hexamethylene bisacetamide inducible 2, transcript variant X1; hexamethylene bisacetamide inducible 2, transcript variant X2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	17,717,605 - 17,722,656 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936541	1,472,027 - 1,477,048 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936541	1,472,041 - 1,476,993 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of DNA-templated transcription (IEA)

negative regulation of transcription by RNA polymerase II (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

nuclear speck (IEA)

nucleoplasm (IEA)

nucleus (IEA)

Molecular Function

7SK snRNA binding (IEA)

cyclin-dependent protein serine/threonine kinase inhibitor activity (IEA)

identical protein binding (IEA)

protein binding (ISO)

snRNA binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Hexim2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	17,717,605 - 17,722,656 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936541	1,472,027 - 1,477,048 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936541	1,472,041 - 1,476,993 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HEXIM2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	45,160,174 - 45,170,040 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	45,160,700 - 45,170,040 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	43,237,541 - 43,247,407 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	40,594,047 - 40,603,189 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	17	39,947,916 - 39,957,031 (+)	NCBI		Celera
Cytogenetic Map	17	q21.31	NCBI
HuRef	17	39,001,091 - 39,009,915 (+)	NCBI		HuRef
CHM1_1	17	43,473,807 - 43,482,952 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	46,014,059 - 46,023,937 (+)	NCBI		T2T-CHM13v2.0

Hexim2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	103,014,086 - 103,030,734 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	103,023,255 - 103,030,702 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	103,123,260 - 103,139,908 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	103,132,429 - 103,139,876 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	102,994,653 - 103,001,222 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	102,949,404 - 102,955,998 (+)	NCBI		MGSCv36	mm8
Celera	11	114,816,349 - 114,849,525 (+)	NCBI		Celera
Cytogenetic Map	11	E1	NCBI
cM Map	11	66.71	NCBI

Hexim2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	88,572,102 - 88,584,856 (+)	NCBI		GRCr8
mRatBN7.2	10	88,077,870 - 88,084,776 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	88,079,014 - 88,084,775 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	93,115,155 - 93,120,921 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	92,581,799 - 92,587,566 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	87,975,151 - 87,980,918 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	91,212,296 - 91,222,841 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	91,217,079 - 91,222,840 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	90,988,728 - 90,994,491 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	92,306,494 - 92,312,256 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	92,320,794 - 92,329,877 (+)	NCBI
Celera	10	86,780,500 - 86,786,262 (+)	NCBI		Celera
Cytogenetic Map	10	q32.1	NCBI

HEXIM2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	19,667,571 - 19,676,969 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	21,636,155 - 21,646,713 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	12,157,392 - 12,167,281 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	12,333,957 - 12,343,424 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	12,333,957 - 12,343,399 (-)	Ensembl	panpan1.1		panPan2

HEXIM2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	18,373,761 - 18,379,185 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	18,373,992 - 18,377,260 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	17,758,535 - 17,763,959 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	19,046,798 - 19,052,222 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	19,046,986 - 19,050,297 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	17,925,068 - 17,930,491 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	18,103,901 - 18,109,325 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	18,259,869 - 18,265,293 (-)	NCBI		UU_Cfam_GSD_1.0

HEXIM2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	18,251,428 - 18,258,295 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	18,251,424 - 18,263,032 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	18,500,139 - 18,509,293 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HEXIM2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	61,236,919 - 61,251,203 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	61,236,566 - 61,248,252 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	31,985,644 - 31,996,088 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005328140	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013359903	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000009445 ⟹ ENSSTOP00000008472

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936541	1,472,027 - 1,477,048 (+)	Ensembl

RefSeq Acc Id:

ENSSTOT00000041991 ⟹ ENSSTOP00000030542

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936541	1,472,027 - 1,477,048 (+)	Ensembl

RefSeq Acc Id:

XM_005328140 ⟹ XP_005328197

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	17,717,605 - 17,722,644 (-)	NCBI
SpeTri2.0	NW_004936541	1,472,041 - 1,476,993 (+)	NCBI

Sequence:

show sequence

CTTAGTGCCTGAGCAGCTTGGTCAGAACTGCTGCAACTGCAGCAAGAGGTAGGGCTGAGGCGTT
GGGAATTTCACAGACAGGCGGTCGCACAGAAAGACACACAGAGGTAGTCGTGTGCATAGCTCTT
GACAGCAAATAGGTGTGACTAGTTAAAGGCATCTGCTGAAAGACTGGGAGAAGAAAAAGATGGC
CACTCTGAATCAGACCAACTGTAATACCAAGTCACCAGCAGCCCTGGAGGAGGCCAAGACCTCT
GGTGATTCGGGGAGCCCCCAAACACCCACTAAGTCTCTTGACTGTGGCAGTTCCCCGTCCCTGG
CACCACGAAAAAAGAGCCATTCAGAGGATGAAGATCTTGCCCAGGCTGCCGGTGGCCTGAGCTG
GAACTGTGGTGGACCCCAAACCCAGAGCCCAGGGGGTTGCTCAGTAGAGGCCGTGCTGGGCCGG
AAGAAGCACCGGAGGAGGCCATCCAAGCGCAAGCGGCACTGGAGGCCCTACCTGGAGCTGAGCT
GGGCGGAGAAGCAGCAGCGTGATGAGAGGCAGAGCCAGAGGGCCTCCAGGGTCCGCGAGGAGAT
GTTTGCCAAAGGCCAGCCTGTGGCGCCCTACAACACCACCCAGTTTCTCATGAATGACCGAGAC
CCCGAGGAGCCCAACCTTGAAGTGCCACCCTATGGGGCGTCCCACCCAGGTTCCAGCGGGGACA
GTGAGGCAGGGGACAGTGACGGGCAGGGCCAAGATCATGGCGAGTTCCAGCAGAGGGACTTCTC
TGAGGCCTATGAGCGCTATCACACTGAGAGCCTGCAGGGCCGCAGCAAGCAGGAGCTGGTAAGA
GACTACCTGGACCTGGAGCGGAGGCTCACGCAGGCCGAGGAGGAGACGCGGAGGCTGCAGCAGC
TGCAGGGGCGCATGGGCCAGCAGCCCTGTCGCCAGGTGGAGGAGCTGGCCGCCGAGGTAGAGAG
GCTCCGCACTGAGAACCAGCGGCTTCGGCAGGAGAAGGAGATGTGGAACCAAGGGGGCAGCCGC
CGCCATGAGGAGCCAGGCACCTAGGGGTGCCCCCCAGCCAGGTGGACCTTGTCCTGATTCTCAG
CCACTCAGGCCAGCTGGGTCTCAAAGAGACAGGTGGCAAATGAAAAGCACTCTTGAAATCACCG
TGCCCCCTGAGAACAGCTGAAACAGGTTCAGACTTCCACCTTTTTTGTCATTTCCACAATTGGT
TCTTTGATGTCATCTTACTTTTTACAAAAAAATTAAATGGTTTTGCTGAGACCCAA

hide sequence

RefSeq Acc Id:

XM_013359903 ⟹ XP_013215357

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	17,717,605 - 17,722,656 (-)	NCBI
SpeTri2.0	NW_004936541	1,472,047 - 1,476,993 (+)	NCBI

Sequence:

show sequence

GCCTGAGCAGCTTGGTCAGAACTGCTGCAACTGCAGCAAGAGGTGTGACTAGTTAAAGGCATCT
GCTGAAAGACTGGGAGAAGAAAAAGATGGCCACTCTGAATCAGACCAACTGTAATACCAAGTCA
CCAGCAGCCCTGGAGGAGGCCAAGACCTCTGGTGATTCGGGGAGCCCCCAAACACCCACTAAGT
CTCTTGACTGTGGCAGTTCCCCGTCCCTGGCACCACGAAAAAAGAGCCATTCAGAGGATGAAGA
TCTTGCCCAGGCTGCCGGTGGCCTGAGCTGGAACTGTGGTGGACCCCAAACCCAGAGCCCAGGG
GGTTGCTCAGTAGAGGCCGTGCTGGGCCGGAAGAAGCACCGGAGGAGGCCATCCAAGCGCAAGC
GGCACTGGAGGCCCTACCTGGAGCTGAGCTGGGCGGAGAAGCAGCAGCGTGATGAGAGGCAGAG
CCAGAGGGCCTCCAGGGTCCGCGAGGAGATGTTTGCCAAAGGCCAGCCTGTGGCGCCCTACAAC
ACCACCCAGTTTCTCATGAATGACCGAGACCCCGAGGAGCCCAACCTTGAAGTGCCACCCTATG
GGGCGTCCCACCCAGGTTCCAGCGGGGACAGTGAGGCAGGGGACAGTGACGGGCAGGGCCAAGA
TCATGGCGAGTTCCAGCAGAGGGACTTCTCTGAGGCCTATGAGCGCTATCACACTGAGAGCCTG
CAGGGCCGCAGCAAGCAGGAGCTGGTAAGAGACTACCTGGACCTGGAGCGGAGGCTCACGCAGG
CCGAGGAGGAGACGCGGAGGCTGCAGCAGCTGCAGGGGCGCATGGGCCAGCAGCCCTGTCGCCA
GGTGGAGGAGCTGGCCGCCGAGGTAGAGAGGCTCCGCACTGAGAACCAGCGGCTTCGGCAGGAG
AAGGAGATGTGGAACCAAGGGGGCAGCCGCCGCCATGAGGAGCCAGGCACCTAGGGGTGCCCCC
CAGCCAGGTGGACCTTGTCCTGATTCTCAGCCACTCAGGCCAGCTGGGTCTCAAAGAGACAGGT
GGCAAATGAAAAGCACTCTTGAAATCACCGTGCCCCCTGAGAACAGCTGAAACAGGTTCAGACT
TCCACCTTTTTTGTCATTTCCACAATTGGTTCTTTGATGTCATCTTACTTTTTACAAAAAAATT
AAATGGTTTTGCTGAGACCCAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005328197	(Get FASTA)	NCBI Sequence Viewer
	XP_013215357	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000008472.3
	ENSSTOP00000030542.1
GenBank Protein	KAG3268761	(Get FASTA)	NCBI Sequence Viewer
	KAG3268762	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_013215357 ⟸ XM_013359903

- UniProtKB:

I3MDK4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MATLNQTNCNTKSPAALEEAKTSGDSGSPQTPTKSLDCGSSPSLAPRKKSHSEDEDLAQAAGGL
SWNCGGPQTQSPGGCSVEAVLGRKKHRRRPSKRKRHWRPYLELSWAEKQQRDERQSQRASRVRE
EMFAKGQPVAPYNTTQFLMNDRDPEEPNLEVPPYGASHPGSSGDSEAGDSDGQGQDHGEFQQRD
FSEAYERYHTESLQGRSKQELVRDYLDLERRLTQAEEETRRLQQLQGRMGQQPCRQVEELAAEV
ERLRTENQRLRQEKEMWNQGGSRRHEEPGT

hide sequence

RefSeq Acc Id:

XP_005328197 ⟸ XM_005328140

- UniProtKB:

I3MDK4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MATLNQTNCNTKSPAALEEAKTSGDSGSPQTPTKSLDCGSSPSLAPRKKSHSEDEDLAQAAGGL
SWNCGGPQTQSPGGCSVEAVLGRKKHRRRPSKRKRHWRPYLELSWAEKQQRDERQSQRASRVRE
EMFAKGQPVAPYNTTQFLMNDRDPEEPNLEVPPYGASHPGSSGDSEAGDSDGQGQDHGEFQQRD
FSEAYERYHTESLQGRSKQELVRDYLDLERRLTQAEEETRRLQQLQGRMGQQPCRQVEELAAEV
ERLRTENQRLRQEKEMWNQGGSRRHEEPGT

hide sequence

RefSeq Acc Id:

ENSSTOP00000030542 ⟸ ENSSTOT00000041991

RefSeq Acc Id:

ENSSTOP00000008472 ⟸ ENSSTOT00000009445

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000009448	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000009445.3	UniProtKB/TrEMBL
	ENSSTOT00000041991.1	UniProtKB/TrEMBL
Gene3D-CATH	6.10.250.2910	UniProtKB/TrEMBL
InterPro	HEXIM	UniProtKB/TrEMBL
NCBI Gene	Hexim2	ENTREZGENE
PANTHER	PTHR13469	UniProtKB/TrEMBL
	PTHR13469:SF3	UniProtKB/TrEMBL
Pfam	HEXIM	UniProtKB/TrEMBL
PRINTS	HEXIMFAMILY	UniProtKB/TrEMBL
UniProt	I3MDK4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-11-29	Hexim2	HEXIM P-TEFb complex subunit 2		hexamethylene bisacetamide inducible 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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