Brca1 (BRCA1 DNA repair associated) - Rat Genome Database

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Pathways
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Gene: Brca1 (BRCA1 DNA repair associated) Ictidomys tridecemlineatus
Analyze
Symbol: Brca1
Name: BRCA1 DNA repair associated
RGD ID: 12588030
Description: ENCODES a protein that exhibits chromatin binding (ortholog); damaged DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); INVOLVED IN cellular response to indole-3-methanol (ortholog); cellular response to ionizing radiation (ortholog); cellular response to tumor necrosis factor (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; forkhead class A signaling pathway; homologous recombination pathway of double-strand break repair; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Animal Mammary Neoplasms (ortholog); bilateral breast cancer (ortholog); FOUND IN BRCA1-B complex (ortholog); BRCA1-BARD1 complex (ortholog); BRCA1-C complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: BRCA1, DNA repair associated; breast cancer type 1 susceptibility protein homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,272,096 - 19,340,929 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493649017,735,444 - 17,801,456 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenoid cystic carcinoma  (ISO)
Animal Mammary Neoplasms  (ISO)
bilateral breast cancer  (ISO)
breast adenocarcinoma  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
breast ductal carcinoma  (ISO)
Breast Neoplasms  (ISO)
Burkitt lymphoma  (ISO)
carcinoma  (ISO)
cervical cancer  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chromosome Breakage  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
disease of cellular proliferation  (ISO)
ductal carcinoma in situ  (ISO)
dysgerminoma  (ISO)
endometrial carcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Mammary Neoplasms  (ISO)
Familial Prostate Cancer  (ISO)
Fanconi anemia complementation group A  (ISO)
Fanconi Anemia Complementation Group S  (ISO)
genetic disease  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
hereditary mixed polyposis syndrome 1  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
infant-type hemispheric glioma  (ISO)
invasive ductal carcinoma  (ISO)
lung cancer  (ISO)
lung non-small cell carcinoma  (ISO)
mouth disease  (ISO)
nasopharynx carcinoma  (ISO)
Neoplastic Cell Transformation  (ISO)
ovarian cancer  (ISO)
ovarian carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
ovary serous adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
peritoneum cancer  (ISO)
Premature Aging  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
punctate palmoplantar keratoderma type II  (ISO)
rhabdomyosarcoma  (ISO)
stomach cancer  (ISO)
stomach carcinoma  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)
uterine corpus cancer  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to indole-3-methanol  (ISO)
cellular response to ionizing radiation  (ISO)
cellular response to tumor necrosis factor  (ISO)
centrosome cycle  (ISO)
chordate embryonic development  (IEA,ISO)
chromosome segregation  (ISO)
DNA damage response  (IEA,ISO)
DNA repair  (IEA)
dosage compensation by inactivation of X chromosome  (IEA)
double-strand break repair  (ISO)
double-strand break repair via homologous recombination  (IEA)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
mitotic G2 DNA damage checkpoint signaling  (ISO)
mitotic G2/M transition checkpoint  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
negative regulation of fatty acid biosynthetic process  (IEA)
negative regulation of gene expression via chromosomal CpG island methylation  (ISO)
negative regulation of intracellular estrogen receptor signaling pathway  (ISO)
negative regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of DNA repair  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of vascular endothelial growth factor production  (ISO)
postreplication repair  (ISO)
protein autoubiquitination  (ISO)
protein K6-linked ubiquitination  (ISO)
protein ubiquitination  (ISO)
random inactivation of X chromosome  (ISO)
regulation of cell cycle  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to estradiol  (ISO)
response to genistein  (ISO)
response to ionizing radiation  (ISO)
response to lipid  (ISO)
response to nutrient  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Brca1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,272,096 - 19,340,929 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493649017,735,444 - 17,801,456 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRCA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381743,044,295 - 43,170,327 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1743,044,295 - 43,170,245 (-)EnsemblGRCh38hg38GRCh38
GRCh371741,196,312 - 41,277,381 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,449,840 - 38,530,994 (-)NCBINCBI36Build 36hg18NCBI36
Build 341738,449,843 - 38,530,934NCBI
Celera1737,853,171 - 37,934,354 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1736,962,663 - 37,043,809 (-)NCBIHuRef
CHM1_11741,431,851 - 41,513,018 (-)NCBICHM1_1
T2T-CHM13v2.01743,902,857 - 44,029,084 (-)NCBIT2T-CHM13v2.0
Brca1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,379,587 - 101,442,808 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,379,590 - 101,442,781 (-)EnsemblGRCm39 Ensembl
GRCm3811101,488,761 - 101,551,955 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,488,764 - 101,551,955 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,350,078 - 101,413,269 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,304,854 - 101,365,210 (-)NCBIMGSCv36mm8
Celera11113,175,987 - 113,239,169 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1165.18NCBI
Brca1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,917,693 - 86,978,012 (-)NCBIGRCr8
mRatBN7.21086,417,441 - 86,477,762 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,418,000 - 86,477,304 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,454,623 - 91,513,795 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,930,035 - 90,990,102 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,323,338 - 86,383,395 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,394,821 - 89,455,093 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,394,803 - 89,454,681 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,192,653 - 89,252,760 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,513,630 - 90,572,676 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,527,999 - 90,587,046 (-)NCBI
Celera1085,140,052 - 85,200,670 (-)NCBICelera
Cytogenetic Map10q31NCBI
Brca1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,819,023 - 16,855,528 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,819,463 - 16,870,780 (-)NCBIChiLan1.0ChiLan1.0
BRCA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21921,865,798 - 21,957,438 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11723,755,123 - 23,836,219 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,197,946 - 14,279,064 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,429,601 - 14,506,815 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,428,526 - 14,506,815 (+)Ensemblpanpan1.1panPan2
BRCA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,958,941 - 20,025,494 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,958,391 - 20,025,494 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,422,566 - 19,486,083 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,677,057 - 20,743,989 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,677,128 - 20,743,989 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,464,421 - 19,527,988 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0919,730,981 - 19,794,752 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0919,833,116 - 19,896,786 (+)NCBIUU_Cfam_GSD_1.0
BRCA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1219,786,020 - 19,854,668 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11219,788,087 - 19,854,515 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,028,878 - 20,093,800 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BRCA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,162,827 - 63,243,928 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607733,932,799 - 34,042,352 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Brca1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,188,136 - 1,241,964 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,186,043 - 1,238,986 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_040268959   ⟹   XP_040124893
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560219,272,096 - 19,340,929 (+)NCBI
Protein Sequences
Protein RefSeqs XP_040124893 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000000449.3
  ENSSTOP00000030725.1
GenBank Protein KAG3268860 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_040124893   ⟸   XM_040268959
Protein Domains
BRCT


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000000494 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000000497.3 UniProtKB/TrEMBL
  ENSSTOT00000031750.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10190 UniProtKB/TrEMBL
InterPro BRCA1 UniProtKB/TrEMBL
  BRCA1-associated UniProtKB/TrEMBL
  BRCT_dom UniProtKB/TrEMBL
  BRCT_dom_sf UniProtKB/TrEMBL
NCBI Gene Brca1 ENTREZGENE
PANTHER BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN UniProtKB/TrEMBL
  PTHR13763 UniProtKB/TrEMBL
Pfam BRCT UniProtKB/TrEMBL
PIRSF BRCA1 UniProtKB/TrEMBL
PRINTS BRSTCANCERI UniProtKB/TrEMBL
PROSITE BRCT UniProtKB/TrEMBL
SMART BRCT UniProtKB/TrEMBL
Superfamily-SCOP SSF52113 UniProtKB/TrEMBL
UniProt A0A287DAY7_ICTTR UniProtKB/TrEMBL
  I3LWR9_ICTTR UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 Brca1  BRCA1 DNA repair associated    BRCA1, DNA repair associated  Symbol and/or name change 5135510 APPROVED