Prkd1 (protein kinase D1) - Rat Genome Database

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Gene: Prkd1 (protein kinase D1) Ictidomys tridecemlineatus
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Symbol: Prkd1
Name: protein kinase D1
RGD ID: 12554491
Description: ENCODES a protein that exhibits heat shock protein binding (ortholog); protein kinase activity (ortholog); protein kinase C binding (ortholog); INVOLVED IN cellular response to angiotensin (ortholog); cellular response to endothelin (ortholog); cellular response to norepinephrine stimulus (ortholog); PARTICIPATES IN insulin-like growth factor signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Brain-Lung-Thyroid Syndrome (ortholog); Cardiac Fibrosis (ortholog); FOUND IN cytoplasm (ortholog); Golgi apparatus (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein kinase D1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864040,963,196 - 41,207,484 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364944,469,089 - 4,601,214 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364944,469,092 - 4,601,183 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to amino acid starvation  (IEA)
cellular response to angiotensin  (ISO)
cellular response to endothelin  (ISO)
cellular response to hydroperoxide  (IEA)
cellular response to norepinephrine stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to oxidative stress  (IEA)
cellular response to phorbol 13-acetate 12-myristate  (ISO)
cellular response to vascular endothelial growth factor stimulus  (IEA)
defense response to Gram-negative bacterium  (IEA)
Golgi organization  (IEA)
Golgi vesicle transport  (IEA)
intracellular signal transduction  (IEA,ISO)
positive regulation of angiogenesis  (IEA)
positive regulation of autophagy  (IEA)
positive regulation of blood vessel endothelial cell migration  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of cell size  (ISO)
positive regulation of endothelial cell chemotaxis  (IEA)
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway  (IEA)
positive regulation of endothelial cell migration  (IEA)
positive regulation of endothelial cell proliferation  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of neuron projection development  (IEA)
positive regulation of NLRP3 inflammasome complex assembly  (IEA)
positive regulation of osteoblast differentiation  (IEA)
positive regulation of peptide hormone secretion  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of protein export from nucleus  (ISO)
positive regulation of protein import into nucleus  (IEA)
positive regulation of sarcomere organization  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
regulation of keratinocyte proliferation  (IEA)
regulation of release of sequestered calcium ion into cytosol  (IEA,ISO)
regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril  (ISO)
response to norepinephrine  (ISO)
vascular endothelial growth factor receptor signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Prkd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864040,963,196 - 41,207,484 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364944,469,089 - 4,601,214 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364944,469,092 - 4,601,183 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381429,576,479 - 29,927,847 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1429,576,479 - 30,191,898 (-)EnsemblGRCh38hg38GRCh38
GRCh371430,045,685 - 30,397,053 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361429,115,436 - 29,466,650 (-)NCBINCBI36Build 36hg18NCBI36
Build 341429,115,439 - 29,466,652NCBI
Celera149,911,927 - 10,263,081 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef1410,161,470 - 10,512,671 (-)NCBIHuRef
CHM1_11430,044,967 - 30,396,713 (-)NCBICHM1_1
T2T-CHM13v2.01423,774,515 - 24,125,722 (-)NCBIT2T-CHM13v2.0
Prkd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391250,388,009 - 50,696,075 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1250,388,014 - 50,695,881 (-)EnsemblGRCm39 Ensembl
GRCm381250,341,226 - 50,649,271 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1250,341,231 - 50,649,098 (-)EnsemblGRCm38mm10GRCm38
MGSCv371251,442,218 - 51,750,210 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361251,217,854 - 51,571,105 (-)NCBIMGSCv36mm8
Celera1251,654,217 - 51,955,593 (-)NCBICelera
Cytogenetic Map12B3NCBI
cM Map1221.78NCBI
Prkd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8673,460,640 - 73,774,433 (-)NCBIGRCr8
mRatBN7.2667,725,193 - 68,039,002 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl667,725,905 - 68,039,042 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx668,177,553 - 68,489,871 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0668,484,172 - 68,796,501 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0667,919,348 - 68,237,248 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0671,035,017 - 71,349,531 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl671,035,332 - 71,349,249 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0680,600,725 - 80,914,319 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4670,364,135 - 70,682,006 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1670,393,721 - 70,394,895 (-)NCBI
Celera666,643,414 - 66,954,727 (-)NCBICelera
Cytogenetic Map6q22NCBI
Prkd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540930,554,013 - 30,860,649 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540930,554,095 - 30,860,588 (+)NCBIChiLan1.0ChiLan1.0
PRKD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21530,905,194 - 31,258,408 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11430,122,170 - 30,474,871 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01410,353,284 - 10,707,841 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11428,499,753 - 28,650,036 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1428,496,282 - 28,650,030 (-)Ensemblpanpan1.1panPan2
PRKD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.189,004,641 - 9,327,054 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl89,005,115 - 9,328,358 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha88,933,899 - 9,256,073 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.089,106,948 - 9,429,506 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl89,107,422 - 9,430,511 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.188,787,713 - 9,109,715 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.088,868,816 - 9,191,637 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.089,140,306 - 9,462,703 (-)NCBIUU_Cfam_GSD_1.0
PRKD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl769,527,811 - 69,872,863 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1769,527,743 - 69,872,374 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2774,585,433 - 74,730,165 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Prkd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248202,408,360 - 2,726,606 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248202,408,562 - 2,726,199 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSSTOT00000003884   ⟹   ENSSTOP00000003482
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364944,469,089 - 4,601,214 (-)Ensembl
RefSeq Acc Id: XM_021724679   ⟹   XP_021580354
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864040,963,196 - 41,095,270 (-)NCBI
SpeTri2.0NW_0049364944,469,092 - 4,601,183 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021724680   ⟹   XP_021580355
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864040,963,196 - 41,095,270 (-)NCBI
SpeTri2.0NW_0049364944,469,092 - 4,601,183 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040273976   ⟹   XP_040129910
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864040,963,196 - 41,207,484 (-)NCBI
RefSeq Acc Id: XR_005728883
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864040,964,135 - 41,095,268 (-)NCBI
RefSeq Acc Id: XR_005728884
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864040,964,173 - 41,095,268 (-)NCBI
RefSeq Acc Id: XP_021580355   ⟸   XM_021724680
- Peptide Label: isoform X2
- UniProtKB: I3M371 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021580354   ⟸   XM_021724679
- Peptide Label: isoform X1
- UniProtKB: I3M371 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040129910   ⟸   XM_040273976
- Peptide Label: isoform X1
- UniProtKB: I3M371 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000003482   ⟸   ENSSTOT00000003884
Protein Domains
PH   Phorbol-ester/DAG-type   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003873 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000003884.3 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro C1-like_sf UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Protein_Kinase_C_mu-related UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Prkd1 ENTREZGENE
PANTHER PTHR22968 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE D1 UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PIRSF PKC_mu_nu_D2 UniProtKB/TrEMBL
PRINTS DAGPEDOMAIN UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt I3M371 ENTREZGENE, UniProtKB/TrEMBL