Cpb2 (carboxypeptidase B2) - Rat Genome Database

Name: Cpb2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Cpb2 (carboxypeptidase B2) Ictidomys tridecemlineatus

Analyze

Symbol:

Cpb2

Name:

carboxypeptidase B2

RGD ID:

12544551

Description:

ENCODES a protein that exhibits carboxypeptidase activity (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); fibrinolysis (ortholog); liver regeneration (ortholog); PARTICIPATES IN fibrinolysis pathway; ASSOCIATED WITH amenorrhea (ortholog); Angina Pectoris (ortholog); Bacteremia (ortholog); FOUND IN extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CPB2 (carboxypeptidase B2)	NCBI	Ortholog
Mus musculus (house mouse):	Cpb2 (carboxypeptidase B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Cpb2 (carboxypeptidase B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cpb2 (carboxypeptidase B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CPB2 (carboxypeptidase B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CPB2 (carboxypeptidase B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CPB2 (carboxypeptidase B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CPB2 (carboxypeptidase B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cpb2 (carboxypeptidase B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	156,155,086 - 156,203,983 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936857	577,585 - 626,267 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936857	577,067 - 609,855 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amenorrhea (ISO)

Angina Pectoris (ISO)

Bacteremia (ISO)

Behcet's disease (ISO)

Burns (ISO)

Chemical and Drug Induced Liver Injury (ISO)

chronic kidney disease (ISO)

diabetes mellitus (ISO)

Diabetic Nephropathies (ISO)

Experimental Autoimmune Encephalomyelitis (ISO)

genetic disease (ISO)

glomerulonephritis (ISO)

Hypercholesterolemia (ISO)

Insulin Resistance (ISO)

Meningococcal Infections (ISO)

Multiple Organ Failure (ISO)

nephrotic syndrome (ISO)

obesity (ISO)

renal fibrosis (ISO)

Sepsis (ISO)

thrombocytosis (ISO)

Thromboembolism (ISO)

Thrombotic Microangiopathies (ISO)

type 2 diabetes mellitus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to glucose stimulus (ISO)

fibrinolysis (IEA,ISO)

liver regeneration (ISO)

negative regulation of fibrinolysis (ISO)

negative regulation of hepatocyte proliferation (ISO)

negative regulation of plasminogen activation (ISO)

positive regulation of extracellular matrix constituent secretion (ISO)

protein catabolic process (ISO)

proteolysis (IEA)

response to xenobiotic stimulus (ISO)

Cellular Component

extracellular space (IEA,ISO)

Molecular Function

carboxypeptidase activity (IEA,ISO)

metal ion binding (IEA)

metallocarboxypeptidase activity (IEA)

metallopeptidase activity (IEA)

peptidase activity (IEA)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

fibrinolysis pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Cpb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	156,155,086 - 156,203,983 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936857	577,585 - 626,267 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936857	577,067 - 609,855 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CPB2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	46,053,186 - 46,105,033 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	13	46,053,186 - 46,105,033 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	13	46,627,321 - 46,679,168 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	45,525,323 - 45,577,212 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	13	45,525,322 - 45,577,169	NCBI
Celera	13	27,682,037 - 27,734,241 (-)	NCBI		Celera
Cytogenetic Map	13	q14.13	NCBI
HuRef	13	27,424,287 - 27,477,016 (-)	NCBI		HuRef
CHM1_1	13	46,596,461 - 46,648,341 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	13	45,274,576 - 45,326,411 (-)	NCBI		T2T-CHM13v2.0

Cpb2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	75,479,727 - 75,520,995 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	75,479,727 - 75,520,995 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	75,242,287 - 75,283,555 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	75,242,287 - 75,283,555 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	75,642,094 - 75,683,362 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	73,976,443 - 74,017,701 (+)	NCBI		MGSCv36	mm8
Celera	14	72,744,408 - 72,785,554 (+)	NCBI		Celera
Cytogenetic Map	14	D3	NCBI
cM Map	14	39.73	NCBI

Cpb2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	56,967,128 - 57,015,964 (+)	NCBI		GRCr8
mRatBN7.2	15	50,557,722 - 50,606,569 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	50,557,717 - 50,606,556 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	54,699,866 - 54,748,774 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	55,818,184 - 55,867,090 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	52,650,058 - 52,698,853 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	57,290,849 - 57,339,762 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	57,290,849 - 57,339,760 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	61,001,889 - 61,050,732 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	56,104,920 - 56,154,321 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	56,120,686 - 56,170,027 (+)	NCBI
Celera	15	50,189,675 - 50,237,544 (+)	NCBI		Celera
Cytogenetic Map	15	q11	NCBI

Cpb2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955518	3,740,348 - 3,803,539 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955518	3,740,348 - 3,803,540 (-)	NCBI	ChiLan1.0	ChiLan1.0

CPB2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	14	45,285,438 - 45,339,238 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	13	36,339,651 - 36,393,445 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	13	26,926,788 - 26,979,767 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

CPB2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	22	5,074,805 - 5,126,635 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	22	5,074,816 - 5,126,170 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	22	5,060,946 - 5,113,389 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	22	5,190,115 - 5,242,228 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	22	5,190,159 - 5,241,792 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	22	4,972,456 - 5,024,301 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	22	5,035,678 - 5,087,765 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	22	5,040,873 - 5,092,730 (+)	NCBI		UU_Cfam_GSD_1.0

CPB2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	21,234,447 - 21,298,241 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	11	21,234,447 - 21,298,250 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	21,696,077 - 21,757,686 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CPB2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	24,108,854 - 24,161,669 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	3	24,109,416 - 24,161,408 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666057	19,855,294 - 19,907,245 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cpb2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624748	8,849,900 - 8,928,853 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624748	8,850,128 - 8,927,986 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021720797	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000010703 ⟹ ENSSTOP00000009607

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936857	577,585 - 626,267 (-)	Ensembl

RefSeq Acc Id:

XM_021720797 ⟹ XP_021576472

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404945	156,155,086 - 156,203,983 (-)	NCBI
SpeTri2.0	NW_004936857	577,067 - 609,855 (-)	NCBI

Sequence:

show sequence

GGTTTTATCTGCTCTTCCTAGAACCTCTAGACAAGTTCAAGTTCTTCAGAATCTTACTACAACC
TATGAGATTGTTCTCTGGCAGCCAGTAACTGCTGAATTTATTGCAAAGAATAAAGAAGTCCATT
TTTTTGTGAATGCATCTGATGTAAGCAATGTGAAAGTCCATTTAAATGCCAGCAGAATTCCATT
CAGCATCTTGATGGTGGATGTGGAAGATCTTATTCGACAGCAGACTTCCAATGACACAGTCAGC
CCCCGAACCTCCTATTCATACTATGAACAGTATCACTCACTCAATGAAATCTATTCTTGGATAG
AAGTTATAACTGCACAGCATCCTAAGATGCTTAAAAAAATCCACATTGGATCCTCATATGAGAA
GTACCCACTGTATGTTTTAAAGGTTTCTGGAAAAGAACAAACAGCCAAAAATGCCATATGGATT
GACTGTGGAATGCATGCCAGAGAATGGATCTCTCCTGCTTTCTGCTTGTGGTTCATCGGCTACG
TAACTCAGTTCTATGAAAAAGAAAAGCTATATACCAATCTTCTAAGACACGTGGATTTCTACAT
TATGCCAGTAATTAATGTGGATGGTTATGACTACACGTGGAAAAAGAATCGAATGTGGAGAAAG
AACCGTTCTTCCCATGAGAACAACCGTTGTATTGGAACAGACCTGAATAGGAACTTTGCTTCCA
AACACTGGTGTGAGGAAGGTGCCTCAAGTTTTTCGTGCTCTGAAACCTACTGTGGACTTTATCC
TGAGTCTGAACCAGAAGTGAAGGCAGTGGCTGATTTCTTGAGGAGAAATATCAACCATATTAAA
GCTTACATTAGCATGCATTCATATGCCCAGCAGATACTATATCCATATTCCTATAATAGAAGCA
AAAGCAAAGACCATGAGGAACTGTCTTTGGTGGCCAGTGAAGCAGTTCGTGCTATTGAGAGTAT
TAATAAAAATACCAGGTATACACATGGCAGTGGCTCAGAGACTTTATACCTAGCTCCTGGAGGT
TCCGATGATTGGATCTATGATTTGGGCATCAAATATTCATTTACAATTGAACTTCGAGATAAAG
GCAGATATGGATTCTTGCTGCCTGAGCGTTACATCAAACCCACTTGTACAGAAGCTCTCGCCGC
TGTTGCTAAAATAGCTTGGCATGTAGTCAGACATGTTTAATGTTCTTGATTTTTCACTTTGCTT
CCATATTATTAATTTACTGATTCCAGCAAAAACCAAATCGTTGTGCAAGTTTCTATTAAGCTTG
ATCCATTGTTTTGATCAAAGGTTTGCCTCGTTCTTGATTTTGTCAAAAACAAAATGCATGCTAC
TTGGAAATCACGATAGACAAGGGAGTTCACGAGTGTTTTTAACTTTTTTTTTTTTTAATCTGTA
AGAGCCCAGATACTGATCTTTTGCTTTCTGATATTTGACTAGCTATCTCAAGCAATTTTAATAA
TTAGTTTCATGCAGATCACTGGATCTTGCAACAAAAGGAAAGGTGGCCAGGAATACACTAAAGA
TTTCTTCCCCGATTTGTCAATAAATTTGTTTGCATCTTCAAAAACACAACCGTGTATTTCAGTT
GCTTCACAGTAATAGACAAAGGCCCTGGAAGGGGAGGGGTGTCAAACATGAGATAAATATCACC
TCTTGCTCCAGCTCAGCCGGTTCCATAAACAATTGTTGAGCGAATGAATGGCTGTGGTTACTTT
CAGCAACGAATATGGCGTTTTGCGCGGTTGTTTATTGCAAAAAAATTATACAATAAAAAGAGGA
AAGTCCTTAACTTTACTTTTAAGGGCGAGTTTCACCGGCCCCTAGCTCCCAGAGTACTCCCCGC
GATCTCACAACACAAGTGCGGATCACCAACGCCCGAAACACGCAGCCGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_021576472	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000009607.3
GenBank Protein	KAG3293043	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_021576472 ⟸ XM_021720797

- UniProtKB:

I3MFZ8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVDVEDLIRQQTSNDTVSPRTSYSYYEQYHSLNEIYSWIEVITAQHPKMLKKIHIGSSYEKYPL
YVLKVSGKEQTAKNAIWIDCGMHAREWISPAFCLWFIGYVTQFYEKEKLYTNLLRHVDFYIMPV
INVDGYDYTWKKNRMWRKNRSSHENNRCIGTDLNRNFASKHWCEEGASSFSCSETYCGLYPESE
PEVKAVADFLRRNINHIKAYISMHSYAQQILYPYSYNRSKSKDHEELSLVASEAVRAIESINKN
TRYTHGSGSETLYLAPGGSDDWIYDLGIKYSFTIELRDKGRYGFLLPERYIKPTCTEALAAVAK
IAWHVVRHV

hide sequence

RefSeq Acc Id:

ENSSTOP00000009607 ⟸ ENSSTOT00000010703

Protein Domains

Peptidase M14 carboxypeptidase A

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000010700	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000010703.3	UniProtKB/TrEMBL
Gene3D-CATH	3.30.70.340	UniProtKB/TrEMBL
	Zn peptidases	UniProtKB/TrEMBL
InterPro	CPB2	UniProtKB/TrEMBL
	M14A-like_propep	UniProtKB/TrEMBL
	M14A_act_pep	UniProtKB/TrEMBL
	Peptidase_M14	UniProtKB/TrEMBL
NCBI Gene	Cpb2	ENTREZGENE
PANTHER	CARBOXYPEPTIDASE B2	UniProtKB/TrEMBL
	PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B	UniProtKB/TrEMBL
Pfam	Peptidase_M14	UniProtKB/TrEMBL
	Propep_M14	UniProtKB/TrEMBL
PRINTS	CRBOXYPTASEA	UniProtKB/TrEMBL
SMART	Zn_pept	UniProtKB/TrEMBL
Superfamily-SCOP	Protease propeptides/inhibitors	UniProtKB/TrEMBL
	Zn-dependent exopeptidases	UniProtKB/TrEMBL
UniProt	I3MFZ8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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