Akr1d1 (aldo-keto reductase family 1 member D1) - Rat Genome Database

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Gene: Akr1d1 (aldo-keto reductase family 1 member D1) Ictidomys tridecemlineatus
Analyze
Symbol: Akr1d1
Name: aldo-keto reductase family 1 member D1
RGD ID: 12535282
Description: ENCODES a protein that exhibits 3-oxo-5-beta-steroid 4-dehydrogenase activity (ortholog); INVOLVED IN bile acid biosynthetic process (ortholog); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; ASSOCIATED WITH congenital bile acid synthesis defect (ortholog); congenital bile acid synthesis defect 2 (ortholog); genetic disease (ortholog); FOUND IN cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 3-oxo-5-beta-steroid 4-dehydrogenase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511816,696,579 - 16,727,564 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365922,491,681 - 2,522,796 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365922,486,219 - 2,522,796 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Akr1d1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511816,696,579 - 16,727,564 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365922,491,681 - 2,522,796 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365922,486,219 - 2,522,796 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKR1D1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387138,076,459 - 138,118,305 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7138,002,324 - 138,118,305 (+)EnsemblGRCh38hg38GRCh38
GRCh377137,761,205 - 137,803,051 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367137,411,736 - 137,453,590 (+)NCBINCBI36Build 36hg18NCBI36
Build 347137,218,450 - 137,260,305NCBI
Celera7132,499,985 - 132,541,839 (+)NCBICelera
Cytogenetic Map7q33NCBI
HuRef7132,069,181 - 132,111,033 (+)NCBIHuRef
CHM1_17137,694,698 - 137,736,587 (+)NCBICHM1_1
T2T-CHM13v2.07139,311,690 - 139,427,796 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27137,106,397 - 137,148,256 (+)NCBI
Akr1d1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39637,506,913 - 37,551,856 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl637,507,108 - 37,545,750 (+)EnsemblGRCm39 Ensembl
GRCm38637,529,978 - 37,574,921 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl637,530,173 - 37,568,815 (+)EnsemblGRCm38mm10GRCm38
MGSCv37637,480,173 - 37,518,815 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36637,459,781 - 37,498,003 (+)NCBIMGSCv36mm8
Celera637,517,252 - 37,556,030 (+)NCBICelera
Cytogenetic Map6B1NCBI
cM Map616.44NCBI
Akr1d1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8467,121,288 - 67,154,543 (+)NCBIGRCr8
mRatBN7.2466,154,246 - 66,187,505 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl466,154,248 - 66,186,372 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx471,096,251 - 71,129,493 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0467,017,336 - 67,050,578 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0465,407,781 - 65,440,769 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0465,110,706 - 65,143,930 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl465,110,746 - 65,143,941 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0464,933,143 - 64,965,930 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4464,972,908 - 65,005,896 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1465,249,037 - 65,282,026 (+)NCBI
Celera461,186,796 - 61,219,854 (+)NCBICelera
Cytogenetic Map4q23NCBI
Akr1d1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554944,799,450 - 4,854,696 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554944,799,706 - 4,856,100 (-)NCBIChiLan1.0ChiLan1.0
AKR1D1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26174,889,295 - 174,931,548 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1726,899,547 - 26,941,800 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07130,023,017 - 130,076,397 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17142,514,914 - 142,568,052 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7142,525,467 - 142,571,331 (+)Ensemblpanpan1.1panPan2
AKR1D1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1161,499,251 - 1,583,965 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1611,172,153 - 11,677,722 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01610,254,191 - 10,279,758 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11610,201,202 - 10,250,574 (-)NCBIUMICH_Zoey_3.1
AKR1D1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1811,416,068 - 11,531,726 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11811,416,065 - 11,532,846 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21812,091,380 - 12,134,240 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AKR1D1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121106,705,197 - 106,822,194 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21106,780,339 - 106,822,696 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660723,643,056 - 3,684,108 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Akr1d1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476518,406,758 - 18,475,918 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476518,406,859 - 18,474,905 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005332448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000000839   ⟹   ENSSTOP00000000753
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365922,491,681 - 2,522,796 (+)Ensembl
RefSeq Acc Id: XM_005332448   ⟹   XP_005332505
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440511816,696,579 - 16,727,564 (-)NCBI
SpeTri2.0NW_0049365922,486,219 - 2,522,796 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005332505 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000000753.3
Reference Protein Sequences
RefSeq Acc Id: XP_005332505   ⟸   XM_005332448
- UniProtKB: I3LXF8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000000753   ⟸   ENSSTOT00000000839
Protein Domains
NADP-dependent oxidoreductase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000000840 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000000839.3 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/TrEMBL
InterPro AKR UniProtKB/TrEMBL
  Aldo/ket_reductase_CS UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/TrEMBL
NCBI Gene Akr1d1 ENTREZGENE
PANTHER ALDO-KETO REDUCTASE FAMILY 1 MEMBER D1 UniProtKB/TrEMBL
  ALDO/KETO REDUCTASE UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/TrEMBL
PIRSF AKR UniProtKB/TrEMBL
PRINTS ALDKETRDTASE UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_2 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF51430 UniProtKB/TrEMBL
UniProt I3LXF8 ENTREZGENE, UniProtKB/TrEMBL