Nr2f1 (nuclear receptor subfamily 2 group F member 1)

Gene: Nr2f1 (nuclear receptor subfamily 2 group F member 1) Ictidomys tridecemlineatus

Analyze

Symbol:

Nr2f1

Name:

nuclear receptor subfamily 2 group F member 1

RGD ID:

12516068

Description:

ENCODES a protein that exhibits retinoic acid-responsive element binding (ortholog); INVOLVED IN cerebral cortex regionalization (ortholog); forebrain development (ortholog); interneuron migration (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); Bosch-Boonstra-Schaaf optic atrophy syndrome (ortholog); Breast Neoplasms (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

COUP transcription factor 1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	171,322,457 - 171,331,829 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936523	9,507,965 - 9,517,272 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936523	9,508,204 - 9,517,266 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

Bosch-Boonstra-Schaaf optic atrophy syndrome (ISO)

Breast Neoplasms (ISO)

Developmental Disabilities (ISO)

epilepsy (ISO)

familial adenomatous polyposis 1 (ISO)

genetic disease (ISO)

Hereditary Neoplastic Syndromes (ISO)

Neurodevelopmental Disorders (ISO)

ovarian cyst (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IEA)

cerebral cortex regionalization (ISO)

forebrain development (ISO)

interneuron migration (ISO)

intracellular receptor signaling pathway (IEA)

negative regulation of neuron projection development (ISO)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

nervous system development (ISO)

neuron migration (ISO)

positive regulation of miRNA transcription (ISO)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

regulation of DNA-templated transcription (IEA)

regulation of gene expression (ISO)

Cellular Component

cytosol (IEA)

nucleoplasm (IEA)

nucleus (IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription factor activity (IEA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IEA)

metal ion binding (IEA)

nuclear receptor activity (IEA)

protein binding (ISO)

retinoic acid-responsive element binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA)

sequence-specific DNA binding (IEA)

sequence-specific double-stranded DNA binding (IEA)

zinc ion binding (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Nr2f1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	171,322,457 - 171,331,829 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936523	9,507,965 - 9,517,272 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936523	9,508,204 - 9,517,266 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NR2F1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	93,583,222 - 93,594,611 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	93,583,222 - 93,594,611 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	92,918,928 - 92,930,317 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	92,944,799 - 92,955,544 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	92,944,798 - 92,955,540	NCBI
Celera	5	88,778,440 - 88,789,186 (+)	NCBI		Celera
Cytogenetic Map	5	q15	NCBI
HuRef	5	88,092,169 - 88,102,739 (+)	NCBI		HuRef
CHM1_1	5	92,351,749 - 92,362,489 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	94,067,283 - 94,078,673 (+)	NCBI		T2T-CHM13v2.0

Nr2f1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	78,337,090 - 78,346,954 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	78,337,092 - 78,347,876 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	78,188,971 - 78,198,873 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	78,188,973 - 78,199,757 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	78,328,234 - 78,338,243 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	78,652,524 - 78,662,420 (-)	NCBI		MGSCv36	mm8
Celera	13	80,475,542 - 80,485,460 (-)	NCBI		Celera
Cytogenetic Map	13	C1	NCBI
cM Map	13	41.38	NCBI

Nr2f1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	9,776,179 - 9,785,924 (-)	NCBI		GRCr8
mRatBN7.2	2	8,040,375 - 8,050,123 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	8,040,377 - 8,050,123 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	15,156,212 - 15,165,958 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	13,255,522 - 13,265,268 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	7,905,787 - 7,915,533 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	5,569,954 - 5,579,894 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	5,569,935 - 5,579,894 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	5,553,211 - 5,563,152 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	5,765,399 - 5,794,104 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	5,791,963 - 5,820,665 (-)	NCBI
Celera	2	4,489,100 - 4,498,590 (-)	NCBI		Celera
Cytogenetic Map	2	q11	NCBI

Nr2f1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	18,614,995 - 18,624,584 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955418	18,615,548 - 18,622,984 (-)	NCBI	ChiLan1.0	ChiLan1.0

NR2F1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	21,798,293 - 21,808,047 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	19,951,902 - 19,964,301 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	21,773,283 - 21,785,746 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	21,909,691 - 21,918,776 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	21,910,463 - 21,918,776 (-)	Ensembl	panpan1.1		panPan2

NR2F1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	15,707,198 - 15,716,875 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	15,707,640 - 15,716,875 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	17,056,142 - 17,065,912 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	15,603,857 - 15,613,637 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	15,603,875 - 15,613,542 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	15,559,980 - 15,569,747 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	15,546,214 - 15,555,980 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	15,764,483 - 15,774,264 (-)	NCBI		UU_Cfam_GSD_1.0

NR2F1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	100,447,705 - 100,457,506 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	100,447,661 - 100,457,510 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	103,839,017 - 103,848,870 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NR2F1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	87,463,514 - 87,475,900 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	87,466,249 - 87,475,112 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666049	36,657,859 - 36,670,290 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nr2f1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624743	12,478,832 - 12,488,458 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624743	12,479,427 - 12,488,178 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013358981	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040272104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040272105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010002273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000015398 ⟹ ENSSTOP00000013789

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936523	9,507,965 - 9,517,272 (-)	Ensembl

RefSeq Acc Id:

ENSSTOT00000036655 ⟹ ENSSTOP00000032029

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936523	9,508,703 - 9,515,425 (-)	Ensembl

RefSeq Acc Id:

XM_013358981 ⟹ XP_013214435

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	171,322,457 - 171,331,829 (-)	NCBI
SpeTri2.0	NW_004936523	9,508,204 - 9,517,266 (-)	NCBI

Sequence:

show sequence

GCCCGGTTCGGGCCAGAGCCAGCAGCATATCGAGTGCGTGGTGTGCGGGGACAAGTCGAGCGGC
AAGCACTACGGCCAATTCACCTGCGAGGGCTGCAAAAGTTTCTTCAAGAGGAGCGTCCGCAGGA
ACTTAACTTACACATGCCGTGCCAACAGGAACTGTCCCATCGACCAGCACCACCGCAACCAGTG
CCAATACTGCCGCCTCAAGAAGTGCCTCAAAGTGGGCATGAGGCGGGAAGCGGTTCAGCGAGGA
AGAATGCCTCCAACCCAGCCCAATCCAGGCCAGTACGCACTCACCAACGGGGACCCCCTCAATG
GCCACTGCTACCTGTCTGGCTACATCTCGCTGCTGCTGCGCGCCGAACCCTACCCCACGTCGCG
CTATGGCAGCCAGTGCATGCAGCCCAACAACATCATGGGCATCGAGAACATCTGCGAGCTGGCC
GCGCGCCTGCTCTTCAGCGCCGTCGAGTGGGCCCGCAACATCCCCTTCTTCCCGGATCTGCAGA
TCACCGACCAGGTGTCCCTACTCCGCCTCACCTGGAGCGAGTTGTTCGTGCTCAACGCGGCCCA
GTGCTCCATGCCGCTGCACGTGGCACCGCTGCTGGCCGCCGCCGGCCTGCACGCCTCGCCCATG
TCCGCCGACCGCGTCGTGGCCTTCATGGACCACATCCGCATCTTTCAGGAGCAGGTGGAGAAGC
TCAAGGCTCTGCACGTCGATTCCGCAGAGTACAGCTGCCTCAAAGCCATCGTGCTCTTCACGTC
AGATGCCTGTGGCCTGTCGGATGCCGCCCACATCGAAAGCCTGCAGGAGAAATCACAATGCGCA
CTGGAGGAATATGTGAGGAGCCAGTATCCCAACCAGCCCAGCCGCTTCGGCAAACTGCTGCTGC
GACTGCCCTCGCTCCGCACCGTGTCCTCCTCTGTCATCGAGCAGCTCTTCTTCGTCCGTTTGGT
AGGTAAAACCCCTATTGAAACTCTCATCCGAGATATGTTACTGTCTGGGAGCAGCTTCAACTGG
CCTTACATGTCCATCCAGTGCTCCTAGACCTTGGGTGCTTCCTGCCTGCCCCTGCCCCCACTAG
AAACTCAGAGGACTCATCCGGGCCAAGGACTCCAACGCCTCGGGGATTCTCCGGGTGTGGAGGA
CCAGGCAGGCCAGGCAGACCAGGCAGGGGAAAGAATGCTGGGGACAGGAGCAGCCCACCCTGCA
GAAATGCAACTGGAGCTGCAAACCAGGAGAAAAAGAAACTCTTTTAGGATCAGATCTATAAGCA
CGTTGCAAAGGAAAGAAAAAAGGATCTTATGTCTGGTGAGAAAATGAAAACATTTTTTTGGAAG
AGAGGACCATAAGAATTTTAATAAAACAGAAGGAGACCAATGGACCTTCCAGGATTTATTGTGG
ACGGATGTGGATATATTCTGTACAGAAAAACAACACATATGGAAATGGACTGAATCCTATGTAG
AAACACACATCACACACACACACACACACACACACACACACACACACACACTGAACATTGTTAT
TCATTTTGTAAAAT

hide sequence

RefSeq Acc Id:

XM_040272104 ⟹ XP_040128038

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	171,322,457 - 171,329,737 (-)	NCBI

RefSeq Acc Id:

XM_040272105 ⟹ XP_040128039

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	171,322,457 - 171,329,973 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_013214435	(Get FASTA)	NCBI Sequence Viewer
	XP_040128038	(Get FASTA)	NCBI Sequence Viewer
	XP_040128039	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000013789.3
	ENSSTOP00000032029.1
GenBank Protein	KAG3266366	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_013214435 ⟸ XM_013358981

- Peptide Label:

isoform X2

- Sequence:

show sequence

MRREAVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIM
GIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLA
AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIE
SLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDM
LLSGSSFNWPYMSIQCS

hide sequence

RefSeq Acc Id:	XP_040128039 ⟸ XM_040272105
- Peptide Label:	isoform X3
- UniProtKB:	A0A287DES0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_040128038 ⟸ XM_040272104
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSSTOP00000032029 ⟸ ENSSTOT00000036655

RefSeq Acc Id:

ENSSTOP00000013789 ⟸ ENSSTOT00000015398

Protein Domains

NR LBD Nuclear receptor

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000015403	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000015398.3	UniProtKB/TrEMBL
	ENSSTOT00000036655.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.565.10	UniProtKB/TrEMBL
	3.30.50.10	UniProtKB/TrEMBL
InterPro	NHR-like_dom_sf	UniProtKB/TrEMBL
	Nucl_hrmn_rcpt_lig-bd	UniProtKB/TrEMBL
	Nuclear_hrmn_rcpt	UniProtKB/TrEMBL
	Znf_hrmn_rcpt	UniProtKB/TrEMBL
	Znf_NHR/GATA	UniProtKB/TrEMBL
NCBI Gene	Nr2f1	ENTREZGENE
PANTHER	COUP TRANSCRIPTION FACTOR 1	UniProtKB/TrEMBL
	NUCLEAR HORMONE RECEPTOR	UniProtKB/TrEMBL
Pfam	Hormone_recep	UniProtKB/TrEMBL
	zf-C4	UniProtKB/TrEMBL
PRINTS	COUPTNFACTOR	UniProtKB/TrEMBL
	STRDHORMONER	UniProtKB/TrEMBL
	STROIDFINGER	UniProtKB/TrEMBL
PROSITE	NR_LBD	UniProtKB/TrEMBL
	NUCLEAR_REC_DBD_1	UniProtKB/TrEMBL
	NUCLEAR_REC_DBD_2	UniProtKB/TrEMBL
SMART	HOLI	UniProtKB/TrEMBL
	ZnF_C4	UniProtKB/TrEMBL
Superfamily-SCOP	Glucocorticoid receptor-like (DNA-binding domain)	UniProtKB/TrEMBL
	SSF48508	UniProtKB/TrEMBL
UniProt	A0A287DES0	ENTREZGENE, UniProtKB/TrEMBL
	I3MPN8_ICTTR	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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