Map3k1 (mitogen-activated protein kinase kinase kinase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Map3k1 (mitogen-activated protein kinase kinase kinase 1) Ictidomys tridecemlineatus
Analyze
Symbol: Map3k1
Name: mitogen-activated protein kinase kinase kinase 1
RGD ID: 12514168
Description: ENCODES a protein that exhibits cytoskeletal protein binding (ortholog); JUN kinase binding (ortholog); JUN kinase kinase kinase activity (ortholog); INVOLVED IN apoptotic mitochondrial changes (ortholog); camera-type eye development (ortholog); epithelial cell morphogenesis (ortholog); PARTICIPATES IN adenosine signaling pathway; altered Wnt signaling, canonical pathway; c-Jun N-terminal kinases MAPK signaling pathway; ASSOCIATED WITH 46,XY sex reversal 6 (ortholog); breast cancer (ortholog); Breast Neoplasms (ortholog); FOUND IN filamentous actin (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213202,144,631 - 202,220,196 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648011,083,605 - 11,156,691 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648011,082,811 - 11,156,691 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Map3k1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213202,144,631 - 202,220,196 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648011,083,605 - 11,156,691 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648011,082,811 - 11,156,691 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38556,815,549 - 56,896,152 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl556,815,549 - 56,896,152 (+)EnsemblGRCh38hg38GRCh38
GRCh37556,111,376 - 56,191,979 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36556,146,657 - 56,227,736 (+)NCBINCBI36Build 36hg18NCBI36
Celera553,065,179 - 53,146,179 (+)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef553,082,897 - 53,163,892 (+)NCBIHuRef
CHM1_1556,113,966 - 56,195,023 (+)NCBICHM1_1
T2T-CHM13v2.0557,643,875 - 57,724,397 (+)NCBIT2T-CHM13v2.0
Map3k1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913111,882,962 - 111,954,803 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13111,882,962 - 111,945,527 (-)EnsemblGRCm39 Ensembl
GRCm3813111,746,428 - 111,818,269 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13111,746,428 - 111,808,993 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713112,536,641 - 112,599,191 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613112,867,468 - 112,929,861 (-)NCBIMGSCv36mm8
Celera13116,043,507 - 116,076,666 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1363.36NCBI
Map3k1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8245,081,889 - 45,150,555 (-)NCBIGRCr8
mRatBN7.2243,348,572 - 43,414,706 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl243,350,098 - 43,414,463 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx250,464,742 - 50,530,977 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0248,523,204 - 48,589,428 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0243,374,713 - 43,440,941 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0243,329,516 - 43,393,203 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl243,329,516 - 43,393,207 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0262,373,717 - 62,440,715 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4243,062,252 - 43,126,058 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1242,987,560 - 43,051,968 (-)NCBI
Celera239,134,930 - 39,199,049 (-)NCBICelera
Cytogenetic Map2q14NCBI
Map3k1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544611,021,971 - 11,090,136 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544611,022,091 - 11,090,136 (-)NCBIChiLan1.0ChiLan1.0
MAP3K1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2457,027,936 - 57,108,549 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1555,181,567 - 55,262,180 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0557,116,405 - 57,197,017 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1558,745,573 - 58,826,959 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl558,745,579 - 58,826,959 (-)Ensemblpanpan1.1panPan2
MAP3K1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1243,918,210 - 43,996,817 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl243,917,604 - 43,995,209 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha240,979,535 - 41,058,128 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0244,400,091 - 44,478,773 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl244,400,091 - 44,476,998 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1241,477,057 - 41,555,639 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0242,280,433 - 42,359,075 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0243,100,342 - 43,179,022 (+)NCBIUU_Cfam_GSD_1.0
MAP3K1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1635,872,131 - 35,946,987 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11635,872,301 - 35,947,097 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21638,138,087 - 38,212,844 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1453,040,731 - 53,120,784 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl453,084,023 - 53,120,772 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660491,934,475 - 2,010,412 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map3k1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247592,363,076 - 2,428,273 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247592,360,655 - 2,429,189 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_021722458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010002273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000007207   ⟹   ENSSTOP00000006441
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648011,083,605 - 11,156,691 (-)Ensembl
RefSeq Acc Id: XM_021722458   ⟹   XP_021578133
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213202,144,631 - 202,220,196 (-)NCBI
SpeTri2.0NW_00493648011,082,811 - 11,156,691 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_021578133 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000006441.3
Reference Protein Sequences
RefSeq Acc Id: XP_021578133   ⟸   XM_021722458
- UniProtKB: I3M9A6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000006441   ⟸   ENSSTOT00000007207
Protein Domains
Protein kinase   RING-type   SWIM-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000007184 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000007207.3 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_SWIM UniProtKB/TrEMBL
NCBI Gene Map3k1 ENTREZGENE
PANTHER MAP KINASE KINASE KINASE SSK2-RELATED-RELATED UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1A UniProtKB/TrEMBL
Pfam CEP104-like_TOG UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  SWIM UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
  ZF_SWIM UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  SSF48371 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt I3M9A6 ENTREZGENE, UniProtKB/TrEMBL