Pdp1 (pyruvate dehydrogenase phosphatase catalytic subunit 1) - Rat Genome Database

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Gene: Pdp1 (pyruvate dehydrogenase phosphatase catalytic subunit 1) Ictidomys tridecemlineatus
Analyze
Symbol: Pdp1
Name: pyruvate dehydrogenase phosphatase catalytic subunit 1 (Ensembl:pyruvate dehyrogenase phosphatase catalytic subunit 1)
RGD ID: 12505618
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); magnesium ion binding (ortholog); protein serine/threonine phosphatase activity (ortholog); PARTICIPATES IN pyruvate metabolic pathway; ASSOCIATED WITH genetic disease (ortholog); Joubert syndrome 1 (ortholog); obesity (ortholog); FOUND IN mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pyruvate dehyrogenase phosphatase catalytic subunit 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530340,775,259 - 40,783,817 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365447,009,486 - 7,018,859 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365447,008,882 - 7,017,446 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pdp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530340,775,259 - 40,783,817 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365447,009,486 - 7,018,859 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365447,008,882 - 7,017,446 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38893,916,923 - 93,926,068 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl893,857,807 - 93,926,068 (+)EnsemblGRCh38hg38GRCh38
GRCh37894,929,151 - 94,938,296 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36894,998,338 - 95,007,472 (+)NCBINCBI36Build 36hg18NCBI36
Build 34894,998,337 - 95,007,470NCBI
Celera891,115,139 - 91,124,357 (+)NCBICelera
Cytogenetic Map8q22.1NCBI
HuRef890,137,033 - 90,146,245 (+)NCBIHuRef
CHM1_1894,969,362 - 94,978,572 (+)NCBICHM1_1
T2T-CHM13v2.0895,042,005 - 95,051,150 (+)NCBIT2T-CHM13v2.0
Pdp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39411,958,183 - 11,966,450 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl411,958,184 - 11,966,452 (-)EnsemblGRCm39 Ensembl
GRCm38411,958,183 - 11,966,450 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl411,958,184 - 11,966,452 (-)EnsemblGRCm38mm10GRCm38
MGSCv37411,885,332 - 11,893,597 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36411,886,958 - 11,893,567 (-)NCBIMGSCv36mm8
Celera411,768,969 - 11,777,217 (-)NCBICelera
Cytogenetic Map4A1NCBI
cM Map45.48NCBI
Pdp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8530,245,699 - 30,252,494 (-)NCBIGRCr8
mRatBN7.2525,446,843 - 25,455,107 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl525,446,272 - 25,455,217 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx527,586,593 - 27,593,283 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0529,179,332 - 29,186,022 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0529,122,462 - 29,129,161 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0525,577,593 - 25,584,325 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl525,577,451 - 25,584,288 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0530,284,064 - 30,290,681 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4526,234,414 - 26,240,301 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1526,234,515 - 26,241,115 (-)NCBI
Celera524,779,851 - 24,786,537 (-)NCBICelera
Cytogenetic Map5q13NCBI
Pdp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541710,219,595 - 10,228,669 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541710,219,096 - 10,227,483 (+)NCBIChiLan1.0ChiLan1.0
PDP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27111,250,551 - 111,259,874 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1886,787,496 - 86,796,800 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0890,541,269 - 90,550,554 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1892,486,271 - 92,494,714 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl892,486,271 - 92,494,714 (+)Ensemblpanpan1.1panPan2
PDP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12938,783,945 - 38,792,141 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2938,782,418 - 38,789,807 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2938,944,677 - 38,954,347 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02938,987,121 - 38,996,745 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2938,987,129 - 38,996,741 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12939,000,780 - 39,010,581 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02938,995,485 - 39,005,504 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02939,437,281 - 39,447,145 (+)NCBIUU_Cfam_GSD_1.0
PDP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl442,764,441 - 42,777,904 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1442,769,232 - 42,777,936 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2446,190,418 - 46,199,021 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1888,896,049 - 88,905,430 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl888,897,030 - 88,903,003 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603951,943,494 - 51,952,923 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247631,356,588 - 1,365,726 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247631,356,193 - 1,364,643 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000026346   ⟹   ENSSTOP00000015799
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365447,009,788 - 7,015,104 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000035783   ⟹   ENSSTOP00000025604
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365447,009,486 - 7,018,859 (+)Ensembl
RefSeq Acc Id: XM_005328652   ⟹   XP_005328709
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530340,775,259 - 40,783,031 (-)NCBI
SpeTri2.0NW_0049365447,009,708 - 7,017,446 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005328653   ⟹   XP_005328710
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530340,775,259 - 40,783,817 (-)NCBI
SpeTri2.0NW_0049365447,008,883 - 7,017,446 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013360112   ⟹   XP_013215566
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530340,775,259 - 40,783,198 (-)NCBI
SpeTri2.0NW_0049365447,009,181 - 7,017,446 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021728669   ⟹   XP_021584344
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530340,775,259 - 40,783,806 (-)NCBI
SpeTri2.0NW_0049365447,008,882 - 7,017,446 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040293858   ⟹   XP_040149792
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530340,775,259 - 40,783,300 (-)NCBI
RefSeq Acc Id: XM_040293859   ⟹   XP_040149793
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530340,775,259 - 40,783,489 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005328710   ⟸   XM_005328653
- Peptide Label: isoform X4
- UniProtKB: A0A287CWG1 (UniProtKB/TrEMBL),   I3MUK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013215566   ⟸   XM_013360112
- Peptide Label: isoform X3
- UniProtKB: I3MUK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005328709   ⟸   XM_005328652
- Peptide Label: isoform X1
- UniProtKB: I3MUK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021584344   ⟸   XM_021728669
- Peptide Label: isoform X3
- UniProtKB: I3MUK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040149793   ⟸   XM_040293859
- Peptide Label: isoform X3
- UniProtKB: I3MUK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040149792   ⟸   XM_040293858
- Peptide Label: isoform X2
- UniProtKB: I3MUK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000015799   ⟸   ENSSTOT00000026346
RefSeq Acc Id: ENSSTOP00000025604   ⟸   ENSSTOT00000035783
Protein Domains
PPM-type phosphatase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000028703 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000026346.2 UniProtKB/TrEMBL
  ENSSTOT00000035783.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.40.10 UniProtKB/TrEMBL
InterPro PP2C UniProtKB/TrEMBL
  PP2C_BS UniProtKB/TrEMBL
  PPM-type_dom_sf UniProtKB/TrEMBL
  PPM-type_phosphatase_dom UniProtKB/TrEMBL
NCBI Gene Pdp1 ENTREZGENE
PANTHER [PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 1, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR13832 UniProtKB/TrEMBL
Pfam PP2C UniProtKB/TrEMBL
PROSITE PPM_1 UniProtKB/TrEMBL
  PPM_2 UniProtKB/TrEMBL
SMART PP2Cc UniProtKB/TrEMBL
Superfamily-SCOP SSF81606 UniProtKB/TrEMBL
UniProt A0A287CWG1 ENTREZGENE, UniProtKB/TrEMBL
  I3MUK4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-02-16 Pdp1  pyruvate dehydrogenase phosphatase catalytic subunit 1  Pdp1  pyruvate dehyrogenase phosphatase catalytic subunit 1  Symbol and/or name change 5135510 APPROVED