Ppp1ca (protein phosphatase 1 catalytic subunit alpha)

Gene: Ppp1ca (protein phosphatase 1 catalytic subunit alpha) Ictidomys tridecemlineatus

Analyze

Symbol:

Ppp1ca

Name:

protein phosphatase 1 catalytic subunit alpha

RGD ID:

12500804

Description:

ENCODES a protein that exhibits phosphoprotein phosphatase activity (ortholog); protein phosphatase 1 binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); lung development (ortholog); positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; Bone morphogenetic proteins signaling pathway; dopamine signaling pathway; ASSOCIATED WITH Aicardi-Goutieres Syndrome 3 (ortholog); congestive heart failure (ortholog); dilated cardiomyopathy (ortholog); FOUND IN dendritic spine (ortholog); glutamatergic synapse (ortholog); glycogen granule (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

serine/threonine-protein phosphatase PP1-alpha catalytic subunit

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	5,903,630 - 5,906,145 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936599	2,344,552 - 2,348,494 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936599	2,345,982 - 2,348,494 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aicardi-Goutieres Syndrome 3 (ISO)

congestive heart failure (ISO)

dilated cardiomyopathy (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

branching morphogenesis of an epithelial tube (IEA,ISO)

cell division (IEA)

cell-cell adhesion (IEA)

circadian regulation of gene expression (IEA)

entrainment of circadian clock by photoperiod (IEA)

glycogen metabolic process (IEA)

lung development (IEA,ISO)

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (IEA,ISO)

protein dephosphorylation (ISO)

regulation of circadian rhythm (IEA)

regulation of glycogen biosynthetic process (ISO)

regulation of glycogen catabolic process (ISO)

response to lead ion (ISO)

rhythmic process (IEA)

telomere maintenance in response to DNA damage (ISO)

Cellular Component

adherens junction (IEA)

chromosome, telomeric region (IEA)

cytoplasm (IEA)

cytosol (IEA)

dendritic spine (ISO)

glutamatergic synapse (ISO)

glycogen granule (ISO)

neuronal cell body (ISO)

nucleolus (IEA)

nucleoplasm (IEA)

nucleus (IEA)

perikaryon (ISO)

plasma membrane (IEA)

postsynapse (ISO)

presynapse (ISO)

protein phosphatase type 1 complex (ISO)

PTW/PP1 phosphatase complex (IEA)

Molecular Function

cadherin binding involved in cell-cell adhesion (IEA)

hydrolase activity (IEA)

myosin phosphatase activity (IEA)

phosphatase activity (IEA)

phosphoprotein phosphatase activity (IEA,ISO)

protein binding (ISO)

protein phosphatase 1 binding (ISO)

protein serine/threonine phosphatase activity (IEA)

protein-containing complex binding (ISO)

ribonucleoprotein complex binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

adenosine monophosphate-activated protein kinase (AMPK) signaling pathway (ISO)

Bone morphogenetic proteins signaling pathway (ISO)

dopamine signaling pathway (ISO)

follicle-stimulating hormone signaling pathway (ISO)

glycogen biosynthetic pathway (ISO)

glycogen degradation pathway (ISO)

histamine signaling pathway, immunological (ISO)

luteinizing hormone signaling pathway (ISO)

serotonin signaling pathway via receptors engaging G alphas protein family (ISO)

transforming growth factor-beta Smad dependent signaling pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Ppp1ca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	5,903,630 - 5,906,145 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936599	2,344,552 - 2,348,494 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936599	2,345,982 - 2,348,494 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PPP1CA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	67,398,183 - 67,401,858 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	67,398,181 - 67,421,183 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	67,165,654 - 67,169,329 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	66,922,228 - 66,925,952 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	66,922,227 - 66,925,952	NCBI
Celera	11	64,498,838 - 64,502,559 (-)	NCBI		Celera
Cytogenetic Map	11	q13.2	NCBI
HuRef	11	63,494,035 - 63,498,137 (-)	NCBI		HuRef
CHM1_1	11	67,048,688 - 67,052,412 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	67,392,298 - 67,395,973 (-)	NCBI		T2T-CHM13v2.0

Ppp1ca
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	4,242,173 - 4,245,418 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	4,242,064 - 4,245,419 (+)	Ensembl		GRCm39 Ensembl
GRCm38	19	4,192,174 - 4,195,419 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	4,192,065 - 4,195,420 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	4,192,174 - 4,195,419 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	4,192,174 - 4,195,419 (+)	NCBI		MGSCv36	mm8
Celera	19	4,063,314 - 4,066,560 (+)	NCBI		Celera
Cytogenetic Map	19	A	NCBI
cM Map	19	3.89	NCBI

Ppp1ca
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	210,914,576 - 210,918,193 (+)	NCBI		GRCr8
mRatBN7.2	1	201,485,117 - 201,488,734 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	201,485,085 - 201,497,327 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	209,837,354 - 209,840,969 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	216,930,585 - 216,934,202 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	209,621,601 - 209,625,218 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	219,439,953 - 219,443,570 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	219,439,953 - 219,443,570 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	226,310,604 - 226,314,221 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	206,774,719 - 206,778,336 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	206,928,171 - 206,931,789 (+)	NCBI
Celera	1	199,029,483 - 199,033,100 (+)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

Ppp1ca
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	18,076,670 - 18,079,859 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	18,076,670 - 18,079,859 (+)	NCBI	ChiLan1.0	ChiLan1.0

PPP1CA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	68,625,172 - 68,628,881 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	69,667,749 - 69,671,458 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	62,756,659 - 62,760,369 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	66,068,007 - 66,071,579 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	66,068,007 - 66,071,611 (-)	Ensembl	panpan1.1		panPan2

PPP1CA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	50,062,352 - 50,065,166 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	50,062,352 - 50,065,166 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	48,672,765 - 48,675,579 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	50,984,259 - 50,987,073 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	50,984,297 - 50,987,279 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	50,197,606 - 50,200,420 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	49,772,313 - 49,775,127 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	50,566,605 - 50,569,419 (+)	NCBI		UU_Cfam_GSD_1.0

PPP1CA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	5,119,939 - 5,123,617 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	5,120,202 - 5,123,168 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	3,838,730 - 3,841,695 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PPP1CA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	6,862,536 - 6,866,212 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	6,862,540 - 6,865,855 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	104,147,620 - 104,151,329 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ppp1ca
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	19,119,883 - 19,123,934 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	19,120,683 - 19,123,935 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021731676	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000023521 ⟹ ENSSTOP00000019420

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936599	2,344,552 - 2,348,494 (+)	Ensembl

RefSeq Acc Id:

ENSSTOT00000039396 ⟹ ENSSTOP00000026302

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936599	2,345,800 - 2,348,154 (+)	Ensembl

RefSeq Acc Id:

XM_021731676 ⟹ XP_021587351

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	5,903,630 - 5,906,145 (+)	NCBI
SpeTri2.0	NW_004936599	2,345,982 - 2,348,494 (+)	NCBI

Sequence:

show sequence

ATTCCGCCCCCAGTGCAGGGCTCACGACCTGGGAAGAATGTACAGCTGACAGAGAACGAGATCC
GTGGTCTGTGCCTCAAATCCCGGGAGATATTCCTGAGCCAGCCCATTCTTCTGGAGCTGGAGGC
TCCCCTTAAGATCTGCGGTGACATCCACGGCCAGTACTATGACCTCCTGCGGCTGTTTGAGTAT
GGTGGCTTCCCTCCAGAGAGCAACTACCTCTTTCTGGGGGACTATGTAGACCGGGGCAAGCAGT
CTTTGGAGACCATCTGCCTGCTACTGGCCTATAAGATCAAGTACCCTGAGAACTTCTTCCTGCT
GCGTGGGAACCACGAGTGTGCCAGCATCAACCGCATCTATGGCTTCTACGATGAATGCAAGAGA
CGCTACAACATCAAACTGTGGAAAACATTCACCGACTGCTTCAACTGCCTGCCCATTGCAGCCA
TTGTGGACGAGAAGATCTTCTGCTGCCATGGAGGCCTGTCTCCAGATCTGCAGTCCATGGAGCA
GATTCGGCGTATCATGCGACCCACAGACGTGCCTGACCAAGGCCTGCTGTGTGACTTGCTGTGG
TCTGACCCTGACAAGGATGTGCAGGGCTGGGGCGAGAATGACCGTGGCGTCTCCTTTACTTTCG
GGGCTGAGGTGGTGGCCAAGTTCCTGCACAAGCACGACTTGGACCTCATCTGCCGGGCACACCA
GGTGGTAGAAGATGGCTATGAGTTCTTTGCCAAACGGCAGCTGGTAACACTTTTCTCAGCTCCC
AATTACTGTGGTGAGTTTGACAATGCCGGTGCCATGATGAGTGTGGACGAGACCCTCATGTGCT
CCTTCCAGATCCTCAAGCCCGCTGACAAGAACAAGGGGAAATATGGGCAGTTCAGTGGCCTGAA
CCCTGGAGGCCGACCCATCACCCCACCCCGCAACTCCGCCAAAGCCAAGAAATAACCTCCGTGT
GCCACCCTCTGCCCCAGATGATGGATTGATTGTAGAGAAATCATGCTGCCATGGGGATCACACA
GGCCCCTTAGGCCCACCCATCACGGGGAACATGGAGCCTTGGTGTATTTTTCTTTTTTTAATGA
ATAAATAGCAGCGTCCAATCCCCCAGGGCTCCTTCCCACCTGTACCTGCGGTGGGTACAAGTGG
GATCCTGGGGCTGAGGCTGCAGCTCAGGGCAATGGCAGGCCAGATTGTGGGTCTCCAGCCGTGC
TTGGCCACAGGGCTGGCAGCCGGATCCTGGGGGAACCCATCTGGTCTCTTGAATAAAGGTCAAA
GCTGGATTCTC

hide sequence

Protein Sequences


Protein RefSeqs	XP_021587351	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000019420.2
	ENSSTOP00000026302.1

RefSeq Acc Id:

XP_021587351 ⟸ XM_021731676

- UniProtKB:

I3N4X4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

IPPPVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEY
GGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKR
RYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLW
SDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAP
NYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK

hide sequence

RefSeq Acc Id:

ENSSTOP00000026302 ⟸ ENSSTOT00000039396

RefSeq Acc Id:

ENSSTOP00000019420 ⟸ ENSSTOT00000023521

Protein Domains

Serine/threonine specific protein phosphatases

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000019550	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000023521.2	UniProtKB/TrEMBL
	ENSSTOT00000039396.1	UniProtKB/TrEMBL
Gene3D-CATH	3.60.21.10	UniProtKB/TrEMBL
InterPro	Calcineurin-like_PHP_ApaH	UniProtKB/TrEMBL
	Metallo-depent_PP-like	UniProtKB/TrEMBL
	Ser/Thr-sp_prot-phosphatase	UniProtKB/TrEMBL
	STPPase_N	UniProtKB/TrEMBL
NCBI Gene	Ppp1ca	ENTREZGENE
PANTHER	PTHR11668:SF377	UniProtKB/TrEMBL
	SERINE/THREONINE PROTEIN PHOSPHATASE	UniProtKB/TrEMBL
Pfam	Metallophos	UniProtKB/TrEMBL
	STPPase_N	UniProtKB/TrEMBL
PRINTS	STPHPHTASE	UniProtKB/TrEMBL
PROSITE	SER_THR_PHOSPHATASE	UniProtKB/TrEMBL
SMART	PP2Ac	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56300	UniProtKB/TrEMBL
UniProt	A0A287CYB5_ICTTR	UniProtKB/TrEMBL
	I3N4X4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)

Send us a Message

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)