Gja8 (gap junction protein alpha 8) - Rat Genome Database

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Gene: Gja8 (gap junction protein alpha 8) Ictidomys tridecemlineatus
Analyze
Symbol: Gja8
Name: gap junction protein alpha 8
RGD ID: 12495593
Description: ENCODES a protein that exhibits gap junction channel activity (ortholog); identical protein binding (ortholog); INVOLVED IN camera-type eye development (ortholog); cell-cell signaling (ortholog); lens development in camera-type eye (ortholog); ASSOCIATED WITH anterior segment dysgenesis (ortholog); autism spectrum disorder (ortholog); cataract (ortholog); FOUND IN connexin complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505820,498,517 - 20,501,991 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936867374,638 - 375,933 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936867374,638 - 378,080 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Gja8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505820,498,517 - 20,501,991 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936867374,638 - 375,933 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936867374,638 - 378,080 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJA8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,902,795 - 147,914,486 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,902,795 - 147,909,269 (+)EnsemblGRCh38hg38GRCh38
GRCh371147,374,921 - 147,381,396 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361145,841,560 - 145,848,017 (+)NCBINCBI36Build 36hg18NCBI36
Build 341144,599,751 - 144,606,209NCBI
Celera1121,602,609 - 121,609,059 (-)NCBICelera
Cytogenetic Map1q21.2NCBI
HuRef1120,788,421 - 120,794,871 (+)NCBIHuRef
CHM1_11149,270,946 - 149,277,395 (+)NCBICHM1_1
T2T-CHM13v2.01146,892,371 - 146,904,865 (-)NCBIT2T-CHM13v2.0
Gja8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,820,882 - 96,833,367 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,820,882 - 96,833,336 (-)EnsemblGRCm39 Ensembl
GRCm38396,913,566 - 96,926,051 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,913,566 - 96,926,020 (-)EnsemblGRCm38mm10GRCm38
MGSCv37396,722,945 - 96,729,853 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36397,004,427 - 97,011,335 (-)NCBIMGSCv36mm8
Celera398,326,218 - 98,333,125 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map342.03NCBI
Gja8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82187,179,668 - 187,181,284 (-)NCBIGRCr8
mRatBN7.22184,490,840 - 184,492,456 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2184,490,840 - 184,492,456 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2192,132,950 - 192,134,566 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02189,930,874 - 189,932,490 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02184,765,517 - 184,767,133 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02199,050,854 - 199,052,470 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2199,050,854 - 199,052,470 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02218,536,831 - 218,538,447 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2176,986,507 - 176,988,123 (-)NCBICelera
Cytogenetic Map2q34NCBI
Gja8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955568515,113 - 516,435 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955568514,905 - 516,551 (-)NCBIChiLan1.0ChiLan1.0
GJA8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21101,790,607 - 101,799,706 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11101,379,904 - 101,388,145 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01123,352,801 - 123,355,625 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11112,176,580 - 112,183,032 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1112,174,365 - 112,177,893 (-)Ensemblpanpan1.1panPan2
GJA8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11758,360,313 - 58,428,751 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1758,424,072 - 58,425,391 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1757,828,663 - 57,898,680 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01759,356,989 - 59,426,996 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1759,419,303 - 59,425,425 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11758,229,994 - 58,300,020 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01758,290,623 - 58,360,697 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01759,017,265 - 59,087,398 (+)NCBIUU_Cfam_GSD_1.0
GJA8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl499,723,341 - 99,724,672 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1499,721,754 - 99,724,943 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24109,541,665 - 109,561,100 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GJA8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603814,328,894 - 14,335,477 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gja8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477216,959,615 - 16,960,937 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477216,959,615 - 16,960,937 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005341308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000029458   ⟹   ENSSTOP00000020332
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936867374,638 - 375,933 (+)Ensembl
RefSeq Acc Id: XM_005341308   ⟹   XP_005341365
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505820,498,517 - 20,501,991 (+)NCBI
SpeTri2.0NW_004936867374,638 - 378,080 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005341365 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000020332.1
GenBank Protein KAG3281393 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005341365   ⟸   XM_005341308
- UniProtKB: I3N7I6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000020332   ⟸   ENSSTOT00000029458
Protein Domains
Connexin N-terminal   Gap junction protein cysteine-rich


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000022242 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000029458.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1440.80 UniProtKB/TrEMBL
InterPro Connexin UniProtKB/TrEMBL
  Connexin50 UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/TrEMBL
  Connexin_CS UniProtKB/TrEMBL
  Connexin_N UniProtKB/TrEMBL
  Connexin_N_sf UniProtKB/TrEMBL
NCBI Gene Gja8 ENTREZGENE
PANTHER PTHR11984 UniProtKB/TrEMBL
  PTHR11984:SF19 UniProtKB/TrEMBL
Pfam Connexin UniProtKB/TrEMBL
  Connexin50 UniProtKB/TrEMBL
PRINTS CONNEXIN UniProtKB/TrEMBL
  CONNEXINA8 UniProtKB/TrEMBL
PROSITE CONNEXINS_1 UniProtKB/TrEMBL
  CONNEXINS_2 UniProtKB/TrEMBL
SMART CNX UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/TrEMBL
UniProt I3N7I6 ENTREZGENE, UniProtKB/TrEMBL