Polg (DNA polymerase gamma, catalytic subunit) - Rat Genome Database

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Gene: Polg (DNA polymerase gamma, catalytic subunit) Ictidomys tridecemlineatus
Analyze
Symbol: Polg
Name: DNA polymerase gamma, catalytic subunit
RGD ID: 12471002
Description: ENCODES a protein that exhibits DNA-directed DNA polymerase activity (ortholog); exonuclease activity (ortholog); INVOLVED IN base-excision repair, gap-filling (ortholog); cellular response to glucose stimulus (ortholog); determination of adult lifespan (ortholog); ASSOCIATED WITH Alpers-Huttenlocher syndrome (ortholog); Ataxia (ortholog); autistic disorder (ortholog); FOUND IN gamma DNA polymerase complex (ortholog); terminal bouton (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA polymerase gamma, catalytic subunit, transcript variant X1; DNA polymerase gamma, catalytic subunit, transcript variant X2; DNA polymerase gamma, catalytic subunit, transcript variant X3; DNA polymerase gamma, catalytic subunit, transcript variant X4; DNA polymerase gamma, catalytic subunit, transcript variant X6; DNA polymerase gamma, catalytic subunit, transcript variant X7; DNA polymerase subunit gamma-1; polymerase (DNA directed), gamma
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640131,138,186 - 131,155,546 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648315,179,342 - 15,195,258 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648315,178,947 - 15,196,277 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Alpers-Huttenlocher syndrome  (ISO)
Ataxia  (ISO)
autistic disorder  (ISO)
autosomal dominant progressive external ophthalmoplegia 1  (ISO)
autosomal recessive progressive external ophthalmoplegia 1  (ISO)
benign neonatal seizures  (ISO)
Bloom syndrome  (ISO)
Camptocormia  (ISO)
cardiomyopathy  (ISO)
cerebellar ataxia  (ISO)
CEREBELLAR ATAXIA INFANTILE WITH PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA  (ISO)
Charcot-Marie-Tooth disease axonal type 2U  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Childhood Myocerebrohepatopathy Spectrum  (ISO)
chronic progressive external ophthalmoplegia  (ISO)
colorectal cancer  (ISO)
D-2-hydroxyglutaric aciduria 2  (ISO)
Developmental Disabilities  (ISO)
epilepsy  (ISO)
Experimental Diabetes Mellitus  (ISO)
Fanconi anemia  (ISO)
Fanconi anemia complementation group I  (ISO)
genetic disease  (ISO)
hepatocellular carcinoma  (ISO)
hereditary spastic paraplegia  (ISO)
hypertrophic cardiomyopathy  (ISO)
intellectual disability  (ISO)
Lennox-Gastaut syndrome  (ISO)
male infertility  (ISO)
MELAS syndrome  (ISO)
microcephaly  (ISO)
mitochondrial DNA depletion syndrome  (ISO)
mitochondrial DNA depletion syndrome 1  (ISO)
mitochondrial DNA depletion syndrome 4B  (ISO)
mitochondrial DNA depletion syndrome 7  (ISO)
mitochondrial DNA depletion syndrome 8A  (ISO)
Mitochondrial DNA Depletion Syndrome, MNGIE Type  (ISO)
mitochondrial encephalomyopathy  (ISO)
mitochondrial metabolism disease  (ISO)
mood disorder  (ISO)
multiple sclerosis  (ISO)
myelodysplastic syndrome  (ISO)
Nervous System Malformations  (ISO)
Parkinson's disease  (ISO)
Parkinson's disease 20  (ISO)
Parkinsonism  (ISO)
Plagiocephaly  (ISO)
polyneuropathy  (ISO)
Premature Aging  (ISO)
premature menopause  (ISO)
Presbycusis  (ISO)
Primary Ovarian Failure  (ISO)
primary ovarian insufficiency  (ISO)
primary progressive multiple sclerosis  (ISO)
Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal Recessive  (ISO)
progressive myoclonus epilepsy 5  (ISO)
sensory ataxic neuropathy, dysarthria, and ophthalmoparesis  (ISO)
Spinocerebellar Ataxia with Epilepsy  (ISO)
Spinocerebellar Ataxias  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
vascular dementia  (ISO)
visual epilepsy  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Polg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640131,138,186 - 131,155,546 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648315,179,342 - 15,195,258 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648315,178,947 - 15,196,277 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381589,316,320 - 89,334,824 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1589,305,198 - 89,334,861 (-)EnsemblGRCh38hg38GRCh38
GRCh371589,859,551 - 89,878,055 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361587,660,554 - 87,679,030 (-)NCBINCBI36Build 36hg18NCBI36
Build 341587,660,552 - 87,679,030NCBI
Celera1566,260,895 - 66,279,201 (-)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1565,971,419 - 65,989,730 (-)NCBIHuRef
CHM1_11589,700,576 - 89,719,066 (-)NCBICHM1_1
T2T-CHM13v2.01587,071,147 - 87,089,647 (-)NCBIT2T-CHM13v2.0
Polg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39779,095,979 - 79,117,659 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl779,095,979 - 79,116,110 (-)EnsemblGRCm39 Ensembl
GRCm38779,446,231 - 79,467,911 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl779,446,231 - 79,466,362 (-)EnsemblGRCm38mm10GRCm38
MGSCv37786,594,269 - 86,611,159 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36779,322,896 - 79,339,786 (-)NCBIMGSCv36mm8
Celera776,851,749 - 76,868,637 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.04NCBI
Polg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81142,792,119 - 142,808,933 (-)NCBIGRCr8
mRatBN7.21133,382,764 - 133,399,578 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1133,382,766 - 133,398,567 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1141,292,744 - 141,307,834 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01148,462,157 - 148,477,247 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01141,379,870 - 141,394,960 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01141,172,117 - 141,188,893 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1141,172,531 - 141,188,031 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01142,133,892 - 142,150,597 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,197,075 - 135,212,178 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11135,275,417 - 135,290,521 (-)NCBI
Celera1125,446,563 - 125,461,666 (-)NCBICelera
Cytogenetic Map1q31NCBI
Polg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541615,773,473 - 15,788,651 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541615,773,005 - 15,788,736 (+)NCBIChiLan1.0ChiLan1.0
POLG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21678,864,098 - 78,883,228 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11582,568,484 - 82,587,617 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01568,008,214 - 68,028,241 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11587,214,451 - 87,234,739 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1587,214,451 - 87,234,739 (-)Ensemblpanpan1.1panPan2
POLG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1352,357,062 - 52,373,768 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl352,357,068 - 52,421,544 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha354,991,836 - 55,008,948 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0352,774,064 - 52,791,169 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl352,774,083 - 52,790,068 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1352,296,790 - 52,313,882 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0352,507,050 - 52,523,743 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0352,846,762 - 52,863,883 (-)NCBIUU_Cfam_GSD_1.0
POLG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl754,889,157 - 54,906,844 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1754,889,150 - 54,907,167 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2759,864,727 - 59,882,439 (-)NCBISscrofa10.2Sscrofa10.2susScr3
POLG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1297,864,319 - 7,881,577 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl297,863,277 - 7,882,068 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605938,932,949 - 38,951,612 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Polg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476816,491,555 - 16,509,900 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476816,493,123 - 16,509,747 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000006879   ⟹   ENSSTOP00000006150
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648315,179,342 - 15,195,258 (-)Ensembl
RefSeq Acc Id: XM_005320130   ⟹   XP_005320187
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640131,139,225 - 131,155,546 (+)NCBI
SpeTri2.0NW_00493648315,178,947 - 15,196,277 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013356317   ⟹   XP_013211771
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640131,138,186 - 131,155,546 (+)NCBI
SpeTri2.0NW_00493648315,178,947 - 15,196,277 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013356318   ⟹   XP_013211772
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640131,138,186 - 131,155,546 (+)NCBI
SpeTri2.0NW_00493648315,178,947 - 15,196,277 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021722897   ⟹   XP_021578572
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640131,138,186 - 131,155,546 (+)NCBI
SpeTri2.0NW_00493648315,178,947 - 15,196,277 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040276255   ⟹   XP_040132189
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640131,138,186 - 131,154,573 (+)NCBI
RefSeq Acc Id: XM_040276256   ⟹   XP_040132190
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640131,138,186 - 131,154,272 (+)NCBI
RefSeq Acc Id: XR_005730016
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640131,138,186 - 131,155,119 (+)NCBI
RefSeq Acc Id: XR_005730017
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640131,138,186 - 131,155,119 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_013211772   ⟸   XM_013356318
- Peptide Label: isoform X3
- UniProtKB: I3M8P7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013211771   ⟸   XM_013356317
- Peptide Label: isoform X1
- UniProtKB: I3M8P7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005320187   ⟸   XM_005320130
- Peptide Label: isoform X4
- UniProtKB: I3M8P7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021578572   ⟸   XM_021722897
- Peptide Label: isoform X2
- UniProtKB: I3M8P7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040132189   ⟸   XM_040276255
- Peptide Label: isoform X5
- UniProtKB: I3M8P7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040132190   ⟸   XM_040276256
- Peptide Label: isoform X6
- UniProtKB: I3M8P7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000006150   ⟸   ENSSTOT00000006879
Protein Domains
DNA-directed DNA polymerase family A palm


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000006860 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000006879.3 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.3960 UniProtKB/TrEMBL
  3.30.420.390 UniProtKB/TrEMBL
  3.30.70.370 UniProtKB/TrEMBL
  5' to 3' exonuclease, C-terminal subdomain UniProtKB/TrEMBL
InterPro DNA-dir_DNA_pol_A_CS UniProtKB/TrEMBL
  DNA-dir_DNA_pol_A_mt UniProtKB/TrEMBL
  DNA-dir_DNA_pol_A_palm_dom UniProtKB/TrEMBL
  DNA/RNA_pol_sf UniProtKB/TrEMBL
  DNApol_Exo UniProtKB/TrEMBL
  POLG_palm_dom UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/TrEMBL
NCBI Gene Polg ENTREZGENE
PANTHER DNA POLYMERASE SUBUNIT GAMMA-1 UniProtKB/TrEMBL
  PTHR10267 UniProtKB/TrEMBL
Pfam DNApol_Exo UniProtKB/TrEMBL
PIRSF DNA_pol_mt UniProtKB/TrEMBL
PRINTS DNAPOLG UniProtKB/TrEMBL
PROSITE DNA_POLYMERASE_A UniProtKB/TrEMBL
SMART POLAc UniProtKB/TrEMBL
Superfamily-SCOP SSF53098 UniProtKB/TrEMBL
  SSF56672 UniProtKB/TrEMBL
UniProt I3M8P7 ENTREZGENE, UniProtKB/TrEMBL