Slc7a5 (solute carrier family 7 member 5)

Gene: Slc7a5 (solute carrier family 7 member 5) Ictidomys tridecemlineatus

Analyze

Symbol:

Slc7a5

Name:

solute carrier family 7 member 5

RGD ID:

12466037

Description:

ENCODES a protein that exhibits amino acid transmembrane transporter activity (ortholog); antiporter activity (ortholog); aromatic amino acid transmembrane transporter activity (ortholog); INVOLVED IN alanine transport (ortholog); amino acid import across plasma membrane (ortholog); cellular response to amino acid stimulus (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH 16Q24.3 Microdeletion Syndrome (ortholog); adenoid cystic carcinoma (ortholog); allergic contact dermatitis (ortholog); FOUND IN amino acid transport complex (ortholog); apical plasma membrane (ortholog); basal plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

large neutral amino acids transporter small subunit 1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	25,759,563 - 25,783,919 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936641	1,513,110 - 1,538,955 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

16Q24.3 Microdeletion Syndrome (ISO)

adenoid cystic carcinoma (ISO)

allergic contact dermatitis (ISO)

autism spectrum disorder (ISO)

autosomal recessive chronic granulomatous disease 4 (ISO)

bile duct adenocarcinoma (ISO)

bile duct carcinoma (ISO)

CARBONIC ANHYDRASE VA DEFICIENCY, HYPERAMMONEMIA DUE TO (ISO)

Chemical and Drug Induced Liver Injury (ISO)

cholangiocarcinoma (ISO)

colon cancer (ISO)

colorectal adenocarcinoma (ISO)

colorectal cancer (ISO)

Disease Progression (ISO)

Endotoxemia (ISO)

esophageal carcinoma (ISO)

esophagitis (ISO)

esophagus squamous cell carcinoma (ISO)

Experimental Liver Neoplasms (ISO)

extrahepatic bile duct adenocarcinoma (ISO)

gastric adenocarcinoma (ISO)

genetic disease (ISO)

glioblastoma (ISO)

hepatocellular carcinoma (ISO)

high grade glioma (ISO)

KBG syndrome (ISO)

large cell neuroendocrine carcinoma (ISO)

Liver Metastasis (ISO)

lung adenocarcinoma (ISO)

Lung Neoplasms (ISO)

lung non-small cell carcinoma (ISO)

lung pleomorphic carcinoma (ISO)

lung squamous cell carcinoma (ISO)

Lymphatic Metastasis (ISO)

malignant astrocytoma (ISO)

malignant pleural mesothelioma (ISO)

Neoplasm Metastasis (ISO)

oral squamous cell carcinoma (ISO)

primary ciliary dyskinesia 33 (ISO)

rectum adenocarcinoma (ISO)

Right Ventricular Hypertrophy (ISO)

Spinal Cord Injuries (ISO)

stomach cancer (ISO)

tongue squamous cell carcinoma (ISO)

transitional cell carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

alanine transport (ISO)

amino acid import across plasma membrane (ISO)

amino acid transmembrane transport (IEA)

amino acid transport (IEA)

cellular response to amino acid stimulus (ISO)

cellular response to glucose starvation (ISO)

cellular response to L-arginine (ISO)

cellular response to lipopolysaccharide (ISO)

isoleucine transport (ISO)

L-alpha-amino acid transmembrane transport (IEA,ISO)

L-amino acid transport (ISO)

L-histidine transport (ISO)

L-leucine import across plasma membrane (ISO)

L-leucine transport (ISO)

L-tryptophan transmembrane transport (ISO)

liver regeneration (ISO)

methionine transport (ISO)

negative regulation of autophagy (ISO)

negative regulation of gene expression (ISO)

negative regulation of vascular associated smooth muscle cell apoptotic process (ISO)

neutral amino acid transport (IEA)

phenylalanine transport (ISO)

positive regulation of glial cell proliferation (ISO)

positive regulation of interleukin-17 production (ISO)

positive regulation of interleukin-4 production (ISO)

positive regulation of L-leucine import across plasma membrane (ISO)

positive regulation of type II interferon production (ISO)

proline transport (ISO)

response to hyperoxia (ISO)

response to muscle activity (ISO)

thyroid hormone transport (ISO)

transmembrane transport (IEA)

tryptophan transport (ISO)

tyrosine transport (ISO)

valine transport (ISO)

xenobiotic transport (ISO)

Cellular Component

amino acid transport complex (ISO)

apical plasma membrane (ISO)

basal plasma membrane (ISO)

basolateral plasma membrane (ISO)

cytosol (ISO)

external side of apical plasma membrane (ISO)

intracellular membrane-bounded organelle (ISO)

membrane (IEA)

microvillus membrane (ISO)

plasma membrane (ISO)

Molecular Function

amino acid transmembrane transporter activity (ISO)

antiporter activity (ISO)

aromatic amino acid transmembrane transporter activity (ISO)

L-amino acid transmembrane transporter activity (IEA)

L-leucine transmembrane transporter activity (ISO)

L-tryptophan transmembrane transporter activity (ISO)

neutral L-amino acid transmembrane transporter activity (IEA)

protein binding (ISO)

thyroid hormone transmembrane transporter activity (ISO)

transmembrane transporter activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

amiloride pharmacodynamics pathway (ISO)

bendroflumethiazide pharmacodynamics pathway (ISO)

bumetanide pharmacodynamics pathway (ISO)

chlorothiazide pharmacodynamics pathway (ISO)

chlorthalidone pharmacodynamics pathway (ISO)

cystinuria pathway (ISO)

eplerenone pharmacodynamics pathway (ISO)

etacrynic acid pharmacodynamics pathway (ISO)

furosemide pharmacodynamics pathway (ISO)

Hartnup disease pathway (ISO)

hydrochlorothiazide pharmacodynamics pathway (ISO)

hydroflumethiazide pharmacodynamics pathway (ISO)

iminoglycinuria pathway (ISO)

lysinuric protein intolerance pathway (ISO)

metolazone pharmacodynamics pathway (ISO)

mTOR signaling pathway (ISO)

nicotinamide adenine dinucleotide metabolic pathway (ISO)

spironolactone pharmacodynamics pathway (ISO)

torasemide pharmacodynamics pathway (ISO)

triamterene pharmacodynamics pathway (ISO)

trichlormethiazide pharmacodynamics pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Slc7a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	25,759,563 - 25,783,919 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936641	1,513,110 - 1,538,955 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC7A5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	87,830,023 - 87,869,507 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	87,830,023 - 87,869,507 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	87,863,629 - 87,903,113 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	86,421,130 - 86,460,601 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	86,421,130 - 86,460,601	NCBI
Celera	16	72,160,934 - 72,200,417 (-)	NCBI		Celera
Cytogenetic Map	16	q24.2	NCBI
HuRef	16	73,604,119 - 73,643,626 (-)	NCBI		HuRef
CHM1_1	16	89,274,981 - 89,314,543 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	93,902,734 - 93,942,286 (-)	NCBI		T2T-CHM13v2.0

Slc7a5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	122,607,885 - 122,634,425 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	122,607,889 - 122,634,433 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	121,881,146 - 121,907,686 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	121,881,150 - 121,907,694 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	124,405,046 - 124,431,586 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	121,952,557 - 121,979,440 (-)	NCBI		MGSCv36	mm8
MGSCv36	8	124,767,240 - 124,802,593 (-)	NCBI		MGSCv36	mm8
Celera	8	126,102,885 - 126,145,803 (-)	NCBI		Celera
Cytogenetic Map	8	E1	NCBI
cM Map	8	70.8	NCBI

Slc7a5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	66,843,808 - 66,872,412 (-)	NCBI		GRCr8
mRatBN7.2	19	49,935,220 - 49,963,823 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	49,935,220 - 49,963,823 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	56,727,676 - 56,756,167 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	57,410,169 - 57,438,773 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	59,626,276 - 59,654,767 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	54,693,959 - 54,722,563 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	54,693,959 - 54,722,563 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	65,412,970 - 65,441,647 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	52,120,728 - 52,149,332 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	52,125,608 - 52,154,213 (-)	NCBI
Celera	19	49,180,586 - 49,208,780 (-)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

Slc7a5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955541	2,103,384 - 2,130,310 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955541	2,103,437 - 2,129,668 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC7A5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	97,600,937 - 97,641,472 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	103,515,885 - 103,556,386 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	68,512,407 - 68,552,763 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	87,827,058 - 87,854,154 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

SLC7A5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	65,313,105 - 65,343,858 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	65,313,105 - 65,343,858 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	65,323,236 - 65,353,508 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	65,532,866 - 65,563,141 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	65,532,793 - 65,565,302 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	65,558,337 - 65,588,569 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	65,390,029 - 65,420,262 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	65,797,114 - 65,827,358 (+)	NCBI		UU_Cfam_GSD_1.0

SLC7A5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	1,545,944 - 1,574,285 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	1,545,940 - 1,574,298 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

SLC7A5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	73,229,953 - 73,269,801 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	73,229,951 - 73,269,754 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	2,438,818 - 2,479,135 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc7a5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624746	1,325,368 - 1,349,616 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005335481	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040279014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010004409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_040279014 ⟹ XP_040134948

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409349	25,759,563 - 25,783,919 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_040134948	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000020330.2
GenBank Protein	KAG3256710	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_040134948 ⟸ XM_040279014
- UniProtKB:	I3N7I4 (UniProtKB/TrEMBL)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000025706	UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000022847.2	UniProtKB/TrEMBL
Gene3D-CATH	Amino acid/polyamine transporter I	UniProtKB/TrEMBL
InterPro	AA/rel_permease1	UniProtKB/TrEMBL
	L_AA_transporter	UniProtKB/TrEMBL
NCBI Gene	Slc7a5	ENTREZGENE
PANTHER	AMINO ACID TRANSPORTER	UniProtKB/TrEMBL
	LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1	UniProtKB/TrEMBL
Pfam	AA_permease_2	UniProtKB/TrEMBL
PIRSF	AA_transporter	UniProtKB/TrEMBL
UniProt	I3N7I4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB