Ogdh (oxoglutarate dehydrogenase) - Rat Genome Database

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Gene: Ogdh (oxoglutarate dehydrogenase) Ictidomys tridecemlineatus
Analyze
Symbol: Ogdh
Name: oxoglutarate dehydrogenase
RGD ID: 12457615
Description: ENCODES a protein that exhibits heat shock protein binding (ortholog); oxoglutarate dehydrogenase (succinyl-transferring) activity (ortholog); protein-folding chaperone binding (ortholog); INVOLVED IN 2-oxoglutarate metabolic process (ortholog); NADH metabolic process (ortholog); succinyl-CoA metabolic process (ortholog); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; mitochondrial complex II deficiency pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); genetic disease (ortholog); oxoglutarate dehydrogenase deficiency (ortholog); FOUND IN oxoglutarate dehydrogenase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 2-oxoglutarate dehydrogenase, mitochondrial; oxoglutarate dehydrogenase, transcript variant X1; oxoglutarate dehydrogenase, transcript variant X2; oxoglutarate dehydrogenase, transcript variant X3; oxoglutarate dehydrogenase, transcript variant X4; oxoglutarate dehydrogenase, transcript variant X5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118100,295,062 - 100,372,678 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647819,506,154 - 19,583,364 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647819,506,845 - 19,584,411 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ogdh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118100,295,062 - 100,372,678 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647819,506,154 - 19,583,364 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647819,506,845 - 19,584,411 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OGDH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38744,606,627 - 44,709,066 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl744,606,572 - 44,709,066 (+)EnsemblGRCh38hg38GRCh38
GRCh37744,646,226 - 44,748,665 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36744,612,696 - 44,715,194 (+)NCBINCBI36Build 36hg18NCBI36
Build 34744,419,410 - 44,521,908NCBI
Celera744,744,966 - 44,847,513 (+)NCBICelera
Cytogenetic Map7p13NCBI
HuRef744,530,268 - 44,633,659 (+)NCBIHuRef
CHM1_1744,650,491 - 44,752,987 (+)NCBICHM1_1
T2T-CHM13v2.0744,766,778 - 44,869,231 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2744,685,639 - 44,788,190 (+)NCBI
Ogdh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39116,241,597 - 6,309,094 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl116,241,633 - 6,306,642 (+)EnsemblGRCm39 Ensembl
GRCm38116,291,597 - 6,359,094 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl116,291,633 - 6,356,642 (+)EnsemblGRCm38mm10GRCm38
MGSCv37116,191,600 - 6,259,096 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36116,191,600 - 6,268,605 (+)NCBIMGSCv36mm8
Celera116,773,507 - 6,842,010 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.94NCBI
Ogdh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81485,363,949 - 85,431,405 (+)NCBIGRCr8
mRatBN7.21481,150,021 - 81,217,479 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1481,150,091 - 81,217,479 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1485,551,494 - 85,617,817 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01486,791,580 - 86,857,903 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01483,240,905 - 83,307,226 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01486,414,924 - 86,481,903 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1486,414,949 - 86,613,327 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01487,376,110 - 87,442,862 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41487,022,994 - 87,090,768 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1480,033,036 - 80,099,636 (+)NCBICelera
Cytogenetic Map14q21NCBI
Ogdh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554567,415,589 - 7,485,515 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554567,416,343 - 7,484,889 (-)NCBIChiLan1.0ChiLan1.0
OGDH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2649,519,160 - 49,621,977 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1797,843,898 - 97,946,715 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0745,321,559 - 45,422,515 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1745,390,679 - 45,492,000 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl745,409,148 - 45,491,636 (+)Ensemblpanpan1.1panPan2
OGDH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha162,363,764 - 2,432,958 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01614,428,589 - 14,497,803 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1614,428,589 - 14,497,757 (-)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.01614,059,830 - 14,129,291 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01614,040,718 - 14,109,906 (-)NCBIUU_Cfam_GSD_1.0
OGDH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1850,609,418 - 50,684,964 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11850,609,415 - 50,684,990 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21855,497,953 - 55,588,004 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OGDH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12113,975,825 - 14,070,216 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2113,973,845 - 14,070,731 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660628,465,981 - 8,560,428 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ogdh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247407,482,314 - 7,549,417 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247407,481,719 - 7,549,809 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000000473   ⟹   ENSSTOP00000000425
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647819,506,154 - 19,583,364 (+)Ensembl
RefSeq Acc Id: XM_005319245   ⟹   XP_005319302
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118100,295,062 - 100,372,678 (+)NCBI
SpeTri2.0NW_00493647819,506,845 - 19,584,411 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013355952   ⟹   XP_013211406
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118100,295,168 - 100,372,678 (+)NCBI
SpeTri2.0NW_00493647819,506,864 - 19,583,364 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013355953   ⟹   XP_013211407
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118100,295,062 - 100,372,678 (+)NCBI
SpeTri2.0NW_00493647819,506,847 - 19,584,411 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021722321   ⟹   XP_021577996
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118100,295,147 - 100,371,727 (+)NCBI
SpeTri2.0NW_00493647819,506,845 - 19,584,411 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040291890   ⟹   XP_040147824
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118100,295,511 - 100,372,678 (+)NCBI
RefSeq Acc Id: XM_040291891   ⟹   XP_040147825
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118100,306,924 - 100,371,727 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005319302   ⟸   XM_005319245
- Peptide Label: isoform X3
- UniProtKB: I3LWQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013211407   ⟸   XM_013355953
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013211406   ⟸   XM_013355952
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_021577996   ⟸   XM_021722321
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_040147824   ⟸   XM_040291890
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040147825   ⟸   XM_040291891
- Peptide Label: isoform X2
RefSeq Acc Id: ENSSTOP00000000425   ⟸   ENSSTOT00000000473
Protein Domains
Transketolase-like pyrimidine-binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000000469 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000000473.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.11610 UniProtKB/TrEMBL
  3.40.50.12470 UniProtKB/TrEMBL
  3.40.50.970 UniProtKB/TrEMBL
  TPP helical domain UniProtKB/TrEMBL
InterPro 2-oxogl_dehyd_N UniProtKB/TrEMBL
  2oxoglutarate_DH_E1 UniProtKB/TrEMBL
  DH_E1 UniProtKB/TrEMBL
  KGD_C UniProtKB/TrEMBL
  KGD_C_sf UniProtKB/TrEMBL
  THDP-binding UniProtKB/TrEMBL
  Transketolase-like_Pyr-bd UniProtKB/TrEMBL
NCBI Gene Ogdh ENTREZGENE
PANTHER 2-OXOGLUTARATE DEHYDROGENASE, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR23152 UniProtKB/TrEMBL
Pfam 2-oxogl_dehyd_N UniProtKB/TrEMBL
  E1_dh UniProtKB/TrEMBL
  OxoGdeHyase_C UniProtKB/TrEMBL
  Transket_pyr UniProtKB/TrEMBL
PIRSF Oxoglu_dh_E1 UniProtKB/TrEMBL
SMART Transket_pyr UniProtKB/TrEMBL
Superfamily-SCOP SSF52518 UniProtKB/TrEMBL
UniProt I3LWQ0 ENTREZGENE, UniProtKB/TrEMBL