Klk4 (kallikrein related peptidase 4) - Rat Genome Database

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Gene: Klk4 (kallikrein related peptidase 4) Ictidomys tridecemlineatus
Analyze
Symbol: Klk4
Name: kallikrein related peptidase 4
RGD ID: 12451457
Description: ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN amelogenesis (ortholog); extracellular matrix disassembly (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); amelogenesis imperfecta type 2A1 (ortholog); breast cancer (ortholog); FOUND IN extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: kallikrein-4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934922,707,186 - 22,711,100 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936889583,302 - 586,412 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936889583,259 - 586,412 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Klk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934922,707,186 - 22,711,100 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936889583,302 - 586,412 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936889583,259 - 586,412 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381950,906,351 - 50,911,395 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1950,906,351 - 50,911,395 (-)EnsemblGRCh38hg38GRCh38
GRCh371951,409,607 - 51,414,651 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,101,420 - 56,105,806 (-)NCBINCBI36Build 36hg18NCBI36
Build 341956,101,419 - 56,105,806NCBI
Celera1948,460,680 - 48,464,998 (-)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1947,742,948 - 47,747,264 (-)NCBIHuRef
CHM1_11951,411,402 - 51,415,787 (-)NCBICHM1_1
T2T-CHM13v2.01953,994,435 - 53,999,407 (-)NCBIT2T-CHM13v2.0
Klk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39743,530,584 - 43,535,228 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl743,530,584 - 43,535,228 (+)EnsemblGRCm39 Ensembl
GRCm38743,881,160 - 43,885,804 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl743,881,160 - 43,885,804 (+)EnsemblGRCm38mm10GRCm38
MGSCv37751,136,542 - 51,141,174 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36743,749,214 - 43,753,846 (+)NCBIMGSCv36mm8
Celera739,349,912 - 39,354,544 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.35NCBI
Klk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81103,480,731 - 103,485,963 (+)NCBIGRCr8
mRatBN7.2194,344,195 - 94,349,425 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl194,344,195 - 94,349,424 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx199,730,033 - 99,734,406 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,202,660 - 108,207,031 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01101,492,287 - 101,496,632 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0199,828,944 - 99,834,642 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,829,351 - 99,834,216 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01100,897,206 - 100,902,435 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4194,321,663 - 94,327,488 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1194,399,773 - 94,405,599 (+)NCBI
Celera188,612,777 - 88,617,038 (+)NCBICelera
Cytogenetic Map1q22NCBI
KLK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22056,976,183 - 56,980,802 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11958,896,711 - 58,901,306 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01947,849,158 - 47,876,522 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11956,739,394 - 56,768,169 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1956,764,073 - 56,768,169 (-)Ensemblpanpan1.1panPan2
KLK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11105,950,948 - 105,955,464 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1105,951,691 - 106,007,581 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1105,526,312 - 105,529,783 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01106,462,891 - 106,466,451 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11106,134,079 - 106,137,554 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01105,775,605 - 105,779,075 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01106,571,164 - 106,574,633 (+)NCBIUU_Cfam_GSD_1.0
KLK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl655,589,999 - 55,594,294 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1655,589,997 - 55,617,514 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2651,488,847 - 51,498,931 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1643,921,920 - 43,935,224 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl643,922,052 - 43,934,253 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607323,952,102 - 23,956,462 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248323,828,679 - 3,831,767 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248323,828,676 - 3,832,025 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000002320   ⟹   ENSSTOP00000002075
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936889583,302 - 586,412 (-)Ensembl
RefSeq Acc Id: XM_005341687   ⟹   XP_005341744
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934922,707,186 - 22,711,100 (-)NCBI
SpeTri2.0NW_004936889583,259 - 586,412 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040279220   ⟹   XP_040135154
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934922,707,186 - 22,709,307 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005341744 (Get FASTA)   NCBI Sequence Viewer  
  XP_040135154 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000002075.2
Reference Protein Sequences
RefSeq Acc Id: XP_005341744   ⟸   XM_005341687
- Peptide Label: isoform X2
- UniProtKB: I3M070 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040135154   ⟸   XM_040279220
- Peptide Label: isoform X1
RefSeq Acc Id: ENSSTOP00000002075   ⟸   ENSSTOT00000002320
Protein Domains
Peptidase S1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000002318 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000002320.3 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
NCBI Gene Klk4 ENTREZGENE
PANTHER TRYPSIN-RELATED UniProtKB/TrEMBL
  TRYPSINOGEN-LIKE PROTEIN 3 UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/TrEMBL
UniProt I3M070 ENTREZGENE, UniProtKB/TrEMBL