Cct4 (chaperonin containing TCP1 subunit 4)

Gene: Cct4 (chaperonin containing TCP1 subunit 4) Ictidomys tridecemlineatus

Analyze

Symbol:

Cct4

Name:

chaperonin containing TCP1 subunit 4

RGD ID:

12448033

Description:

ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); ATP-dependent protein folding chaperone (inferred); INVOLVED IN binding of sperm to zona pellucida (ortholog); positive regulation of protein localization to Cajal body (ortholog); ASSOCIATED WITH genetic disease (ortholog); hereditary sensory neuropathy (ortholog); schizophrenia (ortholog); FOUND IN chaperonin-containing T-complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

T-complex protein 1 subunit delta

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	21,330,016 - 21,346,300 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936491	7,224,692 - 7,241,358 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936491	7,224,989 - 7,241,348 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

hereditary sensory neuropathy (ISO)

schizophrenia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

binding of sperm to zona pellucida (IEA,ISO)

chaperone-mediated protein folding (IEA)

positive regulation of establishment of protein localization to telomere (IEA)

positive regulation of protein localization to Cajal body (ISO)

positive regulation of telomerase RNA localization to Cajal body (IEA)

positive regulation of telomere maintenance via telomerase (IEA)

protein folding (IEA)

protein stabilization (IEA)

scaRNA localization to Cajal body (IEA)

Cellular Component

cell body (IEA)

centrosome (IEA)

chaperonin-containing T-complex (IEA,ISO)

cytoplasm (IEA)

cytosol (IEA)

microtubule (IEA)

nucleoplasm (IEA)

zona pellucida receptor complex (IEA)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IEA)

ATP-dependent protein folding chaperone (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein folding chaperone (IEA)

unfolded protein binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Cct4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	21,330,016 - 21,346,300 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936491	7,224,692 - 7,241,358 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936491	7,224,989 - 7,241,348 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CCT4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	61,868,085 - 61,888,671 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	61,868,085 - 61,888,671 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	62,095,220 - 62,115,806 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	61,948,766 - 61,969,295 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	62,006,913 - 62,027,442	NCBI
Celera	2	61,940,173 - 61,960,736 (-)	NCBI		Celera
Cytogenetic Map	2	p15	NCBI
HuRef	2	61,835,217 - 61,855,722 (-)	NCBI		HuRef
CHM1_1	2	62,025,224 - 62,045,751 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	61,874,246 - 61,894,829 (-)	NCBI		T2T-CHM13v2.0

Cct4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	22,940,593 - 22,953,336 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	22,940,519 - 22,953,780 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	22,990,593 - 23,003,336 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	22,990,519 - 23,003,780 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	22,890,593 - 22,903,336 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	22,890,593 - 22,903,336 (+)	NCBI		MGSCv36	mm8
Celera	11	25,126,226 - 25,138,969 (+)	NCBI		Celera
Cytogenetic Map	11	A3.2	NCBI
cM Map	11	14.25	NCBI

Cct4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	101,193,057 - 101,205,935 (+)	NCBI		GRCr8
mRatBN7.2	14	96,991,853 - 97,004,732 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	96,991,859 - 97,005,267 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	101,325,100 - 101,337,974 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	102,567,399 - 102,580,273 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	99,039,002 - 99,051,876 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	107,767,392 - 107,780,270 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	107,767,392 - 107,780,270 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	107,843,411 - 107,856,260 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	103,675,110 - 103,687,893 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	103,694,320 - 103,707,104 (+)	NCBI
Celera	14	95,973,133 - 95,985,983 (+)	NCBI		Celera
Cytogenetic Map	14	q22	NCBI

Cct4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	22,088,949 - 22,108,514 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	22,088,949 - 22,108,514 (+)	NCBI	ChiLan1.0	ChiLan1.0

CCT4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	64,495,636 - 64,516,010 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	64,499,652 - 64,519,655 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	61,950,477 - 61,970,783 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	63,084,090 - 63,104,530 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	63,084,090 - 63,105,216 (-)	Ensembl	panpan1.1		panPan2

CCT4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	61,859,148 - 61,874,030 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	61,859,245 - 61,874,389 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	61,748,927 - 61,763,778 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	62,867,889 - 62,882,584 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	62,867,244 - 62,882,587 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	62,551,782 - 62,566,434 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	62,855,534 - 62,870,428 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	63,151,020 - 63,165,931 (-)	NCBI		UU_Cfam_GSD_1.0

CCT4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	79,924,507 - 79,946,207 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	79,924,338 - 79,941,926 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	83,760,065 - 83,777,463 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CCT4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	45,086,932 - 45,106,922 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	45,086,920 - 45,111,271 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	66,727,959 - 66,748,110 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cct4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624833	46,076 - 62,665 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624833	46,071 - 62,665 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005322049	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010001352	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000014912 ⟹ ENSSTOP00000013358

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936491	7,225,199 - 7,241,136 (-)	Ensembl

RefSeq Acc Id:

ENSSTOT00000041831 ⟹ ENSSTOP00000032494

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936491	7,224,692 - 7,241,358 (-)	Ensembl

RefSeq Acc Id:

XM_005322049 ⟹ XP_005322106

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024406292	21,330,016 - 21,346,300 (+)	NCBI
SpeTri2.0	NW_004936491	7,224,989 - 7,241,348 (-)	NCBI

Sequence:

show sequence

GCTCAACCACCTCAACCGGCGCGAGGCGGCCAGCCTCTTACGTCAGGCCGGCGACGCGCCACTA
GACAGGCCCCTTCTCCACCTCCGCCCCCTCCCGGCGCCGGCGCCGTTTTCTGGAAGGTTCGTGA
AGGCGCTGGGCGCGTACCGTTAGTCCGGCCGAATCCGCGTCCATCCGTCCTTCCTGAACTCCGG
CAGACTCAGCCAGGTTTGCCATGCCAGAGAATATGGCACCCCGAAGCGGGGCGCCCGCTGGGGC
TTCTGGCAGCCGAGGAAAAGGCGCCTATCAGGACCGCGACAAGCCGGCCCAGATCCGCTTCAGC
AACATTTCCGCGGCCAAAGCGGTTGCTGATGCTATTAGAACAAGCCTTGGACCAAAAGGAATGG
ATAAAATGATTCAAGATGGAAAAGGTGATGTGACCATTACAAATGATGGGGCCACCATTTTGAA
ACAGATGCAAGTGTTGCATCCAGCAGCCAGAATGCTTGTGGAGCTGTCTAAAGCTCAAGATATA
GAAGCAGGAGATGGCACCACATCAGTGGTCATCATTGCTGGCTCTCTCTTAGATTCCTGTACCA
AGCTTCTTCAGAAAGGAATTCATCCAACCATCATTTCCGAGTCATTCCAGAAAGCTTTGGAAAA
GGGTATTGAAGTTTTGACTGACATGTCTCGACCTGTGGAACTGAGTGACAGAGAAACTTTGTTG
AATAGTGCAACCACTTCATTGAATTCAAAGGTTGTCTCTCAGTATTCAAGTCTGCTTTCTCCAA
TGAGTGTAAATGCAGTGATGAAAGTGATTGATCCAGCCACGGCTACTAGTGTAGACCTAAGAGA
TATTAAAATAGTTAAGAAGCTTGGTGGAACAATTGATGACTGTGAATTGGTGGAAGGACTAGTT
CTCACCCAAAAAGTGGCAAATTCGGGCATAAACAGAGTCGAAAAAGCCAAAATTGGGCTTATTC
AATTTTGCTTATCTGCTCCCAAAACTGATATGGATAATCAAATAGTAGTTTCCGACTATGCCCA
GATGGACCGAGTACTGCGAGAAGAGAGAGCCTATATTTTAAATTTAGTGAAGCAAATTAAAAAA
ACAGGATGTAATGTCCTTCTGATACAGAAGTCTATCCTAAGAGATGCTCTTAGTGATCTTGCGT
TACATTTTCTGAATAAGATGAAGATTATGGTGATTAAGGATATTGAAAGGGAAGACATTGAATT
CATTTGTAAGACAATTGGAACCAAACCAGTTGCTCATATTGACCAATTCACTGCTGACATGCTG
GGTTCTGCTGAGTTAGCTGAAGAGATCAATTTAAATGGTTCTGGCAAACTGCTCAAGATTACAG
GCTGTGCAAGCCCTGGAAAAACTGTTACAATTGTGGTTCGTGGTTCTAATAAACTGGTGATTGA
AGAAGCTGAGCGCTCCATTCATGATGCCCTGTGTGTTGTTCGCTGCTTAGTGAAGAAGAGGGCG
CTTATTGCAGGAGGTGGTGCTCCAGAAATAGAGTTGGCCCTACGATTGACTGAATATTCACGAA
CACTGAGTGGCATGGAATCCTATTGTGTTCGTGCTTTCGCAGATGCTATGGAGGTCATTCCATC
TACACTAGCTGAAAATGCTGGCCTGAATCCCATTTCTACAGTAACAGAACTAAGAAATCGGCAT
GCCCAAGGAGAAAAAACTACAGGCATTAATGTTCGAAAGGGTGGTATTTCTAACATTTTGGAAG
AAATGGTTGTACAGCCCCTGTTGGTTTCAGTCAGTGCTCTGACTCTAGCAACTGAAACTGTCCG
GAGCATTCTGAAAATTGATGACGTGGTGAACACTCGATAATCTGGATAGCATTGGCTGGCTGGC
ACCATTTTGGCCACCAATTACTGTGATTAAAGTGGAAGATGATGGCCTTGGTGTTCCTTGTTTT
CTGGAAGATTGTTCCTCTGACTTCCTGGGCTTTGTGTTCTAGTTTGCATTTGCCTGAAATTGTA
TTGAAACACTTTATTGAACAACATTAAATATTTGGTTTCAAACAGGTTAATTCCCTCC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005322106	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000013358.3
	ENSSTOP00000032494.1
GenBank Protein	KAG3267254	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005322106 ⟸ XM_005322049

- UniProtKB:

A0A287DG22 (UniProtKB/TrEMBL), I3MNT1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPENMAPRSGAPAGASGSRGKGAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDG
KGDVTITNDGATILKQMQVLHPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGI
HPTIISESFQKALEKGIEVLTDMSRPVELSDRETLLNSATTSLNSKVVSQYSSLLSPMSVNAVM
KVIDPATATSVDLRDIKIVKKLGGTIDDCELVEGLVLTQKVANSGINRVEKAKIGLIQFCLSAP
KTDMDNQIVVSDYAQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKM
KIMVIKDIEREDIEFICKTIGTKPVAHIDQFTADMLGSAELAEEINLNGSGKLLKITGCASPGK
TVTIVVRGSNKLVIEEAERSIHDALCVVRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMES
YCVRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTTGINVRKGGISNILEEMVVQPL
LVSVSALTLATETVRSILKIDDVVNTR

hide sequence

RefSeq Acc Id:

ENSSTOP00000032494 ⟸ ENSSTOT00000041831

RefSeq Acc Id:

ENSSTOP00000013358 ⟸ ENSSTOT00000014912

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000014911	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000014912.3	UniProtKB/TrEMBL
	ENSSTOT00000041831.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.560.10	UniProtKB/TrEMBL
	3.30.260.10	UniProtKB/TrEMBL
	3.50.7.10	UniProtKB/TrEMBL
InterPro	Chap_CCT_delta	UniProtKB/TrEMBL
	Chaperone_TCP-1	UniProtKB/TrEMBL
	Chaperonin_TCP-1_CS	UniProtKB/TrEMBL
	Cpn60/TCP-1	UniProtKB/TrEMBL
	GroEL-like_apical_dom_sf	UniProtKB/TrEMBL
	GROEL-like_equatorial_sf	UniProtKB/TrEMBL
	TCP-1-like_intermed_sf	UniProtKB/TrEMBL
NCBI Gene	Cct4	ENTREZGENE
PANTHER	PTHR11353	UniProtKB/TrEMBL
	T-COMPLEX PROTEIN 1 SUBUNIT DELTA	UniProtKB/TrEMBL
Pfam	Cpn60_TCP1	UniProtKB/TrEMBL
PRINTS	TCOMPLEXTCP1	UniProtKB/TrEMBL
PROSITE	TCP1_1	UniProtKB/TrEMBL
	TCP1_2	UniProtKB/TrEMBL
	TCP1_3	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48592	UniProtKB/TrEMBL
	SSF52029	UniProtKB/TrEMBL
	SSF54849	UniProtKB/TrEMBL
UniProt	A0A287DG22	ENTREZGENE, UniProtKB/TrEMBL
	I3MNT1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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