SLC30A8 (solute carrier family 30 member 8) - Rat Genome Database

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Gene: SLC30A8 (solute carrier family 30 member 8) Canis lupus familiaris
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Symbol: SLC30A8
Name: solute carrier family 30 member 8
RGD ID: 12435768
Description: ENCODES a protein that exhibits antiporter activity (inferred); monoatomic cation transmembrane transporter activity (inferred); protein homodimerization activity (inferred); INVOLVED IN glucose homeostasis (ortholog); insulin secretion (ortholog); positive regulation of insulin secretion (ortholog); ASSOCIATED WITH genetic disease (ortholog); hereditary multiple exostoses (ortholog); maturity-onset diabetes of the young type 1 (ortholog); FOUND IN Golgi apparatus (ortholog); secretory granule (ortholog); secretory granule membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: zinc transporter 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11316,602,255 - 16,637,299 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1316,601,912 - 16,635,880 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1316,603,610 - 16,638,559 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01316,898,497 - 16,933,443 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1316,898,295 - 16,932,026 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11316,635,055 - 16,670,008 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01316,734,977 - 16,770,163 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01316,978,714 - 17,013,658 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SLC30A8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11316,602,255 - 16,637,299 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1316,601,912 - 16,635,880 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1316,603,610 - 16,638,559 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01316,898,497 - 16,933,443 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1316,898,295 - 16,932,026 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11316,635,055 - 16,670,008 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01316,734,977 - 16,770,163 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01316,978,714 - 17,013,658 (+)NCBIUU_Cfam_GSD_1.0
SLC30A8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388116,950,217 - 117,176,714 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8116,950,273 - 117,176,714 (+)EnsemblGRCh38hg38GRCh38
GRCh378117,962,456 - 118,188,953 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368118,216,518 - 118,258,134 (+)NCBINCBI36Build 36hg18NCBI36
Build 348118,216,747 - 118,254,101NCBI
Celera8114,151,202 - 114,377,691 (+)NCBICelera
Cytogenetic Map8q24.11NCBI
HuRef8113,288,921 - 113,515,635 (+)NCBIHuRef
CHM1_18118,002,722 - 118,228,963 (+)NCBICHM1_1
T2T-CHM13v2.08118,078,388 - 118,305,142 (+)NCBIT2T-CHM13v2.0
Slc30a8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391552,158,949 - 52,199,194 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1552,158,949 - 52,199,194 (+)EnsemblGRCm39 Ensembl
GRCm381552,295,553 - 52,335,798 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1552,295,553 - 52,335,798 (+)EnsemblGRCm38mm10GRCm38
MGSCv371552,127,108 - 52,167,288 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361552,125,636 - 52,165,816 (+)NCBIMGSCv36mm8
Celera1553,863,656 - 53,904,335 (+)NCBICelera
Cytogenetic Map15CNCBI
cM Map1519.88NCBI
Slc30a8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8785,481,864 - 85,517,255 (+)NCBIGRCr8
mRatBN7.2783,591,993 - 83,627,786 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl783,591,993 - 83,626,305 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx785,509,786 - 85,542,609 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0787,710,991 - 87,743,815 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0787,515,694 - 87,548,480 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0791,832,988 - 91,869,329 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl791,832,988 - 91,867,300 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0792,476,024 - 92,512,365 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4788,583,770 - 88,617,145 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1788,604,575 - 88,639,923 (+)NCBI
Celera780,455,350 - 80,488,134 (+)NCBICelera
Cytogenetic Map7q31NCBI
Slc30a8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541723,207,146 - 23,236,874 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541723,207,146 - 23,239,170 (+)NCBIChiLan1.0ChiLan1.0
SLC30A8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27134,356,700 - 134,583,629 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18109,872,083 - 110,098,929 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08113,624,785 - 113,851,633 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18116,167,700 - 116,394,095 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8116,223,595 - 116,394,095 (+)Ensemblpanpan1.1panPan2
Slc30a8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530321,687,819 - 21,725,947 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647029,114,713 - 29,151,993 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647029,114,713 - 29,151,993 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC30A8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl421,517,486 - 21,555,746 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1421,517,009 - 21,557,747 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2422,786,105 - 22,824,455 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC30A8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18111,588,517 - 111,819,908 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8111,769,181 - 111,815,885 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603928,509,132 - 28,557,839 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc30a8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476315,431,806 - 15,461,833 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476315,393,221 - 15,469,819 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SLC30A8
478 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5
Low 7 2 9 2
Below cutoff 4 5 9 5 6 5 4 3 3 8 8 5

Sequence


RefSeq Acc Id: ENSCAFT00000001287   ⟹   ENSCAFP00000001179
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1316,601,912 - 16,635,880 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845025879   ⟹   ENSCAFP00845020395
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1316,898,295 - 16,932,026 (+)Ensembl
RefSeq Acc Id: XM_005627882   ⟹   XP_005627939
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11316,602,255 - 16,637,299 (+)NCBI
Dog10K_Boxer_Tasha1316,603,610 - 16,638,559 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038493112   ⟹   XP_038349040
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11316,635,066 - 16,670,008 (+)NCBI
RefSeq Acc Id: XM_038493113   ⟹   XP_038349041
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11316,635,055 - 16,670,008 (+)NCBI
RefSeq Acc Id: XM_038555382   ⟹   XP_038411310
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01316,978,725 - 17,013,658 (+)NCBI
RefSeq Acc Id: XM_038555383   ⟹   XP_038411311
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01316,978,714 - 17,013,658 (+)NCBI
RefSeq Acc Id: XM_038619279   ⟹   XP_038475207
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01316,734,988 - 16,770,163 (+)NCBI
RefSeq Acc Id: XM_038619280   ⟹   XP_038475208
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01316,734,977 - 16,770,163 (+)NCBI
RefSeq Acc Id: XM_038684894   ⟹   XP_038540822
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01316,898,508 - 16,933,443 (+)NCBI
RefSeq Acc Id: XM_038684895   ⟹   XP_038540823
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01316,898,497 - 16,933,443 (+)NCBI
RefSeq Acc Id: XM_539143   ⟹   XP_539143
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11316,602,255 - 16,637,299 (+)NCBI
Dog10K_Boxer_Tasha1316,603,621 - 16,638,559 (+)NCBI
Sequence:
RefSeq Acc Id: XP_539143   ⟸   XM_539143
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SNE8 (UniProtKB/TrEMBL),   A0A8C0JSG9 (UniProtKB/TrEMBL),   A0A8I3NTT5 (UniProtKB/TrEMBL),   A0A8C0JSI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005627939   ⟸   XM_005627882
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JSI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000001179   ⟸   ENSCAFT00000001287
RefSeq Acc Id: XP_038349041   ⟸   XM_038493113
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038349040   ⟸   XM_038493112
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038475208   ⟸   XM_038619280
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038475207   ⟸   XM_038619279
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038540823   ⟸   XM_038684895
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JSI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038540822   ⟸   XM_038684894
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SNE8 (UniProtKB/TrEMBL),   A0A8C0JSG9 (UniProtKB/TrEMBL),   A0A8I3NTT5 (UniProtKB/TrEMBL),   A0A8C0JSI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038411311   ⟸   XM_038555383
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JSI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038411310   ⟸   XM_038555382
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JSG9 (UniProtKB/TrEMBL),   A0A8C0JSI4 (UniProtKB/TrEMBL),   A0A8C0SNE8 (UniProtKB/TrEMBL),   A0A8I3NTT5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845020395   ⟸   ENSCAFT00845025879


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000825 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030004523 UniProtKB/TrEMBL
  ENSCAFG00040015221 UniProtKB/TrEMBL
  ENSCAFG00845014466 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001287.5 UniProtKB/TrEMBL
  ENSCAFT00030008315.1 UniProtKB/TrEMBL
  ENSCAFT00040027988.1 UniProtKB/TrEMBL
  ENSCAFT00845025879 ENTREZGENE
  ENSCAFT00845025879.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1510.10 UniProtKB/TrEMBL
InterPro Cation_efflux UniProtKB/TrEMBL
  Cation_efflux_CTD_sf UniProtKB/TrEMBL
  Cation_efflux_TMD_sf UniProtKB/TrEMBL
NCBI Gene SLC30A8 ENTREZGENE
PANTHER CATION EFFLUX PROTEIN/ ZINC TRANSPORTER UniProtKB/TrEMBL
  PTHR11562:SF37 UniProtKB/TrEMBL
Pfam Cation_efflux UniProtKB/TrEMBL
Superfamily-SCOP SSF160240 UniProtKB/TrEMBL
  SSF161111 UniProtKB/TrEMBL
UniProt A0A8C0JSG9 ENTREZGENE
  A0A8C0JSI4 ENTREZGENE
  A0A8C0SNE8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NTT5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:46353 ENTREZGENE