KRT10 (keratin 10) - Rat Genome Database

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Gene: KRT10 (keratin 10) Canis lupus familiaris
Analyze
Symbol: KRT10
Name: keratin 10
RGD ID: 12427596
Description: ENCODES a protein that exhibits cytoskeletal protein binding (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); epidermis development (ortholog); intermediate filament organization (ortholog); ASSOCIATED WITH epidermolytic hyperkeratosis; Annular Epidermolytic Ichthyosis (ortholog); Annular Epidermolytic Ichthyosis 1 (ortholog); FOUND IN cornified envelope (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CK-10; cytokeratin-10; epithelial keratin 10; K10; Ker10; keratin 10 (epidermolytic hyperkeratosis, keratosis palmaris et plantaris); keratin, type I cytoskeletal 10; Keratin-10
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1921,863,715 - 21,868,587 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl921,863,767 - 21,868,587 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha921,336,709 - 21,341,572 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0922,656,504 - 22,661,353 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl922,656,547 - 22,661,353 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1921,431,293 - 21,436,162 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0921,690,028 - 21,694,877 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0921,814,216 - 21,819,078 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:16029326   PMID:16147859   PMID:30032202  


Genomics

Comparative Map Data
KRT10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1921,863,715 - 21,868,587 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl921,863,767 - 21,868,587 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha921,336,709 - 21,341,572 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0922,656,504 - 22,661,353 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl922,656,547 - 22,661,353 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1921,431,293 - 21,436,162 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0921,690,028 - 21,694,877 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0921,814,216 - 21,819,078 (+)NCBIUU_Cfam_GSD_1.0
KRT10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381740,818,117 - 40,822,614 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1740,818,117 - 40,822,614 (-)EnsemblGRCh38hg38GRCh38
GRCh371738,974,369 - 38,978,866 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361736,227,895 - 36,232,373 (-)NCBINCBI36Build 36hg18NCBI36
Build 341736,227,895 - 36,232,373NCBI
Celera1735,635,920 - 35,640,414 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1734,768,729 - 34,773,223 (-)NCBIHuRef
CHM1_11739,209,679 - 39,214,200 (-)NCBICHM1_1
T2T-CHM13v2.01741,682,437 - 41,686,934 (-)NCBIT2T-CHM13v2.0
Krt10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391199,276,080 - 99,288,631 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1199,276,080 - 99,280,190 (-)EnsemblGRCm39 Ensembl
GRCm381199,385,254 - 99,397,449 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1199,385,254 - 99,389,364 (-)EnsemblGRCm38mm10GRCm38
MGSCv371199,246,568 - 99,250,678 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361199,201,517 - 99,205,443 (-)NCBIMGSCv36mm8
Cytogenetic Map11DNCBI
cM Map1162.92NCBI
Krt10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,834,865 - 84,839,160 (-)NCBIGRCr8
mRatBN7.21084,338,695 - 84,343,279 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1084,338,706 - 84,343,701 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1089,282,528 - 89,286,524 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01088,780,663 - 88,784,659 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01084,172,644 - 84,176,640 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01087,296,445 - 87,301,307 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1087,296,451 - 87,300,736 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01087,091,976 - 87,100,918 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41088,288,620 - 88,292,615 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11088,302,989 - 88,306,985 (-)NCBI
Celera1083,077,920 - 83,081,916 (-)NCBICelera
Cytogenetic Map10q31NCBI
Krt10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545115,270,222 - 15,274,312 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545115,269,861 - 15,274,351 (-)NCBIChiLan1.0ChiLan1.0
KRT10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21924,129,997 - 24,134,515 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11726,020,443 - 26,024,955 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01716,461,624 - 16,466,136 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11716,686,898 - 16,691,221 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1716,686,898 - 16,690,415 (+)Ensemblpanpan1.1panPan2
Krt10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560221,287,128 - 21,291,503 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649015,783,618 - 15,788,634 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649015,783,636 - 15,788,605 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRT10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1221,641,271 - 21,646,377 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11221,641,263 - 21,645,642 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21221,842,078 - 21,846,439 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KRT10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11665,361,893 - 65,367,634 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1665,362,903 - 65,367,941 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607736,242,450 - 36,246,895 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Krt10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247952,595,072 - 2,599,077 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247952,594,973 - 2,599,433 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KRT10
62 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 6
Medium 5 2 11 2 3 12 3 10 1
Low 3 11 6 4 6 3 5 5
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_014116588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014116589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014116590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038485601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038485602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038485603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038547368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038547369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038547370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038611352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038611353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038611354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038676544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038676545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038676546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY318944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCAFT00000025391   ⟹   ENSCAFP00000023577
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl921,863,767 - 21,868,587 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845024534   ⟹   ENSCAFP00845019294
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl922,656,547 - 22,661,353 (+)Ensembl
RefSeq Acc Id: XM_014116588   ⟹   XP_013972063
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1921,863,715 - 21,868,587 (+)NCBI
Dog10K_Boxer_Tasha921,336,709 - 21,341,572 (+)NCBI
Sequence:
RefSeq Acc Id: XM_014116589   ⟹   XP_013972064
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1921,863,715 - 21,868,587 (+)NCBI
Dog10K_Boxer_Tasha921,336,709 - 21,341,572 (+)NCBI
Sequence:
RefSeq Acc Id: XM_014116590   ⟹   XP_013972065
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1921,863,715 - 21,868,587 (+)NCBI
Dog10K_Boxer_Tasha921,336,709 - 21,341,572 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038485601   ⟹   XP_038341529
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1921,431,293 - 21,436,162 (+)NCBI
RefSeq Acc Id: XM_038485602   ⟹   XP_038341530
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1921,431,293 - 21,436,162 (+)NCBI
RefSeq Acc Id: XM_038485603   ⟹   XP_038341531
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1921,431,293 - 21,436,162 (+)NCBI
RefSeq Acc Id: XM_038547368   ⟹   XP_038403296
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0921,814,216 - 21,819,078 (+)NCBI
RefSeq Acc Id: XM_038547369   ⟹   XP_038403297
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0921,814,216 - 21,819,078 (+)NCBI
RefSeq Acc Id: XM_038547370   ⟹   XP_038403298
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0921,814,216 - 21,819,078 (+)NCBI
RefSeq Acc Id: XM_038611352   ⟹   XP_038467280
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0921,690,028 - 21,694,877 (+)NCBI
RefSeq Acc Id: XM_038611353   ⟹   XP_038467281
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0921,690,028 - 21,694,877 (+)NCBI
RefSeq Acc Id: XM_038611354   ⟹   XP_038467282
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0921,690,028 - 21,694,877 (+)NCBI
RefSeq Acc Id: XM_038676544   ⟹   XP_038532472
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0922,656,504 - 22,661,353 (+)NCBI
RefSeq Acc Id: XM_038676545   ⟹   XP_038532473
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0922,656,504 - 22,661,353 (+)NCBI
RefSeq Acc Id: XM_038676546   ⟹   XP_038532474
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0922,656,504 - 22,661,353 (+)NCBI
RefSeq Acc Id: XP_013972063   ⟸   XM_014116588
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013972065   ⟸   XM_014116590
- Peptide Label: isoform X3
- UniProtKB: Q6EIZ0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_013972064   ⟸   XM_014116589
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000023577   ⟸   ENSCAFT00000025391
RefSeq Acc Id: XP_038341529   ⟸   XM_038485601
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038341531   ⟸   XM_038485603
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038341530   ⟸   XM_038485602
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038467280   ⟸   XM_038611352
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038467282   ⟸   XM_038611354
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038467281   ⟸   XM_038611353
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038532472   ⟸   XM_038676544
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038532474   ⟸   XM_038676546
- Peptide Label: isoform X3
- UniProtKB: A0A8I3NL87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038532473   ⟸   XM_038676545
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038403296   ⟸   XM_038547368
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038403298   ⟸   XM_038547370
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038403297   ⟸   XM_038547369
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCAFP00845019294   ⟸   ENSCAFT00845024534
Protein Domains
IF rod


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016007 Ensembl, UniProtKB/Swiss-Prot
  ENSCAFG00030016765 UniProtKB/Swiss-Prot
  ENSCAFG00040013100 UniProtKB/TrEMBL
  ENSCAFG00845013739 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000025391.5 UniProtKB/Swiss-Prot
  ENSCAFT00030031038.1 UniProtKB/Swiss-Prot
  ENSCAFT00040024323.1 UniProtKB/TrEMBL
  ENSCAFT00845024534 ENTREZGENE
  ENSCAFT00845024534.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Single helix bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IF_conserved UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_rod_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Keratin_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene KRT10 ENTREZGENE
PANTHER KERATIN, TYPE I CYTOSKELETAL 10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TYPE1KERATIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_ROD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0YXG6_CANLF UniProtKB/TrEMBL
  A0A8I3NL87 ENTREZGENE, UniProtKB/TrEMBL
  K1C10_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:42516 ENTREZGENE