NPPB (natriuretic peptide B) - Rat Genome Database

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Gene: NPPB (natriuretic peptide B) Canis lupus familiaris
Analyze
Symbol: NPPB (Ensembl: NPPA)
Name: natriuretic peptide B (Ensembl:natriuretic peptide A)
RGD ID: 12423345
Description: ENCODES a protein that exhibits hormone activity (ortholog); signaling receptor binding (ortholog); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); cardiac muscle hypertrophy in response to stress (ortholog); cell growth involved in cardiac muscle cell development (ortholog); PARTICIPATES IN brain natriuretic peptide signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adult respiratory distress syndrome (ortholog); Animal Disease Models (ortholog); FOUND IN extracellular space (ortholog); perinuclear region of cytoplasm (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: BNP; brain natriuretic factor prohormone; brain natriuretic peptide; Gamma-brain natriuretic peptide; Iso-ANP; natriuretic peptide precursor B; Natriuretic peptides B; preproBNP; proBNP
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,395,844 - 84,397,473 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha280,929,289 - 80,930,932 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0285,060,368 - 85,062,010 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,060,271 - 85,073,309 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,809,597 - 81,811,239 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,809,514 - 82,811,156 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0283,872,280 - 83,873,924 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
adult respiratory distress syndrome  (ISO)
Animal Disease Models  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
aortic valve insufficiency  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Brain Injuries  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
cardiovascular system disease  (ISO)
Cerebral Hemorrhage  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
chromosome 1p36 deletion syndrome  (ISO)
chronic kidney disease  (ISO)
congenital heart disease  (ISO)
congestive heart failure  (ISO)
Contrast-Induced Nephropathy  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Death  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
Dyspnea  (ISO)
Ehlers-Danlos syndrome kyphoscoliotic type 1  (ISO)
Eisenmenger Complex  (ISO)
end stage renal disease  (ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (ISO)
Familial Atrial Fibrillation 6  (ISO)
genetic disease  (ISO)
heart disease  (ISO)
High Cardiac Output  (ISO)
hyperhomocysteinemia  (ISO)
hypertension  (ISO)
hypertensive heart disease  (ISO)
Hypertensive Nephropathy  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypokalemia  (ISO)
Hyponatremia  (ISO)
Hypotension  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
Kawasaki disease  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (ISO)
Metabolic Side Effects of Drugs and Substances  (ISO)
migraine  (ISO)
morbid obesity  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
nephrosis  (ISO)
obesity  (ISO)
Pain  (ISO)
polycystic kidney disease  (ISO)
Postoperative Complications  (ISO)
proteinuria  (ISO)
pulmonary embolism  (ISO)
pulmonary hypertension  (ISO)
renal hypertension  (ISO)
sickle cell anemia  (ISO)
systolic heart failure  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
Vasovagal Syncope  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Dysfunction, Right  (ISO)
Ventricular Remodeling  (ISO)
Ventricular Tachycardia  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:2597152   PMID:10407480   PMID:12948841   PMID:15838287   PMID:18366550   PMID:18681918   PMID:19585255   PMID:19652480   PMID:19709357   PMID:21835711   PMID:22217025   PMID:22301074  
PMID:22439324   PMID:22537461   PMID:22578688   PMID:30032202  


Genomics

Comparative Map Data
NPPB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,395,844 - 84,397,473 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha280,929,289 - 80,930,932 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0285,060,368 - 85,062,010 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,060,271 - 85,073,309 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,809,597 - 81,811,239 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,809,514 - 82,811,156 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0283,872,280 - 83,873,924 (+)NCBIUU_Cfam_GSD_1.0
NPPB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,857,464 - 11,858,945 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,857,464 - 11,858,945 (-)EnsemblGRCh38hg38GRCh38
GRCh37111,917,521 - 11,919,002 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,840,108 - 11,841,579 (-)NCBINCBI36Build 36hg18NCBI36
Build 34111,851,789 - 11,853,254NCBI
Celera111,031,156 - 11,032,627 (-)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef111,073,021 - 11,074,492 (-)NCBIHuRef
CHM1_1111,905,417 - 11,906,888 (-)NCBICHM1_1
T2T-CHM13v2.0111,401,560 - 11,403,041 (-)NCBIT2T-CHM13v2.0
Nppb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,070,264 - 148,071,662 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,070,245 - 148,071,662 (+)EnsemblGRCm39 Ensembl
GRCm384147,985,786 - 147,987,205 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4147,985,788 - 147,987,205 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,359,898 - 147,361,314 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364146,829,697 - 146,830,998 (+)NCBIMGSCv36mm8
Celera4150,250,201 - 150,251,617 (+)NCBICelera
Cytogenetic Map4E1NCBI
cM Map478.57NCBI
Nppb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85163,699,955 - 163,701,314 (+)NCBIGRCr8
mRatBN7.25158,416,813 - 158,418,175 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,416,866 - 158,418,168 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5161,133,613 - 161,134,915 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05162,961,436 - 162,962,738 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05162,917,783 - 162,919,085 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05164,796,176 - 164,797,538 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,796,185 - 164,797,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,454,278 - 168,455,640 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,062,348 - 165,063,650 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15165,072,535 - 165,073,838 (+)NCBI
Celera5156,698,873 - 156,700,175 (+)NCBICelera
Cytogenetic Map5q36NCBI
Nppb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554862,054,775 - 2,056,130 (+)NCBIChiLan1.0ChiLan1.0
NPPB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,361,604 - 216,364,862 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,008,742 - 215,011,988 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0110,621,416 - 10,622,960 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,838,518 - 11,839,999 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,838,518 - 11,839,995 (-)Ensemblpanpan1.1panPan2
Nppb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,858,528 - 34,860,962 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936474683,325 - 684,665 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936474683,325 - 684,662 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPPB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,930,382 - 71,932,254 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,930,374 - 71,931,843 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,840,061 - 65,841,530 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPPB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120119,930,931 - 119,933,391 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20119,932,021 - 119,933,197 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605423,799,168 - 23,801,437 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nppb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248181,139,776 - 1,141,010 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NPPB
49 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3
Low 1 1 3
Below cutoff 4 1 15 1 6 1 6 3 9 8 10 5

Sequence


RefSeq Acc Id: ENSCAFT00845003487   ⟹   ENSCAFP00845002767
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl285,060,271 - 85,073,309 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845003490   ⟹   ENSCAFP00845002768
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl285,060,271 - 85,062,005 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845003501   ⟹   ENSCAFP00845002777
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl285,071,241 - 85,073,039 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845003507   ⟹   ENSCAFP00845002782
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl285,071,241 - 85,072,230 (+)Ensembl
RefSeq Acc Id: XM_014111456   ⟹   XP_013966931
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1284,395,844 - 84,397,473 (+)NCBI
Dog10K_Boxer_Tasha280,929,289 - 80,930,932 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038468934   ⟹   XP_038324862
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1281,809,597 - 81,811,239 (+)NCBI
RefSeq Acc Id: XM_038529657   ⟹   XP_038385585
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0283,872,280 - 83,873,924 (+)NCBI
RefSeq Acc Id: XM_038593894   ⟹   XP_038449822
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0282,809,514 - 82,811,156 (+)NCBI
RefSeq Acc Id: XM_038657971   ⟹   XP_038513899
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0285,060,368 - 85,062,010 (+)NCBI
RefSeq Acc Id: XP_013966931   ⟸   XM_014111456
- UniProtKB: P16859 (UniProtKB/Swiss-Prot),   A0A8P0PRD3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038324862   ⟸   XM_038468934
RefSeq Acc Id: XP_038449822   ⟸   XM_038593894
RefSeq Acc Id: XP_038513899   ⟸   XM_038657971
- UniProtKB: P16859 (UniProtKB/Swiss-Prot),   A0A8I3MHJ9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038385585   ⟸   XM_038529657
- UniProtKB: P16859 (UniProtKB/Swiss-Prot),   A0A8I3MHJ9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845002782   ⟸   ENSCAFT00845003507
RefSeq Acc Id: ENSCAFP00845002767   ⟸   ENSCAFT00845003487
RefSeq Acc Id: ENSCAFP00845002777   ⟸   ENSCAFT00845003501
RefSeq Acc Id: ENSCAFP00845002768   ⟸   ENSCAFT00845003490

Promoters
RGD ID:13682653
Promoter ID:EPDNEW_C721
Type:multiple initiation site
Name:NPPB_1
Description:natriuretic peptide B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1284,395,977 - 84,396,037EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016539 UniProtKB/TrEMBL
  ENSCAFG00845001994 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000094580.1 UniProtKB/TrEMBL
  ENSCAFT00845003487.1 UniProtKB/TrEMBL
  ENSCAFT00845003490 ENTREZGENE
  ENSCAFT00845003490.1 UniProtKB/TrEMBL
  ENSCAFT00845003507.1 UniProtKB/TrEMBL
InterPro Natr_peptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Natr_peptide_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Natriuretic_peptide_atrial UniProtKB/TrEMBL
  Natriuretic_peptide_brain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:487441 UniProtKB/TrEMBL
NCBI Gene NPPB ENTREZGENE
PANTHER ATRIAL NATRIURETIC FACTOR PRECURSOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NATRIURETIC PEPTIDES A UniProtKB/TrEMBL
  NATRIURETIC PEPTIDES B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ANP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ANATPEPTIDE UniProtKB/TrEMBL
  BNATPEPTIDE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NATPEPTIDES UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NATRIURETIC_PEPTIDE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART NAT_PEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I3MHJ9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MJH6_CANLF UniProtKB/TrEMBL
  A0A8I3MJW9_CANLF UniProtKB/TrEMBL
  A0A8P0PRD3 ENTREZGENE, UniProtKB/TrEMBL
  ANFB_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:43926 ENTREZGENE