ERBB2 (erb-b2 receptor tyrosine kinase 2) - Rat Genome Database

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Gene: ERBB2 (erb-b2 receptor tyrosine kinase 2) Canis lupus familiaris
Analyze
Symbol: ERBB2
Name: erb-b2 receptor tyrosine kinase 2
RGD ID: 12416215
Description: ENCODES a protein that exhibits growth factor binding (ortholog); Hsp90 protein binding (ortholog); protein tyrosine kinase activity (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); cellular response to epidermal growth factor stimulus (ortholog); cellular response to growth factor stimulus (ortholog); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; endometrial cancer pathway; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); amblyopia (ortholog); Animal Disease Models (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: c-erbB-2; HER-2; p185erbB2; proto-oncogene c-ErbB-2; receptor tyrosine-protein kinase erbB-2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,760,373 - 22,785,367 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,759,256 - 22,785,294 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha922,233,500 - 22,257,730 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,553,798 - 23,578,971 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,553,919 - 23,606,691 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1922,327,366 - 22,351,570 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,588,363 - 22,612,587 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,713,484 - 22,737,693 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
amblyopia  (ISO)
Animal Disease Models  (ISO)
Animal Mammary Neoplasms  (ISO)
basal cell carcinoma  (ISO)
Breast Cancer, Familial  (ISO)
Breast Neoplasms  (ISO)
calcinosis  (ISO)
Carcinogenesis  (ISO)
cholangiocarcinoma  (ISO)
Circulating Neoplastic Cells  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
Diabetic Cardiomyopathies  (ISO)
dilated cardiomyopathy  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
ductal carcinoma in situ  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
esophageal carcinoma  (ISO)
Esophageal Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Familial Visceral Neuropathy 2, Autosomal Recessive  (ISO)
gallbladder carcinoma  (ISO)
Gallbladder Neoplasms  (ISO)
gastric adenocarcinoma  (ISO)
Gastrointestinal Neoplasms  (ISO)
genetic disease  (ISO)
head and neck squamous cell carcinoma  (ISO)
Helicobacter Infections  (ISO)
HELLP syndrome  (ISO)
high grade glioma  (ISO)
Hirschsprung's disease  (ISO)
hypertrophic cardiomyopathy 25  (ISO)
interstitial cystitis  (ISO)
invasive ductal carcinoma  (ISO)
invasive lobular carcinoma  (ISO)
Kidney Neoplasms  (ISO)
laryngeal squamous cell carcinoma  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
mammary Paget's disease  (ISO)
median neuropathy  (ISO)
medulloblastoma  (ISO)
melanoma  (ISO)
Mouth Neoplasms  (ISO)
myelodysplastic syndrome  (ISO)
Myocardial Ischemia  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasm Recurrence, Local  (ISO)
nephroblastoma  (ISO)
oral squamous cell carcinoma  (ISO)
ovarian cancer  (ISO)
ovarian carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
ovarian serous cystadenocarcinoma  (ISO)
ovary adenocarcinoma  (ISO)
pancreatic adenocarcinoma  (ISO)
papillary renal cell carcinoma  (ISO)
papilloma  (ISO)
Parkinson's disease  (ISO)
pre-eclampsia  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
Recurrence  (ISO)
renal cell carcinoma  (ISO)
skin melanoma  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
stomach cancer  (ISO)
stomach carcinoma  (ISO)
Stomach Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)
uterine cancer  (ISO)
uterine carcinosarcoma  (ISO)
Uterine Cervical Neoplasms  (ISO)
Ventilator-Induced Lung Injury  (ISO)
Wallerian Degeneration  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
cell surface receptor signaling pathway  (IEA,ISO)
cellular response to epidermal growth factor stimulus  (IEA,ISS)
cellular response to growth factor stimulus  (IEA,ISS)
cellular response to mechanical stimulus  (ISO)
ERBB signaling pathway  (IEA)
ERBB2-EGFR signaling pathway  (IEA)
ERBB2-ERBB3 signaling pathway  (IEA)
ERBB2-ERBB4 signaling pathway  (IEA)
estrous cycle  (ISO)
glial cell differentiation  (ISO)
heart development  (IEA,ISO)
immature T cell proliferation in thymus  (IEA,ISO)
intracellular signal transduction  (IEA,ISS)
liver development  (ISO)
mammary gland involution  (ISO)
motor neuron axon guidance  (IEA,ISO)
myelination  (IEA,ISO)
negative regulation of apoptotic process  (IBA,IEA,ISO)
negative regulation of immature T cell proliferation in thymus  (IEA,ISO)
nervous system development  (IEA,ISO)
neurogenesis  (IBA)
neuromuscular junction development  (IEA,ISO)
neuron differentiation  (IBA,IEA)
neurotransmitter receptor localization to postsynaptic specialization membrane  (IEA)
oligodendrocyte differentiation  (IEA,ISO)
peripheral nervous system development  (IEA,ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of cell adhesion  (IEA)
positive regulation of cell growth  (IEA,ISS)
positive regulation of cell population proliferation  (IBA,IEA,ISO)
positive regulation of epithelial cell proliferation  (IEA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of MAPK cascade  (IBA,IEA,ISO)
positive regulation of membrane permeability  (ISO)
positive regulation of neural precursor cell proliferation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein phosphorylation  (IEA)
positive regulation of protein targeting to membrane  (IEA,ISS)
positive regulation of Ras protein signal transduction  (ISO)
positive regulation of Rho protein signal transduction  (IEA)
positive regulation of transcription by RNA polymerase I  (IEA,ISS)
positive regulation of translation  (IEA,ISS)
protein autophosphorylation  (ISO)
regulation of cell communication  (IEA)
regulation of cell population proliferation  (IEA)
regulation of ERK1 and ERK2 cascade  (IEA,ISS)
regulation of microtubule-based process  (IEA,ISS)
regulation of signaling  (IEA)
response to axon injury  (ISO)
response to progesterone  (ISO)
response to vitamin D  (ISO)
response to xenobiotic stimulus  (ISO)
Schwann cell development  (IEA)
semaphorin-plexin signaling pathway  (IEA)
signal transduction  (IEA)
skeletal muscle tissue development  (ISO)
sympathetic nervous system development  (ISO)
tongue development  (ISO)
wound healing  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:18061495   PMID:19010331   PMID:19017630   PMID:22301074   PMID:23141215   PMID:24060151   PMID:26088453   PMID:27490467   PMID:30032202   PMID:31431454   PMID:37756605  


Genomics

Comparative Map Data
ERBB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,760,373 - 22,785,367 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,759,256 - 22,785,294 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha922,233,500 - 22,257,730 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,553,798 - 23,578,971 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,553,919 - 23,606,691 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1922,327,366 - 22,351,570 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,588,363 - 22,612,587 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,713,484 - 22,737,693 (-)NCBIUU_Cfam_GSD_1.0
ERBB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381739,688,094 - 39,728,658 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1739,687,914 - 39,730,426 (+)EnsemblGRCh38hg38GRCh38
GRCh371737,844,347 - 37,884,911 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,097,919 - 35,138,441 (+)NCBINCBI36Build 36hg18NCBI36
Build 341735,109,779 - 35,138,441NCBI
Celera1734,504,111 - 34,544,648 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1733,638,318 - 33,678,659 (+)NCBIHuRef
CHM1_11738,080,177 - 38,120,667 (+)NCBICHM1_1
T2T-CHM13v2.01740,551,660 - 40,592,218 (+)NCBIT2T-CHM13v2.0
Erbb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,303,310 - 98,328,542 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,303,296 - 98,328,542 (+)EnsemblGRCm39 Ensembl
GRCm381198,412,484 - 98,437,716 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,412,470 - 98,437,716 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,273,798 - 98,299,030 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,228,574 - 98,253,806 (+)NCBIMGSCv36mm8
Celera11108,066,701 - 108,091,920 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1161.75NCBI
Erbb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81083,907,491 - 83,931,365 (+)NCBIGRCr8
mRatBN7.21083,411,197 - 83,435,078 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,411,313 - 83,435,078 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,355,647 - 88,379,493 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01087,853,732 - 87,877,578 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,246,384 - 83,270,230 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,367,596 - 86,391,728 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,367,596 - 86,391,728 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,163,531 - 86,187,663 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,219,157 - 87,242,919 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11087,233,617 - 87,256,603 (+)NCBI
Celera1082,158,844 - 82,182,518 (+)NCBICelera
Cytogenetic Map10q31NCBI
Erbb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,442,816 - 14,459,379 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,442,816 - 14,456,009 (+)NCBIChiLan1.0ChiLan1.0
ERBB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21925,226,889 - 25,267,330 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11727,121,704 - 27,162,125 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01717,560,337 - 17,600,808 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11717,777,434 - 17,817,735 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,777,434 - 17,805,862 (-)Ensemblpanpan1.1panPan2
Erbb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560222,165,101 - 22,188,079 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649014,887,043 - 14,909,956 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649014,887,062 - 14,910,038 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERBB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,590,725 - 22,621,351 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,591,621 - 22,621,384 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21223,049,123 - 23,069,842 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ERBB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,435,488 - 66,464,993 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1666,434,251 - 66,464,952 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607737,344,961 - 37,374,824 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Erbb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,373,000 - 3,391,602 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247953,373,313 - 3,391,509 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ERBB2
282 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 1 13 6 6 6 2 10 6
Low 4 9 6 6 10 7
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001003217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022422534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB008451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB968244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU239091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU239092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU239093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU239094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU239095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU239096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM273109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000025936   ⟹   ENSCAFP00000024079
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl922,759,256 - 22,785,294 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000079078   ⟹   ENSCAFP00000063888
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl922,761,393 - 22,785,294 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000084545   ⟹   ENSCAFP00000054581
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl922,759,256 - 22,785,138 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845021300   ⟹   ENSCAFP00845016751
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl923,553,919 - 23,606,691 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845021390   ⟹   ENSCAFP00845016814
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl923,553,919 - 23,606,691 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845021520   ⟹   ENSCAFP00845016914
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl923,553,919 - 23,579,411 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845021567   ⟹   ENSCAFP00845016949
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl923,553,919 - 23,578,764 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845021595   ⟹   ENSCAFP00845016968
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl923,554,929 - 23,606,691 (-)Ensembl
RefSeq Acc Id: NM_001003217   ⟹   NP_001003217
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1922,761,031 - 22,785,294 (-)NCBI
Dog10K_Boxer_Tasha922,233,500 - 22,257,730 (-)NCBI
ROS_Cfam_1.0923,554,567 - 23,578,920 (-)NCBI
UMICH_Zoey_3.1922,327,366 - 22,351,570 (-)NCBI
UNSW_CanFamBas_1.0922,588,363 - 22,612,587 (-)NCBI
UU_Cfam_GSD_1.0922,713,484 - 22,737,693 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038674965   ⟹   XP_038530893
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0923,553,798 - 23,578,971 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001003217   ⟸   NM_001003217
- Peptide Label: precursor
- UniProtKB: A0A8C0N763 (UniProtKB/TrEMBL),   A0A8I3NJW9 (UniProtKB/TrEMBL),   A0A8C0R5Y5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000024079   ⟸   ENSCAFT00000025936
RefSeq Acc Id: ENSCAFP00000054581   ⟸   ENSCAFT00000084545
RefSeq Acc Id: ENSCAFP00000063888   ⟸   ENSCAFT00000079078
RefSeq Acc Id: XP_038530893   ⟸   XM_038674965
- Peptide Label: isoform X1
- UniProtKB: A0A8C0R5Y5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845016814   ⟸   ENSCAFT00845021390
RefSeq Acc Id: ENSCAFP00845016949   ⟸   ENSCAFT00845021567
RefSeq Acc Id: ENSCAFP00845016968   ⟸   ENSCAFT00845021595
RefSeq Acc Id: ENSCAFP00845016914   ⟸   ENSCAFT00845021520
RefSeq Acc Id: ENSCAFP00845016751   ⟸   ENSCAFT00845021300
Protein Domains
Protein kinase

Promoters
RGD ID:13684551
Promoter ID:EPDNEW_C2619
Type:multiple initiation site
Name:ERBB2_1
Description:erb-b2 receptor tyrosine kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1922,785,275 - 22,785,335EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016351 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030011137 UniProtKB/TrEMBL
  ENSCAFG00040001791 UniProtKB/TrEMBL
  ENSCAFG00845011735 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000025936.5 UniProtKB/TrEMBL
  ENSCAFT00000079078.2 UniProtKB/TrEMBL
  ENSCAFT00000084545.2 UniProtKB/TrEMBL
  ENSCAFT00000098021.1 UniProtKB/TrEMBL
  ENSCAFT00000098142.1 UniProtKB/TrEMBL
  ENSCAFT00030020987.1 UniProtKB/TrEMBL
  ENSCAFT00030021185.1 UniProtKB/TrEMBL
  ENSCAFT00030021257.1 UniProtKB/TrEMBL
  ENSCAFT00030021319.1 UniProtKB/TrEMBL
  ENSCAFT00040003493.1 UniProtKB/TrEMBL
  ENSCAFT00040003552.1 UniProtKB/TrEMBL
  ENSCAFT00040003600.1 UniProtKB/TrEMBL
  ENSCAFT00040003611.1 UniProtKB/TrEMBL
  ENSCAFT00845021300.1 UniProtKB/TrEMBL
  ENSCAFT00845021390 ENTREZGENE
  ENSCAFT00845021390.1 UniProtKB/TrEMBL
  ENSCAFT00845021520 ENTREZGENE
  ENSCAFT00845021520.1 UniProtKB/TrEMBL
  ENSCAFT00845021567.1 UniProtKB/TrEMBL
  ENSCAFT00845021595.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.20.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cytochrome c1, transmembrane anchor, C-terminal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  membrane-bound form of the juxtamembrane domain of the epidermal growth factor receptor like domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Furin-like_Cys-rich_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Furin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GF_recep_IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rcpt_L-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rcpt_L-dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TM_ErbB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_EGF/ERB/XmrK_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene ERBB2 ENTREZGENE
PANTHER RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Furin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GF_recep_IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Recep_L_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TM_ErbB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF TyrPK_EGF-R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00261 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A060PY73_CANLF UniProtKB/TrEMBL
  A0A8C0N3C4_CANLF UniProtKB/TrEMBL
  A0A8C0N763 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0NAZ5_CANLF UniProtKB/TrEMBL
  A0A8C0PVY1_CANLF UniProtKB/TrEMBL
  A0A8C0Q7N3_CANLF UniProtKB/TrEMBL
  A0A8C0R5Y5 ENTREZGENE
  A0A8I3NBI5_CANLF UniProtKB/TrEMBL
  A0A8I3NHN0_CANLF UniProtKB/TrEMBL
  A0A8I3NJW9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NLT7_CANLF UniProtKB/TrEMBL
  A0A8I3RZ72_CANLF UniProtKB/TrEMBL
  A0A8P0TRK1_CANLF UniProtKB/TrEMBL
  ERBB2_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:40436 ENTREZGENE