TFRC (transferrin receptor) - Rat Genome Database

Name: TFRC
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: TFRC (transferrin receptor) Canis lupus familiaris

Analyze

Symbol:

TFRC

Name:

transferrin receptor

RGD ID:

12416162

Description:

ENCODES a protein that exhibits Hsp70 protein binding (ortholog); protein-folding chaperone binding (ortholog); transferrin receptor activity (ortholog); INVOLVED IN acute-phase response (ortholog); cellular response to leukemia inhibitory factor (ortholog); cellular response to xenobiotic stimulus (ortholog); PARTICIPATES IN forkhead class A signaling pathway; hypoxia inducible factor pathway; iron uptake pathway; ASSOCIATED WITH Acute-Phase Reaction (ortholog); Arenaviridae infectious disease (ortholog); autism spectrum disorder (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); perinuclear region of cytoplasm (ortholog); INTERACTS WITH mocetinostat

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

tfR; tfR1; TR; transferrin receptor (p90, CD71); transferrin receptor protein 1; trfr

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TFRC (transferrin receptor)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, PhylomeDB, Treefam
Mus musculus (house mouse):	Tfrc (transferrin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Tfrc (transferrin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tfrc (transferrin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TFRC (transferrin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tfrc (transferrin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TFRC (transferrin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TFRC (transferrin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tfrc (transferrin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	33	29,206,024 - 29,237,221 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	33	29,208,609 - 29,238,242 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	33	29,234,803 - 29,256,627 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	33	29,440,415 - 29,471,780 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	33	29,440,415 - 29,471,756 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	33	29,229,617 - 29,251,398 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	33	29,284,382 - 29,306,157 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	33	29,905,548 - 29,927,547 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute-Phase Reaction (ISO)

Arenaviridae infectious disease (ISO)

autism spectrum disorder (ISO)

autistic disorder (ISO)

B-Cell Chronic Lymphocytic Leukemia (ISO)

beta thalassemia (ISO)

breast cancer (ISO)

breast carcinoma (ISO)

Breast Neoplasms (ISO)

celiac disease (ISO)

cervical adenocarcinoma (ISO)

chromosome 3q29 microdeletion syndrome (ISO)

Chronic Cerebral Hypoperfusion (ISO)

Colorectal Neoplasms (ISO)

combined immunodeficiency (ISO)

duodenal ulcer (ISO)

genetic disease (ISO)

Helicobacter Infections (ISO)

hepatocellular carcinoma (ISO)

hereditary breast ovarian cancer syndrome (ISO)

high grade glioma (ISO)

hypochromic microcytic anemia (ISO)

immunodeficiency 46 (ISO)

Inflammation (ISO)

iron deficiency anemia (ISO)

iron metabolism disease (ISO)

Lung Neoplasms (ISO)

Lymphoma, AIDS-Related (ISO)

metabolic dysfunction-associated steatotic liver disease (ISO)

multiple myeloma (ISO)

muscular atrophy (ISO)

Myocardial Ischemia (ISO)

Myocardial Reperfusion Injury (ISO)

Neoplastic Cell Transformation (ISO)

non-Hodgkin lymphoma (ISO)

nutrition disease (ISO)

obesity (ISO)

ovarian cancer (ISO)

Phyllodes Tumor (ISO)

polycystic ovary syndrome (ISO)

prostate cancer (ISO)

renal cell carcinoma (ISO)

schizophrenia (ISO)

severe combined immunodeficiency (ISO)

sideroblastic anemia (ISO)

Spontaneous Abortions (ISO)

transitional cell carcinoma (ISO)

urinary bladder cancer (ISO)

Weissenbacher-Zweymuller syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

mocetinostat (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acute-phase response (ISO)

cellular response to leukemia inhibitory factor (IEA,ISO)

cellular response to xenobiotic stimulus (IEA,ISO)

endocytosis (IEA)

intracellular iron ion homeostasis (IBA,IEA,ISO)

intracellular signal transduction (IEA)

iron ion transport (IBA,IEA)

negative regulation of apoptotic process (IEA)

negative regulation of mitochondrial fusion (IEA)

osteoclast differentiation (IEA)

positive regulation of B cell proliferation (IEA,ISS)

positive regulation of bone resorption (IEA)

positive regulation of canonical NF-kappaB signal transduction (IEA)

positive regulation of gene expression (IEA)

positive regulation of isotype switching (IEA,ISS)

positive regulation of peptidyl-serine phosphorylation (IEA)

positive regulation of protein localization to nucleus (IEA)

positive regulation of protein phosphorylation (IEA)

positive regulation of protein-containing complex assembly (IEA)

positive regulation of T cell proliferation (IEA,ISS)

receptor internalization (IEA,ISS)

regulation of cell growth (ISO)

regulation of cell population proliferation (ISO)

regulation of postsynaptic membrane neurotransmitter receptor levels (ISO)

response to copper ion (ISO)

response to hypoxia (ISO)

response to inorganic substance (ISO)

response to iron ion (ISO)

response to manganese ion (ISO)

response to nutrient (ISO)

response to organic substance (ISO)

response to retinoic acid (ISO)

transferrin transport (IEA,ISS)

Cellular Component

basolateral plasma membrane (IEA)

cell surface (IEA,ISO)

clathrin-coated pit (IEA)

cytoplasmic vesicle (IEA)

early endosome (IEA)

endosome (IEA)

endosome membrane (IEA)

external side of plasma membrane (IBA,IEA)

extracellular exosome (IEA)

extracellular region (IEA)

extracellular space (ISO)

HFE-transferrin receptor complex (IEA)

intracellular membrane-bounded organelle (IEA)

melanosome (IEA)

membrane (IEA)

perinuclear region of cytoplasm (IEA,ISO)

plasma membrane (IEA)

postsynapse (ISO)

recycling endosome (IEA)

recycling endosome membrane (ISO)

Molecular Function

double-stranded RNA binding (IEA)

Hsp70 protein binding (ISO)

identical protein binding (IEA)

protein binding (ISO)

protein homodimerization activity (IEA)

protein kinase binding (IEA)

protein-containing complex binding (IEA)

protein-folding chaperone binding (ISO)

transferrin receptor activity (IEA,ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

forkhead class A signaling pathway (ISO)

hypoxia inducible factor pathway (ISO)

iron uptake pathway (ISO)

References

Additional References at PubMed

PMID:11264378	PMID:16912298	PMID:18003730	PMID:22301074	PMID:23749212	PMID:24089666	PMID:25375184	PMID:30032202

Genomics

Comparative Map Data

TFRC
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	33	29,206,024 - 29,237,221 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	33	29,208,609 - 29,238,242 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	33	29,234,803 - 29,256,627 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	33	29,440,415 - 29,471,780 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	33	29,440,415 - 29,471,756 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	33	29,229,617 - 29,251,398 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	33	29,284,382 - 29,306,157 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	33	29,905,548 - 29,927,547 (-)	NCBI		UU_Cfam_GSD_1.0

TFRC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	196,049,284 - 196,082,090 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	196,012,511 - 196,082,153 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	195,776,155 - 195,808,961 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	197,260,744 - 197,293,338 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	197,264,659 - 197,297,251	NCBI
Celera	3	194,360,605 - 194,393,477 (-)	NCBI		Celera
Cytogenetic Map	3	q29	NCBI
HuRef	3	193,076,917 - 193,109,375 (-)	NCBI		HuRef
CHM1_1	3	195,747,516 - 195,780,405 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	198,738,962 - 198,802,440 (-)	NCBI		T2T-CHM13v2.0

Tfrc
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	32,427,714 - 32,451,612 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	32,427,738 - 32,451,612 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	32,608,896 - 32,632,794 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	32,608,920 - 32,632,794 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	32,608,982 - 32,632,880 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	32,528,768 - 32,552,537 (+)	NCBI		MGSCv36	mm8
Celera	16	33,088,313 - 33,112,331 (+)	NCBI		Celera
Cytogenetic Map	16	B3	NCBI
cM Map	16	23.06	NCBI

Tfrc
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	81,668,478 - 81,690,318 (-)	NCBI		GRCr8
mRatBN7.2	11	68,163,413 - 68,185,257 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	68,163,413 - 68,185,257 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	77,000,479 - 77,022,314 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	69,663,759 - 69,685,697 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	68,689,586 - 68,711,424 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	71,397,423 - 71,419,263 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	71,397,383 - 71,419,223 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	74,479,841 - 74,502,561 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	69,976,258 - 69,998,098 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	70,034,788 - 70,049,347 (-)	NCBI
Celera	11	67,596,761 - 67,618,555 (-)	NCBI		Celera
Cytogenetic Map	11	q22	NCBI

Tfrc
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	12,348,821 - 12,372,691 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	12,348,392 - 12,372,714 (-)	NCBI	ChiLan1.0	ChiLan1.0

TFRC
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	193,908,901 - 193,941,619 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	193,913,621 - 193,946,338 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	193,384,817 - 193,417,532 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	203,333,953 - 203,365,586 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	203,333,953 - 203,373,998 (-)	Ensembl	panpan1.1		panPan2

Tfrc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	125,156,856 - 125,188,523 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936784	696,713 - 728,543 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936784	696,738 - 728,385 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TFRC
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	133,970,985 - 134,000,276 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	133,976,765 - 133,997,554 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	143,414,634 - 143,435,426 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TFRC
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	91,102,153 - 91,134,994 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	91,102,817 - 91,135,584 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	64,945,566 - 64,977,969 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tfrc
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	61,285,334 - 61,313,550 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	61,282,650 - 61,313,487 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in TFRC
330 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium	3	5	11	2	1	2	5	1	6		10	3
Low	2		11	4	5	4	1	5	6	8		3
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001003111	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005639448	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038444561	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF297626	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000336	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000078	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000367	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KJ813896	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000020544 ⟹ ENSCAFP00000019067

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	33	29,208,609 - 29,238,242 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845052866 ⟹ ENSCAFP00845041509

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	33	29,440,415 - 29,471,756 (-)	Ensembl

RefSeq Acc Id:

NM_001003111 ⟹ NP_001003111

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	33	29,208,829 - 29,230,606 (-)	NCBI
Dog10K_Boxer_Tasha	33	29,234,803 - 29,256,627 (-)	NCBI
ROS_Cfam_1.0	33	29,443,220 - 29,465,185 (-)	NCBI
UMICH_Zoey_3.1	33	29,229,617 - 29,251,398 (-)	NCBI
UNSW_CanFamBas_1.0	33	29,284,382 - 29,306,157 (-)	NCBI
UU_Cfam_GSD_1.0	33	29,905,548 - 29,927,547 (-)	NCBI

Sequence:

show sequence

ATGATGGATCAAGCCAGATCAGCATTCTCTACCTTGTTTGGTGGAGAACCATTGTCCTATACCC
GGTTTAGTCTGGCACGGCAAGTAGATGGTGATAACAGCCATGTGGAGATGAAACTAGCTGCAGA
TGAAGAAGAAAATGTTGACAATAACATGAGGGGTAATCATGCCAGTGTCCCAAAACCAAAAAGG
TGTAATGGATTTATCTGCTATGGGACTATTGCTGTAGTCCTCTTTTTCTTGATTGGATTTATGA
TTGGCTACTTGGGCTACTGTAAACGTGTAGAACCAAAAGCTGGATGTGAAAGACCAACAGGAAC
AGAGGCTCTGGGGACAGAGAGAACAGAACCCTCAGAAACAGAAGAGTACTTCCCTGAAACACCT
TCTCGCTTATTTTGGACGGACCTCAAAACAATGTTGTCAGAGAGACTGAGTAACACAGATTTCA
CCAACACCATGAGGTGGCTGAATGAAAATTCGTATGTGCCTCGTGAGGCTGGATCTCAAAAAGA
TGAAAGCCTTGCTTTATTAATTGAGAATCGATTCCGTGAATTTCAACTTAGCAAATCCTGGCGT
GATGAACATTTTGTTGAGATCCAGGTCAAAAGCAGCAATGCTCAAAACACGGTGACCATAGTGG
ATATGGAGAGTGACTTGGTATACCTGGCGGAGAGTCCTGAGGGTTACGTGGCATACAGTAAGGC
AACGACAGTTACCGGTAGATTGGTCCATGTTAATTTTGGCACCAAAAAAGACTTCGAGAATTTA
AAATCTCCTGTGAATGGATCTTTAGTGATCGCTAGAGCAGGGAAAATCACTTTTGCTGAAAAGG
TTGCAAACGCTCAAAGTTATAATGCACTTGGTGTCTTGATATACATGGACCAGGCTAGATTTCC
AATTGTTAATGCACGGATTCCATTCTTTGGACATGCTCACCTGGGAACAGGTGACCCGTACACG
CCTGGATTCCCGTCATTCAATCACACTCAGTTTCCACCGTCTCAGTCGTCAGGATTGCCCAGCA
TACCTGTCCAAACAATTTCCAGAGCTGCTGCAGAAAAGTTGTTTGAAAATATGGAAGGAGACTG
TCCTTCTGCCTGGGAAATAGACCCCTCGTGTAGGCTGGAAACGTCCTCAAACAAGAATGTGAAT
CTCACTGTGAACAATGTGCTGAAAGAGATAAGAATTTTTAACGTTTTTGGAGTTATTAAAGGTT
TTGAAGAACCTGATCGCTATGTTGTAATAGGGGCTCAGAGGGATGCCTGGGGTCCTGGAGCTGC
AAAGTCTAGCGTAGGAACAGCTCTCCTATTGGAACTTGCCCGGATATTCTCTGATATGGTCTTA
AAAGGTGGCTTTAAACCCAGCAGAAGCATTGTCTTTGCCAGCTGGAGTGCTGGAGACTTTGGAG
CAATTGGTGCCACTGAATGGCTAGAGGGATACCTTTCTTCCTTGCATTTAAAGGCTTTCACTTA
CATTAATCTGGATAAAGCTATTCTTGGTACCAGCAACTTCAAGGTTTCTGCAAGCCCACTGTTA
TATTCACTTCTTGAGAAAACGATGAAAGATGTGAAACATCCAATTACTGGGCAGTCTCTTTATC
GGGACAGCAACTGGATCAACAAAGTCGAGAAATTGTCTTTGGATAATGCTGCTTTCCCTTTCCT
TGCGTATTCTGGAATCCCAGCAGTTTCTTTCTGTTTTTGTGAGGACACAGATTATCCTTACTTG
GGTACTACCATGGATCTCTATGAGAACCTGAATCAGAAAATTCCTCAGTTGAACAAAATGGCAC
GTGGAGCAGCAGAAGTAGCTGGTCAGCTTATAATGAAACTTACCTATGATCTTGAATTGAACCT
GAACTACGAGATGTATAATGACAGAATACTTTCATTTGTGAGGGATATGAACCAATTCAGGACA
GACATAAAGGAGATGGGTCTGAACCTACAGTGGCTGTATTCTGCTCGTGGAGACTTTTTCCGAG
CCACCTCCAGACTAACGACAGATTATAAGAACGCAGAGAGAACAAACAGATTTGTTATGAGGGA
GATCAATGACCGTATCATGAAAGTGGAACATAACTTCCTGTCACCCTATGTATCTCCAAGAGAT
TCTCCTTTCCGTCATATCTTCTGGGGTTCTGGCTCTCACACTCTGCCAGCTTTAGTGGAGCATT
TGAAGCTGCGTCAGAAAAATAAGAGTGCTTTTAATGAAACACTGTTGAGAAATCAGTTGGCTCT
AGCAACTTGGACCATTCAAGGAGCTGCAAATGCCCTCTCTGGTGACATATGGGATATTGACAAT
GAGTTTTAA

hide sequence

RefSeq Acc Id:

XM_038444561 ⟹ XP_038300489

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	33	29,440,415 - 29,471,780 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001003111	(Get FASTA)	NCBI Sequence Viewer
	XP_038300489	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG24850	(Get FASTA)	NCBI Sequence Viewer
	AIV42367	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000019067.5
	ENSCAFP00040041457.1
	ENSCAFP00845041509
	ENSCAFP00845041509.1
GenBank Protein	Q9GLD3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001003111 ⟸ NM_001003111

- UniProtKB:

Q9GLD3 (UniProtKB/Swiss-Prot), A0A8C0TWP3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MMDQARSAFSTLFGGEPLSYTRFSLARQVDGDNSHVEMKLAADEEENVDNNMRGNHASVPKPKR
CNGFICYGTIAVVLFFLIGFMIGYLGYCKRVEPKAGCERPTGTEALGTERTEPSETEEYFPETP
SRLFWTDLKTMLSERLSNTDFTNTMRWLNENSYVPREAGSQKDESLALLIENRFREFQLSKSWR
DEHFVEIQVKSSNAQNTVTIVDMESDLVYLAESPEGYVAYSKATTVTGRLVHVNFGTKKDFENL
KSPVNGSLVIARAGKITFAEKVANAQSYNALGVLIYMDQARFPIVNARIPFFGHAHLGTGDPYT
PGFPSFNHTQFPPSQSSGLPSIPVQTISRAAAEKLFENMEGDCPSAWEIDPSCRLETSSNKNVN
LTVNNVLKEIRIFNVFGVIKGFEEPDRYVVIGAQRDAWGPGAAKSSVGTALLLELARIFSDMVL
KGGFKPSRSIVFASWSAGDFGAIGATEWLEGYLSSLHLKAFTYINLDKAILGTSNFKVSASPLL
YSLLEKTMKDVKHPITGQSLYRDSNWINKVEKLSLDNAAFPFLAYSGIPAVSFCFCEDTDYPYL
GTTMDLYENLNQKIPQLNKMARGAAEVAGQLIMKLTYDLELNLNYEMYNDRILSFVRDMNQFRT
DIKEMGLNLQWLYSARGDFFRATSRLTTDYKNAERTNRFVMREINDRIMKVEHNFLSPYVSPRD
SPFRHIFWGSGSHTLPALVEHLKLRQKNKSAFNETLLRNQLALATWTIQGAANALSGDIWDIDN
EF

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RefSeq Acc Id:

ENSCAFP00000019067 ⟸ ENSCAFT00000020544

RefSeq Acc Id:	XP_038300489 ⟸ XM_038444561
- Peptide Label:	isoform X1
- UniProtKB:	A0A0A0RDI7 (UniProtKB/TrEMBL), A0A0A0RBT6 (UniProtKB/TrEMBL), A0A8P0NER3 (UniProtKB/TrEMBL), A0A8C0TWP3 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845041509 ⟸ ENSCAFT00845052866

Protein Domains

PA Peptidase M28 Transferrin receptor-like dimerisation

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000012941	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00040025454	UniProtKB/TrEMBL
	ENSCAFG00845029840	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000020544.5	UniProtKB/TrEMBL
	ENSCAFT00040047496.1	UniProtKB/TrEMBL
	ENSCAFT00845052866	ENTREZGENE
	ENSCAFT00845052866.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.930.40	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.50.30.30	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Zn peptidases	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	PA_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PA_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_M28	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_M28B	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TFR-like_dimer_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TFR-like_dimer_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TfR1/2_PA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	cfa:403703	UniProtKB/Swiss-Prot
NCBI Gene	TFRC	ENTREZGENE
PANTHER	PTHR10404	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10404:SF26	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Peptidase_M28	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PF02225	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TFR_dimer	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	PA domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF47672	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Zn-dependent exopeptidases	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0A0RBT6	ENTREZGENE, UniProtKB/TrEMBL
	A0A0A0RDI7	ENTREZGENE
	A0A8C0TWP3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0NER3	ENTREZGENE, UniProtKB/TrEMBL
	Q9GLD3	ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID	VGNC:47305	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)