AQP4 (aquaporin 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: AQP4 (aquaporin 4) Canis lupus familiaris
Analyze
Symbol: AQP4
Name: aquaporin 4
RGD ID: 12385289
Description: ENCODES a protein that exhibits identical protein binding (ortholog); water channel activity (ortholog); INVOLVED IN carbon dioxide transport (ortholog); cell-cell adhesion (ortholog); cellular response to estradiol stimulus (ortholog); PARTICIPATES IN water transport pathway; ASSOCIATED WITH Alpers-Huttenlocher syndrome (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN astrocyte end-foot (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: aquaporin-4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1761,855,617 - 61,868,953 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl761,855,744 - 61,865,089 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha761,290,817 - 61,304,150 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0761,906,422 - 61,919,761 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl761,906,451 - 61,926,075 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1761,579,168 - 61,592,459 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0761,591,530 - 61,604,873 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0761,894,861 - 61,908,198 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21543416   PMID:22301074   PMID:24058510   PMID:24950246   PMID:27357498   PMID:30032202  


Genomics

Comparative Map Data
AQP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1761,855,617 - 61,868,953 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl761,855,744 - 61,865,089 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha761,290,817 - 61,304,150 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0761,906,422 - 61,919,761 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl761,906,451 - 61,926,075 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1761,579,168 - 61,592,459 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0761,591,530 - 61,604,873 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0761,894,861 - 61,908,198 (+)NCBIUU_Cfam_GSD_1.0
AQP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381826,852,038 - 26,865,803 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1826,852,043 - 26,865,771 (-)EnsemblGRCh38hg38GRCh38
GRCh371824,432,002 - 24,445,767 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361822,686,005 - 22,699,714 (-)NCBINCBI36Build 36hg18NCBI36
Build 341822,686,007 - 22,699,714NCBI
Celera1821,242,174 - 21,255,883 (-)NCBICelera
Cytogenetic Map18q11.2NCBI
HuRef1821,281,696 - 21,295,401 (-)NCBIHuRef
CHM1_11824,359,750 - 24,373,454 (-)NCBICHM1_1
T2T-CHM13v2.01827,046,091 - 27,059,856 (-)NCBIT2T-CHM13v2.0
Aqp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391815,522,451 - 15,544,039 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1815,522,553 - 15,544,039 (-)EnsemblGRCm39 Ensembl
GRCm381815,389,394 - 15,410,982 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1815,389,496 - 15,410,982 (-)EnsemblGRCm38mm10GRCm38
MGSCv371815,547,903 - 15,562,193 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361815,535,839 - 15,546,671 (-)NCBIMGSCv36mm8
Celera1815,609,213 - 15,623,487 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map188.74NCBI
Aqp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,782,389 - 6,799,034 (-)NCBIGRCr8
mRatBN7.2186,507,903 - 6,524,558 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl186,507,903 - 6,524,856 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx186,733,660 - 6,750,099 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0187,521,314 - 7,537,753 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,792,881 - 6,809,322 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0186,766,009 - 6,782,757 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,765,945 - 6,782,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,720,759 - 6,737,703 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4186,626,313 - 6,642,766 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1186,628,189 - 6,642,700 (-)NCBI
Celera186,530,014 - 6,546,446 (-)NCBICelera
RH 3.4 Map1878.3RGD
RH 3.4 Map1886.21RGD
Cytogenetic Map18p13NCBI
Aqp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049557721,159 - 10,709 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049557721,160 - 10,709 (+)NCBIChiLan1.0ChiLan1.0
AQP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21744,280,877 - 44,294,636 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11829,973,472 - 29,987,231 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01820,108,607 - 20,122,381 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11823,713,141 - 23,726,919 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1823,713,146 - 23,726,919 (-)Ensemblpanpan1.1panPan2
Aqp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494457,872,160 - 57,884,958 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365505,931,194 - 5,941,354 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365505,931,201 - 5,943,999 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AQP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6111,407,639 - 111,422,109 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16111,407,632 - 111,422,169 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26104,387,592 - 104,394,409 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AQP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11853,729,143 - 53,742,916 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1853,729,186 - 53,743,156 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605028,456,973 - 28,470,756 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aqp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247705,580,808 - 5,594,628 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247705,581,192 - 5,593,470 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in AQP4
167 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 2 7 3
Low 4 4 9 3 4 2 7 6
Below cutoff 1 1 11 5 3 5 6 3 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000028797   ⟹   ENSCAFP00000026782
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl761,855,744 - 61,865,089 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845021995   ⟹   ENSCAFP00845017292
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl761,906,451 - 61,926,075 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845022029   ⟹   ENSCAFP00845017317
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl761,906,451 - 61,915,745 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845022047   ⟹   ENSCAFP00845017333
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl761,906,451 - 61,915,658 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845022077   ⟹   ENSCAFP00845017358
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl761,906,492 - 61,919,758 (+)Ensembl
RefSeq Acc Id: XM_014115489   ⟹   XP_013970964
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1761,856,152 - 61,868,953 (+)NCBI
Dog10K_Boxer_Tasha761,291,330 - 61,304,150 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038482185   ⟹   XP_038338113
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1761,579,168 - 61,592,459 (+)NCBI
RefSeq Acc Id: XM_038482186   ⟹   XP_038338114
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1761,579,681 - 61,592,459 (+)NCBI
RefSeq Acc Id: XM_038543616   ⟹   XP_038399544
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0761,894,861 - 61,908,198 (+)NCBI
RefSeq Acc Id: XM_038543617   ⟹   XP_038399545
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0761,895,374 - 61,908,198 (+)NCBI
RefSeq Acc Id: XM_038607739   ⟹   XP_038463667
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0761,591,530 - 61,604,873 (+)NCBI
RefSeq Acc Id: XM_038607740   ⟹   XP_038463668
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0761,592,043 - 61,604,873 (+)NCBI
RefSeq Acc Id: XM_038672420   ⟹   XP_038528348
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0761,906,422 - 61,919,761 (+)NCBI
RefSeq Acc Id: XM_038672421   ⟹   XP_038528349
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0761,906,935 - 61,919,761 (+)NCBI
RefSeq Acc Id: XM_850363   ⟹   XP_855456
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1761,855,617 - 61,868,953 (+)NCBI
Dog10K_Boxer_Tasha761,290,817 - 61,304,150 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_855456   ⟸   XM_850363
- Peptide Label: isoform X1
- UniProtKB: A0A8C0R0F3 (UniProtKB/TrEMBL),   A0A8I3RX19 (UniProtKB/TrEMBL),   A0A8P0PLW3 (UniProtKB/TrEMBL),   A0A8I3NCC0 (UniProtKB/TrEMBL),   A0A8P0PNT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013970964   ⟸   XM_014115489
- Peptide Label: isoform X2
- UniProtKB: A0A8I3NCC0 (UniProtKB/TrEMBL),   A0A8P0PNT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000026782   ⟸   ENSCAFT00000028797
RefSeq Acc Id: XP_038338113   ⟸   XM_038482185
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038338114   ⟸   XM_038482186
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038463667   ⟸   XM_038607739
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038463668   ⟸   XM_038607740
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038528348   ⟸   XM_038672420
- Peptide Label: isoform X1
- UniProtKB: A0A8C0R0F3 (UniProtKB/TrEMBL),   A0A8I3RX19 (UniProtKB/TrEMBL),   A0A8P0PLW3 (UniProtKB/TrEMBL),   A0A8I3NCC0 (UniProtKB/TrEMBL),   A0A8P0PNT7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038528349   ⟸   XM_038672421
- Peptide Label: isoform X2
- UniProtKB: A0A8I3NCC0 (UniProtKB/TrEMBL),   A0A8P0PNT7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038399544   ⟸   XM_038543616
- Peptide Label: isoform X1
- UniProtKB: A0A8C0R0F3 (UniProtKB/TrEMBL),   A0A8I3NCC0 (UniProtKB/TrEMBL),   A0A8I3RX19 (UniProtKB/TrEMBL),   A0A8P0PLW3 (UniProtKB/TrEMBL),   A0A8P0PNT7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038399545   ⟸   XM_038543617
- Peptide Label: isoform X2
- UniProtKB: A0A8I3NCC0 (UniProtKB/TrEMBL),   A0A8P0PNT7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845017317   ⟸   ENSCAFT00845022029
RefSeq Acc Id: ENSCAFP00845017358   ⟸   ENSCAFT00845022077
RefSeq Acc Id: ENSCAFP00845017333   ⟸   ENSCAFT00845022047
RefSeq Acc Id: ENSCAFP00845017292   ⟸   ENSCAFT00845021995


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018125 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845012372 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000028797.5 UniProtKB/TrEMBL
  ENSCAFT00000100409.1 UniProtKB/TrEMBL
  ENSCAFT00000106129.1 UniProtKB/TrEMBL
  ENSCAFT00000107955.1 UniProtKB/TrEMBL
  ENSCAFT00845021995.1 UniProtKB/TrEMBL
  ENSCAFT00845022029.1 UniProtKB/TrEMBL
  ENSCAFT00845022047.1 UniProtKB/TrEMBL
  ENSCAFT00845022077 ENTREZGENE
  ENSCAFT00845022077.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1080.10 UniProtKB/TrEMBL
InterPro Aquaporin-like UniProtKB/TrEMBL
  Aquaporin_transptr UniProtKB/TrEMBL
  MIP UniProtKB/TrEMBL
  MIP_CS UniProtKB/TrEMBL
NCBI Gene AQP4 ENTREZGENE
PANTHER AQUAPORIN-4 UniProtKB/TrEMBL
  PTHR19139 UniProtKB/TrEMBL
Pfam MIP UniProtKB/TrEMBL
PRINTS AQUAPORIN4 UniProtKB/TrEMBL
  MINTRINSICP UniProtKB/TrEMBL
PROSITE MIP UniProtKB/TrEMBL
Superfamily-SCOP SSF81338 UniProtKB/TrEMBL
UniProt A0A8C0R0F3 ENTREZGENE
  A0A8I3NCC0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NP65_CANLF UniProtKB/TrEMBL
  A0A8I3RX19 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RZD2_CANLF UniProtKB/TrEMBL
  A0A8P0NJ47_CANLF UniProtKB/TrEMBL
  A0A8P0PLW3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PM88_CANLF UniProtKB/TrEMBL
  A0A8P0PNT7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:38018 ENTREZGENE