IGF1 (insulin like growth factor 1) - Rat Genome Database

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Gene: IGF1 (insulin like growth factor 1) Canis lupus familiaris
Analyze
Symbol: IGF1
Name: insulin like growth factor 1
RGD ID: 12378133
Description: ENCODES a protein that exhibits hormone activity (ortholog); insulin-like growth factor receptor binding (ortholog); protein serine/threonine kinase activator activity (ortholog); INVOLVED IN androgen receptor signaling pathway (ortholog); blood vessel remodeling (ortholog); bone development (ortholog); PARTICIPATES IN altered insulin-like growth factor signaling pathway; cardiovascular system disease pathway; ceramide signaling pathway; ASSOCIATED WITH acoustic neuroma (ortholog); acromegaly (ortholog); acute kidney failure (ortholog); FOUND IN alphav-beta3 integrin-IGF-1-IGF1R complex (ortholog); exocytic vesicle (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IGF-I; IGFI; IGFIA; insulin-like growth factor I; somatomedin C
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11541,203,320 - 41,275,964 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1541,202,518 - 41,275,794 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1541,571,399 - 41,643,792 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01541,855,737 - 41,930,681 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1541,856,552 - 41,930,595 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11541,124,961 - 41,197,284 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01541,221,486 - 41,300,498 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01541,495,479 - 41,567,874 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
acoustic neuroma  (ISO)
acromegaly  (ISO)
acute kidney failure  (ISO)
adenoma  (ISO)
Albuminuria  (ISO)
alcoholic neuropathy  (ISO)
alopecia  (ISO)
Alzheimer's disease  (ISO)
arteriosclerosis  (ISO)
autistic disorder  (ISO)
borna disease  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Burns  (ISO)
Cachexia  (ISO)
Cardiomegaly  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Closed Head Injuries  (ISO)
Cockayne syndrome  (ISO)
colitis  (ISO)
congenital diaphragmatic hernia  (ISO)
congenital disorder of glycosylation Ia  (ISO)
congenital hypothyroidism  (ISO)
congestive heart failure  (ISO)
corneal disease  (ISO)
Coronary Disease  (ISO)
coronary stenosis  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
Deafness  (ISO)
demyelinating disease  (ISO)
depressive disorder  (ISO)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Dwarfism  (ISO)
end stage renal disease  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
familial mediterranean fever  (ISO)
Female Urogenital Diseases  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (ISO)
Fetal Macrosomia  (ISO)
folic acid deficiency anemia  (ISO)
genetic disease  (ISO)
granulomatosis with polyangiitis  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
Growth Disorders  (ISO)
head and neck squamous cell carcinoma  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
Hyperoxia  (ISO)
Hyperphagia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypothyroidism  (ISO)
Insulin-Like Growth Factor I Deficiency  (ISO)
intellectual disability  (ISO)
Intervertebral Disc Displacement  (ISO)
kidney disease  (ISO)
Knee Osteoarthritis  (ISO)
Kuhnt-Junius degeneration  (ISO)
Laron syndrome  (ISO)
lung disease  (ISO)
Malocclusion  (ISO)
Metabolic Bone Diseases  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
microcephaly  (ISO)
middle cerebral artery infarction  (ISO)
muscular atrophy  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
myopia  (ISO)
Nasal Polyps  (ISO)
Neointima  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
Noonan syndrome  (ISO)
osteoarthritis  (ISO)
Osteophytes  (ISO)
osteoporosis  (ISO)
Osteoporotic Fractures  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
PEHO syndrome  (ISO)
peripheral nervous system disease  (ISO)
Pituitary Neoplasms  (ISO)
Plaque, Atherosclerotic  (ISO)
polycystic ovary syndrome  (ISO)
Postmenopausal Osteoporosis  (ISO)
Precocious Puberty  (ISO)
progeria  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
pulmonary fibrosis  (ISO)
pycnodysostosis  (ISO)
Reperfusion Injury  (ISO)
retinopathy of prematurity  (ISO)
rheumatic heart disease  (ISO)
Rhinosinusitis  (ISO)
Right Ventricular Hypertrophy  (ISO)
Sarcopenia  (ISO)
severe acute respiratory syndrome  (ISO)
Skin Neoplasms  (ISO)
Skull Fractures  (ISO)
Spontaneous Abortions  (ISO)
Stroke  (ISO)
Sudden Hearing Loss  (ISO)
Thinness  (ISO)
Tongue Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
Turner syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
uveal melanoma  (ISO)
vascular dementia  (ISO)
Wounds and Injuries  (ISO)
Zinc Deficiency  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
androgen receptor signaling pathway  (ISO)
blood vessel remodeling  (ISO)
bone development  (ISO)
bone mineralization involved in bone maturation  (IEA)
branching morphogenesis of an epithelial tube  (ISO)
cardiac atrium development  (ISO)
cell activation  (IEA,ISO)
cell development  (ISO)
cell population proliferation  (IBA,IEA,ISO)
cellular response to amyloid-beta  (IEA)
cellular response to dexamethasone stimulus  (ISO)
cellular response to electrical stimulus  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to nicotine  (ISO)
cellular response to progesterone stimulus  (ISO)
cellular response to Thyroglobulin triiodothyronine  (ISO)
cellular response to zinc ion starvation  (ISO)
cerebellar granule cell precursor proliferation  (ISO)
chondroitin sulfate proteoglycan biosynthetic process  (ISO)
circadian rhythm  (ISO)
cranial suture morphogenesis  (ISO)
detection of mechanical stimulus involved in sensory perception  (ISO)
exocrine pancreas development  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
female pregnancy  (ISO)
glial cell differentiation  (ISO)
inner ear development  (ISO)
insulin-like growth factor receptor signaling pathway  (IBA,IEA,ISO,ISS)
lung alveolus development  (ISO)
lung development  (ISO)
lung lobe morphogenesis  (ISO)
lung vasculature development  (ISO)
mammary gland development  (ISO)
memory  (ISO)
multicellular organism growth  (ISO)
muscle hypertrophy  (IEA)
myoblast differentiation  (IEA)
myoblast proliferation  (IEA)
myotube cell development  (IEA)
myotube differentiation  (ISO)
negative regulation of amyloid-beta formation  (IEA)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (IBA,IEA,ISO,ISS)
negative regulation of cell population proliferation  (ISO)
negative regulation of cholangiocyte apoptotic process  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IEA)
negative regulation of gene expression  (IEA)
negative regulation of immune system process  (ISO)
negative regulation of interleukin-1 beta production  (IEA)
negative regulation of muscle cell apoptotic process  (ISO)
negative regulation of neuroinflammatory response  (IEA)
negative regulation of oligodendrocyte apoptotic process  (ISO)
negative regulation of oocyte development  (IEA)
negative regulation of peptidyl-tyrosine phosphorylation  (ISO)
negative regulation of release of cytochrome c from mitochondria  (ISS)
negative regulation of smooth muscle cell apoptotic process  (IEA,ISS)
negative regulation of tumor necrosis factor production  (IEA)
negative regulation of vascular associated smooth muscle cell apoptotic process  (IEA)
nervous system development  (ISO)
osteoblast differentiation  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of activated T cell proliferation  (IEA)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of calcineurin-NFAT signaling cascade  (IEA)
positive regulation of cardiac muscle hypertrophy  (IEA)
positive regulation of cell growth  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cell population proliferation  (IBA,IEA,ISS)
positive regulation of cerebellar granule cell precursor proliferation  (ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of epithelial cell proliferation  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of fat cell differentiation  (ISO)
positive regulation of fibroblast proliferation  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of glial cell proliferation  (ISO)
positive regulation of glucose import  (IEA,ISS)
positive regulation of glycogen biosynthetic process  (IEA,ISS)
positive regulation of glycolytic process  (IEA)
positive regulation of glycoprotein biosynthetic process  (IEA)
positive regulation of insulin-like growth factor receptor signaling pathway  (IEA)
positive regulation of MAPK cascade  (IEA,ISS)
positive regulation of mitotic nuclear division  (IEA)
positive regulation of myelination  (ISO)
positive regulation of myoblast proliferation  (ISO)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA,IEA,ISO)
positive regulation of protein secretion  (IEA)
positive regulation of Ras protein signal transduction  (IEA)
positive regulation of smooth muscle cell migration  (IEA)
positive regulation of smooth muscle cell proliferation  (IEA)
positive regulation of steroid hormone biosynthetic process  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of trophectodermal cell proliferation  (IEA)
positive regulation of type B pancreatic cell proliferation  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA)
positive regulation of vascular endothelial cell proliferation  (ISO)
postsynaptic modulation of chemical synaptic transmission  (ISO)
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis  (ISO)
prostate gland epithelium morphogenesis  (ISO)
prostate gland growth  (ISO)
prostate gland stromal morphogenesis  (ISO)
protein stabilization  (IEA)
proteoglycan biosynthetic process  (IEA)
regulation of calcium ion transport  (ISO)
regulation of cell population proliferation  (ISO)
regulation of establishment or maintenance of cell polarity  (ISO)
regulation of gene expression  (IEA)
regulation of nitric oxide biosynthetic process  (ISO)
regulation of protein metabolic process  (ISO)
regulation of protein phosphorylation  (IBA,IEA,ISO)
regulation of translation  (ISO)
response to activity  (ISO)
response to caffeine  (ISO)
response to epidermal growth factor  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to glucocorticoid  (ISO)
response to growth hormone  (ISO)
response to heat  (IEA)
response to hypoxia  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to nicotine  (ISO)
response to nutrient  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to starvation  (ISO)
response to steroid hormone  (ISO)
response to thyroid hormone  (ISO)
retinal cell apoptotic process  (ISO)
signal transduction  (IEA)
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration  (IEA)
type B pancreatic cell proliferation  (ISO)
type I pneumocyte differentiation  (ISO)
type II pneumocyte differentiation  (ISO)
wound healing  (IEA)

References
Additional References at PubMed
PMID:8359700   PMID:17412960   PMID:17502080   PMID:18367392   PMID:19818143   PMID:20181231   PMID:20188584   PMID:20351102   PMID:20406781   PMID:21507690   PMID:22122898   PMID:22301074  
PMID:24674237   PMID:25619516   PMID:28101891   PMID:29755191   PMID:30125572   PMID:32861115   PMID:32894655  


Genomics

Comparative Map Data
IGF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11541,203,320 - 41,275,964 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1541,202,518 - 41,275,794 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1541,571,399 - 41,643,792 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01541,855,737 - 41,930,681 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1541,856,552 - 41,930,595 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11541,124,961 - 41,197,284 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01541,221,486 - 41,300,498 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01541,495,479 - 41,567,874 (-)NCBIUU_Cfam_GSD_1.0
IGF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812102,395,874 - 102,481,839 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12102,395,874 - 102,481,744 (-)EnsemblGRCh38hg38GRCh38
GRCh3712102,789,652 - 102,874,341 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612101,313,806 - 101,398,454 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412101,292,143 - 101,376,791NCBI
Celera12102,453,601 - 102,538,345 (-)NCBICelera
Cytogenetic Map12q23.2NCBI
HuRef1299,849,028 - 99,933,911 (-)NCBIHuRef
CHM1_112102,756,305 - 102,841,104 (-)NCBICHM1_1
T2T-CHM13v2.012102,357,015 - 102,443,074 (-)NCBIT2T-CHM13v2.0
Igf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391087,694,127 - 87,772,909 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1087,694,127 - 87,772,904 (+)EnsemblGRCm39 Ensembl
GRCm381087,858,265 - 87,937,047 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1087,858,265 - 87,937,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv371087,321,801 - 87,399,792 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361087,289,200 - 87,361,600 (+)NCBIMGSCv36mm8
Celera1089,837,923 - 89,916,340 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1043.7NCBI
Igf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8724,169,608 - 24,249,446 (+)NCBIGRCr8
mRatBN7.2722,282,895 - 22,361,972 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl722,282,930 - 22,359,296 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx724,277,579 - 24,351,455 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0726,440,272 - 26,514,144 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0726,217,310 - 26,291,178 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0728,412,123 - 28,491,815 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl728,412,198 - 28,486,609 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0728,528,165 - 28,607,747 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4724,531,669 - 24,605,742 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1724,553,367 - 24,625,089 (+)NCBI
Celera719,453,213 - 19,527,075 (+)NCBICelera
RH 3.4 Map7116.9RGD
RH 3.4 Map7118.8RGD
Cytogenetic Map7q13NCBI
Igf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540537,512,201 - 37,582,152 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540537,505,830 - 37,582,152 (-)NCBIChiLan1.0ChiLan1.0
IGF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210110,469,849 - 110,552,651 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112110,466,247 - 110,549,042 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01299,986,887 - 100,066,773 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112103,385,911 - 103,463,264 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12103,385,911 - 103,462,177 (-)Ensemblpanpan1.1panPan2
Igf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494518,699,022 - 18,773,635 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649211,709,222 - 11,778,351 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649211,709,623 - 11,784,028 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl581,775,970 - 81,848,033 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1581,762,027 - 81,909,253 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2585,700,439 - 85,773,714 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IGF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11197,624,498 - 97,708,730 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1197,631,189 - 97,707,308 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037147,296,425 - 147,379,600 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247505,881,091 - 5,952,300 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247505,881,065 - 5,954,799 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IGF1
479 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 7 6 5 6 1 6
Low 5 5 15 1 6 5 12 8 9
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000011690   ⟹   ENSCAFP00000010833
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1541,203,406 - 41,275,782 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000011691   ⟹   ENSCAFP00000010834
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1541,217,604 - 41,273,771 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000084052   ⟹   ENSCAFP00000058639
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1541,217,579 - 41,275,794 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000086858   ⟹   ENSCAFP00000046181
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1541,202,518 - 41,275,794 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000090952   ⟹   ENSCAFP00000051147
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1541,211,537 - 41,275,794 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845016544   ⟹   ENSCAFP00845012869
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1541,856,552 - 41,930,595 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845016576   ⟹   ENSCAFP00845012895
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1541,856,552 - 41,928,110 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845016603   ⟹   ENSCAFP00845012913
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1541,857,210 - 41,930,595 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845016630   ⟹   ENSCAFP00845012938
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1541,872,281 - 41,930,595 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845016662   ⟹   ENSCAFP00845012965
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1541,872,306 - 41,929,157 (-)Ensembl
RefSeq Acc Id: NM_001313855   ⟹   NP_001300784
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11541,203,406 - 41,275,782 (-)NCBI
Dog10K_Boxer_Tasha1541,571,399 - 41,643,792 (-)NCBI
ROS_Cfam_1.01541,858,098 - 41,930,494 (-)NCBI
UMICH_Zoey_3.11541,124,961 - 41,197,284 (-)NCBI
UNSW_CanFamBas_1.01541,221,486 - 41,300,498 (-)NCBI
UU_Cfam_GSD_1.01541,495,479 - 41,567,874 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038687202   ⟹   XP_038543130
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01541,868,582 - 41,930,681 (-)NCBI
RefSeq Acc Id: XM_038687203   ⟹   XP_038543131
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01541,868,575 - 41,928,559 (-)NCBI
RefSeq Acc Id: XM_038687204   ⟹   XP_038543132
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01541,855,737 - 41,930,681 (-)NCBI
RefSeq Acc Id: XM_038687205   ⟹   XP_038543133
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01541,855,737 - 41,928,559 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001300784   ⟸   NM_001313855
- Peptide Label: precursor
- UniProtKB: P33712 (UniProtKB/Swiss-Prot),   A0A8C0LJP4 (UniProtKB/TrEMBL),   A0A8C0SW86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000058639   ⟸   ENSCAFT00000084052
RefSeq Acc Id: ENSCAFP00000010834   ⟸   ENSCAFT00000011691
RefSeq Acc Id: ENSCAFP00000010833   ⟸   ENSCAFT00000011690
RefSeq Acc Id: ENSCAFP00000046181   ⟸   ENSCAFT00000086858
RefSeq Acc Id: ENSCAFP00000051147   ⟸   ENSCAFT00000090952
RefSeq Acc Id: XP_038543132   ⟸   XM_038687204
- Peptide Label: isoform X3
- UniProtKB: A0A8C0SXI4 (UniProtKB/TrEMBL),   A0A8C0LGN3 (UniProtKB/TrEMBL),   A0A8I3NN66 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038543133   ⟸   XM_038687205
- Peptide Label: isoform X4
- UniProtKB: A0A8C0MW23 (UniProtKB/TrEMBL),   A0A8I3N8M8 (UniProtKB/TrEMBL),   A0A8P0PGD5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038543131   ⟸   XM_038687203
- Peptide Label: isoform X2
- UniProtKB: A0A8C0SXL0 (UniProtKB/TrEMBL),   A0A8I3NBK5 (UniProtKB/TrEMBL),   A0A8C0SXH2 (UniProtKB/TrEMBL),   A0A8I3NBV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038543130   ⟸   XM_038687202
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SXH2 (UniProtKB/TrEMBL),   A0A8I3NBV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845012869   ⟸   ENSCAFT00845016544
RefSeq Acc Id: ENSCAFP00845012938   ⟸   ENSCAFT00845016630
RefSeq Acc Id: ENSCAFP00845012895   ⟸   ENSCAFT00845016576
RefSeq Acc Id: ENSCAFP00845012913   ⟸   ENSCAFT00845016603
RefSeq Acc Id: ENSCAFP00845012965   ⟸   ENSCAFT00845016662
Protein Domains
Insulin-like

Promoters
RGD ID:13685980
Promoter ID:EPDNEW_C4048
Type:initiation region
Name:IGF1_1
Description:insulin like growth factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11541,275,881 - 41,275,941EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007304 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00030009527 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00040017054 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00805019251 UniProtKB/Swiss-Prot
  ENSCAFG00845009366 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000011690.6 UniProtKB/TrEMBL
  ENSCAFT00000011691.4 UniProtKB/TrEMBL
  ENSCAFT00000084052.2 UniProtKB/TrEMBL
  ENSCAFT00000086858.2 UniProtKB/Swiss-Prot
  ENSCAFT00000106676.1 UniProtKB/TrEMBL
  ENSCAFT00030017631.1 UniProtKB/TrEMBL
  ENSCAFT00030017719.1 UniProtKB/TrEMBL
  ENSCAFT00030017761.1 UniProtKB/TrEMBL
  ENSCAFT00030017817.1 UniProtKB/Swiss-Prot
  ENSCAFT00030017841.1 UniProtKB/TrEMBL
  ENSCAFT00040031510.1 UniProtKB/TrEMBL
  ENSCAFT00040031570.1 UniProtKB/Swiss-Prot
  ENSCAFT00040031660.1 UniProtKB/TrEMBL
  ENSCAFT00040031721.1 UniProtKB/TrEMBL
  ENSCAFT00040031770.1 UniProtKB/TrEMBL
  ENSCAFT00805034994 UniProtKB/Swiss-Prot
  ENSCAFT00845016544 ENTREZGENE
  ENSCAFT00845016544.1 UniProtKB/Swiss-Prot
  ENSCAFT00845016576.1 UniProtKB/TrEMBL
  ENSCAFT00845016603 ENTREZGENE
  ENSCAFT00845016603.1 UniProtKB/TrEMBL
  ENSCAFT00845016630 ENTREZGENE
  ENSCAFT00845016630.1 UniProtKB/TrEMBL
  ENSCAFT00845016662 ENTREZGENE
  ENSCAFT00845016662.1 UniProtKB/TrEMBL
Gene3D-CATH Insulin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IGF-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin-like_growth_factor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_family UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:610255 UniProtKB/Swiss-Prot
NCBI Gene IGF1 ENTREZGENE
PANTHER INSULIN-LIKE GROWTH FACTOR I UniProtKB/Swiss-Prot
  INSULIN-LIKE GROWTH FACTOR I UniProtKB/Swiss-Prot
  INSULIN-LIKE GROWTH FACTOR I UniProtKB/TrEMBL
  INSULIN-LIKE GROWTH FACTOR I UniProtKB/TrEMBL
Pfam Insulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS INSLNLIKEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INSLNLIKEGF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INSULINFAMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE INSULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IlGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56994 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0LGN3 ENTREZGENE
  A0A8C0LJP4 ENTREZGENE
  A0A8C0MW23 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SW86 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SXH2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SXI4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SXL0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N8M8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NBK5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NBV2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NN66 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PGD5 ENTREZGENE, UniProtKB/TrEMBL
  IGF1_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:41895 ENTREZGENE