GRM6 (glutamate metabotropic receptor 6) - Rat Genome Database

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Gene: GRM6 (glutamate metabotropic receptor 6) Canis lupus familiaris
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Symbol: GRM6
Name: glutamate metabotropic receptor 6
RGD ID: 12376809
Description: ENCODES a protein that exhibits adenylate cyclase inhibiting G protein-coupled glutamate receptor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway (ortholog); chemical synaptic transmission (ortholog); retina development in camera-type eye (ortholog); ASSOCIATED WITH congenital stationary night blindness (ortholog); congenital stationary night blindness 1B (ortholog); Ehlers-Danlos syndrome dermatosparaxis type (ortholog); FOUND IN cell tip (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: metabotropic glutamate receptor 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1112,577,988 - 2,598,893 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl112,577,988 - 2,597,575 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha112,701,951 - 2,723,668 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0112,554,140 - 2,575,871 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl112,554,140 - 2,573,733 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1112,525,443 - 2,547,158 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0112,603,862 - 2,625,566 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0112,844,699 - 2,866,420 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GRM6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1112,577,988 - 2,598,893 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl112,577,988 - 2,597,575 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha112,701,951 - 2,723,668 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0112,554,140 - 2,575,871 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl112,554,140 - 2,573,733 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1112,525,443 - 2,547,158 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0112,603,862 - 2,625,566 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0112,844,699 - 2,866,420 (+)NCBIUU_Cfam_GSD_1.0
GRM6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385178,978,327 - 178,995,320 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5178,977,587 - 178,996,206 (-)EnsemblGRCh38hg38GRCh38
GRCh375178,405,328 - 178,422,321 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365178,337,934 - 178,354,730 (-)NCBINCBI36Build 36hg18NCBI36
Build 345178,337,937 - 178,354,730NCBI
Celera5174,032,368 - 174,049,143 (-)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5173,132,574 - 173,149,375 (-)NCBIHuRef
CHM1_15177,838,464 - 177,855,246 (-)NCBICHM1_1
T2T-CHM13v2.05179,531,590 - 179,548,578 (-)NCBIT2T-CHM13v2.0
Grm6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391150,741,205 - 50,757,035 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1150,741,512 - 50,757,035 (+)EnsemblGRCm39 Ensembl
GRCm381150,850,369 - 50,866,208 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,850,685 - 50,866,208 (+)EnsemblGRCm38mm10GRCm38
MGSCv371150,664,187 - 50,679,710 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361150,700,247 - 50,709,631 (+)NCBIMGSCv36mm8
MGSCv361151,275,794 - 51,285,178 (+)NCBIMGSCv36mm8
Celera1155,412,795 - 55,423,405 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1130.93NCBI
Grm6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81035,669,003 - 35,683,729 (+)NCBIGRCr8
mRatBN7.21035,167,985 - 35,182,717 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1035,167,985 - 35,182,717 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1039,850,547 - 39,865,320 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01039,340,860 - 39,355,633 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01034,844,228 - 34,859,005 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01036,345,503 - 36,363,416 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1036,345,939 - 36,360,665 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01036,116,940 - 36,133,439 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41036,421,806 - 36,436,909 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11036,422,854 - 36,437,992 (+)NCBI
Celera1034,527,201 - 34,541,916 (+)NCBICelera
Cytogenetic Map10q22NCBI
Grm6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554081,421,132 - 1,433,622 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554081,421,132 - 1,432,010 (+)NCBIChiLan1.0ChiLan1.0
GRM6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24173,919,371 - 173,939,175 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15172,062,606 - 172,078,715 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05174,142,754 - 174,156,294 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15181,434,031 - 181,447,341 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5181,434,031 - 181,447,341 (-)Ensemblpanpan1.1panPan2
Grm6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213120,517,460 - 120,533,914 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367391,727,808 - 1,741,400 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367391,726,382 - 1,742,937 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRM6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl279,466,779 - 79,479,146 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1279,466,899 - 79,480,562 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2281,070,972 - 81,085,309 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRM6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12380,732,687 - 80,747,389 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2380,733,486 - 80,746,708 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607512,088,339 - 12,101,526 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grm6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473341,987,319 - 41,997,541 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473341,984,632 - 41,997,726 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GRM6
338 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 3 8
Below cutoff 5 5 22 6 6 6 6 5 9 10 6

Sequence


RefSeq Acc Id: ENSCAFT00000000509   ⟹   ENSCAFP00000000460
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl112,577,988 - 2,597,575 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845015980   ⟹   ENSCAFP00845012430
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl112,554,140 - 2,573,733 (+)Ensembl
RefSeq Acc Id: XM_038489753   ⟹   XP_038345681
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1112,525,443 - 2,547,158 (+)NCBI
RefSeq Acc Id: XM_038551774   ⟹   XP_038407702
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0112,844,699 - 2,866,420 (+)NCBI
RefSeq Acc Id: XM_038615661   ⟹   XP_038471589
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0112,603,862 - 2,625,566 (+)NCBI
RefSeq Acc Id: XM_038681149   ⟹   XP_038537077
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0112,554,140 - 2,575,871 (+)NCBI
RefSeq Acc Id: XM_538573   ⟹   XP_538573
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1112,577,988 - 2,598,893 (+)NCBI
Dog10K_Boxer_Tasha112,701,951 - 2,723,668 (+)NCBI
Sequence:
RefSeq Acc Id: XP_538573   ⟸   XM_538573
- UniProtKB: A0A8C0QUS1 (UniProtKB/TrEMBL),   A0A8C0MAN6 (UniProtKB/TrEMBL),   A0A8I3RWJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000000460   ⟸   ENSCAFT00000000509
RefSeq Acc Id: XP_038345681   ⟸   XM_038489753
RefSeq Acc Id: XP_038471589   ⟸   XM_038615661
RefSeq Acc Id: XP_038537077   ⟸   XM_038681149
- UniProtKB: A0A8C0QUS1 (UniProtKB/TrEMBL),   A0A8C0MAN6 (UniProtKB/TrEMBL),   A0A8I3RWJ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038407702   ⟸   XM_038551774
- UniProtKB: A0A8C0MAN6 (UniProtKB/TrEMBL),   A0A8C0QUS1 (UniProtKB/TrEMBL),   A0A8I3RWJ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845012430   ⟸   ENSCAFT00845015980

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000332 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030005499 UniProtKB/TrEMBL
  ENSCAFG00845009049 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000509.5 UniProtKB/TrEMBL
  ENSCAFT00030010139.1 UniProtKB/TrEMBL
  ENSCAFT00845015980 ENTREZGENE
  ENSCAFT00845015980.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.50.30 UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/TrEMBL
  GPCR_3 UniProtKB/TrEMBL
  GPCR_3_9-Cys_dom UniProtKB/TrEMBL
  GPCR_3_9-Cys_sf UniProtKB/TrEMBL
  GPCR_3__mGluR6 UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/TrEMBL
  GPCR_3_CS UniProtKB/TrEMBL
  GPCR_3_mtglu_rcpt UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/TrEMBL
NCBI Gene GRM6 ENTREZGENE
PANTHER METABOTROPIC GLUTAMATE RECEPTOR UniProtKB/TrEMBL
  METABOTROPIC GLUTAMATE RECEPTOR 6 UniProtKB/TrEMBL
Pfam 7tm_3 UniProtKB/TrEMBL
  ANF_receptor UniProtKB/TrEMBL
  NCD3G UniProtKB/TrEMBL
PRINTS GPCRMGR UniProtKB/TrEMBL
  MTABOTROPC6R UniProtKB/TrEMBL
  MTABOTROPICR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F3_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_2 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_3 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_4 UniProtKB/TrEMBL
Superfamily-SCOP SSF53822 UniProtKB/TrEMBL
UniProt A0A8C0MAN6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QUS1 ENTREZGENE
  A0A8I3RWJ1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:41513 ENTREZGENE