SCPEP1 (serine carboxypeptidase 1) - Rat Genome Database

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Gene: SCPEP1 (serine carboxypeptidase 1) Canis lupus familiaris
Analyze
Symbol: SCPEP1
Name: serine carboxypeptidase 1
RGD ID: 12371470
Description: ENCODES a protein that exhibits carboxypeptidase activity (inferred); hydrolase activity (inferred); peptidase activity (inferred); INVOLVED IN blood vessel diameter maintenance (ortholog); retinoic acid metabolic process (ortholog); ASSOCIATED WITH COVID-19 (ortholog); genetic disease (ortholog); Joubert syndrome 1 (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: retinoid-inducible serine carboxypeptidase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1931,770,494 - 31,803,741 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl931,774,602 - 31,803,741 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha931,010,418 - 31,043,464 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0932,578,347 - 32,611,364 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl932,578,396 - 32,611,601 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1931,363,955 - 31,397,132 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0931,647,649 - 31,680,837 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0931,731,073 - 31,764,270 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SCPEP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1931,770,494 - 31,803,741 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl931,774,602 - 31,803,741 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha931,010,418 - 31,043,464 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0932,578,347 - 32,611,364 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl932,578,396 - 32,611,601 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1931,363,955 - 31,397,132 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0931,647,649 - 31,680,837 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0931,731,073 - 31,764,270 (+)NCBIUU_Cfam_GSD_1.0
SCPEP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381756,978,131 - 57,006,768 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1756,978,129 - 57,006,768 (+)EnsemblGRCh38hg38GRCh38
GRCh371755,055,492 - 55,084,129 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361752,410,467 - 52,439,128 (+)NCBINCBI36Build 36hg18NCBI36
Build 341752,410,487 - 52,439,123NCBI
Celera1751,517,044 - 51,545,707 (+)NCBICelera
Cytogenetic Map17q22NCBI
HuRef1750,416,496 - 50,445,158 (+)NCBIHuRef
CHM1_11755,120,690 - 55,149,356 (+)NCBICHM1_1
T2T-CHM13v2.01757,855,772 - 57,884,410 (+)NCBIT2T-CHM13v2.0
Scpep1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391188,814,846 - 88,846,268 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1188,814,846 - 88,846,291 (-)EnsemblGRCm39 Ensembl
GRCm381188,924,020 - 88,955,442 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1188,924,020 - 88,955,465 (-)EnsemblGRCm38mm10GRCm38
MGSCv371188,785,334 - 88,816,756 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361188,740,110 - 88,771,522 (-)NCBIMGSCv36mm8
Celera1198,535,098 - 98,568,204 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1154.34NCBI
Scpep1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81074,200,491 - 74,230,107 (-)NCBIGRCr8
mRatBN7.21073,703,275 - 73,732,892 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1073,703,278 - 73,732,850 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1078,318,490 - 78,347,988 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01077,823,415 - 77,852,910 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01073,286,585 - 73,316,078 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01076,230,371 - 76,263,866 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1076,230,373 - 76,263,866 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01073,846,394 - 73,880,406 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41077,347,473 - 77,377,945 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11077,361,844 - 77,392,315 (-)NCBI
Celera1072,609,315 - 72,638,737 (-)NCBICelera
Cytogenetic Map10q26NCBI
Scpep1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554515,846,552 - 5,876,851 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554515,847,371 - 5,876,286 (-)NCBIChiLan1.0ChiLan1.0
SCPEP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21973,151,012 - 73,179,770 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11777,961,953 - 77,990,686 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01751,055,293 - 51,084,032 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11755,915,746 - 55,944,374 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1755,915,746 - 55,944,377 (+)Ensemblpanpan1.1panPan2
Scpep1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560231,143,599 - 31,171,166 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364905,904,396 - 5,939,915 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364905,903,884 - 5,939,953 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCPEP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1233,265,562 - 33,298,142 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11233,265,509 - 33,296,805 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21233,995,016 - 34,027,373 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SCPEP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11636,398,059 - 36,427,429 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1636,398,615 - 36,427,404 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660777,216,719 - 7,246,075 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scpep1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479512,016,302 - 12,042,353 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479512,016,363 - 12,041,615 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SCPEP1
412 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 2 22 6 6 6 6 11 10 6
Low 3 6 1 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022423915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038486043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038486044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038547825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038547826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038607128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038607134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038611807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038611808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038677032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038677033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000027582   ⟹   ENSCAFP00000025652
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl931,774,602 - 31,803,741 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845032578   ⟹   ENSCAFP00845025480
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl932,578,396 - 32,611,601 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845032665   ⟹   ENSCAFP00845025550
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl932,578,396 - 32,611,601 (+)Ensembl
RefSeq Acc Id: XM_038486043   ⟹   XP_038341971
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1931,363,955 - 31,397,132 (+)NCBI
RefSeq Acc Id: XM_038486044   ⟹   XP_038341972
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1931,363,955 - 31,397,132 (+)NCBI
RefSeq Acc Id: XM_038547825   ⟹   XP_038403753
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0931,731,073 - 31,764,270 (+)NCBI
RefSeq Acc Id: XM_038547826   ⟹   XP_038403754
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0931,731,073 - 31,764,270 (+)NCBI
RefSeq Acc Id: XM_038607128   ⟹   XP_038463056
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha931,010,418 - 31,043,464 (+)NCBI
RefSeq Acc Id: XM_038607134   ⟹   XP_038463062
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha931,010,418 - 31,043,464 (+)NCBI
RefSeq Acc Id: XM_038611807   ⟹   XP_038467735
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0931,647,649 - 31,680,837 (+)NCBI
RefSeq Acc Id: XM_038611808   ⟹   XP_038467736
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0931,647,649 - 31,680,837 (+)NCBI
RefSeq Acc Id: XM_038677032   ⟹   XP_038532960
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0932,578,347 - 32,611,364 (+)NCBI
RefSeq Acc Id: XM_038677033   ⟹   XP_038532961
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0932,578,347 - 32,611,364 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000025652   ⟸   ENSCAFT00000027582
RefSeq Acc Id: XP_038341971   ⟸   XM_038486043
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038341972   ⟸   XM_038486044
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038467735   ⟸   XM_038611807
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038467736   ⟸   XM_038611808
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038532960   ⟸   XM_038677032
- Peptide Label: isoform X1
- UniProtKB: A0A8C0MW29 (UniProtKB/TrEMBL),   A0A8I3NVI7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038532961   ⟸   XM_038677033
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038463056   ⟸   XM_038607128
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LSX8 (UniProtKB/TrEMBL),   A0A8P0SLM5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038463062   ⟸   XM_038607134
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038403753   ⟸   XM_038547825
- Peptide Label: isoform X1
- UniProtKB: A0A8C0MW29 (UniProtKB/TrEMBL),   A0A8I3NVI7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038403754   ⟸   XM_038547826
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCAFP00845025480   ⟸   ENSCAFT00845032578
RefSeq Acc Id: ENSCAFP00845025550   ⟸   ENSCAFT00845032665


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000017404 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030010969 UniProtKB/TrEMBL
  ENSCAFG00040026021 UniProtKB/TrEMBL
  ENSCAFG00845018419 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000027582.6 UniProtKB/TrEMBL
  ENSCAFT00000106116.1 UniProtKB/TrEMBL
  ENSCAFT00030020316.1 UniProtKB/TrEMBL
  ENSCAFT00030020444.1 UniProtKB/TrEMBL
  ENSCAFT00040048693.1 UniProtKB/TrEMBL
  ENSCAFT00040048694.1 UniProtKB/TrEMBL
  ENSCAFT00845032578 ENTREZGENE
  ENSCAFT00845032578.1 UniProtKB/TrEMBL
  ENSCAFT00845032665.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  Peptidase_S10 UniProtKB/TrEMBL
  Ser_caboxypep_ser_AS UniProtKB/TrEMBL
NCBI Gene SCPEP1 ENTREZGENE
PANTHER PTHR11802 UniProtKB/TrEMBL
  RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE UniProtKB/TrEMBL
Pfam Peptidase_S10 UniProtKB/TrEMBL
PRINTS CRBOXYPTASEC UniProtKB/TrEMBL
PROSITE CARBOXYPEPT_SER_SER UniProtKB/TrEMBL
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A0A8C0LSX8 ENTREZGENE
  A0A8C0MW29 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Z7F2_CANLF UniProtKB/TrEMBL
  A0A8I3NVI7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S0H5_CANLF UniProtKB/TrEMBL
  A0A8P0SLM5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TM00_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:55815 ENTREZGENE