HPSE2 (heparanase 2 (inactive)) - Rat Genome Database

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Gene: HPSE2 (heparanase 2 (inactive)) Canis lupus familiaris
Analyze
Symbol: HPSE2
Name: heparanase 2 (inactive)
RGD ID: 12349854
Description: ENCODES a protein that exhibits heparanase activity (ortholog); INVOLVED IN cell population proliferation (ortholog); extracellular matrix organization (ortholog); positive regulation of cell population proliferation (ortholog); ASSOCIATED WITH CAKUT (ortholog); genetic disease (ortholog); urofacial syndrome (ortholog); FOUND IN extracellular matrix (inferred); extracellular space (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: inactive heparanase-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12811,584,440 - 12,215,732 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2811,585,807 - 12,215,614 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2811,766,981 - 12,399,809 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02811,909,883 - 12,161,577 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2811,912,217 - 12,683,674 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12811,593,608 - 12,230,470 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02811,630,471 - 12,261,439 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02811,770,213 - 12,402,804 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HPSE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12811,584,440 - 12,215,732 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2811,585,807 - 12,215,614 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2811,766,981 - 12,399,809 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02811,909,883 - 12,161,577 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2811,912,217 - 12,683,674 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12811,593,608 - 12,230,470 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02811,630,471 - 12,261,439 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02811,770,213 - 12,402,804 (-)NCBIUU_Cfam_GSD_1.0
HPSE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381098,457,077 - 99,315,951 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1098,457,077 - 99,235,862 (-)EnsemblGRCh38hg38GRCh38
GRCh3710100,216,834 - 100,995,632 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610100,208,867 - 100,985,609 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410100,208,864 - 100,985,609NCBI
Celera1093,953,460 - 94,732,450 (-)NCBICelera
Cytogenetic Map10q24.2NCBI
HuRef1094,130,091 - 94,622,164 (-)NCBIHuRef
HuRef1093,841,617 - 94,106,699 (-)NCBIHuRef
CHM1_110100,498,701 - 101,277,572 (-)NCBICHM1_1
T2T-CHM13v2.01099,337,053 - 100,197,827 (-)NCBIT2T-CHM13v2.0
Hpse2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391942,774,980 - 43,376,913 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1942,774,978 - 43,376,794 (-)EnsemblGRCm39 Ensembl
GRCm381942,786,541 - 43,388,476 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1942,786,539 - 43,388,355 (-)EnsemblGRCm38mm10GRCm38
MGSCv371942,863,085 - 43,462,801 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361942,841,906 - 43,441,622 (-)NCBIMGSCv36mm8
MGSCv361942,676,998 - 43,277,483 (-)NCBIMGSCv36mm8
Celera1943,584,218 - 44,179,795 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1936.57NCBI
Hpse2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81251,532,149 - 252,231,316 (-)NCBIGRCr8
mRatBN7.21241,582,904 - 242,284,348 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,583,187 - 242,246,118 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1249,730,681 - 250,396,023 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01256,427,848 - 257,093,195 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01249,080,851 - 249,746,182 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01262,020,903 - 263,138,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01270,576,436 - 270,580,047 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01269,475,568 - 270,128,189 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41247,458,939 - 248,100,231 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11247,958,907 - 247,971,603 (+)NCBI
Celera1237,417,175 - 238,067,548 (-)NCBICelera
Cytogenetic Map1q54NCBI
Hpse2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555074,445,772 - 5,205,957 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555074,442,677 - 5,205,976 (-)NCBIChiLan1.0ChiLan1.0
HPSE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28110,363,078 - 111,143,128 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110110,368,396 - 111,148,445 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01095,071,571 - 95,851,896 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11098,566,705 - 99,344,205 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1098,592,019 - 99,344,132 (-)Ensemblpanpan1.1panPan2
Hpse2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721334,735,574 - 35,362,965 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936636774,778 - 1,399,702 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936636774,705 - 1,402,009 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HPSE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14109,764,170 - 110,469,141 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114109,764,511 - 110,469,064 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214119,262,145 - 119,752,959 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103216367
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1991,616,277 - 92,346,206 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604852,670,244 - 52,785,944 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hpse2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473710,058,787 - 10,976,525 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473710,055,408 - 10,976,525 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HPSE2
6558 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 5 6 1 12 8 5
Below cutoff 5 16 6 6 6 5 6 5 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000014941   ⟹   ENSCAFP00000013828
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2811,585,807 - 11,861,232 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000043217   ⟹   ENSCAFP00000037745
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2812,099,866 - 12,215,614 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000060220   ⟹   ENSCAFP00000048841
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2811,588,068 - 12,215,614 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000081301   ⟹   ENSCAFP00000060910
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2811,585,807 - 12,215,614 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000084866   ⟹   ENSCAFP00000060846
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2811,585,807 - 12,215,614 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000090503   ⟹   ENSCAFP00000047221
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2811,585,807 - 12,215,614 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845054523   ⟹   ENSCAFP00845042858
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2811,912,217 - 12,683,674 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845054576   ⟹   ENSCAFP00845042906
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2811,912,217 - 12,683,674 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845054583   ⟹   ENSCAFP00845042914
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2811,912,217 - 12,683,674 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845054586   ⟹   ENSCAFP00845042917
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2811,914,476 - 12,683,674 (-)Ensembl
RefSeq Acc Id: XM_038439709   ⟹   XP_038295637
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02811,909,883 - 12,161,577 (-)NCBI
RefSeq Acc Id: XM_038514853   ⟹   XP_038370781
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12811,593,608 - 12,230,464 (-)NCBI
RefSeq Acc Id: XM_038578487   ⟹   XP_038434415
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02811,770,213 - 12,402,802 (-)NCBI
RefSeq Acc Id: XM_038642650   ⟹   XP_038498578
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02811,630,471 - 12,261,433 (-)NCBI
RefSeq Acc Id: XM_845218   ⟹   XP_850311
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12811,584,440 - 12,215,730 (-)NCBI
Dog10K_Boxer_Tasha2811,766,981 - 12,399,803 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005315694
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2811,769,354 - 12,399,809 (-)NCBI
RefSeq Acc Id: XR_005346710
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12811,595,981 - 12,230,470 (-)NCBI
RefSeq Acc Id: XR_005380481
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02811,772,586 - 12,402,804 (-)NCBI
RefSeq Acc Id: XR_005414243
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02811,632,844 - 12,261,439 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_850311   ⟸   XM_845218
- Peptide Label: isoform X5
- UniProtKB: A0A8C0PC36 (UniProtKB/TrEMBL),   A0A8I3QTG2 (UniProtKB/TrEMBL),   A0A8C0NWI9 (UniProtKB/TrEMBL),   A0A8I3QTL2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000048841   ⟸   ENSCAFT00000060220
RefSeq Acc Id: ENSCAFP00000060846   ⟸   ENSCAFT00000084866
RefSeq Acc Id: ENSCAFP00000013828   ⟸   ENSCAFT00000014941
RefSeq Acc Id: ENSCAFP00000037745   ⟸   ENSCAFT00000043217
RefSeq Acc Id: ENSCAFP00000047221   ⟸   ENSCAFT00000090503
RefSeq Acc Id: ENSCAFP00000060910   ⟸   ENSCAFT00000081301
RefSeq Acc Id: XP_038370781   ⟸   XM_038514853
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038498578   ⟸   XM_038642650
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038295637   ⟸   XM_038439709
- Peptide Label: isoform X1
- UniProtKB: A0A8C0K0M3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038434415   ⟸   XM_038578487
- Peptide Label: isoform X4
- UniProtKB: A0A8C0NWI9 (UniProtKB/TrEMBL),   A0A8C0PC36 (UniProtKB/TrEMBL),   A0A8I3QTG2 (UniProtKB/TrEMBL),   A0A8I3QTL2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845042917   ⟸   ENSCAFT00845054586
RefSeq Acc Id: ENSCAFP00845042906   ⟸   ENSCAFT00845054576
RefSeq Acc Id: ENSCAFP00845042914   ⟸   ENSCAFT00845054583
RefSeq Acc Id: ENSCAFP00845042858   ⟸   ENSCAFT00845054523


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000009386 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030020024 UniProtKB/TrEMBL
  ENSCAFG00040025774 UniProtKB/TrEMBL
  ENSCAFG00845030674 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000043217.3 UniProtKB/TrEMBL
  ENSCAFT00000060220.2 UniProtKB/TrEMBL
  ENSCAFT00000081301.2 UniProtKB/TrEMBL
  ENSCAFT00000084866.2 UniProtKB/TrEMBL
  ENSCAFT00000090503.2 UniProtKB/TrEMBL
  ENSCAFT00030037666.1 UniProtKB/TrEMBL
  ENSCAFT00030037724.1 UniProtKB/TrEMBL
  ENSCAFT00030037756.1 UniProtKB/TrEMBL
  ENSCAFT00030037814.1 UniProtKB/TrEMBL
  ENSCAFT00040048178.1 UniProtKB/TrEMBL
  ENSCAFT00040048183.1 UniProtKB/TrEMBL
  ENSCAFT00040048186.1 UniProtKB/TrEMBL
  ENSCAFT00040048191.1 UniProtKB/TrEMBL
  ENSCAFT00040048195.1 UniProtKB/TrEMBL
  ENSCAFT00845054523.1 UniProtKB/TrEMBL
  ENSCAFT00845054576.1 UniProtKB/TrEMBL
  ENSCAFT00845054583.1 UniProtKB/TrEMBL
  ENSCAFT00845054586.1 UniProtKB/TrEMBL
Gene3D-CATH Glycosidases UniProtKB/TrEMBL
InterPro Glyco_hydro_79 UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/TrEMBL
KEGG Report cfa:486831 UniProtKB/TrEMBL
NCBI Gene HPSE2 ENTREZGENE
PANTHER HEPARANASE UniProtKB/TrEMBL
  INACTIVE HEPARANASE-2 UniProtKB/TrEMBL
Pfam Glyco_hydro_79n UniProtKB/TrEMBL
Superfamily-SCOP SSF51445 UniProtKB/TrEMBL
UniProt A0A8C0K0M3 ENTREZGENE
  A0A8C0NWI9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0P859_CANLF UniProtKB/TrEMBL
  A0A8C0PC36 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TVU8_CANLF UniProtKB/TrEMBL
  A0A8C0TY83_CANLF UniProtKB/TrEMBL
  A0A8I3Q586_CANLF UniProtKB/TrEMBL
  A0A8I3QTG2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3QTL2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3QYX4_CANLF UniProtKB/TrEMBL
UniProt Secondary A0A8P0SSI5 UniProtKB/TrEMBL