FNTA (farnesyltransferase, CAAX box, subunit alpha)

Gene: FNTA (farnesyltransferase, CAAX box, subunit alpha) Canis lupus familiaris

Analyze

Symbol:

FNTA

Name:

farnesyltransferase, CAAX box, subunit alpha (Ensembl:hook microtubule tethering protein 3)

RGD ID:

12348492

Description:

ENCODES a protein that exhibits alpha-tubulin binding (ortholog); CAAX-protein geranylgeranyltransferase activity (ortholog); heterocyclic compound binding (ortholog); INVOLVED IN enzyme-linked receptor protein signaling pathway (ortholog); negative regulation of apoptotic process (ortholog); negative regulation of nitric-oxide synthase biosynthetic process (ortholog); ASSOCIATED WITH congenital muscular dystrophy-dystroglycanopathy type A12 (ortholog); genetic disease (ortholog); Idiopathic Basal Ganglia Calcification 1 (ortholog); FOUND IN CAAX-protein geranylgeranyltransferase complex (ortholog); microtubule associated complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

farnesyltransferase, CAAX box, alpha; protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	22,739,070 - 22,767,942 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	22,739,079 - 22,767,914 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	23,244,269 - 23,273,147 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	24,491,021 - 24,519,909 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	24,491,022 - 24,652,650 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	22,859,185 - 22,888,061 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	23,424,042 - 23,452,916 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	23,475,354 - 23,504,242 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital muscular dystrophy-dystroglycanopathy type A12 (ISO)

genetic disease (ISO)

Idiopathic Basal Ganglia Calcification 1 (ISO)

IMMUNODEFICIENCY 15 (ISO)

immunodeficiency 15B (ISO)

mucopolysaccharidosis type IIIC (ISO)

torsion dystonia 6 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cytoplasmic microtubule organization (IEA)

cytoskeleton-dependent intracellular transport (IEA)

enzyme-linked receptor protein signaling pathway (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of nitric-oxide synthase biosynthetic process (ISO)

positive regulation of cell cycle (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of nitric-oxide synthase biosynthetic process (ISO)

positive regulation of Rac protein signal transduction (ISO)

positive regulation of skeletal muscle acetylcholine-gated channel clustering (ISO)

positive regulation of tubulin deacetylation (ISO)

response to cytokine (ISO)

response to inorganic substance (ISO)

response to organic cyclic compound (ISO)

Cellular Component

CAAX-protein geranylgeranyltransferase complex (IEA,ISO)

centrosome (IEA)

cytoplasm (IEA)

cytoskeleton (IEA)

microtubule (IEA)

microtubule associated complex (ISO)

protein farnesyltransferase complex (IEA)

Molecular Function

alpha-tubulin binding (ISO)

CAAX-protein geranylgeranyltransferase activity (IEA,ISO)

dynein light intermediate chain binding (IEA)

heterocyclic compound binding (ISO)

microtubule binding (IEA)

molecular adaptor activity (ISO)

peptide binding (ISO)

prenyltransferase activity (IEA)

protein binding (ISO)

protein farnesyltransferase activity (IEA,ISO)

protein geranylgeranyltransferase activity (ISO)

protein prenyltransferase activity (IEA)

Rab geranylgeranyltransferase activity (ISO)

receptor tyrosine kinase binding (ISO)

small molecule binding (ISO)

zinc ion binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

FNTA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	22,739,070 - 22,767,942 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	22,739,079 - 22,767,914 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	23,244,269 - 23,273,147 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	24,491,021 - 24,519,909 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	24,491,022 - 24,652,650 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	22,859,185 - 22,888,061 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	23,424,042 - 23,452,916 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	23,475,354 - 23,504,242 (-)	NCBI		UU_Cfam_GSD_1.0

FNTA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	43,056,323 - 43,085,785 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	43,034,194 - 43,085,788 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	42,911,466 - 42,940,928 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	43,030,599 - 43,060,088 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	43,030,640 - 43,060,080	NCBI
Celera	8	41,859,884 - 41,889,630 (+)	NCBI		Celera
Cytogenetic Map	8	p11.21	NCBI
HuRef	8	41,434,064 - 41,463,781 (+)	NCBI		HuRef
CHM1_1	8	42,958,364 - 42,987,853 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	43,325,268 - 43,354,718 (+)	NCBI		T2T-CHM13v2.0

Fnta
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	26,488,716 - 26,505,638 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	26,488,750 - 26,505,678 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	25,998,688 - 26,015,610 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	25,998,722 - 26,015,650 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	27,109,194 - 27,126,073 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	27,464,267 - 27,481,146 (-)	NCBI		MGSCv36	mm8
Celera	8	27,468,460 - 27,485,887 (-)	NCBI		Celera
Cytogenetic Map	8	A2	NCBI
cM Map	8	14.27	NCBI

Fnta
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	72,767,864 - 72,786,193 (+)	NCBI		GRCr8
mRatBN7.2	16	66,065,131 - 66,083,460 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	66,065,132 - 66,083,460 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	71,343,827 - 71,362,199 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	74,750,156 - 74,768,528 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	69,990,195 - 70,008,625 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	70,834,957 - 70,854,724 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	70,834,957 - 70,854,724 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	70,499,605 - 70,519,062 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	70,440,340 - 70,458,433 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	70,440,604 - 70,458,698 (+)	NCBI
Celera	16	63,976,260 - 63,994,463 (+)	NCBI		Celera
RH 3.4 Map	16	622.7	RGD
Cytogenetic Map	16	q12.4	NCBI

Fnta
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955457	13,260,545 - 13,294,025 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955457	13,260,825 - 13,294,025 (+)	NCBI	ChiLan1.0	ChiLan1.0

FNTA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	61,512,173 - 61,542,875 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	37,229,091 - 37,258,862 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	42,303,987 - 42,333,743 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	39,744,142 - 39,774,039 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	39,743,768 - 39,774,031 (+)	Ensembl	panpan1.1		panPan2

Fnta
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	45,764,313 - 45,791,302 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936570	362,655 - 389,649 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FNTA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	11,928,358 - 11,951,684 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	11,928,327 - 11,953,139 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

FNTA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	41,057,798 - 41,088,210 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	41,057,603 - 41,087,705 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	681,570 - 712,699 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in FNTA
273 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium	5	5	22	6	6	6	6	6	12	8	10	6
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005629785	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022403966	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038497455	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038497456	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038559911	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038559912	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038623938	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038623939	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038689699	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038689700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_532786	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000182	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000008664 ⟹ ENSCAFP00000008030

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	16	22,739,079 - 22,767,914 (-)	Ensembl

RefSeq Acc Id:

XM_005629785 ⟹ XP_005629842

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	16	22,740,430 - 22,767,942 (-)	NCBI
Dog10K_Boxer_Tasha	16	23,245,629 - 23,273,147 (-)	NCBI

Sequence:

show sequence

GCCGCCACCACCTCCGCTGCGGGCCGAGGCGAGATGGCGGCCACGGAGGGGGTGGGAGAGGCTG
CGCAGGGCAGCGAGTCCGCACAGCCGGAGCCACCGCCGCCCCAGCCGCACCCTCCGCCGCTCCA
GCCGCAGCAGCAAGAGGAAGCCATGGCGGCAGAACTGGGAGAAGCGGTGGCGTCCCCCATGGAC
GACGGGTTCCTGAGCCTGGACTCGCCCACCTATGTCCTATACAGGGACAGAGCAGAATGGGCTG
ATATAGATCCAGTGCCGCAGAATGATGGCCCCAATCCAGTGGTCCAGATCATTTATAGTGAAAA
ATTTAGAGATGTTTATGATTATTTCCGGGCTGTTCTGCAGCGTGATGAAAGAAGTGAACGAGCT
TTTAAACTAACCAGAGATGCTATTGAGTTAAATGCAGCCAATTACACAGTGTGGCATTTTCGGA
GAGTTCTCTTAAAGTCACTTCAAAAGGATCTGCATGAAGAAATGAACTACATCACTGCGATAAT
TGAGGAACAGCCTAAAAACTATCAAGTTTGGCATCATAGGCGAGTATTAGTGGAATGGCTAAAA
GATCCATCTCAGGAGCTTGAGTTTATTGCTGATATTCTTAATCAGGATGCAAAGAATTATCATG
CCTGGCAACATCGACAATGGGTTATCCAGGAATTTAAACTTTGGGATAATGAGCTGCAGTATGT
AGACCAACTTCTTAAAGAGGATGTGAGAAATAACTCTGTATGGAACCAAAGATACTTCGTAATT
TCTAACACCACTGGCTACAATGATCGTGCTATATTGGAGAGAGAAGTCCAGTACACTCTGGAAA
TGATCAAACTAGTACCGCATAATGAAAGCGCATGGAACTATTTGAAAGGCTTAGAGGTCTCCCT
GGAAACCAGGCCCAAAAAGCATAAAGTTTGGAGCCCAGTCACATTTGGAGATGAATCCTATAAG
ATCTGGAGAGCTATAAGCTATAAAGAACCATCTCAAGAAGAAGCAGAAATATCTCTCCTGTTTT
CTTCCTTTGTAATTTCAAGATGATGGTTTATTTTCTGATTTAATTGTGTGTGTTGCAGTTTGAG
TTATAAATGATCACTTTTAAGTTTCATTATTTTTAACTAATTGTACTCAGCTGAAAATTATCCA
TAATAAAACTTACATAATTTAAAAAATTCA

hide sequence

RefSeq Acc Id:

XM_038497455 ⟹ XP_038353383

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	16	22,859,185 - 22,888,056 (-)	NCBI

RefSeq Acc Id:

XM_038497456 ⟹ XP_038353384

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	16	22,860,545 - 22,888,061 (-)	NCBI

RefSeq Acc Id:

XM_038559911 ⟹ XP_038415839

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	16	23,475,354 - 23,504,237 (-)	NCBI

RefSeq Acc Id:

XM_038559912 ⟹ XP_038415840

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	16	23,476,714 - 23,504,242 (-)	NCBI

RefSeq Acc Id:

XM_038623938 ⟹ XP_038479866

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	16	23,424,042 - 23,452,912 (-)	NCBI

RefSeq Acc Id:

XM_038623939 ⟹ XP_038479867

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	16	23,425,402 - 23,452,916 (-)	NCBI

RefSeq Acc Id:

XM_038689699 ⟹ XP_038545627

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	16	24,491,021 - 24,519,904 (-)	NCBI

RefSeq Acc Id:

XM_038689700 ⟹ XP_038545628

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	16	24,492,381 - 24,519,909 (-)	NCBI

RefSeq Acc Id:

XM_532786 ⟹ XP_532786

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	16	22,739,070 - 22,767,939 (-)	NCBI
Dog10K_Boxer_Tasha	16	23,244,269 - 23,273,142 (-)	NCBI

Sequence:

show sequence

GCCACCACCTCCGCTGCGGGCCGAGGCGAGATGGCGGCCACGGAGGGGGTGGGAGAGGCTGCGC
AGGGCAGCGAGTCCGCACAGCCGGAGCCACCGCCGCCCCAGCCGCACCCTCCGCCGCTCCAGCC
GCAGCAGCAAGAGGAAGCCATGGCGGCAGAACTGGGAGAAGCGGTGGCGTCCCCCATGGACGAC
GGGTTCCTGAGCCTGGACTCGCCCACCTATGTCCTATACAGGGACAGAGCAGAATGGGCTGATA
TAGATCCAGTGCCGCAGAATGATGGCCCCAATCCAGTGGTCCAGATCATTTATAGTGAAAAATT
TAGAGATGTTTATGATTATTTCCGGGCTGTTCTGCAGCGTGATGAAAGAAGTGAACGAGCTTTT
AAACTAACCAGAGATGCTATTGAGTTAAATGCAGCCAATTACACAGTGTGGCATTTTCGGAGAG
TTCTCTTAAAGTCACTTCAAAAGGATCTGCATGAAGAAATGAACTACATCACTGCGATAATTGA
GGAACAGCCTAAAAACTATCAAGTTTGGCATCATAGGCGAGTATTAGTGGAATGGCTAAAAGAT
CCATCTCAGGAGCTTGAGTTTATTGCTGATATTCTTAATCAGGATGCAAAGAATTATCATGCCT
GGCAACATCGACAATGGGTTATCCAGGAATTTAAACTTTGGGATAATGAGCTGCAGTATGTAGA
CCAACTTCTTAAAGAGGATGTGAGAAATAACTCTGTATGGAACCAAAGATACTTCGTAATTTCT
AACACCACTGGCTACAATGATCGTGCTATATTGGAGAGAGAAGTCCAGTACACTCTGGAAATGA
TCAAACTAGTACCGCATAATGAAAGCGCATGGAACTATTTGAAAGGGATTTTACAGGATCGTGG
TCTTTCCAGATACCCCAATCTGTTAAGTCAGTTACTTGATTTACAACCAAGTCACAGTTCCCCC
TACCTGATTGCCTTTCTCGTGGATATCTATGAAGACATGCTAGAAAACCAATGTGACAACAAGG
AGGACATTCTTAATAAAGCATTAGAGTTGTGTGAAATTCTAGCTAAAGAAAAGGACACTATAAG
AAAGGAATATTGGAGATATATTGGAAGATCCCTTCAAAGCAAACATAGCACAGAGAGTGACCCA
CCAACAAATGTACAGCAATAACACCATCTGGAAGAACTCGATGGAATGCTTTTATTTTTTTAAG
AGACTCTAATGCAGGAGTTTAAAGCGATCATTCCCTTTGCCTGTGGTGCAAAATGTGCATTGCA
CAGGTATTGCTTTTTAACAGAACTAAGTGTGATGCTCTTTGGGTGCTGCTGCTATTCAGACTAG
TAATTGATTCTTTTAAAGCAAAGTAATTTGAGGGGAGGGAAAAGAAAGTCCCATGAAGGAACTT
TTGTAGTATTATCAACATTTACTCTAATCCCTTAGCATCAGCTCCTCCCTAAAGAGTATATGTG
TCAGGATTTGCAGCATTAATGAAAGCAGGTAACTTGTATGTAATGGATATAAGGTAACTTAAAT
TTGGGTTCAGGAAGCAGGGAATGTAACTGTTACATTAGAGCTGCTATGCCACACTCACAGTATC
TTACTATCACTGTAACCAACTAATGCCAAAAGAATGGTTTTGTAATAAAATTATAGATGTATCC
TAAAACTTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005629842	(Get FASTA)	NCBI Sequence Viewer
	XP_038353383	(Get FASTA)	NCBI Sequence Viewer
	XP_038353384	(Get FASTA)	NCBI Sequence Viewer
	XP_038415839	(Get FASTA)	NCBI Sequence Viewer
	XP_038415840	(Get FASTA)	NCBI Sequence Viewer
	XP_038479866	(Get FASTA)	NCBI Sequence Viewer
	XP_038479867	(Get FASTA)	NCBI Sequence Viewer
	XP_038545627	(Get FASTA)	NCBI Sequence Viewer
	XP_038545628	(Get FASTA)	NCBI Sequence Viewer
	XP_532786	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000008030.3
	ENSCAFP00000070333.1
	ENSCAFP00030034367.1
	ENSCAFP00030034531.1
	ENSCAFP00030034573.1
	ENSCAFP00040027285.1
	ENSCAFP00040027401.1
	ENSCAFP00040027500.1
	ENSCAFP00040027674.1
	ENSCAFP00040027822.1
	ENSCAFP00040027956.1
	ENSCAFP00845023655
	ENSCAFP00845023655.1
	ENSCAFP00845023680.1
	ENSCAFP00845023714.1

RefSeq Acc Id:	XP_532786 ⟸ XM_532786
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0RQI5 (UniProtKB/TrEMBL), A0A8C0JST8 (UniProtKB/TrEMBL), A0A8I3P9P2 (UniProtKB/TrEMBL), A0A8C0PC84 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAATEGVGEAAQGSESAQPEPPPPQPHPPPLQPQQQEEAMAAELGEAVASPMDDGFLSLDSPTY VLYRDRAEWADIDPVPQNDGPNPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELN AANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIAD ILNQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYNDRAI LEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLSQLLDLQPSHSSPYLIAFLVDIY EDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSTESDPPTNVQQ hide sequence

RefSeq Acc Id:

XP_005629842 ⟸ XM_005629785

- Peptide Label:

isoform X2

- Sequence:

show sequence

MAATEGVGEAAQGSESAQPEPPPPQPHPPPLQPQQQEEAMAAELGEAVASPMDDGFLSLDSPTY
VLYRDRAEWADIDPVPQNDGPNPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELN
AANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIAD
ILNQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYNDRAI
LEREVQYTLEMIKLVPHNESAWNYLKGLEVSLETRPKKHKVWSPVTFGDESYKIWRAISYKEPS
QEEAEISLLFSSFVISR

hide sequence

RefSeq Acc Id:

ENSCAFP00000008030 ⟸ ENSCAFT00000008664

RefSeq Acc Id:	XP_038353383 ⟸ XM_038497455
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038353384 ⟸ XM_038497456
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038479866 ⟸ XM_038623938
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038479867 ⟸ XM_038623939
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038545627 ⟸ XM_038689699
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0RQI5 (UniProtKB/TrEMBL), A0A8C0JST8 (UniProtKB/TrEMBL), A0A8I3P9P2 (UniProtKB/TrEMBL), A0A8C0PC84 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038545628 ⟸ XM_038689700
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038415839 ⟸ XM_038559911
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0JST8 (UniProtKB/TrEMBL), A0A8C0PC84 (UniProtKB/TrEMBL), A0A8C0RQI5 (UniProtKB/TrEMBL), A0A8I3P9P2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038415840 ⟸ XM_038559912
- Peptide Label:	isoform X2

Protein Domains

Calponin-homology (CH)

Promoters

RGD ID:

13686081

Promoter ID:

EPDNEW_C4149

Type:

multiple initiation site

Name:

FNTA_1

Description:

farnesyltransferase, CAAX box, alpha

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	16	22,767,924 - 22,767,984	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000005385	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030021408	UniProtKB/TrEMBL
	ENSCAFG00030021571	UniProtKB/TrEMBL
	ENSCAFG00040016996	UniProtKB/TrEMBL
	ENSCAFG00845017026	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000008664.5	UniProtKB/TrEMBL
	ENSCAFT00000103633.1	UniProtKB/TrEMBL
	ENSCAFT00030039383.1	UniProtKB/TrEMBL
	ENSCAFT00030039572.1	UniProtKB/TrEMBL
	ENSCAFT00030039619.1	UniProtKB/TrEMBL
	ENSCAFT00040031378.1	UniProtKB/TrEMBL
	ENSCAFT00040031507.1	UniProtKB/TrEMBL
	ENSCAFT00040031622.1	UniProtKB/TrEMBL
	ENSCAFT00040031818.1	UniProtKB/TrEMBL
	ENSCAFT00040032002.1	UniProtKB/TrEMBL
	ENSCAFT00040032157.1	UniProtKB/TrEMBL
	ENSCAFT00845030162	ENTREZGENE
	ENSCAFT00845030162.1	UniProtKB/TrEMBL
	ENSCAFT00845030200.1	UniProtKB/TrEMBL
	ENSCAFT00845030242.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.418.10	UniProtKB/TrEMBL
	Protein prenylyltransferase	UniProtKB/TrEMBL
InterPro	CH-domain	UniProtKB/TrEMBL
	CH_dom_sf	UniProtKB/TrEMBL
	Hook_C	UniProtKB/TrEMBL
	HOOK_N	UniProtKB/TrEMBL
	Prenyl_trans_a	UniProtKB/TrEMBL
NCBI Gene	FNTA	ENTREZGENE
PANTHER	HOOK PROTEINS	UniProtKB/TrEMBL
	PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT	UniProtKB/TrEMBL
	PROTEIN FARNESYLTRANSFERASE/GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA	UniProtKB/TrEMBL
	PROTEIN HOOK HOMOLOG 3	UniProtKB/TrEMBL
Pfam	HOOK	UniProtKB/TrEMBL
	HOOK_N	UniProtKB/TrEMBL
	PPTA	UniProtKB/TrEMBL
PROSITE	PFTA	UniProtKB/TrEMBL
	PS50021	UniProtKB/TrEMBL
Superfamily-SCOP	Hook domain	UniProtKB/TrEMBL
	Protein prenylyltransferase	UniProtKB/TrEMBL
UniProt	A0A8C0JST8	ENTREZGENE
	A0A8C0PC84	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0RQI5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0SWY3_CANLF	UniProtKB/TrEMBL
	A0A8C0SWZ6_CANLF	UniProtKB/TrEMBL
	A0A8C0SZB4_CANLF	UniProtKB/TrEMBL
	A0A8C0T144_CANLF	UniProtKB/TrEMBL
	A0A8C0Z0J4_CANLF	UniProtKB/TrEMBL
	A0A8I3P1K7_CANLF	UniProtKB/TrEMBL
	A0A8I3P375_CANLF	UniProtKB/TrEMBL
	A0A8I3P9P2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0PKI8_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:40937	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2024-03-18	FNTA	farnesyltransferase, CAAX box, subunit alpha	FNTA	farnesyltransferase, CAAX box, alpha	Symbol and/or name change	19259463	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar