P3H3 (prolyl 3-hydroxylase 3) - Rat Genome Database

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Gene: P3H3 (prolyl 3-hydroxylase 3) Canis lupus familiaris
Analyze
Symbol: P3H3
Name: prolyl 3-hydroxylase 3
RGD ID: 12342365
Description: ENCODES a protein that exhibits dioxygenase activity (inferred); iron ion binding (inferred); L-ascorbic acid binding (inferred); INVOLVED IN collagen biosynthetic process (inferred); collagen metabolic process (inferred); negative regulation of cell population proliferation (inferred); ASSOCIATED WITH developmental and epileptic encephalopathy 21 (ortholog); genetic disease (ortholog); Hyperphosphatemic Familial Tumoral Calcinosis 1 (ortholog); FOUND IN catalytic complex (inferred); endoplasmic reticulum (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leprecan-like 2; LEPREL2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,182,642 - 38,195,173 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,182,856 - 38,194,902 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,421,931 - 8,434,105 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,535,545 - 38,547,751 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,535,759 - 38,547,751 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,409,597 - 38,421,793 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,450,620 - 38,462,980 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,900,667 - 7,912,837 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
P3H3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,182,642 - 38,195,173 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,182,856 - 38,194,902 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,421,931 - 8,434,105 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,535,545 - 38,547,751 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,535,759 - 38,547,751 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,409,597 - 38,421,793 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,450,620 - 38,462,980 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,900,667 - 7,912,837 (+)NCBIUU_Cfam_GSD_1.0
P3H3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,828,407 - 6,839,847 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,828,407 - 6,839,847 (+)EnsemblGRCh38hg38GRCh38
GRCh37126,937,572 - 6,949,011 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,807,833 - 6,819,279 (+)NCBINCBI36Build 36hg18NCBI36
Build 34126,807,464 - 6,819,271NCBI
Celera128,554,854 - 8,566,302 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,791,512 - 6,802,741 (+)NCBIHuRef
CHM1_1126,936,568 - 6,948,016 (+)NCBICHM1_1
T2T-CHM13v2.0126,837,700 - 6,849,139 (+)NCBIT2T-CHM13v2.0
P3h3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,818,052 - 124,834,680 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,818,052 - 124,834,715 (-)EnsemblGRCm39 Ensembl
GRCm386124,841,089 - 124,857,746 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,841,089 - 124,857,752 (-)EnsemblGRCm38mm10GRCm38
MGSCv376124,791,113 - 124,807,705 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366124,806,714 - 124,823,306 (-)NCBIMGSCv36mm8
Celera6126,517,224 - 126,533,811 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
P3h3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,332,514 - 159,348,428 (-)NCBIGRCr8
mRatBN7.24157,646,242 - 157,662,035 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,646,243 - 157,662,035 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,874,521 - 163,888,373 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,657,430 - 159,671,284 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,292,915 - 158,306,549 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,359,331 - 157,375,186 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,359,332 - 157,372,861 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,377,005 - 224,392,881 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,964,297 - 160,978,321 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14161,209,590 - 161,225,134 (-)NCBI
Celera4146,384,156 - 146,397,672 (-)NCBICelera
Cytogenetic Map4q42NCBI
P3h3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,429,633 - 4,440,256 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,429,558 - 4,440,602 (+)NCBIChiLan1.0ChiLan1.0
P3H3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21012,391,234 - 12,403,013 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11212,387,950 - 12,399,771 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,960,193 - 6,971,691 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1126,872,041 - 6,883,187 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,872,035 - 6,883,187 (+)Ensemblpanpan1.1panPan2
P3h3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,310,306 - 102,322,990 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936709978,229 - 989,874 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936709977,851 - 989,949 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P3H3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,871,508 - 63,885,034 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1563,871,506 - 63,885,294 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,307,000 - 66,319,718 (-)NCBISscrofa10.2Sscrofa10.2susScr3
P3H3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,861,123 - 6,872,934 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl116,860,891 - 6,872,549 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660631,350,632 - 1,362,750 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P3h3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,498,547 - 3,508,682 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,498,493 - 3,508,999 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in P3H3
129 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 11 1 1 8 6 2
Low 4 5 11 6 5 6 5 5 4 4 4
Below cutoff 1 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000023278   ⟹   ENSCAFP00000021617
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2738,182,856 - 38,194,902 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845048616   ⟹   ENSCAFP00845038136
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2738,535,759 - 38,547,751 (-)Ensembl
RefSeq Acc Id: XM_038439138   ⟹   XP_038295066
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02738,535,545 - 38,547,751 (-)NCBI
RefSeq Acc Id: XM_038459754   ⟹   XP_038315682
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha278,421,931 - 8,434,105 (+)NCBI
RefSeq Acc Id: XM_038513800   ⟹   XP_038369728
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12738,409,597 - 38,421,793 (-)NCBI
RefSeq Acc Id: XM_038576636   ⟹   XP_038432564
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0277,900,667 - 7,912,837 (+)NCBI
RefSeq Acc Id: XM_038641648   ⟹   XP_038497576
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02738,450,620 - 38,462,980 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000021617   ⟸   ENSCAFT00000023278
RefSeq Acc Id: XP_038369728   ⟸   XM_038513800
RefSeq Acc Id: XP_038497576   ⟸   XM_038641648
RefSeq Acc Id: XP_038295066   ⟸   XM_038439138
- UniProtKB: A0A8C0JPC1 (UniProtKB/TrEMBL),   A0A8C0TP78 (UniProtKB/TrEMBL),   A0A8I3PU70 (UniProtKB/TrEMBL),   A0A8C0TR56 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038315682   ⟸   XM_038459754
- UniProtKB: A0A8C0JPC1 (UniProtKB/TrEMBL),   A0A8C0TP78 (UniProtKB/TrEMBL),   A0A8I3PU70 (UniProtKB/TrEMBL),   A0A8C0TR56 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038432564   ⟸   XM_038576636
- UniProtKB: A0A8C0JPC1 (UniProtKB/TrEMBL),   A0A8C0TP78 (UniProtKB/TrEMBL),   A0A8C0TR56 (UniProtKB/TrEMBL),   A0A8I3PU70 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845038136   ⟸   ENSCAFT00845048616
Protein Domains
Fe2OG dioxygenase

Promoters
RGD ID:13688204
Promoter ID:EPDNEW_C6274
Type:multiple initiation site
Name:P3H3_1
Description:prolyl 3-hydroxylase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12738,194,938 - 38,194,998EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000031318 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030021392 UniProtKB/TrEMBL
  ENSCAFG00040023575 UniProtKB/TrEMBL
  ENSCAFG00845027539 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000023278.5 UniProtKB/TrEMBL
  ENSCAFT00030039227.1 UniProtKB/TrEMBL
  ENSCAFT00030039348.1 UniProtKB/TrEMBL
  ENSCAFT00030039390.1 UniProtKB/TrEMBL
  ENSCAFT00030039479.1 UniProtKB/TrEMBL
  ENSCAFT00040043885.1 UniProtKB/TrEMBL
  ENSCAFT00040043905.1 UniProtKB/TrEMBL
  ENSCAFT00040043925.1 UniProtKB/TrEMBL
  ENSCAFT00040043960.1 UniProtKB/TrEMBL
  ENSCAFT00040044072.1 UniProtKB/TrEMBL
  ENSCAFT00040044123.1 UniProtKB/TrEMBL
  ENSCAFT00845048616 ENTREZGENE
  ENSCAFT00845048616.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
  q2cbj1_9rhob like domain UniProtKB/TrEMBL
InterPro Atrophin-1 UniProtKB/TrEMBL
  Atrophin-like UniProtKB/TrEMBL
  Oxoglu/Fe-dep_dioxygenase UniProtKB/TrEMBL
  P3H UniProtKB/TrEMBL
  Pro_4_hyd_alph UniProtKB/TrEMBL
  Pro_4_hyd_alph_FE2OG_OXY UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/TrEMBL
NCBI Gene P3H3 ENTREZGENE
PANTHER ATROPHIN-1 UniProtKB/TrEMBL
  ATROPHIN-RELATED UniProtKB/TrEMBL
  PTHR14049 UniProtKB/TrEMBL
  PTHR14049:SF14 UniProtKB/TrEMBL
Pfam 2OG-FeII_Oxy_3 UniProtKB/TrEMBL
  Atrophin-1 UniProtKB/TrEMBL
PRINTS ATROPHIN UniProtKB/TrEMBL
PROSITE FE2OG_OXY UniProtKB/TrEMBL
SMART P4Hc UniProtKB/TrEMBL
UniProt A0A8C0JPC1 ENTREZGENE
  A0A8C0P4S1_CANLF UniProtKB/TrEMBL
  A0A8C0P7N8_CANLF UniProtKB/TrEMBL
  A0A8C0PFF7_CANLF UniProtKB/TrEMBL
  A0A8C0TM98_CANLF UniProtKB/TrEMBL
  A0A8C0TNM3_CANLF UniProtKB/TrEMBL
  A0A8C0TP78 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TQR2_CANLF UniProtKB/TrEMBL
  A0A8C0TR56 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Z5G6_CANLF UniProtKB/TrEMBL
  A0A8I3PU70 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:44221 ENTREZGENE