GDF3 (growth differentiation factor 3) - Rat Genome Database

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Gene: GDF3 (growth differentiation factor 3) Canis lupus familiaris
Analyze
Symbol: GDF3
Name: growth differentiation factor 3
RGD ID: 12342063
Description: ENCODES a protein that exhibits cytokine activity (inferred); growth factor activity (inferred); protein kinase binding (inferred); INVOLVED IN endoderm development (ortholog); formation of anatomical boundary (ortholog); in utero embryonic development (ortholog); ASSOCIATED WITH Camptocormia (ortholog); congenital heart disease (ortholog); developmental and epileptic encephalopathy 21 (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: growth/differentiation factor 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12737,125,845 - 37,129,567 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2737,125,928 - 37,129,484 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha279,486,781 - 9,490,505 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02737,475,220 - 37,478,894 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2737,475,303 - 37,478,814 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12737,356,251 - 37,359,922 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02737,391,174 - 37,394,862 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,972,861 - 8,976,557 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GDF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12737,125,845 - 37,129,567 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2737,125,928 - 37,129,484 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha279,486,781 - 9,490,505 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02737,475,220 - 37,478,894 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2737,475,303 - 37,478,814 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12737,356,251 - 37,359,922 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02737,391,174 - 37,394,862 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,972,861 - 8,976,557 (+)NCBIUU_Cfam_GSD_1.0
GDF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,689,784 - 7,695,775 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl127,689,784 - 7,695,775 (-)EnsemblGRCh38hg38GRCh38
GRCh37127,842,380 - 7,848,371 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,733,648 - 7,739,627 (-)NCBINCBI36Build 36hg18NCBI36
Build 34127,733,647 - 7,739,627NCBI
Celera129,419,392 - 9,425,368 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef127,656,489 - 7,662,465 (-)NCBIHuRef
CHM1_1127,839,618 - 7,847,334 (-)NCBICHM1_1
T2T-CHM13v2.0127,704,552 - 7,710,540 (-)NCBIT2T-CHM13v2.0
Gdf3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396122,582,362 - 122,587,046 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6122,582,362 - 122,587,046 (-)EnsemblGRCm39 Ensembl
GRCm386122,605,403 - 122,610,087 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6122,605,403 - 122,610,087 (-)EnsemblGRCm38mm10GRCm38
MGSCv376122,555,421 - 122,560,089 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366122,571,022 - 122,575,690 (-)NCBIMGSCv36mm8
Celera6124,400,537 - 124,405,205 (-)NCBICelera
Cytogenetic Map6F1NCBI
cM Map657.7NCBI
Gdf3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84157,503,547 - 157,507,923 (-)NCBIGRCr8
mRatBN7.24155,831,572 - 155,835,953 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4155,830,909 - 155,835,937 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4162,096,256 - 162,100,528 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04157,879,466 - 157,883,738 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04156,524,567 - 156,528,834 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04155,417,667 - 155,422,014 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4155,417,004 - 155,421,998 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04222,441,866 - 222,445,551 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44159,064,054 - 159,067,854 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4144,650,730 - 144,655,147 (-)NCBICelera
Cytogenetic Map4q42NCBI
Gdf3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554136,493,734 - 6,516,315 (-)NCBIChiLan1.0ChiLan1.0
GDF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21013,248,001 - 13,262,305 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11213,244,760 - 13,259,063 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,813,288 - 7,819,418 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1127,972,941 - 7,979,654 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,972,907 - 7,979,815 (-)Ensemblpanpan1.1panPan2
Gdf3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494598,790,269 - 98,799,229 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049378477,456 - 16,783 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049378478,179 - 16,783 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GDF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl562,835,880 - 62,841,884 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1562,835,926 - 62,841,827 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2565,666,056 - 65,672,100 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GDF3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,727,818 - 7,733,514 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,727,913 - 7,733,075 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666063470,438 - 475,790 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gdf3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248604,968,624 - 4,970,362 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GDF3
36 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low
Below cutoff 5 5 22 6 6 6 6 6 12 8 10 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000042973   ⟹   ENSCAFP00000041841
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2737,125,928 - 37,129,484 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845052634   ⟹   ENSCAFP00845041307
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2737,475,303 - 37,478,814 (-)Ensembl
RefSeq Acc Id: XM_038439070   ⟹   XP_038294998
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02737,475,220 - 37,478,894 (-)NCBI
RefSeq Acc Id: XM_038513727   ⟹   XP_038369655
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12737,356,251 - 37,359,922 (-)NCBI
RefSeq Acc Id: XM_038576702   ⟹   XP_038432630
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0278,972,861 - 8,976,557 (+)NCBI
RefSeq Acc Id: XM_038641570   ⟹   XP_038497498
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02737,391,174 - 37,394,862 (-)NCBI
RefSeq Acc Id: XM_534896   ⟹   XP_534896
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12737,125,845 - 37,129,567 (-)NCBI
Dog10K_Boxer_Tasha279,486,781 - 9,490,505 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_534896   ⟸   XM_534896
- UniProtKB: A0A8C0JSF7 (UniProtKB/TrEMBL),   A0A8I3Q963 (UniProtKB/TrEMBL),   A0A8P0SVG3 (UniProtKB/TrEMBL),   A0A8C0TCW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000041841   ⟸   ENSCAFT00000042973
RefSeq Acc Id: XP_038369655   ⟸   XM_038513727
RefSeq Acc Id: XP_038497498   ⟸   XM_038641570
RefSeq Acc Id: XP_038294998   ⟸   XM_038439070
- UniProtKB: A0A8C0JSF7 (UniProtKB/TrEMBL),   A0A8I3Q963 (UniProtKB/TrEMBL),   A0A8P0SVG3 (UniProtKB/TrEMBL),   A0A8C0TCW3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038432630   ⟸   XM_038576702
- UniProtKB: A0A8C0P8K4 (UniProtKB/TrEMBL),   A0A8C0TCW3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845041307   ⟸   ENSCAFT00845052634
Protein Domains
TGF-beta family profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000032763 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030022826 UniProtKB/TrEMBL
  ENSCAFG00040021175 UniProtKB/TrEMBL
  ENSCAFG00845029730 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000042973.3 UniProtKB/TrEMBL
  ENSCAFT00030041935.1 UniProtKB/TrEMBL
  ENSCAFT00040039289.1 UniProtKB/TrEMBL
  ENSCAFT00845052634 ENTREZGENE
  ENSCAFT00845052634.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
  2.60.120.970 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  TGF-b_C UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/TrEMBL
  TGFb_CS UniProtKB/TrEMBL
KEGG Report cfa:477702 UniProtKB/TrEMBL
NCBI Gene GDF3 ENTREZGENE
PANTHER GROWTH/DIFFERENTIATION FACTOR 3 UniProtKB/TrEMBL
  PTHR11848 UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/TrEMBL
PRINTS INHIBINA UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/TrEMBL
SMART TGFB UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A0A8C0JSF7 ENTREZGENE
  A0A8C0P8K4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TCW3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q963 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SVG3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:41162 ENTREZGENE