ATP2A1 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1) - Rat Genome Database

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Gene: ATP2A1 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1) Canis lupus familiaris
Analyze
Symbol: ATP2A1
Name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
RGD ID: 12327552
Description: ENCODES a protein that exhibits ATP binding (ortholog); calcium ion binding (ortholog); calcium-dependent ATPase activity (ortholog); INVOLVED IN calcium ion transport (ortholog); negative regulation of striated muscle contraction (ortholog); regulation of striated muscle contraction (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Alcohol Myopathy (ortholog); Brody myopathy (ortholog); Cachexia (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); H zone (ortholog); I band (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sarcoplasmic/endoplasmic reticulum calcium ATPase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1618,384,981 - 18,400,038 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl618,385,007 - 18,400,036 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,963,150 - 19,978,140 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0618,520,899 - 18,535,902 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,520,922 - 18,535,900 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1618,320,443 - 18,335,447 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0618,235,008 - 18,250,003 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,551,136 - 18,566,380 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ATP2A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1618,384,981 - 18,400,038 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl618,385,007 - 18,400,036 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,963,150 - 19,978,140 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0618,520,899 - 18,535,902 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,520,922 - 18,535,900 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1618,320,443 - 18,335,447 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0618,235,008 - 18,250,003 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,551,136 - 18,566,380 (+)NCBIUU_Cfam_GSD_1.0
ATP2A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381628,878,488 - 28,904,466 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1628,878,405 - 28,904,466 (+)EnsemblGRCh38hg38GRCh38
GRCh371628,889,809 - 28,915,787 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361628,797,310 - 28,823,331 (+)NCBINCBI36Build 36hg18NCBI36
Build 341628,797,309 - 28,823,331NCBI
Celera1627,844,578 - 27,896,644 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1626,757,144 - 26,783,172 (+)NCBIHuRef
CHM1_11629,901,645 - 29,927,644 (+)NCBICHM1_1
T2T-CHM13v2.01629,158,988 - 29,184,960 (+)NCBIT2T-CHM13v2.0
Atp2a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,045,032 - 126,062,245 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,045,030 - 126,062,280 (-)EnsemblGRCm39 Ensembl
GRCm387126,445,858 - 126,463,103 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,445,858 - 126,463,108 (-)EnsemblGRCm38mm10GRCm38
MGSCv377133,589,374 - 133,606,587 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367126,237,008 - 126,254,221 (-)NCBIMGSCv36mm8
Celera7126,298,414 - 126,315,638 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.04NCBI
Atp2a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,457,198 - 190,475,410 (-)NCBIGRCr8
mRatBN7.21181,026,606 - 181,044,859 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,026,608 - 181,044,838 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,357,175 - 189,375,401 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01196,543,255 - 196,561,480 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,231,158 - 189,249,385 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01197,855,912 - 197,875,038 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01204,836,393 - 204,854,172 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1178,686,581 - 178,704,188 (-)NCBICelera
Cytogenetic Map1q36NCBI
Atp2a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554936,559,995 - 6,578,461 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554936,559,995 - 6,578,461 (-)NCBIChiLan1.0ChiLan1.0
ATP2A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21831,856,753 - 31,883,308 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11636,674,275 - 36,700,816 (-)NCBINHGRI_mPanPan1
PanPan1.11629,265,107 - 29,274,924 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1629,265,516 - 29,290,807 (+)NCBIpanpan1.1panPan2
PanPan1.1 Ensembl1629,265,516 - 29,290,807 (+)Ensemblpanpan1.1panPan2
Atp2a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344123,720,441 - 123,738,330 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650111,816,585 - 11,836,231 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650111,818,301 - 11,836,221 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP2A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl318,545,071 - 18,568,310 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1318,545,064 - 18,568,312 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2318,733,279 - 18,753,571 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP2A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,165,370 - 26,196,517 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,164,205 - 26,193,172 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660683,421,323 - 3,459,785 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp2a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478212,867,230 - 12,883,685 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478212,867,404 - 12,883,685 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ATP2A1
182 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 4
Medium 2
Low 5 3 22 6 6 6 6 12 8 10 6
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000027373   ⟹   ENSCAFP00000025459
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl618,385,007 - 18,399,805 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000043242   ⟹   ENSCAFP00000042475
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl618,385,007 - 18,400,036 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000070822   ⟹   ENSCAFP00000055299
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl618,385,007 - 18,400,036 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845005702   ⟹   ENSCAFP00845004521
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl618,520,922 - 18,535,900 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845005729   ⟹   ENSCAFP00845004542
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl618,520,922 - 18,535,669 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845005784   ⟹   ENSCAFP00845004592
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl618,520,922 - 18,535,177 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845005845   ⟹   ENSCAFP00845004643
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl618,520,922 - 18,534,769 (+)Ensembl
RefSeq Acc Id: XM_038478710   ⟹   XP_038334638
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1618,320,443 - 18,335,447 (+)NCBI
RefSeq Acc Id: XM_038478711   ⟹   XP_038334639
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1618,320,443 - 18,335,447 (+)NCBI
RefSeq Acc Id: XM_038539954   ⟹   XP_038395882
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0618,551,136 - 18,566,380 (+)NCBI
RefSeq Acc Id: XM_038539955   ⟹   XP_038395883
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0618,551,136 - 18,566,380 (+)NCBI
RefSeq Acc Id: XM_038604036   ⟹   XP_038459964
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0618,235,008 - 18,250,003 (+)NCBI
RefSeq Acc Id: XM_038604037   ⟹   XP_038459965
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0618,235,008 - 18,250,003 (+)NCBI
RefSeq Acc Id: XM_038668752   ⟹   XP_038524680
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0618,520,899 - 18,535,902 (+)NCBI
RefSeq Acc Id: XM_038668753   ⟹   XP_038524681
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0618,520,899 - 18,535,902 (+)NCBI
RefSeq Acc Id: XM_854917   ⟹   XP_860010
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1618,384,981 - 18,400,038 (+)NCBI
Dog10K_Boxer_Tasha619,963,150 - 19,978,140 (+)NCBI
Sequence:
RefSeq Acc Id: XM_855027   ⟹   XP_860120
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1618,384,981 - 18,400,038 (+)NCBI
Dog10K_Boxer_Tasha619,963,150 - 19,978,140 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_860120   ⟸   XM_855027
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PT52 (UniProtKB/TrEMBL),   A0A8I3MN74 (UniProtKB/TrEMBL),   A0A8C0PT12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_860010   ⟸   XM_854917
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PSX5 (UniProtKB/TrEMBL),   A0A8I3MNT3 (UniProtKB/TrEMBL),   A0A8C0PT12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000055299   ⟸   ENSCAFT00000070822
RefSeq Acc Id: ENSCAFP00000025459   ⟸   ENSCAFT00000027373
RefSeq Acc Id: ENSCAFP00000042475   ⟸   ENSCAFT00000043242
RefSeq Acc Id: XP_038334639   ⟸   XM_038478711
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038334638   ⟸   XM_038478710
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038459965   ⟸   XM_038604037
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038459964   ⟸   XM_038604036
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038524681   ⟸   XM_038668753
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PT52 (UniProtKB/TrEMBL),   A0A8I3MN74 (UniProtKB/TrEMBL),   A0A8C0PT12 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038524680   ⟸   XM_038668752
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PSX5 (UniProtKB/TrEMBL),   A0A8I3MNT3 (UniProtKB/TrEMBL),   A0A8C0PT12 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038395883   ⟸   XM_038539955
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PT12 (UniProtKB/TrEMBL),   A0A8C0PT52 (UniProtKB/TrEMBL),   A0A8I3MN74 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038395882   ⟸   XM_038539954
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PSX5 (UniProtKB/TrEMBL),   A0A8C0PT12 (UniProtKB/TrEMBL),   A0A8I3MNT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845004592   ⟸   ENSCAFT00845005784
RefSeq Acc Id: ENSCAFP00845004521   ⟸   ENSCAFT00845005702
RefSeq Acc Id: ENSCAFP00845004542   ⟸   ENSCAFT00845005729
RefSeq Acc Id: ENSCAFP00845004643   ⟸   ENSCAFT00845005845
Protein Domains
Cation-transporting P-type ATPase C-terminal   Cation-transporting P-type ATPase N-terminal

Promoters
RGD ID:13683640
Promoter ID:EPDNEW_C1708
Type:single initiation site
Name:ATP2A1_1
Description:ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1618,384,999 - 18,385,059EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000017254 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030000041 UniProtKB/TrEMBL
  ENSCAFG00040001087 UniProtKB/TrEMBL
  ENSCAFG00845003233 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000027373.5 UniProtKB/TrEMBL
  ENSCAFT00000043242.4 UniProtKB/TrEMBL
  ENSCAFT00030000042.1 UniProtKB/TrEMBL
  ENSCAFT00030000067.1 UniProtKB/TrEMBL
  ENSCAFT00030000106.1 UniProtKB/TrEMBL
  ENSCAFT00040002050.1 UniProtKB/TrEMBL
  ENSCAFT00040002098.1 UniProtKB/TrEMBL
  ENSCAFT00040002144.1 UniProtKB/TrEMBL
  ENSCAFT00040002183.1 UniProtKB/TrEMBL
  ENSCAFT00040002303.1 UniProtKB/TrEMBL
  ENSCAFT00040002319.1 UniProtKB/TrEMBL
  ENSCAFT00845005702 ENTREZGENE
  ENSCAFT00845005702.1 UniProtKB/TrEMBL
  ENSCAFT00845005729 ENTREZGENE
  ENSCAFT00845005729.1 UniProtKB/TrEMBL
  ENSCAFT00845005784.1 UniProtKB/TrEMBL
  ENSCAFT00845005845.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1110.10 UniProtKB/TrEMBL
  3.40.50.1000 UniProtKB/TrEMBL
  Calcium-transporting ATPase, cytoplasmic transduction domain A UniProtKB/TrEMBL
  Calcium-transporting ATPase, transmembrane domain UniProtKB/TrEMBL
InterPro ATPase_P-typ_cation-transptr_C UniProtKB/TrEMBL
  ATPase_P-typ_cation-transptr_N UniProtKB/TrEMBL
  ATPase_P-typ_cyto_dom_N UniProtKB/TrEMBL
  ATPase_P-typ_P_site UniProtKB/TrEMBL
  ATPase_P-typ_TM_dom_sf UniProtKB/TrEMBL
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/TrEMBL
  HAD_sf UniProtKB/TrEMBL
  P-type_ATPase_IIA UniProtKB/TrEMBL
  P_typ_ATPase UniProtKB/TrEMBL
  P_typ_ATPase_HD_dom UniProtKB/TrEMBL
KEGG Report cfa:479797 UniProtKB/TrEMBL
NCBI Gene ATP2A1 ENTREZGENE
PANTHER CALCIUM-TRANSPORTING ATPASE UniProtKB/TrEMBL
  SARCOPLASMIC/ENDOPLASMIC RETICULUM CALCIUM ATPASE 1 UniProtKB/TrEMBL
Pfam Cation_ATPase UniProtKB/TrEMBL
  Cation_ATPase_C UniProtKB/TrEMBL
  Cation_ATPase_N UniProtKB/TrEMBL
  E1-E2_ATPase UniProtKB/TrEMBL
  Hydrolase UniProtKB/TrEMBL
PRINTS CATATPASE UniProtKB/TrEMBL
  HATPASE UniProtKB/TrEMBL
PROSITE ATPASE_E1_E2 UniProtKB/TrEMBL
SMART Cation_ATPase_N UniProtKB/TrEMBL
Superfamily-SCOP SSF56784 UniProtKB/TrEMBL
  SSF81653 UniProtKB/TrEMBL
  SSF81660 UniProtKB/TrEMBL
  SSF81665 UniProtKB/TrEMBL
UniProt A0A8C0PQ66_CANLF UniProtKB/TrEMBL
  A0A8C0PSX5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PT12 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PT52 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PXR6_CANLF UniProtKB/TrEMBL
  A0A8C0R980_CANLF UniProtKB/TrEMBL
  A0A8I3MJQ7_CANLF UniProtKB/TrEMBL
  A0A8I3MN74 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MNT3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MS96_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:38253 ENTREZGENE