NSUN4 (NOP2/Sun RNA methyltransferase 4) - Rat Genome Database

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Gene: NSUN4 (NOP2/Sun RNA methyltransferase 4) Canis lupus familiaris
Analyze
Symbol: NSUN4
Name: NOP2/Sun RNA methyltransferase 4
RGD ID: 12253281
Description: ENCODES a protein that exhibits rRNA (cytosine-C5-)-methyltransferase activity (ortholog); rRNA methyltransferase activity (ortholog); small ribosomal subunit rRNA binding (ortholog); INVOLVED IN cytosolic ribosome assembly (ortholog); positive regulation of mitochondrial translation (ortholog); rRNA methylation (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN mitochondrial large ribosomal subunit (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 5-methylcytosine rRNA methyltransferase NSUN4; NOL1/NOP2/Sun domain family, member 4; NOP2/Sun RNA methyltransferase family member 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11514,054,061 - 14,069,080 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1514,056,004 - 14,068,190 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1514,174,443 - 14,193,244 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01514,204,565 - 14,223,051 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11514,005,796 - 14,024,334 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01514,074,309 - 14,092,843 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01514,143,770 - 14,162,312 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NSUN4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11514,054,061 - 14,069,080 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1514,056,004 - 14,068,190 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1514,174,443 - 14,193,244 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01514,204,565 - 14,223,051 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11514,005,796 - 14,024,334 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01514,074,309 - 14,092,843 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01514,143,770 - 14,162,312 (-)NCBIUU_Cfam_GSD_1.0
NSUN4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38146,340,807 - 46,385,199 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl146,340,789 - 46,365,152 (+)EnsemblGRCh38hg38GRCh38
GRCh37146,806,479 - 46,850,871 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36146,578,977 - 46,603,277 (+)NCBINCBI36Build 36hg18NCBI36
Build 34146,518,409 - 46,542,710NCBI
Celera145,093,753 - 45,118,052 (+)NCBICelera
Cytogenetic Map1p33NCBI
HuRef144,921,478 - 44,946,447 (+)NCBIHuRef
CHM1_1146,922,865 - 46,947,850 (+)NCBICHM1_1
T2T-CHM13v2.0146,218,025 - 46,262,412 (+)NCBIT2T-CHM13v2.0
Nsun4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394115,890,202 - 115,911,076 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4115,890,039 - 115,911,073 (-)EnsemblGRCm39 Ensembl
GRCm384116,033,002 - 116,053,879 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4116,032,842 - 116,053,876 (-)EnsemblGRCm38mm10GRCm38
MGSCv374115,704,375 - 115,726,481 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364115,530,774 - 115,551,808 (-)NCBIMGSCv36mm8
Celera4114,770,482 - 114,792,136 (-)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.1NCBI
Nsun4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85134,749,024 - 134,773,630 (-)NCBIGRCr8
mRatBN7.25129,511,224 - 129,532,498 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5129,512,826 - 129,532,228 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl5129,512,307 - 129,532,423 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5132,128,516 - 132,148,523 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05133,883,402 - 133,903,409 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05133,905,539 - 133,925,544 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05134,885,377 - 134,905,492 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5134,886,497 - 134,905,588 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl5134,362,680 - 134,382,794 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05138,669,115 - 138,689,234 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05138,152,068 - 138,174,158 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,277,224 - 136,297,339 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5128,042,563 - 128,062,561 (-)NCBICelera
Cytogenetic Map5q35NCBI
Nsun4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546411,932,429 - 11,967,414 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546411,934,146 - 11,962,513 (-)NCBIChiLan1.0ChiLan1.0
NSUN4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21180,407,967 - 180,469,443 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11179,549,575 - 179,611,046 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,642,980 - 45,696,476 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1146,999,724 - 47,024,152 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl146,999,749 - 47,024,152 (+)Ensemblpanpan1.1panPan2
Nsun4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505861,531,932 - 61,561,758 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647427,356,134 - 27,387,098 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647427,356,133 - 27,385,710 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NSUN4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6165,091,797 - 165,118,861 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16165,093,511 - 165,119,285 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26152,572,652 - 152,598,585 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NSUN4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12086,432,047 - 86,453,481 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2086,432,414 - 86,453,157 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603330,537,494 - 30,565,092 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nsun4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249062,230,429 - 2,251,296 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249062,231,040 - 2,254,083 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NSUN4
177 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 16 1 10 8 10 3
Low 5 2 6 6 6 6 5 6 2 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005629034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038451682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038451683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038495798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038495799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038495800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038558172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038558173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038558174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038622045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038622047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038622048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038687794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000006832   ⟹   ENSCAFP00000006325
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1514,056,004 - 14,068,190 (-)Ensembl
RefSeq Acc Id: XM_005629034   ⟹   XP_005629091
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11514,054,061 - 14,069,080 (-)NCBI
Dog10K_Boxer_Tasha1514,174,443 - 14,189,816 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038451682   ⟹   XP_038307610
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1514,174,443 - 14,193,244 (-)NCBI
RefSeq Acc Id: XM_038451683   ⟹   XP_038307611
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1514,174,443 - 14,192,252 (-)NCBI
RefSeq Acc Id: XM_038495798   ⟹   XP_038351726
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11514,005,796 - 14,024,334 (-)NCBI
RefSeq Acc Id: XM_038495799   ⟹   XP_038351727
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11514,005,796 - 14,020,908 (-)NCBI
RefSeq Acc Id: XM_038495800   ⟹   XP_038351728
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11514,005,796 - 14,023,344 (-)NCBI
RefSeq Acc Id: XM_038558172   ⟹   XP_038414100
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01514,143,770 - 14,162,312 (-)NCBI
RefSeq Acc Id: XM_038558173   ⟹   XP_038414101
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01514,143,770 - 14,158,896 (-)NCBI
RefSeq Acc Id: XM_038558174   ⟹   XP_038414102
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01514,143,770 - 14,161,332 (-)NCBI
RefSeq Acc Id: XM_038622045   ⟹   XP_038477973
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01514,074,309 - 14,092,843 (-)NCBI
RefSeq Acc Id: XM_038622047   ⟹   XP_038477975
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01514,074,309 - 14,089,422 (-)NCBI
RefSeq Acc Id: XM_038622048   ⟹   XP_038477976
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01514,074,309 - 14,091,858 (-)NCBI
RefSeq Acc Id: XM_038687794   ⟹   XP_038543722
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01514,204,565 - 14,223,051 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005629091   ⟸   XM_005629034
- Peptide Label: isoform X5
- UniProtKB: A0A8I3P7P3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000006325   ⟸   ENSCAFT00000006832
RefSeq Acc Id: XP_038351726   ⟸   XM_038495798
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038351728   ⟸   XM_038495800
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038351727   ⟸   XM_038495799
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038477973   ⟸   XM_038622045
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038477976   ⟸   XM_038622048
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038477975   ⟸   XM_038622047
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038543722   ⟸   XM_038687794
- Peptide Label: isoform X1
- UniProtKB: A0A8C0P7Z6 (UniProtKB/TrEMBL),   A0A8C0R1B1 (UniProtKB/TrEMBL),   A0A8I3NZP8 (UniProtKB/TrEMBL),   A0A8P0N6Z4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038307610   ⟸   XM_038451682
- Peptide Label: isoform X1
- UniProtKB: A0A8C0P7Z6 (UniProtKB/TrEMBL),   A0A8C0R1B1 (UniProtKB/TrEMBL),   A0A8I3NZP8 (UniProtKB/TrEMBL),   A0A8P0N6Z4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038307611   ⟸   XM_038451683
- Peptide Label: isoform X5
- UniProtKB: A0A8I3P7P3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038414100   ⟸   XM_038558172
- Peptide Label: isoform X1
- UniProtKB: A0A8C0P7Z6 (UniProtKB/TrEMBL),   A0A8C0R1B1 (UniProtKB/TrEMBL),   A0A8I3NZP8 (UniProtKB/TrEMBL),   A0A8P0N6Z4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038414102   ⟸   XM_038558174
- Peptide Label: isoform X4
- UniProtKB: A0A8I3P7P3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038414101   ⟸   XM_038558173
- Peptide Label: isoform X4
- UniProtKB: A0A8I3P7P3 (UniProtKB/TrEMBL)
Protein Domains
SAM-dependent MTase RsmB/NOP-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004259 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030019404 UniProtKB/TrEMBL
  ENSCAFG00040016227 UniProtKB/TrEMBL
  ENSCAFG00845019757 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000006832.5 UniProtKB/TrEMBL
  ENSCAFT00000094011.1 UniProtKB/TrEMBL
  ENSCAFT00000095396.1 UniProtKB/TrEMBL
  ENSCAFT00030035646.1 UniProtKB/TrEMBL
  ENSCAFT00040029883.1 UniProtKB/TrEMBL
  ENSCAFT00845034820 ENTREZGENE
  ENSCAFT00845034820.1 UniProtKB/TrEMBL
  ENSCAFT00845034899.1 UniProtKB/TrEMBL
  ENSCAFT00845034957.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/TrEMBL
  6.20.240.40 UniProtKB/TrEMBL
InterPro MeTrfase_RsmB-F_NOP2_cat UniProtKB/TrEMBL
  MeTrfase_RsmB/NOP2 UniProtKB/TrEMBL
  RCMT UniProtKB/TrEMBL
  SAM-dependent_MTases_sf UniProtKB/TrEMBL
KEGG Report cfa:610446 UniProtKB/TrEMBL
NCBI Gene NSUN4 ENTREZGENE
PANTHER 5-METHYLCYTOSINE RRNA METHYLTRANSFERASE NSUN-4 UniProtKB/TrEMBL
  PROTEIN CBG01349-RELATED UniProtKB/TrEMBL
Pfam Methyltr_RsmB-F UniProtKB/TrEMBL
PRINTS RCMTFAMILY UniProtKB/TrEMBL
PROSITE SAM_MT_RSMB_NOP UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A0A8C0P7Z6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0R1B1 ENTREZGENE
  A0A8I3NZP8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P7P3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PBJ0_CANLF UniProtKB/TrEMBL
  A0A8P0N6Z4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PML6_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:54217 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-16 NSUN4  NOP2/Sun RNA methyltransferase 4    NOP2/Sun RNA methyltransferase family member 4  Symbol and/or name change 5135510 APPROVED