SIRT1 (sirtuin 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: SIRT1 (sirtuin 1) Canis lupus familiaris
Analyze
Symbol: SIRT1
Name: sirtuin 1
RGD ID: 12213926
Description: ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); caspase binding (ortholog); deacetylase activity (ortholog); INVOLVED IN angiogenesis (ortholog); behavioral response to starvation (ortholog); cardiac muscle cell apoptotic process (ortholog); PARTICIPATES IN histone modification pathway; hypoxia inducible factor pathway; p53 signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN axon (ortholog); chromatin (ortholog); chromatin silencing complex (ortholog); INTERACTS WITH nicotinamide; resveratrol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; sirtuin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1419,188,616 - 19,220,031 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl419,188,675 - 19,218,279 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha419,317,273 - 19,349,181 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0419,454,692 - 19,486,553 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl419,454,710 - 19,546,039 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1419,337,295 - 19,369,150 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0419,559,257 - 19,591,114 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0419,901,939 - 19,934,337 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
autoimmune disease  (ISO)
Autosomal Dominant Intellectual Developmental Disorder 70  (ISO)
Binge Drinking  (ISO)
brain infarction  (ISO)
Brain Injuries  (ISO)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
Cardiomegaly  (ISO)
Carotid Atherosclerosis  (ISO)
cocaine dependence  (ISO)
colitis  (ISO)
congestive heart failure  (ISO)
demyelinating disease  (ISO)
diabetes mellitus  (ISO)
diabetic retinopathy  (ISO)
epilepsy  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Fibrosis  (ISO)
genetic disease  (ISO)
Genomic Instability  (ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Hemorrhagic Shock  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Huntington's disease  (ISO)
Hypertrophy  (ISO)
impotence  (ISO)
Insulin Resistance  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
Lung Injury  (ISO)
macular degeneration  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephrogenic diabetes insipidus  (ISO)
Nerve Degeneration  (ISO)
neurodegenerative disease  (ISO)
neuronal ceroid lipofuscinosis 1  (ISO)
obesity  (ISO)
osteoporosis  (ISO)
osteosarcoma  (ISO)
Paralysis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
retinal disease  (ISO)
senile cataract  (ISO)
steatotic liver disease  (ISO)
systemic scleroderma  (ISO)
thrombosis  (ISO)
type 2 diabetes mellitus  (ISO)
Ventricular Dysfunction, Left  (ISO)
Wallerian Degeneration  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
behavioral response to starvation  (ISO)
cardiac muscle cell apoptotic process  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to antibiotic  (ISO)
cellular response to curcumin  (ISO)
cellular response to glucose starvation  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
cellular response to ionizing radiation  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to resveratrol  (ISO)
cellular response to rotenone  (ISO)
cellular response to starvation  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to vitamin B3  (ISO)
cholesterol homeostasis  (ISO)
chromatin organization  (ISO)
circadian regulation of gene expression  (ISO)
circadian rhythm  (ISO)
DNA damage response  (ISO)
DNA repair-dependent chromatin remodeling  (ISO)
DNA synthesis involved in DNA repair  (ISO)
energy homeostasis  (ISO)
fatty acid homeostasis  (ISO)
heterochromatin formation  (ISO)
intracellular glucose homeostasis  (ISO)
intracellular triglyceride homeostasis  (ISO)
intrinsic apoptotic signaling pathway  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
leptin-mediated signaling pathway  (ISO)
macrophage differentiation  (ISO)
maintenance of nucleus location  (ISO)
mitochondrion organization  (ISO)
negative regulation of adipose tissue development  (ISO)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of attachment of mitotic spindle microtubules to kinetochore  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cellular response to testosterone stimulus  (ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of DNA binding  (ISO)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of fibroblast apoptotic process  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of growth hormone secretion  (ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of peptidyl-lysine acetylation  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of phosphorylation  (ISO)
negative regulation of prostaglandin biosynthetic process  (ISO)
negative regulation of protein acetylation  (ISO)
negative regulation of protein localization to nucleus  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of TOR signaling  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of triglyceride biosynthetic process  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
neuron apoptotic process  (ISO)
ovulation from ovarian follicle  (ISO)
positive regulation of adaptive immune response  (ISO)
positive regulation of adipose tissue development  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular senescence  (ISO)
positive regulation of cholesterol efflux  (ISO)
positive regulation of DNA repair  (ISO)
positive regulation of double-strand break repair  (ISO)
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of granulosa cell apoptotic process  (ISO)
positive regulation of heart rate  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of macroautophagy  (ISO)
positive regulation of macrophage apoptotic process  (ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of MHC class II biosynthetic process  (ISO)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein deacetylation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of skeletal muscle cell proliferation  (ISO)
positive regulation of smooth muscle cell differentiation  (ISO)
positive regulation of thyroid-stimulating hormone secretion  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of triglyceride catabolic process  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
protein deacetylation  (ISO)
protein destabilization  (ISO)
protein ubiquitination  (ISO)
pyrimidine dimer repair by nucleotide-excision repair  (ISO)
rDNA heterochromatin formation  (ISO)
regulation of apoptotic process  (ISO)
regulation of bile acid biosynthetic process  (ISO)
regulation of brown fat cell differentiation  (ISO)
regulation of cell population proliferation  (ISO)
regulation of centrosome duplication  (ISO)
regulation of glucose metabolic process  (ISO)
regulation of lipid storage  (ISO)
regulation of mitotic cell cycle  (ISO)
regulation of peroxisome proliferator activated receptor signaling pathway  (ISO)
regulation of smooth muscle cell apoptotic process  (ISO)
regulation of transcription by glucose  (ISO)
response to cocaine  (ISO)
response to ethanol  (ISO)
response to fluoride  (ISO)
response to hydrogen peroxide  (ISO)
response to insulin  (ISO)
response to kainic acid  (ISO)
response to leptin  (ISO)
response to mycotoxin  (ISO)
response to nutrient levels  (ISO)
response to oxidative stress  (ISO)
response to resveratrol  (ISO)
single strand break repair  (ISO)
spermatogenesis  (ISO)
stress-induced premature senescence  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
triglyceride mobilization  (ISO)
UV-damage excision repair  (ISO)
vasodilation  (ISO)
white fat cell differentiation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21239502   PMID:22301074  


Genomics

Comparative Map Data
SIRT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1419,188,616 - 19,220,031 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl419,188,675 - 19,218,279 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha419,317,273 - 19,349,181 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0419,454,692 - 19,486,553 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl419,454,710 - 19,546,039 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1419,337,295 - 19,369,150 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0419,559,257 - 19,591,114 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0419,901,939 - 19,934,337 (+)NCBIUU_Cfam_GSD_1.0
SIRT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381067,884,656 - 67,918,390 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1067,884,656 - 67,918,390 (+)EnsemblGRCh38hg38GRCh38
GRCh371069,644,414 - 69,678,147 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361069,314,433 - 69,348,149 (+)NCBINCBI36Build 36hg18NCBI36
Build 341069,314,432 - 69,348,147NCBI
Celera1062,919,307 - 62,953,016 (+)NCBICelera
Cytogenetic Map10q21.3NCBI
HuRef1063,643,871 - 63,677,731 (+)NCBIHuRef
CHM1_11069,926,404 - 69,960,153 (+)NCBICHM1_1
T2T-CHM13v2.01068,753,401 - 68,787,131 (+)NCBIT2T-CHM13v2.0
Sirt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391063,154,784 - 63,174,814 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1063,154,784 - 63,217,483 (-)EnsemblGRCm39 Ensembl
GRCm381063,319,005 - 63,339,035 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1063,319,005 - 63,381,704 (-)EnsemblGRCm38mm10GRCm38
MGSCv371062,781,753 - 62,801,783 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361062,714,418 - 62,734,374 (-)NCBIMGSCv36mm8
Celera1064,419,012 - 64,437,105 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.57NCBI
Sirt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82025,305,953 - 25,328,000 (+)NCBIGRCr8
mRatBN7.22025,307,225 - 25,329,273 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2025,306,917 - 25,329,260 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2026,008,013 - 26,022,190 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02025,361,037 - 25,375,213 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02025,947,577 - 25,961,754 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02026,831,971 - 26,851,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2026,833,357 - 26,852,199 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,139,854 - 8,159,830 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42025,675,302 - 25,686,494 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12025,681,998 - 25,700,388 (-)NCBI
Celera2026,607,505 - 26,627,344 (+)NCBICelera
Cytogenetic Map20p11NCBI
Sirt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542520,279,963 - 20,307,663 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542520,280,725 - 20,307,663 (+)NCBIChiLan1.0ChiLan1.0
SIRT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2880,046,153 - 80,080,740 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11080,053,299 - 80,086,063 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01064,368,878 - 64,401,684 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11066,681,983 - 66,714,065 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1066,681,598 - 66,715,069 (+)Ensemblpanpan1.1panPan2
Sirt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721361,803,376 - 61,829,477 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493652110,296,097 - 10,322,215 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493652110,296,097 - 10,316,673 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1471,091,167 - 71,123,297 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11471,091,167 - 71,126,351 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21477,182,651 - 77,184,716 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21477,053,991 - 77,079,850 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SIRT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1963,463,059 - 63,497,893 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl963,462,389 - 63,497,867 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604824,231,602 - 24,266,452 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sirt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247542,304,634 - 2,330,946 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247542,304,476 - 2,332,705 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SIRT1
390 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 11 3 6 8 10 2
Low 5 5 11 6 6 6 3 6 6 4
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005618933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022417473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038473052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038473053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038473054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038473055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038489791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038534097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038534098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038534099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038534100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038598417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038598418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038598419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038598420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038662720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038662721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038662722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038662723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_546130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC342295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC342296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC342297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000021123   ⟹   ENSCAFP00000019617
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl419,188,675 - 19,218,279 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000066709   ⟹   ENSCAFP00000046446
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl419,204,691 - 19,218,279 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845002061   ⟹   ENSCAFP00845001611
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl419,454,710 - 19,484,258 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845002088   ⟹   ENSCAFP00845001637
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl419,467,529 - 19,546,039 (+)Ensembl
RefSeq Acc Id: XM_005618933   ⟹   XP_005618990
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1419,189,369 - 19,220,031 (+)NCBI
Dog10K_Boxer_Tasha419,317,985 - 19,348,641 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022417473   ⟹   XP_022273181
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1419,195,244 - 19,220,031 (+)NCBI
Dog10K_Boxer_Tasha419,323,854 - 19,348,641 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038473052   ⟹   XP_038328980
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1419,337,298 - 19,368,610 (+)NCBI
RefSeq Acc Id: XM_038473053   ⟹   XP_038328981
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1419,337,295 - 19,369,150 (+)NCBI
RefSeq Acc Id: XM_038473054   ⟹   XP_038328982
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1419,338,007 - 19,368,610 (+)NCBI
RefSeq Acc Id: XM_038473055   ⟹   XP_038328983
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1419,343,838 - 19,368,610 (+)NCBI
RefSeq Acc Id: XM_038489791   ⟹   XP_038345719
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha419,317,273 - 19,349,181 (+)NCBI
RefSeq Acc Id: XM_038534097   ⟹   XP_038390025
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0419,901,942 - 19,933,794 (+)NCBI
RefSeq Acc Id: XM_038534098   ⟹   XP_038390026
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0419,901,939 - 19,934,337 (+)NCBI
RefSeq Acc Id: XM_038534099   ⟹   XP_038390027
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0419,902,651 - 19,933,794 (+)NCBI
RefSeq Acc Id: XM_038534100   ⟹   XP_038390028
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0419,908,546 - 19,933,794 (+)NCBI
RefSeq Acc Id: XM_038598417   ⟹   XP_038454345
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0419,559,261 - 19,590,571 (+)NCBI
RefSeq Acc Id: XM_038598418   ⟹   XP_038454346
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0419,559,257 - 19,591,114 (+)NCBI
RefSeq Acc Id: XM_038598419   ⟹   XP_038454347
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0419,559,970 - 19,590,571 (+)NCBI
RefSeq Acc Id: XM_038598420   ⟹   XP_038454348
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0419,565,790 - 19,590,571 (+)NCBI
RefSeq Acc Id: XM_038662720   ⟹   XP_038518648
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0419,454,695 - 19,486,010 (+)NCBI
RefSeq Acc Id: XM_038662721   ⟹   XP_038518649
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0419,454,692 - 19,486,553 (+)NCBI
RefSeq Acc Id: XM_038662722   ⟹   XP_038518650
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0419,455,404 - 19,486,010 (+)NCBI
RefSeq Acc Id: XM_038662723   ⟹   XP_038518651
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0419,461,229 - 19,486,010 (+)NCBI
RefSeq Acc Id: XM_546130   ⟹   XP_546130
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1419,188,616 - 19,220,031 (+)NCBI
Dog10K_Boxer_Tasha419,317,276 - 19,348,641 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005618990 (Get FASTA)   NCBI Sequence Viewer  
  XP_022273181 (Get FASTA)   NCBI Sequence Viewer  
  XP_038328980 (Get FASTA)   NCBI Sequence Viewer  
  XP_038328981 (Get FASTA)   NCBI Sequence Viewer  
  XP_038328982 (Get FASTA)   NCBI Sequence Viewer  
  XP_038328983 (Get FASTA)   NCBI Sequence Viewer  
  XP_038345719 (Get FASTA)   NCBI Sequence Viewer  
  XP_038390025 (Get FASTA)   NCBI Sequence Viewer  
  XP_038390026 (Get FASTA)   NCBI Sequence Viewer  
  XP_038390027 (Get FASTA)   NCBI Sequence Viewer  
  XP_038390028 (Get FASTA)   NCBI Sequence Viewer  
  XP_038454345 (Get FASTA)   NCBI Sequence Viewer  
  XP_038454346 (Get FASTA)   NCBI Sequence Viewer  
  XP_038454347 (Get FASTA)   NCBI Sequence Viewer  
  XP_038454348 (Get FASTA)   NCBI Sequence Viewer  
  XP_038518648 (Get FASTA)   NCBI Sequence Viewer  
  XP_038518649 (Get FASTA)   NCBI Sequence Viewer  
  XP_038518650 (Get FASTA)   NCBI Sequence Viewer  
  XP_038518651 (Get FASTA)   NCBI Sequence Viewer  
  XP_546130 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BBC21266 (Get FASTA)   NCBI Sequence Viewer  
  BBC21267 (Get FASTA)   NCBI Sequence Viewer  
  BBC21268 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000019617.4
  ENSCAFP00000046446.1
  ENSCAFP00030011146.1
  ENSCAFP00030011189.1
  ENSCAFP00040003891.1
  ENSCAFP00040003904.1
  ENSCAFP00845001611
  ENSCAFP00845001611.1
  ENSCAFP00845001637
  ENSCAFP00845001637.1
Reference Protein Sequences
RefSeq Acc Id: XP_546130   ⟸   XM_546130
- Peptide Label: isoform X1
- UniProtKB: A0A8P0SHY1 (UniProtKB/TrEMBL),   A0A8C0LS40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005618990   ⟸   XM_005618933
- Peptide Label: isoform X2
- UniProtKB: A0A2Z5WQD9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022273181   ⟸   XM_022417473
- Peptide Label: isoform X3
- UniProtKB: A0A8C0PXT4 (UniProtKB/TrEMBL),   A0A8I3MJV3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000019617   ⟸   ENSCAFT00000021123
RefSeq Acc Id: ENSCAFP00000046446   ⟸   ENSCAFT00000066709
RefSeq Acc Id: XP_038328981   ⟸   XM_038473053
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038328980   ⟸   XM_038473052
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038328982   ⟸   XM_038473054
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038328983   ⟸   XM_038473055
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038454346   ⟸   XM_038598418
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038454345   ⟸   XM_038598417
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038454347   ⟸   XM_038598419
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038454348   ⟸   XM_038598420
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038518649   ⟸   XM_038662721
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PXS3 (UniProtKB/TrEMBL),   A0A8I3ME48 (UniProtKB/TrEMBL),   A0A8C0LS40 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038518648   ⟸   XM_038662720
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PXS3 (UniProtKB/TrEMBL),   A0A8I3ME48 (UniProtKB/TrEMBL),   A0A8C0LS40 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038518650   ⟸   XM_038662722
- Peptide Label: isoform X2
- UniProtKB: A0A2Z5WQD9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038518651   ⟸   XM_038662723
- Peptide Label: isoform X3
- UniProtKB: A0A8C0PXT4 (UniProtKB/TrEMBL),   A0A8I3MJV3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038345719   ⟸   XM_038489791
- Peptide Label: isoform X1
- UniProtKB: A0A8P0SHY1 (UniProtKB/TrEMBL),   A0A8C0LS40 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038390026   ⟸   XM_038534098
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LS40 (UniProtKB/TrEMBL),   A0A8C0PXS3 (UniProtKB/TrEMBL),   A0A8I3ME48 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038390025   ⟸   XM_038534097
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LS40 (UniProtKB/TrEMBL),   A0A8C0PXS3 (UniProtKB/TrEMBL),   A0A8I3ME48 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038390027   ⟸   XM_038534099
- Peptide Label: isoform X2
- UniProtKB: A0A2Z5WQD9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038390028   ⟸   XM_038534100
- Peptide Label: isoform X3
- UniProtKB: A0A8C0PXT4 (UniProtKB/TrEMBL),   A0A8I3MJV3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845001637   ⟸   ENSCAFT00845002088
RefSeq Acc Id: ENSCAFP00845001611   ⟸   ENSCAFT00845002061
Protein Domains
Deacetylase sirtuin-type

Promoters
RGD ID:13682893
Promoter ID:EPDNEW_C961
Type:multiple initiation site
Name:SIRT1_1
Description:sirtuin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1419,188,609 - 19,188,669EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013316 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030006914 UniProtKB/TrEMBL
  ENSCAFG00040002384 UniProtKB/TrEMBL
  ENSCAFG00845001191 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000021123.5 UniProtKB/TrEMBL
  ENSCAFT00000066709.2 UniProtKB/TrEMBL
  ENSCAFT00030012739.1 UniProtKB/TrEMBL
  ENSCAFT00030012795.1 UniProtKB/TrEMBL
  ENSCAFT00040004530.1 UniProtKB/TrEMBL
  ENSCAFT00040004544.1 UniProtKB/TrEMBL
  ENSCAFT00845002061 ENTREZGENE
  ENSCAFT00845002061.1 UniProtKB/TrEMBL
  ENSCAFT00845002088 ENTREZGENE
  ENSCAFT00845002088.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1600.10 UniProtKB/TrEMBL
  TPP-binding domain UniProtKB/TrEMBL
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/TrEMBL
  Sirtuin UniProtKB/TrEMBL
  Sirtuin_cat_small_dom_sf UniProtKB/TrEMBL
  Ssirtuin_cat_dom UniProtKB/TrEMBL
NCBI Gene SIRT1 ENTREZGENE
PANTHER NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1 UniProtKB/TrEMBL
  NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED UniProtKB/TrEMBL
Pfam SIR2 UniProtKB/TrEMBL
PROSITE SIRTUIN UniProtKB/TrEMBL
Superfamily-SCOP SSF52467 UniProtKB/TrEMBL
UniProt A0A2Z5WQD9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0LS40 ENTREZGENE
  A0A8C0PXS3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PXT4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3ME48 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MJV3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SHY1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:46183 ENTREZGENE