ACTA1 (actin alpha 1, skeletal muscle) - Rat Genome Database

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Gene: ACTA1 (actin alpha 1, skeletal muscle) Canis lupus familiaris
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Symbol: ACTA1
Name: actin alpha 1, skeletal muscle
RGD ID: 12210553
Description: INVOLVED IN cellular response to organonitrogen compound (ortholog); cellular response to potassium ion (ortholog); response to mechanical stimulus (ortholog); ASSOCIATED WITH Actin-Accumulation Myopathy (ortholog); aortic dissection (ortholog); centronuclear myopathy (ortholog); FOUND IN actin cytoskeleton (ortholog); sarcomere (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: actin, alpha 1, skeletal muscle; actin, alpha skeletal muscle
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.149,811,726 - 9,814,533 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl49,811,801 - 9,814,530 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha49,802,887 - 9,805,701 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.049,842,369 - 9,845,196 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.149,846,012 - 9,848,831 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.049,960,597 - 9,963,412 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0410,212,935 - 10,215,761 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:19553474   PMID:30032202  


Genomics

Comparative Map Data
ACTA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.149,811,726 - 9,814,533 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl49,811,801 - 9,814,530 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha49,802,887 - 9,805,701 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.049,842,369 - 9,845,196 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.149,846,012 - 9,848,831 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.049,960,597 - 9,963,412 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0410,212,935 - 10,215,761 (+)NCBIUU_Cfam_GSD_1.0
ACTA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381229,431,245 - 229,434,094 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1229,430,365 - 229,434,104 (-)EnsemblGRCh38hg38GRCh38
GRCh371229,566,992 - 229,569,841 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361227,633,615 - 227,636,466 (-)NCBINCBI36Build 36hg18NCBI36
Build 341225,873,729 - 225,876,578NCBI
Celera1202,835,304 - 202,838,155 (-)NCBICelera
Cytogenetic Map1q42.13NCBI
HuRef1200,057,954 - 200,060,804 (-)NCBIHuRef
CHM1_11230,839,339 - 230,842,183 (-)NCBICHM1_1
T2T-CHM13v2.01228,809,946 - 228,812,800 (-)NCBIT2T-CHM13v2.0
Acta1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398124,618,497 - 124,621,514 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8124,618,508 - 124,621,490 (-)EnsemblGRCm39 Ensembl
GRCm388123,891,758 - 123,894,775 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8123,891,769 - 123,894,751 (-)EnsemblGRCm38mm10GRCm38
MGSCv378126,415,667 - 126,418,636 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368126,777,857 - 126,780,826 (-)NCBIMGSCv36mm8
Celera8128,158,816 - 128,161,785 (-)NCBICelera
Cytogenetic Map8E2NCBI
cM Map872.26NCBI
Acta1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81968,781,168 - 68,784,194 (-)NCBIGRCr8
mRatBN7.21951,883,709 - 51,886,735 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1951,883,715 - 51,886,742 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1958,675,301 - 58,678,329 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01959,519,721 - 59,522,747 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01961,601,732 - 61,604,760 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01956,674,072 - 56,677,084 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1956,674,074 - 56,677,084 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01967,389,899 - 67,392,911 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41954,081,496 - 54,084,508 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11954,086,370 - 54,089,389 (-)NCBI
Celera1951,258,256 - 51,261,324 (-)NCBICelera
Cytogenetic Map19q12NCBI
Acta1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554928,644,146 - 8,647,523 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554928,644,696 - 8,647,412 (+)NCBIChiLan1.0ChiLan1.0
ACTA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2119,778,035 - 19,780,912 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1119,970,319 - 19,973,196 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01204,975,646 - 204,978,523 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11210,007,622 - 210,010,459 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1210,007,622 - 210,010,469 (-)Ensemblpanpan1.1panPan2
Acta1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934444,071,243 - 44,074,156 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648420,236,320 - 20,239,430 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648420,236,320 - 20,239,385 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1460,412,812 - 60,415,674 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11460,412,651 - 60,415,687 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21465,236,192 - 65,239,197 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACTA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12566,700,448 - 66,703,325 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2566,700,369 - 66,714,891 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605568,553,718 - 68,559,732 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acta1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477519,650,822 - 19,654,730 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477519,650,923 - 19,653,707 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ACTA1
116 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 5 6
Medium 4 6 4 1 5 8 1
Low 11 2 2 2 3 7 7 5
Below cutoff 1 5 4 4 2 2 1

Sequence


RefSeq Acc Id: ENSCAFT00000013094   ⟹   ENSCAFP00000012116
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl49,811,801 - 9,814,530 (+)Ensembl
RefSeq Acc Id: XM_005618839   ⟹   XP_005618896
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.149,811,726 - 9,814,533 (+)NCBI
Dog10K_Boxer_Tasha49,802,887 - 9,805,701 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038472924   ⟹   XP_038328852
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.149,846,012 - 9,848,831 (+)NCBI
RefSeq Acc Id: XM_038533952   ⟹   XP_038389880
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0410,212,935 - 10,215,761 (+)NCBI
RefSeq Acc Id: XM_038598270   ⟹   XP_038454198
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.049,960,597 - 9,963,412 (+)NCBI
RefSeq Acc Id: XM_038662577   ⟹   XP_038518505
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.049,842,369 - 9,845,196 (+)NCBI
RefSeq Acc Id: XP_005618896   ⟸   XM_005618839
- UniProtKB: A0A8C0LYE1 (UniProtKB/TrEMBL),   A0A8C0N2I3 (UniProtKB/TrEMBL),   A0A8P0NAG9 (UniProtKB/TrEMBL),   A0A8C0RXG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000012116   ⟸   ENSCAFT00000013094
RefSeq Acc Id: XP_038328852   ⟸   XM_038472924
RefSeq Acc Id: XP_038454198   ⟸   XM_038598270
RefSeq Acc Id: XP_038518505   ⟸   XM_038662577
- UniProtKB: A0A8C0LYE1 (UniProtKB/TrEMBL),   A0A8C0N2I3 (UniProtKB/TrEMBL),   A0A8P0NAG9 (UniProtKB/TrEMBL),   A0A8C0RXG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038389880   ⟸   XM_038533952
- UniProtKB: A0A8C0LYE1 (UniProtKB/TrEMBL),   A0A8C0N2I3 (UniProtKB/TrEMBL),   A0A8C0RXG1 (UniProtKB/TrEMBL),   A0A8P0NAG9 (UniProtKB/TrEMBL)

Promoters
RGD ID:13682878
Promoter ID:EPDNEW_C947
Type:multiple initiation site
Name:ACTA1_1
Description:actin, alpha 1, skeletal muscle
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.149,812,755 - 9,812,815EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008253 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030012637 UniProtKB/TrEMBL
  ENSCAFG00040003826 UniProtKB/TrEMBL
  ENSCAFG00845001416 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000013094.5 UniProtKB/TrEMBL
  ENSCAFT00030023384.1 UniProtKB/TrEMBL
  ENSCAFT00030023459.1 UniProtKB/TrEMBL
  ENSCAFT00030023554.1 UniProtKB/TrEMBL
  ENSCAFT00030023624.1 UniProtKB/TrEMBL
  ENSCAFT00030023714.1 UniProtKB/TrEMBL
  ENSCAFT00040007292.1 UniProtKB/TrEMBL
  ENSCAFT00845002426.1 UniProtKB/TrEMBL
  ENSCAFT00845002450 ENTREZGENE
  ENSCAFT00845002450.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.40 UniProtKB/TrEMBL
InterPro Actin UniProtKB/TrEMBL
  Actin/actin-like_CS UniProtKB/TrEMBL
  Actin_CS UniProtKB/TrEMBL
  ATPase_NBD UniProtKB/TrEMBL
NCBI Gene ACTA1 ENTREZGENE
PANTHER ACTIN UniProtKB/TrEMBL
  ACTIN, ALPHA SKELETAL MUSCLE UniProtKB/TrEMBL
  PTHR11937 UniProtKB/TrEMBL
Pfam Actin UniProtKB/TrEMBL
PRINTS ACTIN UniProtKB/TrEMBL
PROSITE ACTINS_1 UniProtKB/TrEMBL
  ACTINS_2 UniProtKB/TrEMBL
  ACTINS_ACT_LIKE UniProtKB/TrEMBL
SMART ACTIN UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/TrEMBL
UniProt A0A8C0LYE1 ENTREZGENE
  A0A8C0N224_CANLF UniProtKB/TrEMBL
  A0A8C0N2I3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0N5G9_CANLF UniProtKB/TrEMBL
  A0A8C0NGT2_CANLF UniProtKB/TrEMBL
  A0A8C0RIY7_CANLF UniProtKB/TrEMBL
  A0A8C0RXG1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MHG9_CANLF UniProtKB/TrEMBL
  A0A8I3MKF4_CANLF UniProtKB/TrEMBL
  A0A8P0NAG9 ENTREZGENE
UniProt Secondary A0A8P0NAG9 UniProtKB/TrEMBL
VGNC ID VGNC:37538 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-22 ACTA1  actin alpha 1, skeletal muscle    actin, alpha 1, skeletal muscle  Symbol and/or name change 5135510 APPROVED